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Q8CH18 (CCAR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division cycle and apoptosis regulator protein 1
Alternative name(s):
Cell cycle and apoptosis regulatory protein 1
Short name=CARP-1
Gene names
Name:Ccar1
Synonyms:Carp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1146 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the retinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation By similarity. Ref.4

Subunit structure

Directly interacts with CALCOCO1, ESR1, NR3C1 and TP53. Ref.4

Subcellular location

Cytoplasmperinuclear region By similarity.

Sequence similarities

Contains 1 SAP domain.

Sequence caution

The sequence AAH10199.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH34174.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH39939.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH51052.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH60130.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH79652.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8CH18-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8CH18-2)

The sequence of this isoform differs from the canonical sequence as follows:
     316-327: SRERDRERRRSR → RYVLRQCGGLEK
     328-1146: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8CH18-3)

The sequence of this isoform differs from the canonical sequence as follows:
     638-699: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11461146Cell division cycle and apoptosis regulator protein 1
PRO_0000233149

Regions

Domain633 – 66735SAP
Coiled coil591 – 61525 Potential
Coiled coil1029 – 111082 Potential
Compositional bias3 – 287285Gln-rich
Compositional bias290 – 35869Arg-rich
Compositional bias670 – 886217Glu-rich

Amino acid modifications

Modified residue6821Phosphoserine By similarity
Modified residue6941Phosphoserine By similarity
Modified residue8581Phosphothreonine By similarity
Cross-link634Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Natural variations

Alternative sequence316 – 32712SRERD…RRRSR → RYVLRQCGGLEK in isoform 2.
VSP_018054
Alternative sequence328 – 1146819Missing in isoform 2.
VSP_018055
Alternative sequence638 – 69962Missing in isoform 3.
VSP_037737

Experimental info

Sequence conflict2791P → L in AAH79652. Ref.3
Sequence conflict5581T → A in AAH39939. Ref.3
Sequence conflict8021K → E in BAC37267. Ref.2
Sequence conflict8211E → G in BAC37267. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 6005A057B4F0BFF0

FASTA1,146132,060
        10         20         30         40         50         60 
MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA AGLTTQTPAN 

        70         80         90        100        110        120 
YQLTQTAALQ QQAAAVLQQQ YSQPQQALYS VQQQLQQPQQ TILTQPAVAL PTSLSLSTPQ 

       130        140        150        160        170        180 
PAAQITVSYP TPRSSQQQTQ PQKQRVFTGV VTKLHDTFGF VDEDVFFQLG AVKGKTPQVG 

       190        200        210        220        230        240 
DRVLVEATYN PNMPFKWNAQ RIQTLPNQNQ SQTQPLLKTP TAVIQPIVPQ TTFGVQAQPQ 

       250        260        270        280        290        300 
PQSLLQAQIS AASITPLLQT QPQPLLQQPQ QKAGLLQPPV RIVSQPQPAR RLDPPSRFSG 

       310        320        330        340        350        360 
RNDRGDQVPN RKDDRSRERD RERRRSRERS PQRKRSRERS PRRERERSPR RVRRVVPRYT 

       370        380        390        400        410        420 
VQFSKFSLDC PSCDMMELRR RYQNLYIPSD FFDAQFTWVD AFPLSRPFQL GNYCNFYVMH 

       430        440        450        460        470        480 
REVESLEKNM AVLDPPDADH LYSAKVMLMA SPSMEDLYHK SCALAEDPQD LRDGFQHPAR 

       490        500        510        520        530        540 
LVKFLVGMKG KDEAMAIGGH WSPSLDGPNP EKDPSVLIKT AIRCCKALTG IDLSVCTQWY 

       550        560        570        580        590        600 
RFAEIRYHRP EETHKGRTVP AHVETVVLFF PDVWHCLPTR SEWETLSRGY KQQLVEKLQG 

       610        620        630        640        650        660 
ERKKADGEQD EEEKDDGEVK EIATPTHWSK LDPKAMKVND LRKELESRAL SSKGLKSQLI 

       670        680        690        700        710        720 
ARLTKQLKIE EQKEEQKELE KSEKEEEDED DKKSEDDKEE EERKRQEEVE RQRQERRYIL 

       730        740        750        760        770        780 
PDEPAIIVHP NWAAKSGKFD CSIMSLSVLL DYRLEDNKEH SFEVSLFAEL FNEMLQRDFG 

       790        800        810        820        830        840 
VRIYKSLLSL PEKEDKKDKE KKSKKEERKD KKEEREDDID EPKPKRRKSG DDKDKKEDRD 

       850        860        870        880        890        900 
ERKKEEKRKD DSKDDDETEE DNNQDEYDPM EAEEAEDEDD DREEEEVKRD DKRDVSRYCK 

       910        920        930        940        950        960 
DRPAKDKEKE KPQMVTVNRD LLMAFVYFDQ SHCGYLLEKD LEEILYTLGL HLSRAQVKKL 

       970        980        990       1000       1010       1020 
LNKVVLRESC FYRKLTDTSK DDENHEESEA LQEDMLGNRL LLPTPTIKQE SKDGEENVGL 

      1030       1040       1050       1060       1070       1080 
IVYNGAMVDV GSLLQKLEKS EKVRAEVEQK LQLLEEKTDE DGKTILNLEN SNKSLSGELR 

      1090       1100       1110       1120       1130       1140 
EVKKDLGQLQ ENLEVSENMN LQFENQLNKT LRNLSTVMDD IHTVLKKDNV KSEDRDEKSK 


ENGSGV 

« Hide

Isoform 2 [UniParc].

Checksum: 42FF713BD7603559
Show »

FASTA32735,718
Isoform 3 [UniParc].

Checksum: AB6C39FC58378B7C
Show »

FASTA1,084124,746

References

« Hide 'large scale' references
[1]"TAZ binding partners identified by mass spectrometry."
Tian Y., Li D., Benjamin T.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: Swiss Webster.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Embryo, Testis and Wolffian duct.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-833 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-797 (ISOFORM 3).
Strain: C57BL/6, Czech II and FVB/N.
Tissue: Brain, Kidney and Mammary tumor.
[4]"CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes."
Kim J.H., Yang C.K., Heo K., Roeder R.G., An W., Stallcup M.R.
Mol. Cell 31:510-519(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CALCOCO1; ESR1 AND NR3C.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF465615 mRNA. Translation: AAO17318.1.
AK012111 mRNA. Translation: BAB28040.2.
AK077151 mRNA. Translation: BAC36646.1.
AK078424 mRNA. Translation: BAC37267.1.
BC010199 mRNA. Translation: AAH10199.1. Sequence problems.
BC034174 mRNA. Translation: AAH34174.1. Sequence problems.
BC039939 mRNA. Translation: AAH39939.1. Sequence problems.
BC051052 mRNA. Translation: AAH51052.1. Sequence problems.
BC060130 mRNA. Translation: AAH60130.1. Sequence problems.
BC079652 mRNA. Translation: AAH79652.1. Sequence problems.
RefSeqNP_080477.1. NM_026201.3.
XP_006514057.1. XM_006513994.1.
XP_006514058.1. XM_006513995.1.
XP_006514059.1. XM_006513996.1.
XP_006514060.1. XM_006513997.1.
UniGeneMm.196371.

3D structure databases

ProteinModelPortalQ8CH18.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid212231. 4 interactions.
IntActQ8CH18. 3 interactions.
MINTMINT-1550931.

PTM databases

PhosphoSiteQ8CH18.

Proteomic databases

PaxDbQ8CH18.
PRIDEQ8CH18.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020268; ENSMUSP00000020268; ENSMUSG00000020074. [Q8CH18-1]
GeneID67500.
KEGGmmu:67500.
UCSCuc007fja.2. mouse. [Q8CH18-1]
uc007fjc.2. mouse. [Q8CH18-2]
uc011xff.1. mouse. [Q8CH18-3]

Organism-specific databases

CTD55749.
MGIMGI:1914750. Ccar1.

Phylogenomic databases

eggNOGNOG313311.
GeneTreeENSGT00530000063672.
HOVERGENHBG079908.
InParanoidQ05BR1.
OMAELYHKSC.
OrthoDBEOG7CK365.
PhylomeDBQ8CH18.
TreeFamTF316387.

Gene expression databases

BgeeQ8CH18.
CleanExMM_CCAR1.
GenevestigatorQ8CH18.

Family and domain databases

Gene3D1.10.720.30. 1 hit.
InterProIPR025224. DBC1/CARP1.
IPR025954. DBC1/CARP1_inactive_NUDIX_dom.
IPR025223. S1-like_RNA-bd_dom.
IPR003034. SAP_dom.
[Graphical view]
PANTHERPTHR14304. PTHR14304. 1 hit.
PfamPF14443. DBC1. 1 hit.
PF14444. S1-like. 1 hit.
PF02037. SAP. 1 hit.
[Graphical view]
SMARTSM00513. SAP. 1 hit.
[Graphical view]
PROSITEPS50800. SAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCCAR1. mouse.
NextBio324750.
PROQ8CH18.
SOURCESearch...

Entry information

Entry nameCCAR1_MOUSE
AccessionPrimary (citable) accession number: Q8CH18
Secondary accession number(s): Q05BR1 expand/collapse secondary AC list , Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot