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Q8CHG7

- RPGF2_MOUSE

UniProt

Q8CHG7 - RPGF2_MOUSE

Protein

Rap guanine nucleotide exchange factor 2

Gene

Rapgef2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions.6 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi135 – 254120cNMPAdd
    BLAST

    GO - Molecular functioni

    1. beta-1 adrenergic receptor binding Source: UniProtKB
    2. cAMP binding Source: UniProtKB
    3. GTPase activator activity Source: UniProtKB-KW
    4. PDZ domain binding Source: UniProtKB
    5. Rap guanyl-nucleotide exchange factor activity Source: UniProtKB
    6. Ras guanyl-nucleotide exchange factor activity Source: UniProtKB
    7. WW domain binding Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-activating adrenergic receptor signaling pathway Source: UniProtKB
    2. blood vessel development Source: UniProtKB
    3. brain-derived neurotrophic factor receptor signaling pathway Source: UniProtKB
    4. cAMP-mediated signaling Source: UniProtKB
    5. cellular response to cAMP Source: UniProtKB
    6. cellular response to cGMP Source: UniProtKB
    7. cellular response to nerve growth factor stimulus Source: UniProtKB
    8. establishment of endothelial barrier Source: UniProtKB
    9. forebrain neuron development Source: UniProtKB
    10. G-protein coupled receptor signaling pathway Source: UniProtKB
    11. negative regulation of cell proliferation Source: UniProtKB
    12. negative regulation of dendrite morphogenesis Source: UniProtKB
    13. negative regulation of melanin biosynthetic process Source: UniProtKB
    14. nerve growth factor signaling pathway Source: UniProtKB
    15. neuron migration Source: UniProtKB
    16. neuron projection development Source: UniProtKB
    17. neuropeptide signaling pathway Source: UniProtKB
    18. positive regulation of cAMP-dependent protein kinase activity Source: UniProtKB
    19. positive regulation of cAMP-mediated signaling Source: UniProtKB
    20. positive regulation of dendritic cell apoptotic process Source: UniProtKB
    21. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    22. positive regulation of neuron migration Source: UniProtKB
    23. positive regulation of neuron projection development Source: UniProtKB
    24. positive regulation of protein binding Source: UniProtKB
    25. positive regulation of protein kinase activity Source: UniProtKB
    26. positive regulation of Rap GTPase activity Source: UniProtKB
    27. positive regulation of Ras GTPase activity Source: UniProtKB
    28. positive regulation of vasculogenesis Source: UniProtKB
    29. Rap protein signal transduction Source: UniProtKB
    30. regulation of cell junction assembly Source: UniProtKB
    31. regulation of synaptic plasticity Source: UniProtKB
    32. ventricular system development Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, GTPase activation, Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rap guanine nucleotide exchange factor 2
    Alternative name(s):
    Cyclic nucleotide ras GEF
    Short name:
    CNrasGEF
    Neural RAP guanine nucleotide exchange protein
    Short name:
    nRap GEP
    PDZ domain-containing guanine nucleotide exchange factor 1
    Short name:
    PDZ-GEF1
    RA-GEF-1
    Ras/Rap1-associating GEF-1
    Gene namesi
    Name:Rapgef2
    Synonyms:Kiaa0313, Pdzgef1
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2659071. Rapgef2.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Cell membrane By similarity. Late endosome By similarity. Cell junction By similarity
    Note: Associated with the synaptic plasma membrane. Localized diffusely in the cytoplasm before neuronal growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with the high affinity nerve growth factor receptor NTRK1 at late endosomes. Translocated to the perinuclear region in a RAP1A-dependent manner. Translocated to the cell membrane. Colocalized with CTNNB1 at cell-cell contacts By similarity.By similarity

    GO - Cellular componenti

    1. cell-cell junction Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. late endosome Source: UniProtKB
    4. membrane Source: UniProtKB
    5. neuronal cell body Source: UniProtKB
    6. neuron projection Source: UniProtKB
    7. perinuclear region of cytoplasm Source: UniProtKB
    8. plasma membrane Source: UniProtKB
    9. protein complex Source: UniProtKB
    10. synapse Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Endosome, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice appear normal until 7.5 dpc, but become grossly abnormal and dead at mid-gestation. Show severe defects in yolk sac blood and major vessels formation. Show impair callosal axons to cross the midline during cortical development. Show disruption of all three midline commissure fibers crossing, the corpus callosum, the anterior commissure and the dorsal hippocampal commissure during cortical develpoment. Conditional knockout mice in which rapgef2 is lacking within the dorsal telencephalon result in malformation of the cortical brain structures: developed an ectopic cortical mass (ECM) extending throughout the rostro-caudal axis of the cerebral hemisphere. Mice show also an enlargement of the lateral ventricles and the agenesis of interhemispheric connections: the corpus callosum, the dorsal hippocampus commissure and the anterior commissure (PubMed:19453629).3 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14961496Rap guanine nucleotide exchange factor 2PRO_0000068866Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei644 – 6441Phosphothreonine; by PLK2By similarity
    Modified residuei806 – 8061Phosphoserine; by PLK2By similarity
    Modified residuei933 – 9331Phosphoserine; by PLK2By similarity
    Modified residuei1022 – 10221Phosphoserine; alternate1 Publication
    Modified residuei1022 – 10221Phosphoserine; by PLK2; alternate1 Publication
    Modified residuei1175 – 11751Phosphoserine; by PLK2By similarity

    Post-translational modificationi

    Ubiquitinated by NEDD4, leading to proteasomal degradation.By similarity
    Phosphorylation by PLK2 promotes its activity.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ8CHG7.
    PRIDEiQ8CHG7.

    PTM databases

    PhosphoSiteiQ8CHG7.

    Expressioni

    Tissue specificityi

    Expressed in all layers of the cerebral cortex, hippocampus and cerebellum. Expressed in the cortical plate, cingulate cortex and the subventricular zone. Expressed in neurons and endocrine cells (at protein level). Expressed in melanoma cells.4 Publications

    Developmental stagei

    Expressed in the yolk sacs at vascular endothelial cells at 7.5 dpc. Expressed in the glial sling (GS) at the cortico-septal boundary at 17.5 dpc (at proteion level).2 Publications

    Gene expression databases

    ArrayExpressiQ8CHG7.
    BgeeiQ8CHG7.
    CleanExiMM_RAPGEF2.
    GenevestigatoriQ8CHG7.

    Interactioni

    Subunit structurei

    Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a neuronal growth factor (NGF)-dependent manner. Interacts (via C-terminal domain) with NEDD4 (via WW domains); this interaction leads to ubiquitination and degradation via the proteasome pathway in a cAMP-independent manner. Interacts with MAGI1 (via PDZ domain). Interacts with ADRB1 (via C-terminal PDZ motif); the interaction is direct. Interacts (via Ras-associating domain) with RAP1A (via GTP-bound active form). Interacts weakly with HRAS (via GDP- and GTP-bound forms). Interacts (via C-terminal domain) with MAGI2 (via PDZ and WW domains). Interacts with CDH1, CTNNB1 and TJP1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ8CHG7. 3 interactions.
    MINTiMINT-4133098.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CHG7.
    SMRiQ8CHG7. Positions 107-366, 397-464, 668-913.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini267 – 380114N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini385 – 47086PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini606 – 69287Ras-associatingPROSITE-ProRule annotationAdd
    BLAST
    Domaini717 – 944228Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1107 – 116559Ser-richAdd
    BLAST
    Compositional biasi1398 – 147982Pro-richAdd
    BLAST

    Domaini

    The Ras-associating domain is necessary for the Rap guanine nucleotide exchange activity. The N-terminal regionis necessary for cAMP-binding. The PDZ domain is necessary for its targeting to the cell membrane By similarity.By similarity

    Sequence similaritiesi

    Belongs to the RAPGEF2 family.Curated
    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 Ras-associating domain.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.CuratedPROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG307777.
    GeneTreeiENSGT00750000117360.
    HOGENOMiHOG000247009.
    HOVERGENiHBG056658.
    InParanoidiQ8CHG7.
    KOiK08018.
    OMAiRILDFNT.
    OrthoDBiEOG71VSRT.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    2.30.42.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001478. PDZ.
    IPR000159. Ras-assoc.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR014710. RmlC-like_jellyroll.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00788. RA. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00314. RA. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 3 hits.
    SSF50156. SSF50156. 1 hit.
    SSF51206. SSF51206. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS50200. RA. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CHG7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPLAAPANH GVLGQQEKQS LPADFTKLHL TDSLHPQVTH VSSSHSGCSI     50
    TSDSGSSSLS DIYQATESEA GDMDLSGLPE TAVDSEDDDD EEDIERASDP 100
    LMSRDIVRDC LEKDPIDRTD DDIEQLLEFM HQLPAFANMT MSVRRELCAV 150
    MVFAVVERAG TIVLNDGEEL DSWSVILNGS VEVTYPDGKA EILCMGNSFG 200
    VSPTMDKEYM KGVMRTKVDD CQFVCIAQQD YCRILNQVEK NMQKVEEEGE 250
    IVMVKEHREL DRTGTRKGHI VIKGTSERLT MHLVEEHSVV DPTFIEDFLL 300
    TYRTFLSSPM EVGKKLLEWF NDPSLRDKVT RVVLLWVNNH FNDFEGDPAM 350
    TRFLEEFENN LEREKMGGHL RLLNIACAAK AKRRLMTLTK PSREAPLPFI 400
    LLGGSEKGFG IFVDSVDSCS KATEAGLKRG DQILEVNGQN FENIQLSKAM 450
    EILRNNTHLS ITVKTNLFVF KELLTRLSEE KRNGAPHLPK IGDIKKASRY 500
    SIPDLAVDVE QVIGLEKVNK KSKANTVGGR NKLKKILDKT RISILPQKPY 550
    NDIGIGQSQD DSIVGLRQTK HIPAALPVSG TLSSSNPDLL QSHHRILDFS 600
    TTPDLPDQVL RVFKADQQSR YIMISKDTTA KEVVIQAIRE FAVTATPEQY 650
    SLCEVSVTPE GVIKQRRLPD QLSKLADRIQ LSGRYYLKNN METETLCSDE 700
    DAQELLRESQ ISLLQLSTVE VATQLSMRNF ELFRNIEPTE YIDDLFKLKS 750
    KTSCANLKKF EEVINQETFW VASEILRETN QLKRMKIIKH FIKIALHCRE 800
    CKNFNSMFAI ISGLNLAPVA RLRTTWEKLP NKYEKLFQDL QDLFDPSRNM 850
    AKYRNVLSGQ NLQPPVIPLF PVIKKDLTFL HEGNDSKVDG LVNFEKLRMI 900
    AKEIRHVGRM ASVNMDPALM FRTRKKKWRS LGSLSQGSAN ATVLDVAQTG 950
    GHKKRVRRSS FLNAKKLYED AQMARKVKQY LSNLELEMDE ESLQTLSLQC 1000
    EPATSTLPKN PGDKKPVKSE TSPVAPRAGP QQKVQPQQPL AQPQPPHKVS 1050
    QGLQVPAVSL YPSRKKVPVK DLPPFGINSP QALKKILSLS EEGSLERHRK 1100
    QAEDTISNAS SQLSSPPTSP QSSPRKGYAL ALSGTVDNFS DSGHSEISSR 1150
    SSIVSNSSFD SVPVSLHDER RQRHSVSIVE SNLGVGRMER RTLMEPDQYS 1200
    LGSYAPVSES RGLYAAATVI SSPSTEELSH DQGDRASLDA ADSGRGSWTS 1250
    CSSGSHDNIQ TIQHQRSWET LPFGHTHFDY SGDAASIWAS GGHMDQMMFS 1300
    DHSTKYNRQN QSRESLEQAQ SRASWASSTG YWGEDSEGDT GTIKRRGGKD 1350
    VSAEAESSSM VPVTTEEAKP VPMPAHIAVT PSTTKGLIAR KEGRYREPPP 1400
    TPPGYVGIPI ADFPEGPCHP ARKPPDYNVA LQRSRMVARP TEAPAPGQTP 1450
    PAAAASRPGS KPQWHKPSDA DPRLAPFQPQ GFAGAEEDED EQVSAV 1496
    Length:1,496
    Mass (Da):166,415
    Last modified:December 14, 2011 - v2
    Checksum:iC2FDE48E5E21A86F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC124358 Genomic DNA. No translation available.
    AC157941 Genomic DNA. No translation available.
    AC164560 Genomic DNA. No translation available.
    AB093228 mRNA. Translation: BAC41412.1.
    RefSeqiXP_006502317.1. XM_006502254.1.
    UniGeneiMm.31220.
    Mm.462396.

    Genome annotation databases

    EnsembliENSMUST00000118100; ENSMUSP00000114119; ENSMUSG00000062232.
    GeneIDi76089.
    KEGGimmu:76089.
    UCSCiuc008pnl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC124358 Genomic DNA. No translation available.
    AC157941 Genomic DNA. No translation available.
    AC164560 Genomic DNA. No translation available.
    AB093228 mRNA. Translation: BAC41412.1 .
    RefSeqi XP_006502317.1. XM_006502254.1.
    UniGenei Mm.31220.
    Mm.462396.

    3D structure databases

    ProteinModelPortali Q8CHG7.
    SMRi Q8CHG7. Positions 107-366, 397-464, 668-913.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CHG7. 3 interactions.
    MINTi MINT-4133098.

    PTM databases

    PhosphoSitei Q8CHG7.

    Proteomic databases

    PaxDbi Q8CHG7.
    PRIDEi Q8CHG7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000118100 ; ENSMUSP00000114119 ; ENSMUSG00000062232 .
    GeneIDi 76089.
    KEGGi mmu:76089.
    UCSCi uc008pnl.1. mouse.

    Organism-specific databases

    CTDi 9693.
    MGIi MGI:2659071. Rapgef2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG307777.
    GeneTreei ENSGT00750000117360.
    HOGENOMi HOG000247009.
    HOVERGENi HBG056658.
    InParanoidi Q8CHG7.
    KOi K08018.
    OMAi RILDFNT.
    OrthoDBi EOG71VSRT.

    Miscellaneous databases

    PROi Q8CHG7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8CHG7.
    Bgeei Q8CHG7.
    CleanExi MM_RAPGEF2.
    Genevestigatori Q8CHG7.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    2.30.42.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001478. PDZ.
    IPR000159. Ras-assoc.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR014710. RmlC-like_jellyroll.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00788. RA. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00314. RA. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 3 hits.
    SSF50156. SSF50156. 1 hit.
    SSF51206. SSF51206. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS50200. RA. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
      DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 359-1496.
      Tissue: Brain1 Publication.
    3. "The guanine nucleotide exchange factor CNrasGEF regulates melanogenesis and cell survival in melanoma cells."
      Amsen E.M., Pham N., Pak Y., Rotin D.
      J. Biol. Chem. 281:121-128(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    5. "Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1."
      Wei P., Satoh T., Edamatsu H., Aiba A., Setsu T., Terashima T., Kitazawa S., Nakao K., Yoshikawa Y., Tamada M., Kataoka T.
      Biochem. Biophys. Res. Commun. 363:106-112(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    7. "Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1."
      Kanemura H., Satoh T., Bilasy S.E., Ueda S., Hirashima M., Kataoka T.
      Biochem. Biophys. Res. Commun. 387:754-759(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotopic cortical mass and commissural fiber defect."
      Bilasy S.E., Satoh T., Ueda S., Wei P., Kanemura H., Aiba A., Terashima T., Kataoka T.
      Eur. J. Neurosci. 29:1994-2008(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
    9. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1022, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "RA-GEF-1 (Rapgef2) is essential for proper development of the midline commissures."
      Bilasy S.E., Satoh T., Terashima T., Kataoka T.
      Neurosci. Res. 71:200-209(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    11. "Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells."
      Emery A.C., Eiden M.V., Mustafa T., Eiden L.E.
      Sci. Signal. 6:RA51-RA51(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRPGF2_MOUSE
    AccessioniPrimary (citable) accession number: Q8CHG7
    Secondary accession number(s): E9QMD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3