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Protein

Calcium homeostasis endoplasmic reticulum protein

Gene

Cherp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in calcium homeostasis, growth and proliferation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium homeostasis endoplasmic reticulum protein
Alternative name(s):
SR-related CTD-associated factor 6
Gene namesi
Name:CherpImported
Synonyms:Scaf6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:106417. Cherp.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmperinuclear region By similarity
  • Endoplasmic reticulum By similarity

  • Note: Distributed throughout the cytoplasm and also localizes to the perinuclear region. Colocalizes with ITPR1 (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002994931 – 936Calcium homeostasis endoplasmic reticulum proteinAdd BLAST936

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei18N6-acetyllysineBy similarity1
Modified residuei723PhosphotyrosineCombined sources1
Modified residuei822PhosphoserineCombined sources1
Modified residuei824PhosphoserineCombined sources1
Modified residuei826PhosphoserineCombined sources1
Modified residuei828PhosphothreonineCombined sources1
Modified residuei837PhosphoserineBy similarity1
Modified residuei864PhosphoserineBy similarity1
Modified residuei866PhosphoserineBy similarity1
Modified residuei888N6-acetyllysineBy similarity1
Modified residuei913PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8CGZ0.
MaxQBiQ8CGZ0.
PaxDbiQ8CGZ0.
PRIDEiQ8CGZ0.

PTM databases

iPTMnetiQ8CGZ0.
PhosphoSitePlusiQ8CGZ0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052488.
CleanExiMM_CHERP.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SF1Q156373EBI-2366446,EBI-744603From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205695. 1 interactor.
IntActiQ8CGZ0. 3 interactors.
MINTiMINT-4115833.
STRINGi10090.ENSMUSP00000078469.

Structurei

3D structure databases

ProteinModelPortaliQ8CGZ0.
SMRiQ8CGZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 57SURP motifSequence analysisAdd BLAST43
Domaini149 – 289CIDPROSITE-ProRule annotationAdd BLAST141
Domaini850 – 900G-patchPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi279 – 355Gln-richSequence analysisAdd BLAST77
Compositional biasi343 – 691Pro-richSequence analysisAdd BLAST349
Compositional biasi727 – 825Arg-richSequence analysisAdd BLAST99

Sequence similaritiesi

Contains 1 CID domain.PROSITE-ProRule annotation
Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 1 SURP motif repeat.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4368. Eukaryota.
ENOG410YVN1. LUCA.
HOGENOMiHOG000010294.
HOVERGENiHBG052716.
InParanoidiQ8CGZ0.
KOiK12841.
PhylomeDBiQ8CGZ0.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR000467. G_patch_dom.
IPR006903. RNA_pol_II-bd.
IPR000061. Surp.
[Graphical view]
PfamiPF04818. CTD_bind. 1 hit.
PF01585. G-patch. 1 hit.
PF01805. Surp. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00648. SWAP. 1 hit.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 1 hit.
SSF48464. SSF48464. 1 hit.
PROSITEiPS51391. CID. 1 hit.
PS50174. G_PATCH. 1 hit.
PS50128. SURP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CGZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMPMPPDDQ ELRNVIDKLA QFVARNGPEF EKMTMEKQKD NPKFSFLFGG
60 70 80 90 100
EFYSYYKCKL ALEQQQLICK QQAPELEPTS AMPPLPQPPL APTASLTPAQ
110 120 130 140 150
GTPSMDELIQ QSQWSLQQQE QHLLALRQEQ VTTAVAHAVE QQMQKLLEET
160 170 180 190 200
QLDMSEFDNL LQPIIDTCTK DAISAGKNWM FSNAKSPPHC ELMAGHLRNR
210 220 230 240 250
ITADGAHFEL RLHLIYLIND VLHHCQRKQA RELLAALQKV VVPIYCTSFL
260 270 280 290 300
AVEEDKQQKI ARLLQLWEKN GYFDDSIIQQ LQSPALGLGQ YQATLINEYS
310 320 330 340 350
SVVQPVQLAF QQQIQSLKTQ HEEFVSSLAQ QQQQQQQQQQ QQPQPQPQPQ
360 370 380 390 400
IQLPQMEADV KATPPPPAPP PASAPAPTIP PTTQPDDNKP PIQMPGSSEY
410 420 430 440 450
DTSAGVQDPA AAGPRGPGPH EQIPPNKPPW FDQPHPVAPW GQQQPPEQPP
460 470 480 490 500
YPHHQGGPPH CPPWNNSHEG MWGEQRGDPG WNGQRDAPWN NQPDPNWNNQ
510 520 530 540 550
FEGPWNNQHE PPPWGGAQRE PPFRMQRPPH FRGPFPPHQQ HPQFNQPPHP
560 570 580 590 600
HNFNRFPPRF MQDDFPPRHP FERPPYPHRF DYPQGDFPAD MGPPHHHPGH
610 620 630 640 650
RMPHPGINEH PPWAGPQHPD FGPPPHGFNG QPPHMRRQGP PHINHDDPSL
660 670 680 690 700
VPNVPYFDLP AGLMAPLVKL EDHEYKPLDP KDIRLPPPMP PSERLLAAVE
710 720 730 740 750
AFYSPPSHDR PRNSEGWEQN GLYEFFRAKM RARRRKGQEK RNSGPSRSRS
760 770 780 790 800
RSKSRGRSSS RSSSRSSKSS RSSSRSHSRS RSRSSSRSRS RSRSRSRSSR
810 820 830 840 850
SRSRSRSRSR SKSYSPGRRR RSRSRSPTPP SAAGLGSNSA PPIPDSRLGE
860 870 880 890 900
ENKGHQMLVK MGWSGSGGLG AKEQGIQDPI KGGDVRDKWD QYKGVGVALD
910 920 930
DPYENYRRNK SYSFIARMKA RDEFSTFGTR KEEKED
Length:936
Mass (Da):106,169
Last modified:March 1, 2003 - v1
Checksum:i8C29DF0822CA9EB3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti348 – 349Missing in BC020488 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF536541 mRNA. Translation: AAN77182.1.
BC020488 mRNA. No translation available.
RefSeqiNP_613051.3. NM_138585.3.
UniGeneiMm.30136.

Genome annotation databases

GeneIDi27967.
KEGGimmu:27967.
UCSCiuc009mgb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF536541 mRNA. Translation: AAN77182.1.
BC020488 mRNA. No translation available.
RefSeqiNP_613051.3. NM_138585.3.
UniGeneiMm.30136.

3D structure databases

ProteinModelPortaliQ8CGZ0.
SMRiQ8CGZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205695. 1 interactor.
IntActiQ8CGZ0. 3 interactors.
MINTiMINT-4115833.
STRINGi10090.ENSMUSP00000078469.

PTM databases

iPTMnetiQ8CGZ0.
PhosphoSitePlusiQ8CGZ0.

Proteomic databases

EPDiQ8CGZ0.
MaxQBiQ8CGZ0.
PaxDbiQ8CGZ0.
PRIDEiQ8CGZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi27967.
KEGGimmu:27967.
UCSCiuc009mgb.1. mouse.

Organism-specific databases

CTDi10523.
MGIiMGI:106417. Cherp.

Phylogenomic databases

eggNOGiKOG4368. Eukaryota.
ENOG410YVN1. LUCA.
HOGENOMiHOG000010294.
HOVERGENiHBG052716.
InParanoidiQ8CGZ0.
KOiK12841.
PhylomeDBiQ8CGZ0.

Miscellaneous databases

PROiQ8CGZ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052488.
CleanExiMM_CHERP.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR006569. CID_dom.
IPR008942. ENTH_VHS.
IPR000467. G_patch_dom.
IPR006903. RNA_pol_II-bd.
IPR000061. Surp.
[Graphical view]
PfamiPF04818. CTD_bind. 1 hit.
PF01585. G-patch. 1 hit.
PF01805. Surp. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00648. SWAP. 1 hit.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 1 hit.
SSF48464. SSF48464. 1 hit.
PROSITEiPS51391. CID. 1 hit.
PS50174. G_PATCH. 1 hit.
PS50128. SURP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHERP_MOUSE
AccessioniPrimary (citable) accession number: Q8CGZ0
Secondary accession number(s): Q8K291, Q8VCD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.