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Protein

SURP and G-patch domain-containing protein 2

Gene

Sugp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in mRNA splicing.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
SURP and G-patch domain-containing protein 2
Alternative name(s):
Arginine/serine-rich-splicing factor 14
Splicing factor, arginine/serine-rich 14
Gene namesi
Name:Sugp2
Synonyms:Sfrs14, Srsf14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2678085. Sugp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977091 – 1067SURP and G-patch domain-containing protein 2Add BLAST1067

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93PhosphoserineBy similarity1
Modified residuei206PhosphoserineCombined sources1
Modified residuei265PhosphothreonineBy similarity1
Modified residuei267PhosphoserineBy similarity1
Modified residuei586PhosphoserineBy similarity1
Modified residuei740PhosphoserineCombined sources1
Modified residuei744PhosphothreonineCombined sources1
Modified residuei838PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CH09.
MaxQBiQ8CH09.
PaxDbiQ8CH09.
PeptideAtlasiQ8CH09.
PRIDEiQ8CH09.

PTM databases

iPTMnetiQ8CH09.
PhosphoSitePlusiQ8CH09.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036054.
CleanExiMM_SFRS14.
ExpressionAtlasiQ8CH09. baseline and differential.
GenevisibleiQ8CH09. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8CH09. 1 interactor.
MINTiMINT-4113430.
STRINGi10090.ENSMUSP00000091167.

Structurei

3D structure databases

ProteinModelPortaliQ8CH09.
SMRiQ8CH09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati573 – 616SURP motif 1Add BLAST44
Repeati770 – 813SURP motif 2Add BLAST44
Domaini996 – 1042G-patchPROSITE-ProRule annotationAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi980 – 985Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi844 – 884Glu-richAdd BLAST41

Sequence similaritiesi

Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 2 SURP motif repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0965. Eukaryota.
ENOG4111IFE. LUCA.
GeneTreeiENSGT00410000025695.
HOVERGENiHBG079176.
InParanoidiQ8CH09.
KOiK13166.
OMAiGHFRSQD.
OrthoDBiEOG091G00SX.
PhylomeDBiQ8CH09.
TreeFamiTF326321.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR000061. Surp.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF01805. Surp. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50128. SURP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CH09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARRMAQES LDSVLQEKSK RYGDSEAVGE ALHLKAQDLL RTGSRARADV
60 70 80 90 100
YEDIHGDSRY SASGSGVYSL DMGREGLRGD MFVGPSFRSS NQSVGEDSYL
110 120 130 140 150
RKECGRDLEP AHTDSRDQSF GHRNLGHFPS QDWKLALRGS WEQDLGHSVS
160 170 180 190 200
QESSWSQEYG FGPSLLGDLA SSRRMEKESR DYDLDHPGEV DSVSRSSGQV
210 220 230 240 250
LTRGRSLNIA DQEGTLLGKG DTQGLLGAKG VGKLITLKSM TTKKIPVASR
260 270 280 290 300
ITSKPQGTNQ IQKPTPSPDV TIGTSPVLDE IQFAALKIPL GLDLRTLGLP
310 320 330 340 350
RRKMGFDAID KADVFSRFGI EIIKWAGFHT IKDDLKFSQL FQTLFELETE
360 370 380 390 400
TCAKMLASFK CSLKPEHRDF CFFTIKFLKH SALKTPRVDN EFLNMLLDKG
410 420 430 440 450
AVKTKNCFFE IIKPFDKSIM RLQDRLLKGV TPLLMACNAY ELSVKMKTLT
460 470 480 490 500
SPLDLAMALE TTNSLCRKSL ALLGQTFSLA SSFRQEKILE AVGLQDIAPS
510 520 530 540 550
PAYFPNFEDS TLFGREYIDH LKAWLMASGY PLQLKRAVPP ESREQKTTAQ
560 570 580 590 600
TWASSTLSQA VPQRADHRVV DTIDQLVMRV IQGRLSPRER TLLLQDPAYW
610 620 630 640 650
FLSDESSLEY KYYKLKLAES QRLNHSWPIV ERRPTPAQCA VRAMLYAQAV
660 670 680 690 700
RSLKRRLLPW QRRRLIRSQG PRGLKAKKAT TAQQTSLSSG TRQKHHGRQA
710 720 730 740 750
SGSLRVKPPP RDSSDAAQDC LSEPAKPCPQ PSSPGALGPS PRPTGADDSE
760 770 780 790 800
ALPASSRCPS ANMDAKTMET AEKLARFVAQ VGPEIEQFSI ENSTDNPDLW
810 820 830 840 850
FLHDQSSSAF KFYREKVLEL CPSISFQSTG EAGDSVQSPT AGKEGKGEPQ
860 870 880 890 900
EGHPEQEASL EGTEVLPEEE EEDEEESEDE GGEETSTLRP QAGAAKCPGS
910 920 930 940 950
EGSSPTDSIP GEGSREDQAS TPGLSQASSG SCFPRKRISS KSLKVGMIPA
960 970 980 990 1000
PKRVCLIQES KVHEPVRIAY DRPRGRPIAK KKKPKDMEFS QQKLTDKNVG
1010 1020 1030 1040 1050
FQMLQKMGWK EGHGLGSLGK GIREPVSVGA LSEGEGLGAD GPEQKEDTFD
1060
VFRQRMMQMY RHKRASK
Length:1,067
Mass (Da):118,103
Last modified:March 15, 2005 - v2
Checksum:i8A191DC7C71C4949
GO

Sequence cautioni

The sequence AAH57305 differs from that shown. Reason: Frameshift at position 679.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti923G → A in AAN77118 (PubMed:12594045).Curated1
Sequence conflicti949P → T in BAC31218 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti666I → L in strain: FVB/N. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518875 mRNA. Translation: AAN77118.1.
AK042293 mRNA. Translation: BAC31218.1.
BC023276 mRNA. Translation: AAH23276.1.
BC042763 mRNA. Translation: AAH42763.1.
BC057305 mRNA. Translation: AAH57305.1. Frameshift.
CCDSiCCDS22362.1.
RefSeqiNP_001161762.1. NM_001168290.1.
NP_766343.3. NM_172755.3.
XP_006509707.1. XM_006509644.2.
XP_006509708.1. XM_006509645.3.
XP_006509709.1. XM_006509646.1.
UniGeneiMm.284505.

Genome annotation databases

EnsembliENSMUST00000093458; ENSMUSP00000091167; ENSMUSG00000036054.
ENSMUST00000131489; ENSMUSP00000114833; ENSMUSG00000036054.
ENSMUST00000164403; ENSMUSP00000128029; ENSMUSG00000036054.
GeneIDi234373.
KEGGimmu:234373.
UCSCiuc009lzk.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518875 mRNA. Translation: AAN77118.1.
AK042293 mRNA. Translation: BAC31218.1.
BC023276 mRNA. Translation: AAH23276.1.
BC042763 mRNA. Translation: AAH42763.1.
BC057305 mRNA. Translation: AAH57305.1. Frameshift.
CCDSiCCDS22362.1.
RefSeqiNP_001161762.1. NM_001168290.1.
NP_766343.3. NM_172755.3.
XP_006509707.1. XM_006509644.2.
XP_006509708.1. XM_006509645.3.
XP_006509709.1. XM_006509646.1.
UniGeneiMm.284505.

3D structure databases

ProteinModelPortaliQ8CH09.
SMRiQ8CH09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CH09. 1 interactor.
MINTiMINT-4113430.
STRINGi10090.ENSMUSP00000091167.

PTM databases

iPTMnetiQ8CH09.
PhosphoSitePlusiQ8CH09.

Proteomic databases

EPDiQ8CH09.
MaxQBiQ8CH09.
PaxDbiQ8CH09.
PeptideAtlasiQ8CH09.
PRIDEiQ8CH09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093458; ENSMUSP00000091167; ENSMUSG00000036054.
ENSMUST00000131489; ENSMUSP00000114833; ENSMUSG00000036054.
ENSMUST00000164403; ENSMUSP00000128029; ENSMUSG00000036054.
GeneIDi234373.
KEGGimmu:234373.
UCSCiuc009lzk.2. mouse.

Organism-specific databases

CTDi10147.
MGIiMGI:2678085. Sugp2.

Phylogenomic databases

eggNOGiKOG0965. Eukaryota.
ENOG4111IFE. LUCA.
GeneTreeiENSGT00410000025695.
HOVERGENiHBG079176.
InParanoidiQ8CH09.
KOiK13166.
OMAiGHFRSQD.
OrthoDBiEOG091G00SX.
PhylomeDBiQ8CH09.
TreeFamiTF326321.

Miscellaneous databases

ChiTaRSiSugp2. mouse.
PROiQ8CH09.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036054.
CleanExiMM_SFRS14.
ExpressionAtlasiQ8CH09. baseline and differential.
GenevisibleiQ8CH09. MM.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR000061. Surp.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF01805. Surp. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50128. SURP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUGP2_MOUSE
AccessioniPrimary (citable) accession number: Q8CH09
Secondary accession number(s): Q6PG19
, Q80UY8, Q8BY32, Q8CFM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.