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Q8CHL0

- FZD5_RAT

UniProt

Q8CHL0 - FZD5_RAT

Protein

Frizzled-5

Gene

Fzd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. PDZ domain binding Source: RefGenome
    3. Wnt-activated receptor activity Source: RefGenome
    4. Wnt-protein binding Source: RGD

    GO - Biological processi

    1. angiogenesis Source: RefGenome
    2. apoptotic process Source: RefGenome
    3. axonogenesis Source: RefGenome
    4. brain development Source: RefGenome
    5. canonical Wnt signaling pathway Source: RefGenome
    6. embryonic camera-type eye development Source: RefGenome
    7. gonad development Source: RefGenome
    8. labyrinthine layer blood vessel development Source: RefGenome
    9. post-embryonic camera-type eye development Source: RefGenome
    10. T cell differentiation in thymus Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Frizzled-5
    Short name:
    Fz-5
    Gene namesi
    Name:Fzd5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi631406. Fzd5.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity
    Note: Localized at the plasma membrane and also found at the Golgi.By similarity

    GO - Cellular componenti

    1. cell projection Source: RefGenome
    2. cytoplasm Source: RefGenome
    3. Golgi membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 585559Frizzled-5PRO_0000243937Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 94PROSITE-ProRule annotation
    Disulfide bondi41 ↔ 87PROSITE-ProRule annotation
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi78 ↔ 116PROSITE-ProRule annotation
    Disulfide bondi105 ↔ 147PROSITE-ProRule annotation
    Disulfide bondi109 ↔ 133PROSITE-ProRule annotation
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ8CHL0.

    PTM databases

    PhosphoSiteiQ8CHL0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8CHL0.

    Interactioni

    Subunit structurei

    Interacts with GOPC.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000062259.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CHL0.
    SMRiQ8CHL0. Positions 33-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 238212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31524ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini337 – 35822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini380 – 40223ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini424 – 44926CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini471 – 50030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini522 – 58564CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei239 – 25921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei359 – 37921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei450 – 47021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei501 – 52121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 150123FZPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi525 – 5306Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity
    Motifi583 – 5853PDZ-bindingBy similarity

    Domaini

    The PDZ-binding motif mediates interaction with GOPC.By similarity
    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257258.
    HOGENOMiHOG000233236.
    HOVERGENiHBG006977.
    KOiK02375.
    PhylomeDBiQ8CHL0.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026547. FZD5.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF29. PTHR11309:SF29. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CHL0-1 [UniParc]FASTAAdd to Basket

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    MARPDPSAPP SLLLLLLAQL VGRAAAASKA PVCQEITVPM CRGIGYNLTH    50
    MPNQFNHDTQ DEAGLEVHQF WPLVEIHCSP DLRFFLCSMY TPICLPDYHK 100
    PLPPCRSVCE RAKAGCSPLM RQYGFAWPER MSCDRLPVLG GDAEVLCMDY 150
    NRSEATTASP KSFPAKPTLP GPPGAPSSGG ECPSGGPSVC TCREPFVPIL 200
    KESHPLYNKV RTGQVPNCAV PCYQPSFSPD ERTFATFWIG LWSVLCFIST 250
    STTVATFLID MERFRYPERP IIFLSACYLC VSLGFLVRLV VGHASVACSR 300
    EHSHIHYETT GPALCTVVFL LVYFFGMASS IWWVILSLTW FLAAGMKWGN 350
    EAIAGYAQYF HLAAWLIPSV KSITALALSS VDGDPVAGVC YVGNQNLNSL 400
    RGFVLGPLVL YLLVGTLFLL AGFVSLFRIR SVIKQGGTKT DKLEKLMIRI 450
    GIFTLLYTVP ASIVVACYLY EQHYRESWEA ALTCACPGSD AGQPRAKPEY 500
    WVLMLKYFMC LVVGITSGVW IWSGKTLESW RRFTSRCCCS SRRGHKSGGA 550
    MVAGDYAEAS AALTGRTGPP GPAAAYHKQV SLSHV 585
    Length:585
    Mass (Da):64,112
    Last modified:March 1, 2003 - v1
    Checksum:iBF26772B29FA12C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052909 mRNA. Translation: BAC53980.1.
    RefSeqiNP_776210.1. NM_173838.1.
    UniGeneiRn.24792.

    Genome annotation databases

    GeneIDi317674.
    KEGGirno:317674.
    UCSCiRGD:631406. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052909 mRNA. Translation: BAC53980.1 .
    RefSeqi NP_776210.1. NM_173838.1.
    UniGenei Rn.24792.

    3D structure databases

    ProteinModelPortali Q8CHL0.
    SMRi Q8CHL0. Positions 33-152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000062259.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8CHL0.

    Proteomic databases

    PaxDbi Q8CHL0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 317674.
    KEGGi rno:317674.
    UCSCi RGD:631406. rat.

    Organism-specific databases

    CTDi 7855.
    RGDi 631406. Fzd5.

    Phylogenomic databases

    eggNOGi NOG257258.
    HOGENOMi HOG000233236.
    HOVERGENi HBG006977.
    KOi K02375.
    PhylomeDBi Q8CHL0.

    Miscellaneous databases

    NextBioi 672065.
    PROi Q8CHL0.

    Gene expression databases

    Genevestigatori Q8CHL0.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026547. FZD5.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF29. PTHR11309:SF29. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a gene encoding for rat Frizzled 5."
      Ito S., Imamura T., Shiota K.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiFZD5_RAT
    AccessioniPrimary (citable) accession number: Q8CHL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3