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Protein

Calcipressin-2

Gene

Rcan2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-2
Alternative name(s):
Calcineurin inhibitory protein ZAKI-4
Down syndrome candidate region 1-like protein 1
Regulator of calcineurin 2
Gene namesi
Name:Rcan2
Synonyms:Dscr1l1, Zaki4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi69198. Rcan2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Calcipressin-2PRO_0000295271Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei167 – 1671PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

PTM databases

PhosphoSiteiQ8CH27.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010350.
ExpressionAtlasiQ8CH27. baseline and differential.
GenevisibleiQ8CH27. RN.

Structurei

3D structure databases

ProteinModelPortaliQ8CH27.
SMRiQ8CH27. Positions 11-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

GeneTreeiENSGT00400000022053.
HOGENOMiHOG000254788.
HOVERGENiHBG018932.
InParanoidiQ8CH27.
KOiK17903.
PhylomeDBiQ8CH27.
TreeFamiTF313579.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR006931. Calcipressin.
IPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
PANTHERiPTHR10300. PTHR10300. 1 hit.
PfamiPF04847. Calcipressin. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CH27-1) [UniParc]FASTAAdd to basket
Also known as: ZAKI-4 alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD ECVTFQLFKS
60 70 80 90 100
FRRVRINFSH PKAAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL
110 120 130 140 150
APPQPAKQFL ISPPSSPPVG WKPISDATPV LNYDLLYAVA KLGPGEKYEL
160 170 180 190
HAGTESTPSV VVHVCDSDLE EEEDPKTSPK PKIIQTRRPG LPPSVSN
Length:197
Mass (Da):21,991
Last modified:March 1, 2003 - v1
Checksum:iD8C906B7A7F46F4B
GO
Isoform 2 (identifier: Q8CH27-2) [UniParc]FASTAAdd to basket
Also known as: ZAKI-4 beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MPAPSMDCDVSTLVACVVDVEVFTNQEV → MRGDAYFIGR...HQSVFEEEES

Show »
Length:242
Mass (Da):27,180
Checksum:i2481D0ACC45058A6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2828MPAPS…TNQEV → MRGDAYFIGRSLGQQASVPE DGGLFFLCCIDRDWAVTQCF AEEAFQALTDFNDLPNSLFA CNVHQSVFEEEES in isoform 2. 2 PublicationsVSP_026924Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF459022 mRNA. Translation: AAO15540.1.
AF459023 mRNA. Translation: AAO15541.1.
BC086974 mRNA. Translation: AAH86974.1.
RefSeqiNP_783168.1. NM_175578.3.
XP_006244655.1. XM_006244593.2. [Q8CH27-1]
UniGeneiRn.24428.

Genome annotation databases

EnsembliENSRNOT00000029593; ENSRNOP00000029489; ENSRNOG00000010350. [Q8CH27-1]
GeneIDi140666.
KEGGirno:140666.
UCSCiRGD:69198. rat. [Q8CH27-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF459022 mRNA. Translation: AAO15540.1.
AF459023 mRNA. Translation: AAO15541.1.
BC086974 mRNA. Translation: AAH86974.1.
RefSeqiNP_783168.1. NM_175578.3.
XP_006244655.1. XM_006244593.2. [Q8CH27-1]
UniGeneiRn.24428.

3D structure databases

ProteinModelPortaliQ8CH27.
SMRiQ8CH27. Positions 11-116.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8CH27.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000029593; ENSRNOP00000029489; ENSRNOG00000010350. [Q8CH27-1]
GeneIDi140666.
KEGGirno:140666.
UCSCiRGD:69198. rat. [Q8CH27-1]

Organism-specific databases

CTDi10231.
RGDi69198. Rcan2.

Phylogenomic databases

GeneTreeiENSGT00400000022053.
HOGENOMiHOG000254788.
HOVERGENiHBG018932.
InParanoidiQ8CH27.
KOiK17903.
PhylomeDBiQ8CH27.
TreeFamiTF313579.

Miscellaneous databases

PROiQ8CH27.

Gene expression databases

BgeeiENSRNOG00000010350.
ExpressionAtlasiQ8CH27. baseline and differential.
GenevisibleiQ8CH27. RN.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR006931. Calcipressin.
IPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
PANTHERiPTHR10300. PTHR10300. 1 hit.
PfamiPF04847. Calcipressin. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRCAN2_RAT
AccessioniPrimary (citable) accession number: Q8CH27
Secondary accession number(s): Q8CH26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.