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Q8CHK7

- NQO1_CAVPO

UniProt

Q8CHK7 - NQO1_CAVPO

Protein

NAD(P)H dehydrogenase [quinone] 1

Gene

NQO1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.By similarity

    Catalytic activityi

    NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.

    Cofactori

    FAD.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei13 – 131FADBy similarity
    Binding sitei68 – 681FADBy similarity
    Binding sitei157 – 1571FADBy similarity
    Binding sitei202 – 2021FADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 202FADBy similarity
    Nucleotide bindingi105 – 1084FADBy similarity
    Nucleotide bindingi149 – 1524FADBy similarity

    GO - Molecular functioni

    1. NAD(P)H dehydrogenase (quinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. negative regulation of catalytic activity Source: Ensembl
    2. response to oxidative stress Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD(P)H dehydrogenase [quinone] 1 (EC:1.6.5.2)
    Alternative name(s):
    Azoreductase
    DT-diaphorase
    Short name:
    DTD
    Menadione reductase
    NAD(P)H:quinone oxidoreductase 1
    Phylloquinone reductase
    Quinone reductase 1
    Short name:
    QR1
    Gene namesi
    Name:NQO1
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275NAD(P)H dehydrogenase [quinone] 1PRO_0000071621Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000011185.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CHK7.
    SMRiQ8CHK7. Positions 3-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni127 – 1293Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2249.
    GeneTreeiENSGT00440000033410.
    HOGENOMiHOG000149970.
    HOVERGENiHBG029104.
    InParanoidiQ8CHK7.
    OMAiYDKGPFQ.
    OrthoDBiEOG7CZK6F.
    TreeFamiTF300296.

    Family and domain databases

    Gene3Di3.40.50.360. 1 hit.
    InterProiIPR003680. Flavodoxin_fold.
    IPR029039. Flavoprotein-like.
    [Graphical view]
    PfamiPF02525. Flavodoxin_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF52218. SSF52218. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8CHK7-1 [UniParc]FASTAAdd to Basket

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    MAALRRALII LAHSEKTSFN YAMKEAAVEA LQRKGWEVAV SDLYAMKFDP    50
    IISRKDITGA LKDPENFQYP AESALAYKES RLSPDIVTEQ KKVEEADLLI 100
    FQFPLQWFGV PAILKGWFER VFTGGFAYTY AAMYDKGPFQ NKKAVLSITT 150
    GGSESMYSLK GIHGDMNIIL WPIQSGTLHF CGFQVLEPQL TYGIGHTPPD 200
    VRTEILAGWK KRLENIWDET PLYFAPSSLF DLNFQAGFLL KKEIEDEQKN 250
    NKYGLSVGHH LGKPIPTDNQ IKARK 275
    Length:275
    Mass (Da):31,086
    Last modified:March 1, 2003 - v1
    Checksum:i15C475E39A7176C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB055403 mRNA. Translation: BAC53985.1.
    RefSeqiNP_001166457.1. NM_001172986.1.

    Genome annotation databases

    EnsembliENSCPOT00000012549; ENSCPOP00000011185; ENSCPOG00000012430.
    GeneIDi100135582.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB055403 mRNA. Translation: BAC53985.1 .
    RefSeqi NP_001166457.1. NM_001172986.1.

    3D structure databases

    ProteinModelPortali Q8CHK7.
    SMRi Q8CHK7. Positions 3-275.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000011185.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCPOT00000012549 ; ENSCPOP00000011185 ; ENSCPOG00000012430 .
    GeneIDi 100135582.

    Organism-specific databases

    CTDi 1728.

    Phylogenomic databases

    eggNOGi COG2249.
    GeneTreei ENSGT00440000033410.
    HOGENOMi HOG000149970.
    HOVERGENi HBG029104.
    InParanoidi Q8CHK7.
    OMAi YDKGPFQ.
    OrthoDBi EOG7CZK6F.
    TreeFami TF300296.

    Family and domain databases

    Gene3Di 3.40.50.360. 1 hit.
    InterProi IPR003680. Flavodoxin_fold.
    IPR029039. Flavoprotein-like.
    [Graphical view ]
    Pfami PF02525. Flavodoxin_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52218. SSF52218. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Inhibition of the transcription of the guinea pig NAD(P)H: quinone oxidoreductase1 (NQO1) gene by specificity protein 1 (Sp1)."
      Itoh K., Takahashi Y., Kitagawa M., Kamataki T.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Hartley.

    Entry informationi

    Entry nameiNQO1_CAVPO
    AccessioniPrimary (citable) accession number: Q8CHK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3