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Protein

Neuron navigator 1

Gene

Nav1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuronal migration.1 Publication

GO - Biological processi

  • microtubule bundle formation Source: MGI
  • neuron migration Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron navigator 1
Alternative name(s):
Pore membrane and/or filament-interacting-like protein 3
Gene namesi
Name:Nav1
Synonyms:Kiaa1151, Pomfil3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2183683. Nav1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • microtubule Source: UniProtKB-KW
  • microtubule cytoskeleton Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002869751 – 1875Neuron navigator 1Add BLAST1875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei93PhosphoserineCombined sources1
Modified residuei145PhosphoserineBy similarity1
Modified residuei162PhosphothreonineBy similarity1
Modified residuei197PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei299PhosphoserineBy similarity1
Modified residuei311PhosphoserineBy similarity1
Modified residuei315PhosphoserineCombined sources1
Modified residuei365PhosphoserineBy similarity1
Modified residuei394PhosphoserineCombined sources1
Modified residuei455PhosphoserineBy similarity1
Modified residuei477PhosphoserineCombined sources1
Modified residuei479PhosphoserineCombined sources1
Modified residuei493PhosphoserineBy similarity1
Modified residuei531PhosphoserineBy similarity1
Modified residuei537PhosphothreonineBy similarity1
Modified residuei544PhosphoserineBy similarity1
Modified residuei547PhosphothreonineBy similarity1
Modified residuei575PhosphothreonineBy similarity1
Modified residuei651PhosphoserineBy similarity1
Modified residuei690Omega-N-methylarginineCombined sources1
Modified residuei752PhosphoserineBy similarity1
Modified residuei756PhosphoserineBy similarity1
Modified residuei762PhosphoserineBy similarity1
Modified residuei799PhosphoserineBy similarity1
Modified residuei810PhosphoserineCombined sources1
Modified residuei998PhosphoserineBy similarity1
Modified residuei1004PhosphothreonineBy similarity1
Modified residuei1168PhosphothreonineBy similarity1
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1263PhosphoserineBy similarity1
Modified residuei1380PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ8CH77.
PeptideAtlasiQ8CH77.
PRIDEiQ8CH77.

PTM databases

iPTMnetiQ8CH77.
PhosphoSitePlusiQ8CH77.

Expressioni

Tissue specificityi

Expressed in heart and brain. Present in brain (at protein level). In adult brain, found almost exclusively in areas of secondary neurogenesis from the hippocampus and the subventricular zone.1 Publication

Developmental stagei

Expressed in neural structures at E10. At E13 and E15, highly expressed in neural tube, somites, heart and dispersed cells in tongue and face. At P5, widely expressed through the central nervous system in post-mitotic post-migratory zones. Brain expression decreases rapidly from P5 to P21 (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000009418.
CleanExiMM_NAV1.
ExpressionAtlasiQ8CH77. baseline and differential.
GenevisibleiQ8CH77. MM.

Interactioni

Subunit structurei

Interacts with tubulin.1 Publication

Protein-protein interaction databases

BioGridi229647. 2 interactors.
STRINGi10090.ENSMUSP00000067241.

Structurei

3D structure databases

ProteinModelPortaliQ8CH77.
SMRiQ8CH77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili258 – 283Sequence analysisAdd BLAST26
Coiled coili733 – 758Sequence analysisAdd BLAST26
Coiled coili1070 – 1161Sequence analysisAdd BLAST92
Coiled coili1301 – 1360Sequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1204 – 1209Poly-Lys6

Sequence similaritiesi

Belongs to the Nav/unc-53 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEKD. Eukaryota.
ENOG410ZIQK. LUCA.
GeneTreeiENSGT00530000063334.
HOVERGENiHBG058814.
InParanoidiQ8CH77.
KOiK16776.
OMAiVNGRMDW.
OrthoDBiEOG091G03NO.
PhylomeDBiQ8CH77.
TreeFamiTF329881.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CH77-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGSSVKSVQ PEVELSGGSG SGGDEGADES RGASRKAAAA DGRGMLPKRA
60 70 80 90 100
KAAGGSGSMA KASAAELKVF KSGSVDSRVP GGLPTSNLRK QKSLTNLSFL
110 120 130 140 150
TDSEKKLQLY EPEWSDDMAK APKGLGKLGP KGRETPLMSK TLSKSEHSLF
160 170 180 190 200
QPKGGSTGGA KTPLAPLAPS LGKPSRIPRG PYAEVKPLSK APEAAVSDDG
210 220 230 240 250
KSDDELLSSK AKAQKGSGTV PSAKGQEERA FLKVDPELVV TVLGDLEQLL
260 270 280 290 300
FSQMLDPESQ RKRTVQNVLD LRQNLEETMS SLRGSQVTHS SLEMPCYDSD
310 320 330 340 350
DANPRSVSSL SNRSSPLSWR YGQSSPRLQA GDAPSVGGSC RSEGPPAWYM
360 370 380 390 400
HGERAHYSHT MPMRSPSKLS HISRLELVES LDSDEVDLKS GYMSDSDLMG
410 420 430 440 450
KTMTEDDDIT TGWDESSSIS SGLSDASDNL SSEEFNASSS LNSLPTTPTA
460 470 480 490 500
SRRSSTIVLR TDSEKRSLAE SGLNWFSESE EKTPKKLEYD SGSLKMEPGT
510 520 530 540 550
SKWRRERPES CDDASKGGEL KKPISLGHPG SLKKGKTPPV AVTSPITHTA
560 570 580 590 600
QSALKVAGKP EGKATDKGKL AVKNTGLQRS SSDAGRDRLS DAKKPPSGIA
610 620 630 640 650
RPSTSGSFGY KKPPPATGTA TVMQTGSSAT LSKIQKSSGI PVKPVNGRKT
660 670 680 690 700
SLDVSNSVEP GFLAPGARSN IQYRSLPRPA KSSSMSVTGR GGPRPVSSSI
710 720 730 740 750
DPSLLSTKQG GLTPSRLKEP SKVASGRSTP APVNQTDREK EKAKAKAVAL
760 770 780 790 800
DSDNISLKSI GSPESTPKNQ ASHPPATKLA ELPPTPLRAT AKSFVKPPSL
810 820 830 840 850
ANLDKVNSNS LDLPSSSDTH ASKVPDLHAP SSSTGGPLPS CFTPSPAPIL
860 870 880 890 900
NINSASFSQG LELMSGFSVP KETRMYPKLS GLHRSMESLQ MPMSLPSAFP
910 920 930 940 950
SSAPIPTPPT APSEEDTEEL PWSGSPRAGQ LDSSQRDRNT LPKKGLRYQL
960 970 980 990 1000
QSQEETKERR HSHTAGGLPE SDDQAELPSP PALSMSLSAK GQLTNIVSPT
1010 1020 1030 1040 1050
AATTPRITRS NSIPTHEAAF ELYSGSQMGS TLSLAERPKG MIRSGSFRDP
1060 1070 1080 1090 1100
TDDVHGSVLS LASSASSTYS SAEERMQSEQ IRKLRRELES SQEKVATLTS
1110 1120 1130 1140 1150
QLSANANLVA AFEQSLVNMT SRLRHLAETA EEKDTELLDL RETIDFLKKK
1160 1170 1180 1190 1200
NSEAQAVIQG ALNASEATPK ELRIKRQNSS DSISSLNSIT SHSSIGSSKD
1210 1220 1230 1240 1250
ADAKKKKKKS WVYELRSSFN KAFSIKKGPK SASSYSDIEE IATPDSSAPS
1260 1270 1280 1290 1300
SPKLQHGSTE TASPSIKSST SSSVGTEVTE TPAHSVPHTR LFQANEEEEP
1310 1320 1330 1340 1350
EKKEVSELRS ELWEKEMKLT DIRLEALNSA HQLDQLRETM HNMQLEVDLL
1360 1370 1380 1390 1400
KAENDRLKVA PGPSSGCTPG QVPGSSALSS PRRSLGLALS HPFSPSLTDT
1410 1420 1430 1440 1450
DLSPMDGIST CGSKEEVTLR VVVRMPPQHI IKGDLKQQEF FLGCSKVSGK
1460 1470 1480 1490 1500
VDWKMLDEAV FQVFKDYISK MDPASTLGLS TESIHGYSLS HVKRVLDAEP
1510 1520 1530 1540 1550
PEMPPCRRGV NNISVALKGL KEKCVDSLVF ETLIPKPMMQ HYISLLLKHR
1560 1570 1580 1590 1600
RLVLSGPSGT GKTYLTNRLA EYLVERSGRE VTDGIVSTFN MHQQSCKDLQ
1610 1620 1630 1640 1650
LYLSNLANQI DRETGIGDVP LVILLDDLSE AGSISELVNG ALTCKYHKCP
1660 1670 1680 1690 1700
YIIGTTNQPV KMTPNHGLHL SFRMLTFSNN VEPANGFLVR YLRRKLVESD
1710 1720 1730 1740 1750
SDVNANKEEL LRVLDWVPKL WYHLHTFLEK HSTSDFLIGP CFFLSCPIGI
1760 1770 1780 1790 1800
EDFRTWFIDL WNNSIIPYLQ EGAKDGIKVH GQKAAWEDPV EWVRDTLPWP
1810 1820 1830 1840 1850
SAQQDQSKLY HLPPPSVGPH STASPPEDRT VKDSTPNSLD SDPLMAMLLK
1860 1870
LQEAANYIES PDRETILDPN LQATL
Length:1,875
Mass (Da):202,368
Last modified:May 15, 2007 - v2
Checksum:i6EDEF58B6953DBB7
GO
Isoform 2 (identifier: Q8CH77-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     997-1053: Missing.
     1212-1214: Missing.

Show »
Length:1,815
Mass (Da):195,896
Checksum:i2D8677445D24656F
GO
Isoform 3 (identifier: Q8CH77-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1214: Missing.
     1225-1225: I → L
     1226-1875: Missing.

Show »
Length:1,222
Mass (Da):129,744
Checksum:i85DBF0D3994D3008
GO
Isoform 4 (identifier: Q8CH77-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-392: Missing.
     393-412: MSDSDLMGKTMTEDDDITTG → MLHLPLPRSGRTANFPRS
     1213-1221: YELRSSFNK → CKGLGIGLC
     1222-1875: Missing.

Show »
Length:827
Mass (Da):87,805
Checksum:i485A0AA74881C107
GO

Sequence cautioni

The sequence BAC65740 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132G → D in AAO13290 (PubMed:15797708).Curated1
Sequence conflicti310L → F in BAC65740 (PubMed:12693553).Curated1
Sequence conflicti386V → G in AAO13290 (PubMed:15797708).Curated1
Sequence conflicti437A → G in AAO13290 (PubMed:15797708).Curated1
Sequence conflicti899F → Y in BAC38568 (PubMed:16141072).Curated1
Sequence conflicti933Missing in AAH59840 (PubMed:15489334).Curated1
Sequence conflicti954E → D in AAH59840 (PubMed:15489334).Curated1
Sequence conflicti960R → G in AAO13290 (PubMed:15797708).Curated1
Sequence conflicti975A → E in AAO13290 (PubMed:15797708).Curated1
Sequence conflicti981P → L in AAO13290 (PubMed:15797708).Curated1
Sequence conflicti1361P → S in AAH80292 (PubMed:15489334).Curated1
Sequence conflicti1686G → V in BAC65740 (PubMed:12693553).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0252601 – 392Missing in isoform 4. 1 PublicationAdd BLAST392
Alternative sequenceiVSP_025261393 – 412MSDSD…DITTG → MLHLPLPRSGRTANFPRS in isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_025262997 – 1053Missing in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0252631212 – 1214Missing in isoform 2 and isoform 3. 2 Publications3
Alternative sequenceiVSP_0252641213 – 1221YELRSSFNK → CKGLGIGLC in isoform 4. 1 Publication9
Alternative sequenceiVSP_0252651222 – 1875Missing in isoform 4. 1 PublicationAdd BLAST654
Alternative sequenceiVSP_0252661225I → L in isoform 3. 1 Publication1
Alternative sequenceiVSP_0252671226 – 1875Missing in isoform 3. 1 PublicationAdd BLAST650

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF307453 mRNA. Translation: AAO13290.1.
AK122458 mRNA. Translation: BAC65740.1. Different initiation.
AK053255 mRNA. Translation: BAC35323.1.
AK082667 mRNA. Translation: BAC38568.1.
AK153742 mRNA. Translation: BAE32163.1.
BC059840 mRNA. Translation: AAH59840.1.
BC080292 mRNA. Translation: AAH80292.1.
CCDSiCCDS35720.1. [Q8CH77-1]
RefSeqiNP_775613.2. NM_173437.2. [Q8CH77-1]
UniGeneiMm.34977.

Genome annotation databases

EnsembliENSMUST00000040599; ENSMUSP00000043803; ENSMUSG00000009418. [Q8CH77-1]
ENSMUST00000067414; ENSMUSP00000067241; ENSMUSG00000009418. [Q8CH77-1]
ENSMUST00000190298; ENSMUSP00000140322; ENSMUSG00000009418. [Q8CH77-2]
GeneIDi215690.
KEGGimmu:215690.
UCSCiuc007ctg.2. mouse. [Q8CH77-1]
uc007ctj.2. mouse. [Q8CH77-2]
uc007ctl.1. mouse. [Q8CH77-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF307453 mRNA. Translation: AAO13290.1.
AK122458 mRNA. Translation: BAC65740.1. Different initiation.
AK053255 mRNA. Translation: BAC35323.1.
AK082667 mRNA. Translation: BAC38568.1.
AK153742 mRNA. Translation: BAE32163.1.
BC059840 mRNA. Translation: AAH59840.1.
BC080292 mRNA. Translation: AAH80292.1.
CCDSiCCDS35720.1. [Q8CH77-1]
RefSeqiNP_775613.2. NM_173437.2. [Q8CH77-1]
UniGeneiMm.34977.

3D structure databases

ProteinModelPortaliQ8CH77.
SMRiQ8CH77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229647. 2 interactors.
STRINGi10090.ENSMUSP00000067241.

PTM databases

iPTMnetiQ8CH77.
PhosphoSitePlusiQ8CH77.

Proteomic databases

PaxDbiQ8CH77.
PeptideAtlasiQ8CH77.
PRIDEiQ8CH77.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040599; ENSMUSP00000043803; ENSMUSG00000009418. [Q8CH77-1]
ENSMUST00000067414; ENSMUSP00000067241; ENSMUSG00000009418. [Q8CH77-1]
ENSMUST00000190298; ENSMUSP00000140322; ENSMUSG00000009418. [Q8CH77-2]
GeneIDi215690.
KEGGimmu:215690.
UCSCiuc007ctg.2. mouse. [Q8CH77-1]
uc007ctj.2. mouse. [Q8CH77-2]
uc007ctl.1. mouse. [Q8CH77-4]

Organism-specific databases

CTDi89796.
MGIiMGI:2183683. Nav1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IEKD. Eukaryota.
ENOG410ZIQK. LUCA.
GeneTreeiENSGT00530000063334.
HOVERGENiHBG058814.
InParanoidiQ8CH77.
KOiK16776.
OMAiVNGRMDW.
OrthoDBiEOG091G03NO.
PhylomeDBiQ8CH77.
TreeFamiTF329881.

Miscellaneous databases

ChiTaRSiNav1. mouse.
PROiQ8CH77.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009418.
CleanExiMM_NAV1.
ExpressionAtlasiQ8CH77. baseline and differential.
GenevisibleiQ8CH77. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNAV1_MOUSE
AccessioniPrimary (citable) accession number: Q8CH77
Secondary accession number(s): Q3U5B6
, Q68EE8, Q6PB78, Q80TI7, Q8BKG2, Q8BUT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.