Q8CHJ2 (AQP12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aquaporin-12
Short name=AQP-12

Gene names

Name:

Aqp12

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Aquaporins facilitate the transport of water and small neutral solutes across cell membranes By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Restricted to pancreatic acinar cells. Ref.1
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily. [View classification]

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay Ref.1. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Aquaporin-12		PRO_0000063972
Regions
	Transmembrane	1 – 21	21	Helical; Name=1; Potential
	Transmembrane	67 – 87	21	Helical; Name=2; Potential
	Transmembrane	112 – 138	27	Helical; Name=3; Potential
	Transmembrane	158 – 178	21	Helical; Name=4; Potential
	Transmembrane	191 – 211	21	Helical; Name=5; Potential
	Transmembrane	228 – 248	21	Helical; Name=6; Potential
	Motif	93 – 95	3	NPA 1
	Motif	212 – 214	3	NPA 2

Sequences

	Sequence		Length	Mass (Da)
	Q8CHJ2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 2945B01824429C63	FASTA	290	31,290
	10 20 30 40 50 60 MASLNVSLCF FFATCAICEV ARRASKALLP AGTYASFARG AVGAAQLAAC CLEMRVLVEL 70 80 90 100 110 120 GPWAGGFGPD LLLTLVFLLF LVHGVTFDGA SANPTVALQE FLMVEASLPN TLLKLSAQVL 130 140 150 160 170 180 GAQAACALTQ RCWAWELSEL HLLQSLMAAH CSSTLRTSVL QGMLVEGACT FFFHLSLLHL 190 200 210 220 230 240 QHSLLVYRVP ALALLVTLMA YTAGPYTSAF FNPALAASVT FHCPGNTLLE YAHVYCLGPV 250 260 270 280 290 AGMILAVLLH QGHLPRLFQR NLFYRQKSKY RTPRGKLSPG SVDAKMHKGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells." Itoh T., Rai T., Kuwahara M., Ko S.B., Uchida S., Sasaki S., Ishibashi K. Biochem. Biophys. Res. Commun. 330:832-838(2005) [PubMed: 15809071] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB084104 mRNA. Translation: BAC45227.1. BC107213 mRNA. Translation: AAI07214.1.
IPI	IPI00229660.
RefSeq	NP_808255.1. NM_177587.2.
UniGene	Mm.235537.
3D structure databases
ProteinModelPortal	Q8CHJ2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CHJ2.
Proteomic databases
PRIDE	Q8CHJ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000059676; ENSMUSP00000060622; ENSMUSG00000045091.
GeneID	208760.
KEGG	mmu:208760.
UCSC	uc007cdc.2. mouse.
Organism-specific databases
CTD	208760.
MGI	MGI:2664636. Aqp12.
Phylogenomic databases
GeneTree	ENSGT00530000063816.
HOGENOM	HBG506431.
HOVERGEN	HBG050557.
InParanoid	Q8CHJ2.
OMA	HMIKNLM.
OrthoDB	EOG4VT5Z2.
PhylomeDB	Q8CHJ2.
Gene expression databases
ArrayExpress	Q8CHJ2.
Bgee	Q8CHJ2.
CleanEx	MM_AQP12.
Genevestigator	Q8CHJ2.
GermOnline	ENSMUSG00000045091. Mus musculus.
Family and domain databases
InterPro	IPR023271. Aquaporin-like. IPR016697. Aquaporin_11/12. IPR023265. Aquaporin_12. IPR000425. MIP. [Graphical view]
Gene3D	G3DSA:1.20.1080.10. MIP. 1 hit.
KO	K09871.
PANTHER	PTHR21191:SF8. Aquaporin_12. 1 hit.
Pfam	PF00230. MIP. 1 hit. [Graphical view]
PIRSF	PIRSF017529. Aquaporin_11/12. 1 hit.
PRINTS	PR02025. AQUAPORIN12. PR00783. MINTRINSICP.
SUPFAM	SSF81338. MIP. 1 hit.
PROSITE	PS00221. MIP. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	372407.
SOURCE	Search...

Entry information

Entry name

AQP12_MOUSE

Accession

Primary (citable) accession number: Q8CHJ2
Secondary accession number(s): Q3KNM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	March 1, 2003
Last modified:	November 16, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program