Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcipressin-2

Gene

Rcan2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-2
Alternative name(s):
Calcineurin inhibitory protein ZAKI-4
Down syndrome candidate region 1-like protein 1
Regulator of calcineurin 2
Gene namesi
Name:Rcan2
Synonyms:Dscr1l1, Zaki4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi69198 Rcan2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002952711 – 197Calcipressin-2Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

PTM databases

PhosphoSitePlusiQ8CH27

Expressioni

Gene expression databases

BgeeiENSRNOG00000010350
ExpressionAtlasiQ8CH27 baseline and differential
GenevisibleiQ8CH27 RN

Structurei

3D structure databases

ProteinModelPortaliQ8CH27
SMRiQ8CH27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

GeneTreeiENSGT00400000022053
HOGENOMiHOG000254788
HOVERGENiHBG018932
InParanoidiQ8CH27
KOiK17903
PhylomeDBiQ8CH27
TreeFamiTF313579

Family and domain databases

CDDicd12709 RRM_RCAN2, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034921 RCAN2
IPR034919 RCAN2_RRM
PANTHERiPTHR10300 PTHR10300, 1 hit
PTHR10300:SF5 PTHR10300:SF5, 1 hit
PfamiView protein in Pfam
PF04847 Calcipressin, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CH27-1) [UniParc]FASTAAdd to basket
Also known as: ZAKI-4 alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD ECVTFQLFKS
60 70 80 90 100
FRRVRINFSH PKAAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL
110 120 130 140 150
APPQPAKQFL ISPPSSPPVG WKPISDATPV LNYDLLYAVA KLGPGEKYEL
160 170 180 190
HAGTESTPSV VVHVCDSDLE EEEDPKTSPK PKIIQTRRPG LPPSVSN
Length:197
Mass (Da):21,991
Last modified:March 1, 2003 - v1
Checksum:iD8C906B7A7F46F4B
GO
Isoform 2 (identifier: Q8CH27-2) [UniParc]FASTAAdd to basket
Also known as: ZAKI-4 beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MPAPSMDCDVSTLVACVVDVEVFTNQEV → MRGDAYFIGR...HQSVFEEEES

Show »
Length:242
Mass (Da):27,180
Checksum:i2481D0ACC45058A6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0269241 – 28MPAPS…TNQEV → MRGDAYFIGRSLGQQASVPE DGGLFFLCCIDRDWAVTQCF AEEAFQALTDFNDLPNSLFA CNVHQSVFEEEES in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF459022 mRNA Translation: AAO15540.1
AF459023 mRNA Translation: AAO15541.1
BC086974 mRNA Translation: AAH86974.1
RefSeqiNP_783168.1, NM_175578.3
XP_006244655.1, XM_006244593.3 [Q8CH27-1]
UniGeneiRn.24428

Genome annotation databases

EnsembliENSRNOT00000029593; ENSRNOP00000029489; ENSRNOG00000010350 [Q8CH27-1]
GeneIDi140666
KEGGirno:140666
UCSCiRGD:69198 rat [Q8CH27-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRCAN2_RAT
AccessioniPrimary (citable) accession number: Q8CH27
Secondary accession number(s): Q8CH26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health