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Q8CHK2 (REL3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Relaxin-3
Alternative name(s):
Insulin-like peptide INSL7
Short name=Insulin-like peptide 7
Prorelaxin M3

Cleaved into the following 2 chains:

  1. Relaxin-3 B chain
  2. Relaxin-3 A chain
Gene names
Name:Rln3
Synonyms:Insl7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length141 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 By similarity.

Subunit structure

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Subcellular location

Secreted.

Tissue specificity

High expression in the brain localized to the pons/medulla with highest levels in pars ventromedialis of the dorsal tegmental nucleus. Significant expression is also detected in the spleen, thymus, lung, testis and ovary. Ref.2

Sequence similarities

Belongs to the insulin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpositive regulation of cAMP biosynthetic process

Inferred from sequence alignment Ref.2. Source: MGI

   Cellular_componentextracellular region

Traceable author statement Ref.2. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Peptide25 – 5127Relaxin-3 B chain By similarity
PRO_0000016085
Propeptide54 – 11764Connecting peptide By similarity
PRO_0000016086
Peptide118 – 14124Relaxin-3 A chain By similarity
PRO_0000016087

Amino acid modifications

Disulfide bond34 ↔ 128Interchain (between B and A chains) By similarity
Disulfide bond46 ↔ 141Interchain (between B and A chains) By similarity
Disulfide bond127 ↔ 132 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CHK2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 0899CD9F57552951

FASTA14114,926
        10         20         30         40         50         60 
MAMLGLLLLA SWALLGALGL QAEARPAPYG VKLCGREFIR AVIFTCGGSR WRRADILAHE 

        70         80         90        100        110        120 
SLGDFFADGE ANTDHLASEL DEAVGSSEWL ALTKSPQAFY GGRASWQGSP GVVRGSRDVL 

       130        140 
AGLSSSCCEW GCSKSQISSL C 

« Hide

References

[1]"Production of recombinant human relaxin 3 in AtT20 cells."
Kizawa H., Nishi K., Ishibashi Y., Harada M., Asano T., Ito Y., Suzuki N., Hinuma S., Fujisawa Y., Onda H., Nishimura O., Fujino M.
Regul. Pept. 113:79-84(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family."
Bathgate R.A.D., Samuel C.S., Burazin T.C.D., Layfield S., Claasz A.A., Reytomas I.G.T., Dawson N.F., Zhao C., Bond C., Summers R.J., Parry L.J., Wade J.D., Tregear G.W.
J. Biol. Chem. 277:1148-1157(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB076565 mRNA. Translation: BAC53760.1.
RefSeqNP_775276.1. NM_173184.1.
UniGeneMm.261583.

3D structure databases

ProteinModelPortalQ8CHK2.
SMRQ8CHK2. Positions 25-51, 112-141.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000051392.

PTM databases

PhosphoSiteQ8CHK2.

Proteomic databases

PRIDEQ8CHK2.

Protocols and materials databases

DNASU212108.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000061923; ENSMUSP00000051392; ENSMUSG00000045232.
GeneID212108.
KEGGmmu:212108.
UCSCuc009mls.1. mouse.

Organism-specific databases

CTD117579.
MGIMGI:2158015. Rln3.

Phylogenomic databases

eggNOGNOG45013.
GeneTreeENSGT00510000048203.
HOGENOMHOG000111888.
HOVERGENHBG045048.
InParanoidQ8CHK2.
KOK05255.
OMARPSWQGT.
OrthoDBEOG7H1JNG.
PhylomeDBQ8CHK2.
TreeFamTF333404.

Gene expression databases

BgeeQ8CHK2.
CleanExMM_RLN3.
GenevestigatorQ8CHK2.

Family and domain databases

InterProIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSPR00276. INSULINFAMLY.
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMSSF56994. SSF56994. 2 hits.
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio373450.
PROQ8CHK2.
SOURCESearch...

Entry information

Entry nameREL3_MOUSE
AccessionPrimary (citable) accession number: Q8CHK2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot