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Protein

Relaxin-3

Gene

Rln3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_298562. Relaxin receptors.
REACT_313192. G alpha (s) signalling events.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin-3
Alternative name(s):
Insulin-like peptide INSL7
Short name:
Insulin-like peptide 7
Prorelaxin M3
Cleaved into the following 2 chains:
Gene namesi
Name:Rln3
Synonyms:Insl7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2158015. Rln3.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Peptidei25 – 5127Relaxin-3 B chainBy similarityPRO_0000016085Add
BLAST
Propeptidei54 – 11764Connecting peptideBy similarityPRO_0000016086Add
BLAST
Peptidei118 – 14124Relaxin-3 A chainBy similarityPRO_0000016087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 128Interchain (between B and A chains)By similarity
Disulfide bondi46 ↔ 141Interchain (between B and A chains)By similarity
Disulfide bondi127 ↔ 132By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiQ8CHK2.

PTM databases

PhosphoSiteiQ8CHK2.

Expressioni

Tissue specificityi

High expression in the brain localized to the pons/medulla with highest levels in pars ventromedialis of the dorsal tegmental nucleus. Significant expression is also detected in the spleen, thymus, lung, testis and ovary.1 Publication

Gene expression databases

BgeeiQ8CHK2.
CleanExiMM_RLN3.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051392.

Structurei

3D structure databases

ProteinModelPortaliQ8CHK2.
SMRiQ8CHK2. Positions 25-51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45013.
GeneTreeiENSGT00510000048203.
HOGENOMiHOG000111888.
HOVERGENiHBG045048.
InParanoidiQ8CHK2.
KOiK05255.
OMAiEARASPY.
OrthoDBiEOG7H1JNG.
PhylomeDBiQ8CHK2.
TreeFamiTF333404.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CHK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMLGLLLLA SWALLGALGL QAEARPAPYG VKLCGREFIR AVIFTCGGSR
60 70 80 90 100
WRRADILAHE SLGDFFADGE ANTDHLASEL DEAVGSSEWL ALTKSPQAFY
110 120 130 140
GGRASWQGSP GVVRGSRDVL AGLSSSCCEW GCSKSQISSL C
Length:141
Mass (Da):14,926
Last modified:March 1, 2003 - v1
Checksum:i0899CD9F57552951
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076565 mRNA. Translation: BAC53760.1.
CCDSiCCDS22466.1.
RefSeqiNP_775276.1. NM_173184.1.
UniGeneiMm.261583.

Genome annotation databases

EnsembliENSMUST00000061923; ENSMUSP00000051392; ENSMUSG00000045232.
GeneIDi212108.
KEGGimmu:212108.
UCSCiuc009mls.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076565 mRNA. Translation: BAC53760.1.
CCDSiCCDS22466.1.
RefSeqiNP_775276.1. NM_173184.1.
UniGeneiMm.261583.

3D structure databases

ProteinModelPortaliQ8CHK2.
SMRiQ8CHK2. Positions 25-51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051392.

PTM databases

PhosphoSiteiQ8CHK2.

Proteomic databases

PRIDEiQ8CHK2.

Protocols and materials databases

DNASUi212108.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061923; ENSMUSP00000051392; ENSMUSG00000045232.
GeneIDi212108.
KEGGimmu:212108.
UCSCiuc009mls.1. mouse.

Organism-specific databases

CTDi117579.
MGIiMGI:2158015. Rln3.

Phylogenomic databases

eggNOGiNOG45013.
GeneTreeiENSGT00510000048203.
HOGENOMiHOG000111888.
HOVERGENiHBG045048.
InParanoidiQ8CHK2.
KOiK05255.
OMAiEARASPY.
OrthoDBiEOG7H1JNG.
PhylomeDBiQ8CHK2.
TreeFamiTF333404.

Enzyme and pathway databases

ReactomeiREACT_298562. Relaxin receptors.
REACT_313192. G alpha (s) signalling events.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi373450.
PROiQ8CHK2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CHK2.
CleanExiMM_RLN3.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family."
    Bathgate R.A.D., Samuel C.S., Burazin T.C.D., Layfield S., Claasz A.A., Reytomas I.G.T., Dawson N.F., Zhao C., Bond C., Summers R.J., Parry L.J., Wade J.D., Tregear G.W.
    J. Biol. Chem. 277:1148-1157(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiREL3_MOUSE
AccessioniPrimary (citable) accession number: Q8CHK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.