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Protein

Activity-dependent neuroprotector homeobox protein 2

Gene

Adnp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri73 – 96C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri106 – 128C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri155 – 178C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri215 – 240C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri696 – 718C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri724 – 746C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri777 – 798C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri800 – 823C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri905 – 935C2H2-type 9PROSITE-ProRule annotationAdd BLAST31
DNA bindingi1073 – 1132HomeoboxAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: UniProtKB
  • cellular response to retinoic acid Source: UniProtKB
  • negative regulation of cell death Source: UniProtKB
  • neuron differentiation Source: UniProtKB
  • positive regulation of cell growth Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Activity-dependent neuroprotector homeobox protein 2
Short name:
ADNP homeobox protein 2
Alternative name(s):
Zinc finger protein 508
Gene namesi
Name:Adnp2
Synonyms:Kiaa0863, Zfp508, Znf508
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2448562. Adnp2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804171 – 1165Activity-dependent neuroprotector homeobox protein 2Add BLAST1165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1009Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1048Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8CHC8.
PaxDbiQ8CHC8.
PeptideAtlasiQ8CHC8.
PRIDEiQ8CHC8.

PTM databases

iPTMnetiQ8CHC8.
PhosphoSitePlusiQ8CHC8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053950.
CleanExiMM_ADNP2.
GenevisibleiQ8CHC8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068560.

Structurei

3D structure databases

ProteinModelPortaliQ8CHC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri73 – 96C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri106 – 128C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri155 – 178C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri215 – 240C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri696 – 718C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri724 – 746C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri777 – 798C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri800 – 823C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri905 – 935C2H2-type 9PROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHQQ. Eukaryota.
ENOG410ZPT3. LUCA.
GeneTreeiENSGT00530000063631.
HOGENOMiHOG000247070.
HOVERGENiHBG059494.
InParanoidiQ8CHC8.
OMAiDVASFFG.
OrthoDBiEOG091G03Q0.
PhylomeDBiQ8CHC8.
TreeFamiTF328818.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CHC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQIPVQNLD NIRKVRKRVK GILVDIGLDS CKELMKDLKS FDPGEKYFYN
60 70 80 90 100
TSWGDVSPWE PSGKKARYRT KPYCCSLCRY STKVLTSLKN HLHRYHEDEA
110 120 130 140 150
DQELMIPCPN CPFSSQPRVV GKHFRMFHAP ARKVQSYTVN ILGETKTSRS
160 170 180 190 200
DVISFTCLKC NFSNTLYYSM KKHVLVAHFN YLINSYFGLR TEETGEQPKA
210 220 230 240 250
SDPVSVDKIL PFDKYYCKKC SAIASSQDAL MYHILTSDAH RDLENKLRSV
260 270 280 290 300
ISEHIKRTGF LKQMHIAPKP VTHLALPPNS SAPSIAAPPP CFQLALPQNS
310 320 330 340 350
QSSGTVQSVT VTPGTSGSLT HSPPTTAQSH VALVSSSLPV CQSSLSLQQS
360 370 380 390 400
APPPVFLSHS VALNQPVNTA VLPLTQPVGP VNKSVGTSIL PVNQAMCSVN
410 420 430 440 450
QAVRPGLLPL TKPMGPMNRP VGPAVLPMGP SVNSGVLQAT SPGVISVGRA
460 470 480 490 500
VPSGVLPAGQ VTPAGVIPGQ TATSGVLPTG QVVQSSTLPV GQTAPSRGLP
510 520 530 540 550
PGQTVPLRVL PAGQVVPSGL LSSNQTVPSG VVPVNQGVNS GVLQLGQPVT
560 570 580 590 600
PGVLPVGPPV RPGVLQLSPS VSTSILPMSQ PVRAGTSQNT TFFTSGSILR
610 620 630 640 650
QLIPTGKQVN GIPTYTLAPV SVTLPVPSGG GLAAVGPPPQ VPVQFLPSGS
660 670 680 690 700
GTQMGSSLPS LPSPQVLVSP APSVFVQATP PLADANQALK QAKQWKTCPV
710 720 730 740 750
CNELFPSNVY QVHMEVAHKQ SEAQLCQVCN ELFPANVYQV HMEVAHKQSE
760 770 780 790 800
SKSSEKLEPE KLAACAPFLK WMREKTVRCL SCKCLVSQEE LMHHLLMHGL
810 820 830 840 850
GCLFCPCTFH DVRGLVEHSR TKHLGKKRLS MDYSNRGFQL DLDANGNLLF
860 870 880 890 900
PHLDFITILP REKLGEREVY LAILAGIHSK SLVPVYVKVR PQPEVAPKIP
910 920 930 940 950
NKQKLTCPFC LSTFMTADAY ELHLKERHHV MPTVHTMLRS PAFKCIHCCG
960 970 980 990 1000
VYTGNMTLGA IAVHLLRCRS APKDSSSDLQ VQPGFIESSE LLMVNGDVIP
1010 1020 1030 1040 1050
ESTFPVKRKL PEGHLGPEDQ RDGEEPQLTL DADASSGSEK GLGAVPLKRQ
1060 1070 1080 1090 1100
KSEIRTEGSG PSEDSLQALA LDPSKYEGRS YEEKKQFLRD YFHRRPYPSR
1110 1120 1130 1140 1150
KEVELLSSLL WVWKIDVASF FGKRRYICMK AIKTHKPSVL LGFDMSELKN
1160
VKHRLNFGEC ESQKL
Length:1,165
Mass (Da):126,768
Last modified:March 20, 2007 - v2
Checksum:i6965AEF434A6FDDA
GO

Sequence cautioni

The sequence AAH24969 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH44898 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC41452 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093268 mRNA. Translation: BAC41452.1. Different initiation.
BC024969 mRNA. Translation: AAH24969.1. Different initiation.
BC044898 mRNA. Translation: AAH44898.1. Different initiation.
BC044904 mRNA. Translation: AAH44904.1.
BC064672 mRNA. Translation: AAH64672.1.
CCDSiCCDS50332.1.
RefSeqiNP_778193.1. NM_175028.1.
XP_006526529.1. XM_006526466.2.
UniGeneiMm.26594.

Genome annotation databases

EnsembliENSMUST00000066743; ENSMUSP00000068560; ENSMUSG00000053950.
GeneIDi240442.
KEGGimmu:240442.
UCSCiuc008fsk.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiADNP2_MOUSE
AccessioniPrimary (citable) accession number: Q8CHC8
Secondary accession number(s): Q6P294
, Q80VS0, Q811H5, Q8R1A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: August 30, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families