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Q8CHK7

- NQO1_CAVPO

UniProt

Q8CHK7 - NQO1_CAVPO

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Protein

NAD(P)H dehydrogenase [quinone] 1

Gene

NQO1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.By similarity

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.

Cofactori

FAD.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131FADBy similarity
Binding sitei68 – 681FADBy similarity
Binding sitei157 – 1571FADBy similarity
Binding sitei202 – 2021FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 202FADBy similarity
Nucleotide bindingi105 – 1084FADBy similarity
Nucleotide bindingi149 – 1524FADBy similarity

GO - Molecular functioni

  1. NAD(P)H dehydrogenase (quinone) activity Source: UniProtKB-EC
  2. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. negative regulation of catalytic activity Source: Ensembl
  2. response to oxidative stress Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H dehydrogenase [quinone] 1 (EC:1.6.5.2)
Alternative name(s):
Azoreductase
DT-diaphorase
Short name:
DTD
Menadione reductase
NAD(P)H:quinone oxidoreductase 1
Phylloquinone reductase
Quinone reductase 1
Short name:
QR1
Gene namesi
Name:NQO1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275NAD(P)H dehydrogenase [quinone] 1PRO_0000071621Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000011185.

Structurei

3D structure databases

ProteinModelPortaliQ8CHK7.
SMRiQ8CHK7. Positions 3-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2249.
GeneTreeiENSGT00440000033410.
HOGENOMiHOG000149970.
HOVERGENiHBG029104.
InParanoidiQ8CHK7.
OMAiYDKGPFQ.
OrthoDBiEOG7CZK6F.
TreeFamiTF300296.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like.
[Graphical view]
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CHK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALRRALII LAHSEKTSFN YAMKEAAVEA LQRKGWEVAV SDLYAMKFDP
60 70 80 90 100
IISRKDITGA LKDPENFQYP AESALAYKES RLSPDIVTEQ KKVEEADLLI
110 120 130 140 150
FQFPLQWFGV PAILKGWFER VFTGGFAYTY AAMYDKGPFQ NKKAVLSITT
160 170 180 190 200
GGSESMYSLK GIHGDMNIIL WPIQSGTLHF CGFQVLEPQL TYGIGHTPPD
210 220 230 240 250
VRTEILAGWK KRLENIWDET PLYFAPSSLF DLNFQAGFLL KKEIEDEQKN
260 270
NKYGLSVGHH LGKPIPTDNQ IKARK
Length:275
Mass (Da):31,086
Last modified:March 1, 2003 - v1
Checksum:i15C475E39A7176C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB055403 mRNA. Translation: BAC53985.1.
RefSeqiNP_001166457.1. NM_001172986.1.

Genome annotation databases

EnsembliENSCPOT00000012549; ENSCPOP00000011185; ENSCPOG00000012430.
GeneIDi100135582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB055403 mRNA. Translation: BAC53985.1 .
RefSeqi NP_001166457.1. NM_001172986.1.

3D structure databases

ProteinModelPortali Q8CHK7.
SMRi Q8CHK7. Positions 3-275.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000011185.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCPOT00000012549 ; ENSCPOP00000011185 ; ENSCPOG00000012430 .
GeneIDi 100135582.

Organism-specific databases

CTDi 1728.

Phylogenomic databases

eggNOGi COG2249.
GeneTreei ENSGT00440000033410.
HOGENOMi HOG000149970.
HOVERGENi HBG029104.
InParanoidi Q8CHK7.
OMAi YDKGPFQ.
OrthoDBi EOG7CZK6F.
TreeFami TF300296.

Family and domain databases

Gene3Di 3.40.50.360. 1 hit.
InterProi IPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like.
[Graphical view ]
Pfami PF02525. Flavodoxin_2. 1 hit.
[Graphical view ]
SUPFAMi SSF52218. SSF52218. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Inhibition of the transcription of the guinea pig NAD(P)H: quinone oxidoreductase1 (NQO1) gene by specificity protein 1 (Sp1)."
    Itoh K., Takahashi Y., Kitagawa M., Kamataki T.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hartley.

Entry informationi

Entry nameiNQO1_CAVPO
AccessioniPrimary (citable) accession number: Q8CHK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3