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Reviewed, UniProtKB/Swiss-Prot Q8CHK7 (NQO1_CAVPO)

Last modified June 16, 2009. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    NAD(P)H dehydrogenase [quinone] 1
    EC=1.6.5.2
Alternative name(s):
    Quinone reductase 1
    NAD(P)H:quinone oxidoreductase 1
      Short name=QR1
    DT-diaphorase
      Short name=DTD
    Azoreductase
    Phylloquinone reductase
    Menadione reductase
Gene names
Name: NQO1
OrganismCavia porcellus (Guinea pig)
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

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Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis By similarity.

Catalytic activity

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.

Cofactor

FAD By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the NAD(P)H dehydrogenase (quinone) family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
NAD
NADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD(P)H dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: EC

coenzyme binding

Inferred from electronic annotation. Source: InterPro

electron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275NAD(P)H dehydrogenase [quinone] 1
PRO_0000071621

Regions

Nucleotide binding19 – 202FAD By similarity
Nucleotide binding105 – 1084FAD By similarity
Nucleotide binding149 – 1524FAD By similarity
Region127 – 1293Substrate binding By similarity

Sites

Binding site131FAD By similarity
Binding site681FAD By similarity
Binding site1571FAD By similarity
Binding site2021FAD By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q8CHK7-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 15C475E39A7176C0

FASTA27531,086
        10         20         30         40         50         60 
MAALRRALII LAHSEKTSFN YAMKEAAVEA LQRKGWEVAV SDLYAMKFDP IISRKDITGA 

        70         80         90        100        110        120 
LKDPENFQYP AESALAYKES RLSPDIVTEQ KKVEEADLLI FQFPLQWFGV PAILKGWFER 

       130        140        150        160        170        180 
VFTGGFAYTY AAMYDKGPFQ NKKAVLSITT GGSESMYSLK GIHGDMNIIL WPIQSGTLHF 

       190        200        210        220        230        240 
CGFQVLEPQL TYGIGHTPPD VRTEILAGWK KRLENIWDET PLYFAPSSLF DLNFQAGFLL 

       250        260        270 
KKEIEDEQKN NKYGLSVGHH LGKPIPTDNQ IKARK

« Hide

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References

[1]"Inhibition of the transcription of the guinea pig NAD(P)H: quinone oxidoreductase1 (NQO1) gene by specificity protein 1 (Sp1)."
Itoh K., Takahashi Y., Kitagawa M., Kamataki T.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Hartley.

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Cross-references

Sequence databases

AB055403 mRNA. Translation: BAC53985.1.

3D structure databases

HSSPHSSP built from PDB template 1H69 based on UniProtKB P15559.
SMRQ8CHK7. Positions 5-275.
ModBaseSearch...

Genome annotation databases

EnsemblENSCPOG00000012430. Cavia porcellus. [Contig view]

Phylogenomic databases

HOVERGENQ8CHK7.
OMAQ8CHK7. ESIWDET.

Enzyme and pathway databases

BRENDA1.6.5.2. 44.

Family and domain databases

InterProIPR003680. Flavodoxin_fold.
[Graphical view]
PfamPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameNQO1_CAVPO
AccessionPrimary (citable) accession number: Q8CHK7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 1, 2003
Last modified: June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents