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Q8CH18

- CCAR1_MOUSE

UniProt

Q8CH18 - CCAR1_MOUSE

Protein

Cell division cycle and apoptosis regulator protein 1

Gene

Ccar1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the retinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation By similarity.By similarity

    GO - Molecular functioni

    1. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
    2. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cell cycle Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Cell cycle, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division cycle and apoptosis regulator protein 1
    Alternative name(s):
    Cell cycle and apoptosis regulatory protein 1
    Short name:
    CARP-1
    Gene namesi
    Name:Ccar1
    Synonyms:Carp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1914750. Ccar1.

    Subcellular locationi

    Cytoplasmperinuclear region By similarity

    GO - Cellular componenti

    1. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11461146Cell division cycle and apoptosis regulator protein 1PRO_0000233149Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki634 – 634Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei682 – 6821PhosphoserineBy similarity
    Modified residuei694 – 6941PhosphoserineBy similarity
    Modified residuei858 – 8581PhosphothreonineBy similarity

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ8CH18.
    PaxDbiQ8CH18.
    PRIDEiQ8CH18.

    PTM databases

    PhosphoSiteiQ8CH18.

    Expressioni

    Gene expression databases

    BgeeiQ8CH18.
    CleanExiMM_CCAR1.
    GenevestigatoriQ8CH18.

    Interactioni

    Subunit structurei

    Directly interacts with CALCOCO1, ESR1, NR3C1 and TP53.1 Publication

    Protein-protein interaction databases

    BioGridi212231. 6 interactions.
    IntActiQ8CH18. 3 interactions.
    MINTiMINT-1550931.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CH18.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini633 – 66735SAPPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili591 – 61525Sequence AnalysisAdd
    BLAST
    Coiled coili1029 – 111082Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 287285Gln-richAdd
    BLAST
    Compositional biasi290 – 35869Arg-richAdd
    BLAST
    Compositional biasi670 – 886217Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SAP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG313311.
    GeneTreeiENSGT00530000063672.
    HOVERGENiHBG079908.
    InParanoidiQ05BR1.
    OMAiELYHKSC.
    OrthoDBiEOG7CK365.
    PhylomeDBiQ8CH18.
    TreeFamiTF316387.

    Family and domain databases

    Gene3Di1.10.720.30. 1 hit.
    InterProiIPR025224. DBC1/CARP1.
    IPR025954. DBC1/CARP1_inactive_NUDIX_dom.
    IPR025223. S1-like_RNA-bd_dom.
    IPR003034. SAP_dom.
    [Graphical view]
    PANTHERiPTHR14304. PTHR14304. 1 hit.
    PfamiPF14443. DBC1. 1 hit.
    PF14444. S1-like. 1 hit.
    PF02037. SAP. 1 hit.
    [Graphical view]
    SMARTiSM00513. SAP. 1 hit.
    [Graphical view]
    PROSITEiPS50800. SAP. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8CH18-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA     50
    AGLTTQTPAN YQLTQTAALQ QQAAAVLQQQ YSQPQQALYS VQQQLQQPQQ 100
    TILTQPAVAL PTSLSLSTPQ PAAQITVSYP TPRSSQQQTQ PQKQRVFTGV 150
    VTKLHDTFGF VDEDVFFQLG AVKGKTPQVG DRVLVEATYN PNMPFKWNAQ 200
    RIQTLPNQNQ SQTQPLLKTP TAVIQPIVPQ TTFGVQAQPQ PQSLLQAQIS 250
    AASITPLLQT QPQPLLQQPQ QKAGLLQPPV RIVSQPQPAR RLDPPSRFSG 300
    RNDRGDQVPN RKDDRSRERD RERRRSRERS PQRKRSRERS PRRERERSPR 350
    RVRRVVPRYT VQFSKFSLDC PSCDMMELRR RYQNLYIPSD FFDAQFTWVD 400
    AFPLSRPFQL GNYCNFYVMH REVESLEKNM AVLDPPDADH LYSAKVMLMA 450
    SPSMEDLYHK SCALAEDPQD LRDGFQHPAR LVKFLVGMKG KDEAMAIGGH 500
    WSPSLDGPNP EKDPSVLIKT AIRCCKALTG IDLSVCTQWY RFAEIRYHRP 550
    EETHKGRTVP AHVETVVLFF PDVWHCLPTR SEWETLSRGY KQQLVEKLQG 600
    ERKKADGEQD EEEKDDGEVK EIATPTHWSK LDPKAMKVND LRKELESRAL 650
    SSKGLKSQLI ARLTKQLKIE EQKEEQKELE KSEKEEEDED DKKSEDDKEE 700
    EERKRQEEVE RQRQERRYIL PDEPAIIVHP NWAAKSGKFD CSIMSLSVLL 750
    DYRLEDNKEH SFEVSLFAEL FNEMLQRDFG VRIYKSLLSL PEKEDKKDKE 800
    KKSKKEERKD KKEEREDDID EPKPKRRKSG DDKDKKEDRD ERKKEEKRKD 850
    DSKDDDETEE DNNQDEYDPM EAEEAEDEDD DREEEEVKRD DKRDVSRYCK 900
    DRPAKDKEKE KPQMVTVNRD LLMAFVYFDQ SHCGYLLEKD LEEILYTLGL 950
    HLSRAQVKKL LNKVVLRESC FYRKLTDTSK DDENHEESEA LQEDMLGNRL 1000
    LLPTPTIKQE SKDGEENVGL IVYNGAMVDV GSLLQKLEKS EKVRAEVEQK 1050
    LQLLEEKTDE DGKTILNLEN SNKSLSGELR EVKKDLGQLQ ENLEVSENMN 1100
    LQFENQLNKT LRNLSTVMDD IHTVLKKDNV KSEDRDEKSK ENGSGV 1146
    Length:1,146
    Mass (Da):132,060
    Last modified:March 1, 2003 - v1
    Checksum:i6005A057B4F0BFF0
    GO
    Isoform 2 (identifier: Q8CH18-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         316-327: SRERDRERRRSR → RYVLRQCGGLEK
         328-1146: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:327
    Mass (Da):35,718
    Checksum:i42FF713BD7603559
    GO
    Isoform 3 (identifier: Q8CH18-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         638-699: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,084
    Mass (Da):124,746
    Checksum:iAB6C39FC58378B7C
    GO

    Sequence cautioni

    The sequence AAH10199.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH34174.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH39939.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH51052.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH60130.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH79652.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti279 – 2791P → L in AAH79652. (PubMed:15489334)Curated
    Sequence conflicti558 – 5581T → A in AAH39939. (PubMed:15489334)Curated
    Sequence conflicti802 – 8021K → E in BAC37267. (PubMed:16141072)Curated
    Sequence conflicti821 – 8211E → G in BAC37267. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei316 – 32712SRERD…RRRSR → RYVLRQCGGLEK in isoform 2. 1 PublicationVSP_018054Add
    BLAST
    Alternative sequencei328 – 1146819Missing in isoform 2. 1 PublicationVSP_018055Add
    BLAST
    Alternative sequencei638 – 69962Missing in isoform 3. 1 PublicationVSP_037737Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF465615 mRNA. Translation: AAO17318.1.
    AK012111 mRNA. Translation: BAB28040.2.
    AK077151 mRNA. Translation: BAC36646.1.
    AK078424 mRNA. Translation: BAC37267.1.
    BC010199 mRNA. Translation: AAH10199.1. Sequence problems.
    BC034174 mRNA. Translation: AAH34174.1. Sequence problems.
    BC039939 mRNA. Translation: AAH39939.1. Sequence problems.
    BC051052 mRNA. Translation: AAH51052.1. Sequence problems.
    BC060130 mRNA. Translation: AAH60130.1. Sequence problems.
    BC079652 mRNA. Translation: AAH79652.1. Sequence problems.
    CCDSiCCDS35922.1. [Q8CH18-1]
    RefSeqiNP_080477.1. NM_026201.3. [Q8CH18-1]
    XP_006514057.1. XM_006513994.1. [Q8CH18-1]
    XP_006514058.1. XM_006513995.1. [Q8CH18-1]
    XP_006514059.1. XM_006513996.1. [Q8CH18-1]
    XP_006514060.1. XM_006513997.1. [Q8CH18-3]
    UniGeneiMm.196371.

    Genome annotation databases

    EnsembliENSMUST00000020268; ENSMUSP00000020268; ENSMUSG00000020074. [Q8CH18-1]
    GeneIDi67500.
    KEGGimmu:67500.
    UCSCiuc007fja.2. mouse. [Q8CH18-1]
    uc007fjc.2. mouse. [Q8CH18-2]
    uc011xff.1. mouse. [Q8CH18-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF465615 mRNA. Translation: AAO17318.1 .
    AK012111 mRNA. Translation: BAB28040.2 .
    AK077151 mRNA. Translation: BAC36646.1 .
    AK078424 mRNA. Translation: BAC37267.1 .
    BC010199 mRNA. Translation: AAH10199.1 . Sequence problems.
    BC034174 mRNA. Translation: AAH34174.1 . Sequence problems.
    BC039939 mRNA. Translation: AAH39939.1 . Sequence problems.
    BC051052 mRNA. Translation: AAH51052.1 . Sequence problems.
    BC060130 mRNA. Translation: AAH60130.1 . Sequence problems.
    BC079652 mRNA. Translation: AAH79652.1 . Sequence problems.
    CCDSi CCDS35922.1. [Q8CH18-1 ]
    RefSeqi NP_080477.1. NM_026201.3. [Q8CH18-1 ]
    XP_006514057.1. XM_006513994.1. [Q8CH18-1 ]
    XP_006514058.1. XM_006513995.1. [Q8CH18-1 ]
    XP_006514059.1. XM_006513996.1. [Q8CH18-1 ]
    XP_006514060.1. XM_006513997.1. [Q8CH18-3 ]
    UniGenei Mm.196371.

    3D structure databases

    ProteinModelPortali Q8CH18.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212231. 6 interactions.
    IntActi Q8CH18. 3 interactions.
    MINTi MINT-1550931.

    PTM databases

    PhosphoSitei Q8CH18.

    Proteomic databases

    MaxQBi Q8CH18.
    PaxDbi Q8CH18.
    PRIDEi Q8CH18.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020268 ; ENSMUSP00000020268 ; ENSMUSG00000020074 . [Q8CH18-1 ]
    GeneIDi 67500.
    KEGGi mmu:67500.
    UCSCi uc007fja.2. mouse. [Q8CH18-1 ]
    uc007fjc.2. mouse. [Q8CH18-2 ]
    uc011xff.1. mouse. [Q8CH18-3 ]

    Organism-specific databases

    CTDi 55749.
    MGIi MGI:1914750. Ccar1.

    Phylogenomic databases

    eggNOGi NOG313311.
    GeneTreei ENSGT00530000063672.
    HOVERGENi HBG079908.
    InParanoidi Q05BR1.
    OMAi ELYHKSC.
    OrthoDBi EOG7CK365.
    PhylomeDBi Q8CH18.
    TreeFami TF316387.

    Miscellaneous databases

    ChiTaRSi CCAR1. mouse.
    NextBioi 324750.
    PROi Q8CH18.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CH18.
    CleanExi MM_CCAR1.
    Genevestigatori Q8CH18.

    Family and domain databases

    Gene3Di 1.10.720.30. 1 hit.
    InterProi IPR025224. DBC1/CARP1.
    IPR025954. DBC1/CARP1_inactive_NUDIX_dom.
    IPR025223. S1-like_RNA-bd_dom.
    IPR003034. SAP_dom.
    [Graphical view ]
    PANTHERi PTHR14304. PTHR14304. 1 hit.
    Pfami PF14443. DBC1. 1 hit.
    PF14444. S1-like. 1 hit.
    PF02037. SAP. 1 hit.
    [Graphical view ]
    SMARTi SM00513. SAP. 1 hit.
    [Graphical view ]
    PROSITEi PS50800. SAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TAZ binding partners identified by mass spectrometry."
      Tian Y., Li D., Benjamin T.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: Swiss Webster.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Embryo, Testis and Wolffian duct.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-833 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-797 (ISOFORM 3).
      Strain: C57BL/6, Czech II and FVB/N.
      Tissue: Brain, Kidney and Mammary tumor.
    4. "CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes."
      Kim J.H., Yang C.K., Heo K., Roeder R.G., An W., Stallcup M.R.
      Mol. Cell 31:510-519(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CALCOCO1; ESR1 AND NR3C.

    Entry informationi

    Entry nameiCCAR1_MOUSE
    AccessioniPrimary (citable) accession number: Q8CH18
    Secondary accession number(s): Q05BR1
    , Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3