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Protein

NAD(P)H dehydrogenase [quinone] 1

Gene

NQO1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.By similarity

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei13FADBy similarity1
Binding sitei68FADBy similarity1
Binding sitei157FADBy similarity1
Binding sitei202FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 20FADBy similarity2
Nucleotide bindingi105 – 108FADBy similarity4
Nucleotide bindingi149 – 152FADBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD, NADP

Enzyme and pathway databases

BRENDAi1.6.5.2. 1225.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H dehydrogenase [quinone] 1 (EC:1.6.5.2)
Alternative name(s):
Azoreductase
DT-diaphorase
Short name:
DTD
Menadione reductase
NAD(P)H:quinone oxidoreductase 1
Phylloquinone reductase
Quinone reductase 1
Short name:
QR1
Gene namesi
Name:NQO1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000716211 – 275NAD(P)H dehydrogenase [quinone] 1Add BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineBy similarity1
Cross-linki252Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Expressioni

Gene expression databases

BgeeiENSCPOG00000012430.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000011185.

Structurei

3D structure databases

ProteinModelPortaliQ8CHK7.
SMRiQ8CHK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 129Substrate bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IKWF. Eukaryota.
COG2249. LUCA.
HOGENOMiHOG000149970.
HOVERGENiHBG029104.
InParanoidiQ8CHK7.
OMAiLFPIHHG.
OrthoDBiEOG091G183R.
TreeFamiTF300296.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiView protein in InterPro
IPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like_sf.
PfamiView protein in Pfam
PF02525. Flavodoxin_2. 1 hit.
SUPFAMiSSF52218. SSF52218. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CHK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALRRALII LAHSEKTSFN YAMKEAAVEA LQRKGWEVAV SDLYAMKFDP
60 70 80 90 100
IISRKDITGA LKDPENFQYP AESALAYKES RLSPDIVTEQ KKVEEADLLI
110 120 130 140 150
FQFPLQWFGV PAILKGWFER VFTGGFAYTY AAMYDKGPFQ NKKAVLSITT
160 170 180 190 200
GGSESMYSLK GIHGDMNIIL WPIQSGTLHF CGFQVLEPQL TYGIGHTPPD
210 220 230 240 250
VRTEILAGWK KRLENIWDET PLYFAPSSLF DLNFQAGFLL KKEIEDEQKN
260 270
NKYGLSVGHH LGKPIPTDNQ IKARK
Length:275
Mass (Da):31,086
Last modified:March 1, 2003 - v1
Checksum:i15C475E39A7176C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055403 mRNA. Translation: BAC53985.1.
RefSeqiNP_001166457.1. NM_001172986.1.

Genome annotation databases

GeneIDi100135582.

Similar proteinsi

Entry informationi

Entry nameiNQO1_CAVPO
AccessioniPrimary (citable) accession number: Q8CHK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families