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Protein

Lysophospholipid acyltransferase 7

Gene

Mboat7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a lysophospholipid acyltransferase (LPLAT). LPLATs catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (By similarity).By similarity

GO - Molecular functioni

  • lysophospholipid acyltransferase activity Source: MGI

GO - Biological processi

  • layer formation in cerebral cortex Source: MGI
  • phosphatidylinositol metabolic process Source: MGI
  • phospholipid biosynthetic process Source: UniProtKB-KW
  • ventricular system development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-1482922. Acyl chain remodelling of PI.

Chemistry

SwissLipidsiSLP:000000285.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipid acyltransferase 7 (EC:2.3.1.-)
Short name:
LPLAT 7
Alternative name(s):
Bladder and breast carcinoma-overexpressed gene 1 protein
Leukocyte receptor cluster member 4
Membrane-bound O-acyltransferase domain-containing protein 7
Short name:
O-acyltransferase domain-containing protein 7
Short name:
m-mboa-7
Gene namesi
Name:Mboat7
Synonyms:Bb1, Leng4, Oact7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1924832. Mboat7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence analysisAdd
BLAST
Transmembranei44 – 6421HelicalSequence analysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence analysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence analysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence analysisAdd
BLAST
Transmembranei429 – 44921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Lysophospholipid acyltransferase 7PRO_0000317458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8CHK3.
MaxQBiQ8CHK3.
PaxDbiQ8CHK3.
PRIDEiQ8CHK3.

PTM databases

PhosphoSiteiQ8CHK3.

Expressioni

Gene expression databases

BgeeiQ8CHK3.
ExpressionAtlasiQ8CHK3. baseline and differential.
GenevisibleiQ8CHK3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037107.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2706. Eukaryota.
COG5202. LUCA.
GeneTreeiENSGT00550000074565.
HOGENOMiHOG000045421.
HOVERGENiHBG105712.
InParanoidiQ8CHK3.
KOiK13516.
OMAiFFVFRMR.
OrthoDBiEOG7BGHKQ.
PhylomeDBiQ8CHK3.
TreeFamiTF320024.

Family and domain databases

InterProiIPR004299. MBOAT_fam.
[Graphical view]
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CHK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPEEWTYLM VLLISIPVGF LFKKAGPGLK RWGAAAVGLG LTLFTCGPHS
60 70 80 90 100
LHSLITILGT WALIQAQPCS CHALALAWTF SYLLFFRALS LLGLPTPTPF
110 120 130 140 150
TNAVQLLLTL KLVSLASEVQ DLHLAQRKEI ASGFHKEPTL GLLPEVPSLM
160 170 180 190 200
ETLSYSYCYV GIMTGPFFRY RTYLDWLEQP FPEAVPSLRP LLRRAWPAPL
210 220 230 240 250
FGLLFLLSSH LFPLEAVRED AFYARPLPTR LFYMIPVFFA FRMRFYVAWI
260 270 280 290 300
AAECGCIAAG FGAYPVAAKA RAGGGPTLQC PPPSSPEIAA SLEYDYETIR
310 320 330 340 350
NIDCYGTDFC VRVRDGMRYW NMTVQWWLAQ YIYKSAPFRS YVLRSAWTML
360 370 380 390 400
LSAYWHGLHP GYYLSFMTIP LCLAAEGYLE SALRRHLSPG GQKAWDWVHW
410 420 430 440 450
FLKMRAYDYM CMGFVLLSMA DTLRYWASIY FWVHFLALAC LGLGLVLGGG
460 470
SPSKRKTPSQ ATSSQAKEKL REE
Length:473
Mass (Da):53,436
Last modified:March 1, 2003 - v1
Checksum:iCFB4FE0DB2951C4F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti335 – 3351S → R in BAB31950 (PubMed:16141072).Curated
Sequence conflicti339 – 3391R → C in BAE41580 (PubMed:16141072).Curated
Sequence conflicti339 – 3391R → C in AAI18959 (PubMed:15489334).Curated
Sequence conflicti339 – 3391R → C in AAH23417 (PubMed:15489334).Curated
Sequence conflicti341 – 3411Y → C in BAE29235 (PubMed:16141072).Curated
Sequence conflicti386 – 3861H → Q in BAE29235 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055410 mRNA. Translation: BAC53808.1.
EU016380 mRNA. Translation: ABV66272.1.
AK019981 mRNA. Translation: BAB31950.1.
AK150010 mRNA. Translation: BAE29235.1.
AK154606 mRNA. Translation: BAE32708.1.
AK170124 mRNA. Translation: BAE41580.1.
BC023417 mRNA. Translation: AAH23417.1.
BC118958 mRNA. Translation: AAI18959.1.
CCDSiCCDS20724.1.
RefSeqiNP_084210.2. NM_029934.3.
XP_006540495.1. XM_006540432.2.
UniGeneiMm.397541.

Genome annotation databases

EnsembliENSMUST00000038608; ENSMUSP00000037107; ENSMUSG00000035596.
GeneIDi77582.
KEGGimmu:77582.
UCSCiuc009evq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055410 mRNA. Translation: BAC53808.1.
EU016380 mRNA. Translation: ABV66272.1.
AK019981 mRNA. Translation: BAB31950.1.
AK150010 mRNA. Translation: BAE29235.1.
AK154606 mRNA. Translation: BAE32708.1.
AK170124 mRNA. Translation: BAE41580.1.
BC023417 mRNA. Translation: AAH23417.1.
BC118958 mRNA. Translation: AAI18959.1.
CCDSiCCDS20724.1.
RefSeqiNP_084210.2. NM_029934.3.
XP_006540495.1. XM_006540432.2.
UniGeneiMm.397541.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037107.

Chemistry

SwissLipidsiSLP:000000285.

PTM databases

PhosphoSiteiQ8CHK3.

Proteomic databases

EPDiQ8CHK3.
MaxQBiQ8CHK3.
PaxDbiQ8CHK3.
PRIDEiQ8CHK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038608; ENSMUSP00000037107; ENSMUSG00000035596.
GeneIDi77582.
KEGGimmu:77582.
UCSCiuc009evq.1. mouse.

Organism-specific databases

CTDi79143.
MGIiMGI:1924832. Mboat7.

Phylogenomic databases

eggNOGiKOG2706. Eukaryota.
COG5202. LUCA.
GeneTreeiENSGT00550000074565.
HOGENOMiHOG000045421.
HOVERGENiHBG105712.
InParanoidiQ8CHK3.
KOiK13516.
OMAiFFVFRMR.
OrthoDBiEOG7BGHKQ.
PhylomeDBiQ8CHK3.
TreeFamiTF320024.

Enzyme and pathway databases

ReactomeiR-MMU-1482922. Acyl chain remodelling of PI.

Miscellaneous databases

NextBioi347150.
PROiQ8CHK3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CHK3.
ExpressionAtlasiQ8CHK3. baseline and differential.
GenevisibleiQ8CHK3. MM.

Family and domain databases

InterProiIPR004299. MBOAT_fam.
[Graphical view]
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of novel mouse genes that were differentially expressed in W/W(v) mouse fundus."
    Daigo Y., Takayama I., Ward S.M., Sanders K.M., Fujino M.A.
    J. Gastroenterol. 39:238-241(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: W/Wv.
  2. "Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol."
    Lee H.C., Inoue T., Imae R., Kono N., Shirae S., Matsuda S., Gengyo-Ando K., Mitani S., Arai H.
    Mol. Biol. Cell 19:1174-1184(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiMBOA7_MOUSE
AccessioniPrimary (citable) accession number: Q8CHK3
Secondary accession number(s): Q3UDM6, Q8R1P9, Q9CY76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.