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Protein

Proton-coupled amino acid transporter 4

Gene

Slc36a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Proton-coupled amino acid transporter 4
Short name:
Proton/amino acid transporter 4
Alternative name(s):
Solute carrier family 36 member 4
Gene namesi
Name:Slc36a4
Synonyms:Pat4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2442595 Slc36a4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083191 – 500Proton-coupled amino acid transporter 4Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi492N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

MaxQBiQ8CH36
PaxDbiQ8CH36
PRIDEiQ8CH36

PTM databases

iPTMnetiQ8CH36
PhosphoSitePlusiQ8CH36
SwissPalmiQ8CH36

Interactioni

Protein-protein interaction databases

IntActiQ8CH36, 1 interactor
MINTiQ8CH36
STRINGi10090.ENSMUSP00000057355

Structurei

3D structure databases

ProteinModelPortaliQ8CH36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1304 Eukaryota
COG0814 LUCA
HOGENOMiHOG000006823
HOVERGENiHBG057183
InParanoidiQ8CH36
KOiK14209
PhylomeDBiQ8CH36
TreeFamiTF314873

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CH36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPAPAETA GCEELDMDVM RPLINEQNFD GSSDEEQEQT LVPIQKHYQL
60 70 80 90 100
DGQHGISFLQ TLVHLLKGNI GTGLLGLPLA IKNAGIVLGP ISLVFIGIIS
110 120 130 140 150
VHCMHILVRC SHFLCQRFKK STLGYSDTVS FAMEASPWSC LQRQAAWGRQ
160 170 180 190 200
VVDFFLVITQ LGFCSVYIVF LAENVKQVHE GFLGSTPIVS NGSDLSHACE
210 220 230 240 250
RRSVDLRVYM LCFLPLIILL VFIRELKNLF VLSFLANISM AASLVIIYQY
260 270 280 290 300
VVRNMPDPHN LPIVAGWKKY PLFFGTAVFA FEGIGVVLPL ENQMRESKRF
310 320 330 340 350
PQALNIGMAI VTVLYISLAT LGYMCFRDEI KGSITLNLPQ DMWLYQSVKI
360 370 380 390 400
LYSFGIFVTY SIQFYVPAEI IIPGVTARLH AKWKRICEFG IRSLLVSITR
410 420 430 440 450
AGAILIPRLD IVISFVGAVS SSTLALILPP LVEILTFSKD HYNIWMILKN
460 470 480 490 500
ISIAFTGVVG FLLGTYVTVE EIIYPTTAVV AGTSQSPFLN VNSTCITSGL
Length:500
Mass (Da):55,448
Last modified:March 1, 2003 - v1
Checksum:iDDD849B6FAAE7E0B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150Q → S in BAC27683 (PubMed:16141072).Curated1
Sequence conflicti150Q → S in AAI15965 (PubMed:15489334).Curated1
Sequence conflicti400R → C in BAC27683 (PubMed:16141072).Curated1
Sequence conflicti400R → C in AAI15965 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF453746 mRNA Translation: AAN76274.1
AK032074 mRNA Translation: BAC27683.1
BC115964 mRNA Translation: AAI15965.1
CCDSiCCDS22840.1
RefSeqiNP_758493.2, NM_172289.4
UniGeneiMm.138815

Genome annotation databases

GeneIDi234967
KEGGimmu:234967
UCSCiuc009ogg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiS36A4_MOUSE
AccessioniPrimary (citable) accession number: Q8CH36
Secondary accession number(s): Q8C077
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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