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Q8CHK2

- REL3_MOUSE

UniProt

Q8CHK2 - REL3_MOUSE

Protein

Relaxin-3

Gene

Rln3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 By similarity.By similarity

    GO - Biological processi

    1. positive regulation of cAMP biosynthetic process Source: MGI

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_198713. Relaxin receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Relaxin-3
    Alternative name(s):
    Insulin-like peptide INSL7
    Short name:
    Insulin-like peptide 7
    Prorelaxin M3
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Rln3
    Synonyms:Insl7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2158015. Rln3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Peptidei25 – 5127Relaxin-3 B chainBy similarityPRO_0000016085Add
    BLAST
    Propeptidei54 – 11764Connecting peptideBy similarityPRO_0000016086Add
    BLAST
    Peptidei118 – 14124Relaxin-3 A chainBy similarityPRO_0000016087Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 128Interchain (between B and A chains)By similarity
    Disulfide bondi46 ↔ 141Interchain (between B and A chains)By similarity
    Disulfide bondi127 ↔ 132By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiQ8CHK2.

    PTM databases

    PhosphoSiteiQ8CHK2.

    Expressioni

    Tissue specificityi

    High expression in the brain localized to the pons/medulla with highest levels in pars ventromedialis of the dorsal tegmental nucleus. Significant expression is also detected in the spleen, thymus, lung, testis and ovary.1 Publication

    Gene expression databases

    BgeeiQ8CHK2.
    CleanExiMM_RLN3.
    GenevestigatoriQ8CHK2.

    Interactioni

    Subunit structurei

    Heterodimer of a B chain and an A chain linked by two disulfide bonds.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000051392.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CHK2.
    SMRiQ8CHK2. Positions 25-51.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45013.
    GeneTreeiENSGT00510000048203.
    HOGENOMiHOG000111888.
    HOVERGENiHBG045048.
    InParanoidiQ8CHK2.
    KOiK05255.
    OMAiEARASPY.
    OrthoDBiEOG7H1JNG.
    PhylomeDBiQ8CHK2.
    TreeFamiTF333404.

    Family and domain databases

    InterProiIPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    PRINTSiPR00276. INSULINFAMLY.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 2 hits.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CHK2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMLGLLLLA SWALLGALGL QAEARPAPYG VKLCGREFIR AVIFTCGGSR    50
    WRRADILAHE SLGDFFADGE ANTDHLASEL DEAVGSSEWL ALTKSPQAFY 100
    GGRASWQGSP GVVRGSRDVL AGLSSSCCEW GCSKSQISSL C 141
    Length:141
    Mass (Da):14,926
    Last modified:March 1, 2003 - v1
    Checksum:i0899CD9F57552951
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076565 mRNA. Translation: BAC53760.1.
    CCDSiCCDS22466.1.
    RefSeqiNP_775276.1. NM_173184.1.
    UniGeneiMm.261583.

    Genome annotation databases

    EnsembliENSMUST00000061923; ENSMUSP00000051392; ENSMUSG00000045232.
    GeneIDi212108.
    KEGGimmu:212108.
    UCSCiuc009mls.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076565 mRNA. Translation: BAC53760.1 .
    CCDSi CCDS22466.1.
    RefSeqi NP_775276.1. NM_173184.1.
    UniGenei Mm.261583.

    3D structure databases

    ProteinModelPortali Q8CHK2.
    SMRi Q8CHK2. Positions 25-51.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000051392.

    PTM databases

    PhosphoSitei Q8CHK2.

    Proteomic databases

    PRIDEi Q8CHK2.

    Protocols and materials databases

    DNASUi 212108.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061923 ; ENSMUSP00000051392 ; ENSMUSG00000045232 .
    GeneIDi 212108.
    KEGGi mmu:212108.
    UCSCi uc009mls.1. mouse.

    Organism-specific databases

    CTDi 117579.
    MGIi MGI:2158015. Rln3.

    Phylogenomic databases

    eggNOGi NOG45013.
    GeneTreei ENSGT00510000048203.
    HOGENOMi HOG000111888.
    HOVERGENi HBG045048.
    InParanoidi Q8CHK2.
    KOi K05255.
    OMAi EARASPY.
    OrthoDBi EOG7H1JNG.
    PhylomeDBi Q8CHK2.
    TreeFami TF333404.

    Enzyme and pathway databases

    Reactomei REACT_198713. Relaxin receptors.

    Miscellaneous databases

    NextBioi 373450.
    PROi Q8CHK2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CHK2.
    CleanExi MM_RLN3.
    Genevestigatori Q8CHK2.

    Family and domain databases

    InterProi IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    PRINTSi PR00276. INSULINFAMLY.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 2 hits.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family."
      Bathgate R.A.D., Samuel C.S., Burazin T.C.D., Layfield S., Claasz A.A., Reytomas I.G.T., Dawson N.F., Zhao C., Bond C., Summers R.J., Parry L.J., Wade J.D., Tregear G.W.
      J. Biol. Chem. 277:1148-1157(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiREL3_MOUSE
    AccessioniPrimary (citable) accession number: Q8CHK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3