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Q8CHK7 (NQO1_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD(P)H dehydrogenase [quinone] 1

EC=1.6.5.2
Alternative name(s):
Azoreductase
DT-diaphorase
Short name=DTD
Menadione reductase
NAD(P)H:quinone oxidoreductase 1
Phylloquinone reductase
Quinone reductase 1
Short name=QR1
Gene names
Name:NQO1
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis By similarity.

Catalytic activity

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.

Cofactor

FAD By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the NAD(P)H dehydrogenase (quinone) family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
NAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of catalytic activity

Inferred from electronic annotation. Source: Ensembl

response to oxidative stress

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNAD(P)H dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275NAD(P)H dehydrogenase [quinone] 1
PRO_0000071621

Regions

Nucleotide binding19 – 202FAD By similarity
Nucleotide binding105 – 1084FAD By similarity
Nucleotide binding149 – 1524FAD By similarity
Region127 – 1293Substrate binding By similarity

Sites

Binding site131FAD By similarity
Binding site681FAD By similarity
Binding site1571FAD By similarity
Binding site2021FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CHK7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 15C475E39A7176C0

FASTA27531,086
        10         20         30         40         50         60 
MAALRRALII LAHSEKTSFN YAMKEAAVEA LQRKGWEVAV SDLYAMKFDP IISRKDITGA 

        70         80         90        100        110        120 
LKDPENFQYP AESALAYKES RLSPDIVTEQ KKVEEADLLI FQFPLQWFGV PAILKGWFER 

       130        140        150        160        170        180 
VFTGGFAYTY AAMYDKGPFQ NKKAVLSITT GGSESMYSLK GIHGDMNIIL WPIQSGTLHF 

       190        200        210        220        230        240 
CGFQVLEPQL TYGIGHTPPD VRTEILAGWK KRLENIWDET PLYFAPSSLF DLNFQAGFLL 

       250        260        270 
KKEIEDEQKN NKYGLSVGHH LGKPIPTDNQ IKARK 

« Hide

References

[1]"Inhibition of the transcription of the guinea pig NAD(P)H: quinone oxidoreductase1 (NQO1) gene by specificity protein 1 (Sp1)."
Itoh K., Takahashi Y., Kitagawa M., Kamataki T.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Hartley.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB055403 mRNA. Translation: BAC53985.1.
RefSeqNP_001166457.1. NM_001172986.1.

3D structure databases

ProteinModelPortalQ8CHK7.
SMRQ8CHK7. Positions 3-275.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000011185.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCPOT00000012549; ENSCPOP00000011185; ENSCPOG00000012430.
GeneID100135582.

Organism-specific databases

CTD1728.

Phylogenomic databases

eggNOGCOG2249.
GeneTreeENSGT00440000033410.
HOGENOMHOG000149970.
HOVERGENHBG029104.
InParanoidQ8CHK7.
OMAYDVLPPF.
OrthoDBEOG7CZK6F.
TreeFamTF300296.

Family and domain databases

InterProIPR003680. Flavodoxin_fold.
[Graphical view]
PfamPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNQO1_CAVPO
AccessionPrimary (citable) accession number: Q8CHK7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families