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Protein

Septin-8

Gene

Sept8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106GTP; via amide nitrogenBy similarity1
Binding sitei241GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei256GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 58GTPBy similarity8
Nucleotide bindingi187 – 195GTPBy similarity9

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-8
Gene namesi
Name:Sept8
Synonyms:Kiaa0202
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:894310 Sept8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001735342 – 429Septin-8Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei10PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8CHH9
PaxDbiQ8CHH9
PRIDEiQ8CHH9

2D gel databases

UCD-2DPAGEiQ8CHH9

PTM databases

iPTMnetiQ8CHH9
PhosphoSitePlusiQ8CHH9
SwissPalmiQ8CHH9

Expressioni

Gene expression databases

BgeeiENSMUSG00000018398
CleanExiMM_SEPT8
ExpressionAtlasiQ8CHH9 baseline and differential
GenevisibleiQ8CHH9 MM

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with CDK14, SEPT4, SEPT5 and SEPT7 (By similarity).By similarity

Protein-protein interaction databases

BioGridi203177, 1 interactor
IntActiQ8CHH9, 5 interactors
MINTiQ8CHH9
STRINGi10090.ENSMUSP00000112920

Structurei

3D structure databases

ProteinModelPortaliQ8CHH9
SMRiQ8CHH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 307Septin-type GPROSITE-ProRule annotationAdd BLAST267

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 58G1 motifPROSITE-ProRule annotation8
Regioni103 – 106G3 motifPROSITE-ProRule annotation4
Regioni186 – 189G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili320 – 412Sequence analysisAdd BLAST93

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144070
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ8CHH9
KOiK16939
PhylomeDBiQ8CHH9
TreeFamiTF101080

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR030646 SEPT8
IPR016491 Septin
PANTHERiPTHR18884:SF54 PTHR18884:SF54, 1 hit
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CHH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATDLERVS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV
60 70 80 90 100
GETGIGKSTL MNTLFNTTFE TEEASHHEEC VRLRPQTYDL QESNVHLKLT
110 120 130 140 150
IVDAVGFGDQ INKDDSYRPI VDYIDAQFEN YLQEELKIRR SLFDYHDTRI
160 170 180 190 200
HVCLYFITPT GHSLKSLDLV TMKKLDSKVN IIPIIAKADT ISKSELHKFK
210 220 230 240 250
IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV GSTEEVKVGN
260 270 280 290 300
KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY
310 320 330 340 350
RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN
360 370 380 390 400
KVKETELELK EKERELHEKF EHLKRIHQEE KRKVEEKRRE LEEETNAFNC
410 420
RKAAMEALQS QALHATSQQP LRKDKDKKN
Length:429
Mass (Da):49,812
Last modified:January 23, 2007 - v4
Checksum:i133485FF0E8D3300
GO
Isoform 2 (identifier: Q8CHH9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-429: N → KF

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:430
Mass (Da):49,974
Checksum:i69B44485FF0E8D33
GO

Sequence cautioni

The sequence AAH49819 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC41399 differs from that shown. Reason: Frameshift at position 37.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58S → A in BAC41399 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009645429N → KF in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093215 mRNA Translation: BAC41399.1 Sequence problems.
AL596095 Genomic DNA No translation available.
BC049819 mRNA Translation: AAH49819.1 Different initiation.
BC059248 mRNA Translation: AAH59248.1
AF179996 mRNA Translation: AAG09408.1
CCDSiCCDS48794.1 [Q8CHH9-2]
CCDS56768.1 [Q8CHH9-1]
RefSeqiNP_001239261.1, NM_001252332.1 [Q8CHH9-1]
NP_001239262.1, NM_001252333.1
NP_149156.1, NM_033144.2 [Q8CHH9-2]
UniGeneiMm.274399
Mm.359575

Genome annotation databases

EnsembliENSMUST00000108987; ENSMUSP00000104615; ENSMUSG00000018398 [Q8CHH9-1]
ENSMUST00000117061; ENSMUSP00000112920; ENSMUSG00000018398 [Q8CHH9-2]
GeneIDi20362
KEGGimmu:20362
UCSCiuc007iwh.2 mouse [Q8CHH9-1]
uc007iwj.2 mouse [Q8CHH9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSEPT8_MOUSE
AccessioniPrimary (citable) accession number: Q8CHH9
Secondary accession number(s): B1AQY7, Q80YC7, Q9ESF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 132 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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