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Protein

Tachykinin-4

Gene

Tac4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior. Increases sperm motility. Induces potent analgesic effects and may play a role in pain modulation. Promotes survival of bone marrow B lineage cells and of cultured LPS-stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and proliferation. Lowers systemic arterial pressure following intravenous injection. Induces interferon-gamma production and may play a role in the inflammatory response. Shows potent affinity and specificity for the NK-1 receptor.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHypotensive agent
Biological processMast cell degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinin-4
Alternative name(s):
Preprotachykinin-C
Short name:
PPT-C
Cleaved into the following chain:
Alternative name(s):
HK1
Hemokinin-1
Hemokinin-I
Short name:
HK-I
Gene namesi
Name:Tac4Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi628842 Tac4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000032001917 – 54By similarityAdd BLAST38
PeptideiPRO_000032002057 – 66Hemokinin1 Publication10
PropeptideiPRO_000032002167 – 170By similarityAdd BLAST104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66Methionine amide1 PublicationSequence analysis1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8CH01

Expressioni

Gene expression databases

BgeeiENSRNOG00000004404

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029541

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2QI Eukaryota
ENOG41113ZV LUCA
GeneTreeiENSGT00390000015220
HOGENOMiHOG000154596
HOVERGENiHBG097570
InParanoidiQ8CH01
KOiK05241
OMAiYQLGRIV
OrthoDBiEOG091G0TYJ
TreeFamiTF338519

Family and domain databases

InterProiView protein in InterPro
IPR013055 Tachy_Neuro_lke_CS
IPR008216 Tachykinin_fam
PANTHERiPTHR11250 PTHR11250, 1 hit
PROSITEiView protein in PROSITE
PS00267 TACHYKININ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CH01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLLALFLL IGPAVSTTTR DREDLTFGAE AESWVTVNLK GIPVPSIELK
60 70 80 90 100
LQELKRSRTR QFYGLMGKRV EGVHPIQSAE RTGYQLGRIV QDLLGTRGLS
110 120 130 140 150
IEGSCRQETN HQSAGPGAVA RESLQSQRGR SEPPNHQQHV ALSLGTEEDD
160 170
QSSERAPRDA SQMMPRPSRP
Length:170
Mass (Da):18,751
Last modified:March 1, 2003 - v1
Checksum:i036845638A845567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521561 mRNA Translation: AAN77129.1
AY471575 mRNA Translation: AAS46597.1
RefSeqiNP_758831.1, NM_172328.2
UniGeneiRn.91139

Genome annotation databases

EnsembliENSRNOT00000035023; ENSRNOP00000029541; ENSRNOG00000004404
GeneIDi282829
KEGGirno:282829
UCSCiRGD:628842 rat

Similar proteinsi

Entry informationi

Entry nameiTKN4_RAT
AccessioniPrimary (citable) accession number: Q8CH01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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