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Protein
Submitted name:

Hyaluronan synthase 1

Gene

Has1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi2.4.1.212. 5301.
ReactomeiR-RNO-2142850. Hyaluronan biosynthesis and export.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Submitted name:
Hyaluronan synthase 1Imported
Submitted name:
Protein Has1Imported
Gene namesi
Name:Has1Imported
Synonyms:HAS1Imported, LOC282821Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi708528. Has1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4020HelicalSequence analysisAdd
BLAST
Transmembranei52 – 7524HelicalSequence analysisAdd
BLAST
Transmembranei410 – 42920HelicalSequence analysisAdd
BLAST
Transmembranei435 – 45723HelicalSequence analysisAdd
BLAST
Transmembranei464 – 48522HelicalSequence analysisAdd
BLAST
Transmembranei505 – 52319HelicalSequence analysisAdd
BLAST
Transmembranei544 – 56623HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014824.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2571. Eukaryota.
COG1215. LUCA.
GeneTreeiENSGT00390000010337.
HOGENOMiHOG000112847.
HOVERGENiHBG000189.
KOiK00752.
OMAiRTHRCVC.
OrthoDBiEOG091G04P3.
TreeFamiTF332506.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR026107. HAS/NodC.
IPR028385. HAS1.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR22913. PTHR22913. 1 hit.
PTHR22913:SF4. PTHR22913:SF4. 1 hit.
SUPFAMiSSF53448. SSF53448. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8CH93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQDMPKPSE AARCCSGLAR RVLTITFALL ILGLMTWAYA AGVPLASDPY
60 70 80 90 100
GLLAFGLYGA FLSAHLVAQS LFAYLEHRRV TVAARRAFAK GPLDAATARS
110 120 130 140 150
VALTISAYQE DPTYLRQCLT SARALLYPRT RLRVLMVVDG NRAEDLYMVD
160 170 180 190 200
MFREVFADED PATYVWDGNY HQPWEPAEAA GAVGEGAYRE VEAEDPGRLA
210 220 230 240 250
VEALVRTRRC VCVAQRWGGK REVMYTAFKA LGDSVDYVQV CDSDTRLDPM
260 270 280 290 300
ALLELVRVLD EDPRVGAVGG DVRILNPLDS WVSFLSSLRY WVAFNVERAC
310 320 330 340 350
QSYFHCVSCI SGPLGLYRNN LLQQFLEAWY NQKFLGTHCT FGDDRHLTNR
360 370 380 390 400
MLSMGYATKY TSRSRCYSET PSSFLRWLSQ QTRWSKSYFR EWLYNALWWH
410 420 430 440 450
RHHAWMTYEA VVSGLFPFFV AATVLRLFYA GRPWALLWVL LCVQGVALAK
460 470 480 490 500
AAFAAWLRGC LRMVLLSLYA PLYMCGLLPA KFLALVTMNQ SGWGTSGRKK
510 520 530 540 550
LAANYVPVLP LALWALLLLG GLIRSVAQEV RADWSGPSRA AEAYHLAAGA
560 570 580
SAYVAYWVIM LTIYWVGVRR LCRRRSGGYR VQV
Length:583
Mass (Da):65,725
Last modified:March 1, 2003 - v1
Checksum:i35513C6B21DE4E8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07001847 Genomic DNA. No translation available.
AB097568 mRNA. Translation: BAC43730.1.
RefSeqiNP_758826.1. NM_172323.1.
UniGeneiRn.91138.

Genome annotation databases

EnsembliENSRNOT00000014824; ENSRNOP00000014824; ENSRNOG00000010994.
GeneIDi282821.
KEGGirno:282821.
UCSCiRGD:708528. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07001847 Genomic DNA. No translation available.
AB097568 mRNA. Translation: BAC43730.1.
RefSeqiNP_758826.1. NM_172323.1.
UniGeneiRn.91138.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014824.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014824; ENSRNOP00000014824; ENSRNOG00000010994.
GeneIDi282821.
KEGGirno:282821.
UCSCiRGD:708528. rat.

Organism-specific databases

CTDi3036.
RGDi708528. Has1.

Phylogenomic databases

eggNOGiKOG2571. Eukaryota.
COG1215. LUCA.
GeneTreeiENSGT00390000010337.
HOGENOMiHOG000112847.
HOVERGENiHBG000189.
KOiK00752.
OMAiRTHRCVC.
OrthoDBiEOG091G04P3.
TreeFamiTF332506.

Enzyme and pathway databases

BRENDAi2.4.1.212. 5301.
ReactomeiR-RNO-2142850. Hyaluronan biosynthesis and export.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR026107. HAS/NodC.
IPR028385. HAS1.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR22913. PTHR22913. 1 hit.
PTHR22913:SF4. PTHR22913:SF4. 1 hit.
SUPFAMiSSF53448. SSF53448. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8CH93_RAT
AccessioniPrimary (citable) accession number: Q8CH93
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.