Calcium homeostasis endoplasmic reticulum protein

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Q8CGZ0 (CHERP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 62. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Calcium homeostasis endoplasmic reticulum protein

Alternative name(s):
SR-related CTD-associated factor 6

Gene names

Name:	Cherp
Synonyms:	Scaf6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	936 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

Involved in calcium homeostasis, growth and proliferation By similarity. UniProtKB Q8IWX8

Subcellular location

Cytoplasm By similarity. Cytoplasm › perinuclear region By similarity. Endoplasmic reticulum By similarity. Note: Distributed throughout the cytoplasm and also localizes to the perinuclear region. Colocalizes with ITPR1 By similarity. UniProtKB Q8IWX8

Sequence similarities

Contains 1 CID domain.

Contains 1 G-patch domain.

Contains 1 SURP motif repeat.

Ontologies

Keywords
Cellular component	Cytoplasm Endoplasmic reticulum
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 936

936

Calcium homeostasis endoplasmic reticulum protein

PRO_0000299493

Regions

Repeat

15 – 57

SURP motif

Domain

149 – 289

141

CID

Domain

850 – 900

G-patch

Compositional bias

279 – 355

Gln-rich

Compositional bias

343 – 691

349

Pro-rich

Compositional bias

727 – 825

Arg-rich

Amino acid modifications

Modified residue

N-acetylmethionine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

723

Phosphotyrosine Ref.3

Modified residue

822

Phosphoserine Ref.4

Modified residue

824

Phosphoserine By similarity

Modified residue

826

Phosphoserine Ref.5

Modified residue

828

Phosphothreonine Ref.5

Modified residue

831

Phosphoserine By similarity

Modified residue

837

Phosphoserine By similarity

Modified residue

839

Phosphoserine By similarity

Modified residue

888

N6-acetyllysine By similarity

Modified residue

910

N6-acetyllysine By similarity

Modified residue

913

Phosphoserine By similarity

Experimental info

Sequence conflict

348 – 349

Missing in BC020488. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q8CGZ0 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 8C29DF0822CA9EB3
Show »

FASTA

936

106,169

        10         20         30         40         50         60 
MEMPMPPDDQ ELRNVIDKLA QFVARNGPEF EKMTMEKQKD NPKFSFLFGG EFYSYYKCKL 

        70         80         90        100        110        120 
ALEQQQLICK QQAPELEPTS AMPPLPQPPL APTASLTPAQ GTPSMDELIQ QSQWSLQQQE 

       130        140        150        160        170        180 
QHLLALRQEQ VTTAVAHAVE QQMQKLLEET QLDMSEFDNL LQPIIDTCTK DAISAGKNWM 

       190        200        210        220        230        240 
FSNAKSPPHC ELMAGHLRNR ITADGAHFEL RLHLIYLIND VLHHCQRKQA RELLAALQKV 

       250        260        270        280        290        300 
VVPIYCTSFL AVEEDKQQKI ARLLQLWEKN GYFDDSIIQQ LQSPALGLGQ YQATLINEYS 

       310        320        330        340        350        360 
SVVQPVQLAF QQQIQSLKTQ HEEFVSSLAQ QQQQQQQQQQ QQPQPQPQPQ IQLPQMEADV 

       370        380        390        400        410        420 
KATPPPPAPP PASAPAPTIP PTTQPDDNKP PIQMPGSSEY DTSAGVQDPA AAGPRGPGPH 

       430        440        450        460        470        480 
EQIPPNKPPW FDQPHPVAPW GQQQPPEQPP YPHHQGGPPH CPPWNNSHEG MWGEQRGDPG 

       490        500        510        520        530        540 
WNGQRDAPWN NQPDPNWNNQ FEGPWNNQHE PPPWGGAQRE PPFRMQRPPH FRGPFPPHQQ 

       550        560        570        580        590        600 
HPQFNQPPHP HNFNRFPPRF MQDDFPPRHP FERPPYPHRF DYPQGDFPAD MGPPHHHPGH 

       610        620        630        640        650        660 
RMPHPGINEH PPWAGPQHPD FGPPPHGFNG QPPHMRRQGP PHINHDDPSL VPNVPYFDLP 

       670        680        690        700        710        720 
AGLMAPLVKL EDHEYKPLDP KDIRLPPPMP PSERLLAAVE AFYSPPSHDR PRNSEGWEQN 

       730        740        750        760        770        780 
GLYEFFRAKM RARRRKGQEK RNSGPSRSRS RSKSRGRSSS RSSSRSSKSS RSSSRSHSRS 

       790        800        810        820        830        840 
RSRSSSRSRS RSRSRSRSSR SRSRSRSRSR SKSYSPGRRR RSRSRSPTPP SAAGLGSNSA 

       850        860        870        880        890        900 
PPIPDSRLGE ENKGHQMLVK MGWSGSGGLG AKEQGIQDPI KGGDVRDKWD QYKGVGVALD 

       910        920        930 
DPYENYRRNK SYSFIARMKA RDEFSTFGTR KEEKED

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional characterization of the novel SR-related CTD associated factor, SCAF6." Sampson N.D., Hewitt J.E. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
[3]	"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling." Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R. J. Immunol. 179:5864-5876(2007) [PubMed: 17947660] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-723, MASS SPECTROMETRY. Tissue: Mast cell.
[4]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-822, MASS SPECTROMETRY. Tissue: Liver.
[5]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed: 19144319] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826 AND THR-828, MASS SPECTROMETRY. Tissue: Macrophage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF536541 mRNA. Translation: AAN77182.1. BC020488 mRNA. No translation available.
IPI	IPI00229604.
RefSeq	NP_613051.3. NM_138585.3.
UniGene	Mm.30136.
3D structure databases
HSSP	HSSP built from PDB template 1UG0 based on UniProtKB Q8CH02.
ProteinModelPortal	Q8CGZ0.
SMR	Q8CGZ0. Positions 5-67.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8CGZ0. 1 interaction.
STRING	Q8CGZ0.
PTM databases
PhosphoSite	Q8CGZ0.
Proteomic databases
PRIDE	Q8CGZ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	27967.
KEGG	mmu:27967.
UCSC	uc009mga.1. mouse.
Organism-specific databases
CTD	10523.
MGI	MGI:106417. Cherp.
Phylogenomic databases
eggNOG	roNOG15209.
GeneTree	ENSGT00600000084415.
HOGENOM	HBG445457.
HOVERGEN	HBG052716.
InParanoid	Q8CGZ0.
OrthoDB	EOG4BCDMG.
Gene expression databases
ArrayExpress	Q8CGZ0.
Bgee	Q8CGZ0.
CleanEx	MM_CHERP.
Genevestigator	Q8CGZ0.
Family and domain databases
InterPro	IPR006903. DUF618. IPR008942. ENTH_VHS. IPR000467. G_patch. IPR006569. RNA_polymerase_II_lsu_CTD. IPR000061. Surp. [Graphical view]
Gene3D	G3DSA:1.25.40.90. ENTH_VHS. 1 hit.
KO	K12841.
Pfam	PF04818. DUF618. 1 hit. PF01585. G-patch. 1 hit. PF01805. Surp. 1 hit. [Graphical view]
SMART	SM00443. G_patch. 1 hit. SM00582. RPR. 1 hit. SM00648. SWAP. 1 hit. [Graphical view]
SUPFAM	SSF48464. ENTH_VHS. 1 hit.
PROSITE	PS51391. CID. 1 hit. PS50174. G_PATCH. 1 hit. PS50128. SURP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	306460.
SOURCE	Search...

Entry information

Entry name

CHERP_MOUSE

Accession

Primary (citable) accession number: Q8CGZ0
Secondary accession number(s): Q8K291, Q8VCD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	March 1, 2003
Last modified:	November 16, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents