ID   NQO1_CAVPO              Reviewed;         275 AA.
AC   Q8CHK7;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=NAD(P)H dehydrogenase [quinone] 1;
DE            EC=1.6.5.2;
DE   AltName: Full=Quinone reductase 1;
DE   AltName: Full=NAD(P)H:quinone oxidoreductase 1;
DE            Short=QR1;
DE   AltName: Full=DT-diaphorase;
DE            Short=DTD;
DE   AltName: Full=Azoreductase;
DE   AltName: Full=Phylloquinone reductase;
DE   AltName: Full=Menadione reductase;
GN   Name=NQO1;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hartley;
RA   Itoh K., Takahashi Y., Kitagawa M., Kamataki T.;
RT   "Inhibition of the transcription of the guinea pig NAD(P)H: quinone
RT   oxidoreductase1 (NQO1) gene by specificity protein 1 (Sp1).";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The enzyme apparently serves as a quinone reductase in
CC       connection with conjugation reactions of hydroquinons involved in
CC       detoxification pathways as well as in biosynthetic processes such
CC       as the vitamin K-dependent gamma-carboxylation of glutamate
CC       residues in prothrombin synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: NAD(P)H + a quinone = NAD(P)(+) + a
CC       hydroquinone.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the NAD(P)H dehydrogenase (quinone) family.
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DR   EMBL; AB055403; BAC53985.1; -; mRNA.
DR   HSSP; P15559; 1H69.
DR   SMR; Q8CHK7; 5-275.
DR   Ensembl; ENSCPOG00000012430; Cavia porcellus.
DR   HOVERGEN; Q8CHK7; -.
DR   OMA; Q8CHK7; ESIWDET.
DR   BRENDA; 1.6.5.2; 44.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0003955; F:NAD(P)H dehydrogenase (quinone) activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR003680; Flavodoxin_fold.
DR   Pfam; PF02525; Flavodoxin_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; FAD; Flavoprotein; NAD; NADP; Oxidoreductase.
FT   CHAIN         1    275       NAD(P)H dehydrogenase [quinone] 1.
FT                                /FTId=PRO_0000071621.
FT   NP_BIND      19     20       FAD (By similarity).
FT   NP_BIND     105    108       FAD (By similarity).
FT   NP_BIND     149    152       FAD (By similarity).
FT   REGION      127    129       Substrate binding (By similarity).
FT   BINDING      13     13       FAD (By similarity).
FT   BINDING      68     68       FAD (By similarity).
FT   BINDING     157    157       FAD (By similarity).
FT   BINDING     202    202       FAD (By similarity).
SQ   SEQUENCE   275 AA;  31086 MW;  15C475E39A7176C0 CRC64;
     MAALRRALII LAHSEKTSFN YAMKEAAVEA LQRKGWEVAV SDLYAMKFDP IISRKDITGA
     LKDPENFQYP AESALAYKES RLSPDIVTEQ KKVEEADLLI FQFPLQWFGV PAILKGWFER
     VFTGGFAYTY AAMYDKGPFQ NKKAVLSITT GGSESMYSLK GIHGDMNIIL WPIQSGTLHF
     CGFQVLEPQL TYGIGHTPPD VRTEILAGWK KRLENIWDET PLYFAPSSLF DLNFQAGFLL
     KKEIEDEQKN NKYGLSVGHH LGKPIPTDNQ IKARK
//