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Q8CHK2

- REL3_MOUSE

UniProt

Q8CHK2 - REL3_MOUSE

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Protein

Relaxin-3

Gene

Rln3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity).By similarity

GO - Biological processi

  1. positive regulation of cAMP biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_198713. Relaxin receptors.
REACT_242871. G alpha (s) signalling events.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin-3
Alternative name(s):
Insulin-like peptide INSL7
Short name:
Insulin-like peptide 7
Prorelaxin M3
Cleaved into the following 2 chains:
Gene namesi
Name:Rln3
Synonyms:Insl7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2158015. Rln3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Peptidei25 – 5127Relaxin-3 B chainBy similarityPRO_0000016085Add
BLAST
Propeptidei54 – 11764Connecting peptideBy similarityPRO_0000016086Add
BLAST
Peptidei118 – 14124Relaxin-3 A chainBy similarityPRO_0000016087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 128Interchain (between B and A chains)By similarity
Disulfide bondi46 ↔ 141Interchain (between B and A chains)By similarity
Disulfide bondi127 ↔ 132By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiQ8CHK2.

PTM databases

PhosphoSiteiQ8CHK2.

Expressioni

Tissue specificityi

High expression in the brain localized to the pons/medulla with highest levels in pars ventromedialis of the dorsal tegmental nucleus. Significant expression is also detected in the spleen, thymus, lung, testis and ovary.1 Publication

Gene expression databases

BgeeiQ8CHK2.
CleanExiMM_RLN3.
GenevestigatoriQ8CHK2.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051392.

Structurei

3D structure databases

ProteinModelPortaliQ8CHK2.
SMRiQ8CHK2. Positions 25-51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45013.
GeneTreeiENSGT00510000048203.
HOGENOMiHOG000111888.
HOVERGENiHBG045048.
InParanoidiQ8CHK2.
KOiK05255.
OMAiEARASPY.
OrthoDBiEOG7H1JNG.
PhylomeDBiQ8CHK2.
TreeFamiTF333404.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CHK2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMLGLLLLA SWALLGALGL QAEARPAPYG VKLCGREFIR AVIFTCGGSR
60 70 80 90 100
WRRADILAHE SLGDFFADGE ANTDHLASEL DEAVGSSEWL ALTKSPQAFY
110 120 130 140
GGRASWQGSP GVVRGSRDVL AGLSSSCCEW GCSKSQISSL C
Length:141
Mass (Da):14,926
Last modified:March 1, 2003 - v1
Checksum:i0899CD9F57552951
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076565 mRNA. Translation: BAC53760.1.
CCDSiCCDS22466.1.
RefSeqiNP_775276.1. NM_173184.1.
UniGeneiMm.261583.

Genome annotation databases

EnsembliENSMUST00000061923; ENSMUSP00000051392; ENSMUSG00000045232.
GeneIDi212108.
KEGGimmu:212108.
UCSCiuc009mls.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076565 mRNA. Translation: BAC53760.1 .
CCDSi CCDS22466.1.
RefSeqi NP_775276.1. NM_173184.1.
UniGenei Mm.261583.

3D structure databases

ProteinModelPortali Q8CHK2.
SMRi Q8CHK2. Positions 25-51.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000051392.

PTM databases

PhosphoSitei Q8CHK2.

Proteomic databases

PRIDEi Q8CHK2.

Protocols and materials databases

DNASUi 212108.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061923 ; ENSMUSP00000051392 ; ENSMUSG00000045232 .
GeneIDi 212108.
KEGGi mmu:212108.
UCSCi uc009mls.1. mouse.

Organism-specific databases

CTDi 117579.
MGIi MGI:2158015. Rln3.

Phylogenomic databases

eggNOGi NOG45013.
GeneTreei ENSGT00510000048203.
HOGENOMi HOG000111888.
HOVERGENi HBG045048.
InParanoidi Q8CHK2.
KOi K05255.
OMAi EARASPY.
OrthoDBi EOG7H1JNG.
PhylomeDBi Q8CHK2.
TreeFami TF333404.

Enzyme and pathway databases

Reactomei REACT_198713. Relaxin receptors.
REACT_242871. G alpha (s) signalling events.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 373450.
PROi Q8CHK2.
SOURCEi Search...

Gene expression databases

Bgeei Q8CHK2.
CleanExi MM_RLN3.
Genevestigatori Q8CHK2.

Family and domain databases

InterProi IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF00049. Insulin. 1 hit.
[Graphical view ]
PRINTSi PR00276. INSULINFAMLY.
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 2 hits.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family."
    Bathgate R.A.D., Samuel C.S., Burazin T.C.D., Layfield S., Claasz A.A., Reytomas I.G.T., Dawson N.F., Zhao C., Bond C., Summers R.J., Parry L.J., Wade J.D., Tregear G.W.
    J. Biol. Chem. 277:1148-1157(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiREL3_MOUSE
AccessioniPrimary (citable) accession number: Q8CHK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3