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Protein

Proton-coupled amino acid transporter 4

Gene

Slc36a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Proton-coupled amino acid transporter 4
Short name:
Proton/amino acid transporter 4
Alternative name(s):
Solute carrier family 36 member 4
Gene namesi
Name:Slc36a4
Synonyms:Pat4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2442595. Slc36a4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10421HelicalSequence analysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence analysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence analysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence analysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence analysisAdd
BLAST
Transmembranei354 – 37421HelicalSequence analysisAdd
BLAST
Transmembranei411 – 43121HelicalSequence analysisAdd
BLAST
Transmembranei444 – 46421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Proton-coupled amino acid transporter 4PRO_0000308319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

MaxQBiQ8CH36.
PaxDbiQ8CH36.
PRIDEiQ8CH36.

PTM databases

iPTMnetiQ8CH36.
PhosphoSiteiQ8CH36.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043885.

Interactioni

Protein-protein interaction databases

IntActiQ8CH36. 1 interaction.
STRINGi10090.ENSMUSP00000057355.

Structurei

3D structure databases

ProteinModelPortaliQ8CH36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1304. Eukaryota.
COG0814. LUCA.
HOGENOMiHOG000006823.
HOVERGENiHBG057183.
InParanoidiQ8CH36.
KOiK14209.
PhylomeDBiQ8CH36.
TreeFamiTF314873.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CH36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPAPAETA GCEELDMDVM RPLINEQNFD GSSDEEQEQT LVPIQKHYQL
60 70 80 90 100
DGQHGISFLQ TLVHLLKGNI GTGLLGLPLA IKNAGIVLGP ISLVFIGIIS
110 120 130 140 150
VHCMHILVRC SHFLCQRFKK STLGYSDTVS FAMEASPWSC LQRQAAWGRQ
160 170 180 190 200
VVDFFLVITQ LGFCSVYIVF LAENVKQVHE GFLGSTPIVS NGSDLSHACE
210 220 230 240 250
RRSVDLRVYM LCFLPLIILL VFIRELKNLF VLSFLANISM AASLVIIYQY
260 270 280 290 300
VVRNMPDPHN LPIVAGWKKY PLFFGTAVFA FEGIGVVLPL ENQMRESKRF
310 320 330 340 350
PQALNIGMAI VTVLYISLAT LGYMCFRDEI KGSITLNLPQ DMWLYQSVKI
360 370 380 390 400
LYSFGIFVTY SIQFYVPAEI IIPGVTARLH AKWKRICEFG IRSLLVSITR
410 420 430 440 450
AGAILIPRLD IVISFVGAVS SSTLALILPP LVEILTFSKD HYNIWMILKN
460 470 480 490 500
ISIAFTGVVG FLLGTYVTVE EIIYPTTAVV AGTSQSPFLN VNSTCITSGL
Length:500
Mass (Da):55,448
Last modified:March 1, 2003 - v1
Checksum:iDDD849B6FAAE7E0B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501Q → S in BAC27683 (PubMed:16141072).Curated
Sequence conflicti150 – 1501Q → S in AAI15965 (PubMed:15489334).Curated
Sequence conflicti400 – 4001R → C in BAC27683 (PubMed:16141072).Curated
Sequence conflicti400 – 4001R → C in AAI15965 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453746 mRNA. Translation: AAN76274.1.
AK032074 mRNA. Translation: BAC27683.1.
BC115964 mRNA. Translation: AAI15965.1.
CCDSiCCDS22840.1.
RefSeqiNP_758493.2. NM_172289.4.
UniGeneiMm.138815.

Genome annotation databases

GeneIDi234967.
KEGGimmu:234967.
UCSCiuc009ogg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453746 mRNA. Translation: AAN76274.1.
AK032074 mRNA. Translation: BAC27683.1.
BC115964 mRNA. Translation: AAI15965.1.
CCDSiCCDS22840.1.
RefSeqiNP_758493.2. NM_172289.4.
UniGeneiMm.138815.

3D structure databases

ProteinModelPortaliQ8CH36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CH36. 1 interaction.
STRINGi10090.ENSMUSP00000057355.

PTM databases

iPTMnetiQ8CH36.
PhosphoSiteiQ8CH36.

Proteomic databases

MaxQBiQ8CH36.
PaxDbiQ8CH36.
PRIDEiQ8CH36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi234967.
KEGGimmu:234967.
UCSCiuc009ogg.1. mouse.

Organism-specific databases

CTDi120103.
MGIiMGI:2442595. Slc36a4.

Phylogenomic databases

eggNOGiKOG1304. Eukaryota.
COG0814. LUCA.
HOGENOMiHOG000006823.
HOVERGENiHBG057183.
InParanoidiQ8CH36.
KOiK14209.
PhylomeDBiQ8CH36.
TreeFamiTF314873.

Miscellaneous databases

PROiQ8CH36.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043885.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS36A4_MOUSE
AccessioniPrimary (citable) accession number: Q8CH36
Secondary accession number(s): Q8C077
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.