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Protein

Lysophospholipid acyltransferase 7

Gene

Mboat7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor (PubMed:23097495). Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (By similarity). Required for cortical lamination during brain development (PubMed:23097495).By similarity1 Publication

Catalytic activityi

Acyl-CoA + 1-acyl-sn-glycero-3-phosphatidylinositol = CoA + 1,2-diacyl-sn-glycero-3-phosphatidylinositol.By similarity
Acyl-[acyl-carrier-protein] + 1-acyl-sn-glycerol 3-phosphate = [acyl-carrier-protein] + 1,2-diacyl-sn-glycerol 3-phosphate.By similarity

Pathwayi: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

GO - Molecular functioni

  • lysophospholipid acyltransferase activity Source: MGI

GO - Biological processi

  • layer formation in cerebral cortex Source: MGI
  • phosphatidylinositol metabolic process Source: MGI
  • phospholipid biosynthetic process Source: UniProtKB-KW
  • ventricular system development Source: MGI

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-1482922. Acyl chain remodelling of PI.
UniPathwayiUPA00085.

Chemistry databases

SwissLipidsiSLP:000000285.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipid acyltransferase 7Curated (EC:2.3.1.-By similarity)
Short name:
LPLAT 7Curated
Alternative name(s):
1-acylglycerophosphatidylinositol O-acyltransferaseBy similarity (EC:2.3.1.n4By similarity)
Bladder and breast carcinoma-overexpressed gene 1 proteinCurated
Leukocyte receptor cluster member 4Curated
Lysophosphatidylinositol acyltransferase 11 Publication
Short name:
LPIAT11 Publication
Membrane-bound O-acyltransferase domain-containing protein 7Curated
Short name:
O-acyltransferase domain-containing protein 7Curated
Short name:
m-mboa-7Curated
Gene namesi
Name:Mboat7Imported
Synonyms:Bb1, Leng4, Lpiat11 Publication, Oact7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1924832. Mboat7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Knockout mice die within a month and show atrophy of the cerebral cortex and hippocampus. Embryos at E18.5 have a forebrain smaller in size and show disordered cortical lamination and delayed neuronal migration in the cortex.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174581 – 473Lysophospholipid acyltransferase 7Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8CHK3.
MaxQBiQ8CHK3.
PaxDbiQ8CHK3.
PeptideAtlasiQ8CHK3.
PRIDEiQ8CHK3.

PTM databases

iPTMnetiQ8CHK3.
PhosphoSitePlusiQ8CHK3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035596.
ExpressionAtlasiQ8CHK3. baseline and differential.
GenevisibleiQ8CHK3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037107.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2706. Eukaryota.
COG5202. LUCA.
GeneTreeiENSGT00550000074565.
HOGENOMiHOG000045421.
HOVERGENiHBG105712.
InParanoidiQ8CHK3.
KOiK13516.
OMAiLSECVCT.
OrthoDBiEOG091G074Q.
PhylomeDBiQ8CHK3.
TreeFamiTF320024.

Family and domain databases

InterProiView protein in InterPro
IPR004299. MBOAT_fam.
PfamiView protein in Pfam
PF03062. MBOAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CHK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPEEWTYLM VLLISIPVGF LFKKAGPGLK RWGAAAVGLG LTLFTCGPHS
60 70 80 90 100
LHSLITILGT WALIQAQPCS CHALALAWTF SYLLFFRALS LLGLPTPTPF
110 120 130 140 150
TNAVQLLLTL KLVSLASEVQ DLHLAQRKEI ASGFHKEPTL GLLPEVPSLM
160 170 180 190 200
ETLSYSYCYV GIMTGPFFRY RTYLDWLEQP FPEAVPSLRP LLRRAWPAPL
210 220 230 240 250
FGLLFLLSSH LFPLEAVRED AFYARPLPTR LFYMIPVFFA FRMRFYVAWI
260 270 280 290 300
AAECGCIAAG FGAYPVAAKA RAGGGPTLQC PPPSSPEIAA SLEYDYETIR
310 320 330 340 350
NIDCYGTDFC VRVRDGMRYW NMTVQWWLAQ YIYKSAPFRS YVLRSAWTML
360 370 380 390 400
LSAYWHGLHP GYYLSFMTIP LCLAAEGYLE SALRRHLSPG GQKAWDWVHW
410 420 430 440 450
FLKMRAYDYM CMGFVLLSMA DTLRYWASIY FWVHFLALAC LGLGLVLGGG
460 470
SPSKRKTPSQ ATSSQAKEKL REE
Length:473
Mass (Da):53,436
Last modified:March 1, 2003 - v1
Checksum:iCFB4FE0DB2951C4F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti335S → R in BAB31950 (PubMed:16141072).Curated1
Sequence conflicti339R → C in BAE41580 (PubMed:16141072).Curated1
Sequence conflicti339R → C in AAI18959 (PubMed:15489334).Curated1
Sequence conflicti339R → C in AAH23417 (PubMed:15489334).Curated1
Sequence conflicti341Y → C in BAE29235 (PubMed:16141072).Curated1
Sequence conflicti386H → Q in BAE29235 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055410 mRNA. Translation: BAC53808.1.
EU016380 mRNA. Translation: ABV66272.1.
AK019981 mRNA. Translation: BAB31950.1.
AK150010 mRNA. Translation: BAE29235.1.
AK154606 mRNA. Translation: BAE32708.1.
AK170124 mRNA. Translation: BAE41580.1.
BC023417 mRNA. Translation: AAH23417.1.
BC118958 mRNA. Translation: AAI18959.1.
CCDSiCCDS20724.1.
RefSeqiNP_084210.2. NM_029934.3.
XP_006540495.1. XM_006540432.3.
UniGeneiMm.397541.

Genome annotation databases

EnsembliENSMUST00000038608; ENSMUSP00000037107; ENSMUSG00000035596.
GeneIDi77582.
KEGGimmu:77582.
UCSCiuc009evq.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMBOA7_MOUSE
AccessioniPrimary (citable) accession number: Q8CHK3
Secondary accession number(s): Q3UDM6, Q8R1P9, Q9CY76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families