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Protein

ELAV-like protein 2

Gene

Elavl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 2
Alternative name(s):
Hu-antigen B
Short name:
HuB
Gene namesi
Name:Elavl2
Synonyms:Hub
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628611. Elavl2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002327681 – 359ELAV-like protein 2Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineBy similarity1
Modified residuei221PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CH84.
PRIDEiQ8CH84.

PTM databases

iPTMnetiQ8CH84.
PhosphoSitePlusiQ8CH84.

Interactioni

Subunit structurei

Interacts with IGF2BP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009034.

Structurei

3D structure databases

ProteinModelPortaliQ8CH84.
SMRiQ8CH84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 117RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini125 – 205RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini276 – 354RRM 3PROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the RRM elav family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0145. Eukaryota.
ENOG410XP7S. LUCA.
HOGENOMiHOG000231162.
HOVERGENiHBG002295.
InParanoidiQ8CH84.
PhylomeDBiQ8CH84.

Family and domain databases

CDDicd12650. RRM1_Hu. 1 hit.
cd12775. RRM2_HuB. 1 hit.
cd12654. RRM3_HuB. 1 hit.
InterProiView protein in InterPro
IPR006548. ELAD_HU_SF.
IPR034775. ELAV/Hu_RRM1.
IPR034999. HuB_RRM2.
IPR034914. HuB_RRM3.
IPR002343. Hud_Sxl_RNA.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 3 hits.
PRINTSiPR00961. HUDSXLRNA.
SMARTiView protein in SMART
SM00360. RRM. 3 hits.
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8CH84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQLSNGPT CNNTANGPTT VNNNCSSPVD SGNTEDSKTN LIDNYLPQNM
60 70 80 90 100
TQEELKSLFG SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL
110 120 130 140 150
NGLRLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMTQKE LEQLFSQYGR
160 170 180 190 200
IITSRILVDQ VTGISRGVGF IRFDKRIEAE EAIKGLNGQK PPGATEPITV
210 220 230 240 250
KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD NLLNMAYGVK
260 270 280 290 300
RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG
310 320 330 340 350
AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS

FKTNKTHKA
Length:359
Mass (Da):39,506
Last modified:March 1, 2003 - v1
Checksum:i1F07FBCA37DEFE72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098713 mRNA. Translation: BAC53775.1.
UniGeneiRn.12662.

Genome annotation databases

UCSCiRGD:628611. rat.

Similar proteinsi

Entry informationi

Entry nameiELAV2_RAT
AccessioniPrimary (citable) accession number: Q8CH84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families