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Protein

SURP and G-patch domain-containing protein 1

Gene

Sugp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in pre-mRNA splicing.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
SURP and G-patch domain-containing protein 1
Alternative name(s):
Splicing factor 4
Gene namesi
Name:Sugp1
Synonyms:Sf4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1917866. Sugp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977021 – 643SURP and G-patch domain-containing protein 1Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128PhosphothreonineBy similarity1
Modified residuei252PhosphoserineBy similarity1
Modified residuei322PhosphoserineBy similarity1
Modified residuei407PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei412PhosphoserineBy similarity1
Modified residuei483PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CH02.
MaxQBiQ8CH02.
PaxDbiQ8CH02.
PeptideAtlasiQ8CH02.
PRIDEiQ8CH02.

PTM databases

iPTMnetiQ8CH02.
PhosphoSitePlusiQ8CH02.

Expressioni

Gene expression databases

BgeeiENSMUSG00000011306.
CleanExiMM_SF4.
GenevisibleiQ8CH02. MM.

Interactioni

Subunit structurei

Component of the spliceosome.By similarity

Protein-protein interaction databases

BioGridi214168. 1 interactor.
IntActiQ8CH02. 2 interactors.
MINTiMINT-4115847.
STRINGi10090.ENSMUSP00000011450.

Structurei

Secondary structure

1643
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi167 – 172Combined sources6
Helixi179 – 181Combined sources3
Helixi182 – 198Combined sources17
Helixi200 – 209Combined sources10
Turni210 – 212Combined sources3
Beta strandi214 – 216Combined sources3
Helixi217 – 220Combined sources4
Helixi225 – 239Combined sources15
Helixi257 – 272Combined sources16
Helixi277 – 287Combined sources11
Turni291 – 295Combined sources5
Beta strandi297 – 300Combined sources4
Helixi301 – 313Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UG0NMR-A165-239[»]
1X4ONMR-A250-314[»]
ProteinModelPortaliQ8CH02.
SMRiQ8CH02.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8CH02.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati187 – 229SURP motif 1Add BLAST43
Repeati262 – 305SURP motif 2Add BLAST44
Domaini560 – 607G-patchPROSITE-ProRule annotationAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi378 – 384Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi324 – 371Pro-richAdd BLAST48
Compositional biasi439 – 478Gln/Met-richAdd BLAST40

Sequence similaritiesi

Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 2 SURP motif repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0965. Eukaryota.
ENOG410ZSH4. LUCA.
GeneTreeiENSGT00410000025695.
HOVERGENiHBG079172.
InParanoidiQ8CH02.
KOiK13096.
OMAiNYKDNPA.
OrthoDBiEOG091G04E7.
PhylomeDBiQ8CH02.
TreeFamiTF326321.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR000061. Surp.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF01805. Surp. 2 hits.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50128. SURP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CH02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKMDNRDV AGKANRWFGM AQPKSGKMNM NILHQEELIA QKKREIEARM
60 70 80 90 100
EQKARQSHVP SPQPPHPGEI ADAHNSCISN KFANDGSFLQ QFLKLQKAQT
110 120 130 140 150
STDSAPRAPP SMPTPSSLKK PLVLSKRTGL GLSSPTGPVK NYSHAKQLPV
160 170 180 190 200
AHRPSVFQSP DDDEEEDYEQ WLEIKVSPPE GAETRRVIEK LARFVAEGGP
210 220 230 240 250
ELEKVAMEDY KDNPAFTFLH DKNSREFLYY RRKVAEIRKE AQKPQAATQK
260 270 280 290 300
VSPPEDEEAK NLAEKLARFI ADGGPEVETI ALQNNRENQA FSFLYDPNSQ
310 320 330 340 350
GYRYYRQKLD EFRKAKAGST GSFPAPAPNP SLRRKSAPEA LSGAVPPITA
360 370 380 390 400
CPTPVAPAPA VNPTPSIPGK PTATAAVKRK RKSRWGPEED KVELPPAELA
410 420 430 440 450
QRDIDASPSP LSVQDLKGLG YEKGKPVGLV GVTELSDAQK KQLKEQQEMQ
460 470 480 490 500
QMYDMIMQHK RAMQDMQLLW EKALQQHQHG YDSDEEVDSE LGTWEHQLRR
510 520 530 540 550
MEMDKTREWA EQLTQMGRGK HFIGDFLPPD ELEKFMETFK ALKEGREPDY
560 570 580 590 600
SEYKEFKLTV ENIGYQMLMK MGWKEGEGLG TEGQGIKNPV NKGATTIDGA
610 620 630 640
GFGIDRPAEL SKEDDEYEAF RKRMMLAYRF RPNPLNNPRR PYY
Length:643
Mass (Da):72,649
Last modified:March 1, 2003 - v1
Checksum:iA1FCD38A26998E78
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326P → L in AAI20920 (PubMed:15489334).Curated1
Sequence conflicti326P → L in AAI20921 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521129 mRNA. Translation: AAN77124.1.
AK156508 mRNA. Translation: BAE33738.1.
BC120919 mRNA. Translation: AAI20920.1.
BC120920 mRNA. Translation: AAI20921.1.
CCDSiCCDS22356.1.
RefSeqiNP_081757.1. NM_027481.2.
XP_006509801.1. XM_006509738.1.
UniGeneiMm.17665.

Genome annotation databases

EnsembliENSMUST00000011450; ENSMUSP00000011450; ENSMUSG00000011306.
GeneIDi70616.
KEGGimmu:70616.
UCSCiuc009lyn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521129 mRNA. Translation: AAN77124.1.
AK156508 mRNA. Translation: BAE33738.1.
BC120919 mRNA. Translation: AAI20920.1.
BC120920 mRNA. Translation: AAI20921.1.
CCDSiCCDS22356.1.
RefSeqiNP_081757.1. NM_027481.2.
XP_006509801.1. XM_006509738.1.
UniGeneiMm.17665.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UG0NMR-A165-239[»]
1X4ONMR-A250-314[»]
ProteinModelPortaliQ8CH02.
SMRiQ8CH02.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214168. 1 interactor.
IntActiQ8CH02. 2 interactors.
MINTiMINT-4115847.
STRINGi10090.ENSMUSP00000011450.

PTM databases

iPTMnetiQ8CH02.
PhosphoSitePlusiQ8CH02.

Proteomic databases

EPDiQ8CH02.
MaxQBiQ8CH02.
PaxDbiQ8CH02.
PeptideAtlasiQ8CH02.
PRIDEiQ8CH02.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000011450; ENSMUSP00000011450; ENSMUSG00000011306.
GeneIDi70616.
KEGGimmu:70616.
UCSCiuc009lyn.1. mouse.

Organism-specific databases

CTDi57794.
MGIiMGI:1917866. Sugp1.

Phylogenomic databases

eggNOGiKOG0965. Eukaryota.
ENOG410ZSH4. LUCA.
GeneTreeiENSGT00410000025695.
HOVERGENiHBG079172.
InParanoidiQ8CH02.
KOiK13096.
OMAiNYKDNPA.
OrthoDBiEOG091G04E7.
PhylomeDBiQ8CH02.
TreeFamiTF326321.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

EvolutionaryTraceiQ8CH02.
PROiQ8CH02.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000011306.
CleanExiMM_SF4.
GenevisibleiQ8CH02. MM.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR000061. Surp.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF01805. Surp. 2 hits.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 2 hits.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50128. SURP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUGP1_MOUSE
AccessioniPrimary (citable) accession number: Q8CH02
Secondary accession number(s): Q0VAT9, Q3U0W3, Q8R094
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.