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Protein

Protein unc-45 homolog B

Gene

Unc45b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development (PubMed:12356907, PubMed:18326487, PubMed:18478096). Is necessary for normal early lens development (By similarity).By similarity3 Publications

GO - Molecular functioni

  • Hsp90 protein binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionChaperone, Developmental protein
Biological processDifferentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-45 homolog B
Short name:
Unc-45B
Gene namesi
Name:Unc45b
Synonyms:Cmya4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2443377 Unc45b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002498931 – 931Protein unc-45 homolog BAdd BLAST931

Proteomic databases

PaxDbiQ8CGY6
PeptideAtlasiQ8CGY6
PRIDEiQ8CGY6

PTM databases

iPTMnetiQ8CGY6
PhosphoSitePlusiQ8CGY6

Expressioni

Tissue specificityi

Highly expressed in adult skeletal muscle and heart. Detected at intermediate levels in lung. Highly expressed in embryonic heart.1 Publication

Developmental stagei

Detected in fusing myoblasts during muscle cell differentiation. Highly expressed in young myotubes that are in the process of assembling and remodeling myofibrils. Subsequently, levels decrease during myotube maturation.

Gene expression databases

BgeeiENSMUSG00000018845
CleanExiMM_UNC45B
GenevisibleiQ8CGY6 MM

Interactioni

Subunit structurei

Interacts with HSP90 in an ATP-independent manner.2 Publications

GO - Molecular functioni

  • Hsp90 protein binding Source: MGI

Protein-protein interaction databases

BioGridi229832, 2 interactors
STRINGi10090.ENSMUSP00000018989

Structurei

3D structure databases

ProteinModelPortaliQ8CGY6
SMRiQ8CGY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 39TPR 1Add BLAST34
Repeati43 – 76TPR 2Add BLAST34
Repeati77 – 110TPR 3Add BLAST34
Repeati169 – 208ARM 1Add BLAST40
Repeati211 – 250ARM 2Add BLAST40
Repeati751 – 790ARM 3Add BLAST40

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4151 Eukaryota
ENOG410XQNT LUCA
GeneTreeiENSGT00900000140844
HOGENOMiHOG000285994
HOVERGENiHBG057344
InParanoidiQ8CGY6
KOiK21991
OMAiQHRGLVI
OrthoDBiEOG091G02FM
PhylomeDBiQ8CGY6
TreeFamiTF314096

Family and domain databases

Gene3Di1.25.10.10, 2 hits
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR024660 UCS_central_dom
PfamiView protein in Pfam
PF11701 UNC45-central, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 3 hits
SM00028 TPR, 3 hits
SUPFAMiSSF48371 SSF48371, 3 hits
SSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CGY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAEAAQLK EEGNRHFQLQ DYKAATKSYS QALKLTKDKA LLATLYRNRA
60 70 80 90 100
ACGLKMESYA QAASDASRAI DINSADIKAL YRRCQALEHL GKLDQAFKDV
110 120 130 140 150
QRCATLEPRN QNFQETLRRL NTSIQEQLRV QFSTDSRVQT MFEILLNENS
160 170 180 190 200
EADKREKAAN NLIVLGREEA GAERIFQSNG VALLLQLMNT QRPELLLAAV
210 220 230 240 250
RTLSGMCSGH RARATAILHA VRIDRICSLM ALENEEMSLA VCNLLQAIID
260 270 280 290 300
SLSGEDKREH RGKEEALVLD TKKDLKQITS HLLDMLVSKK VSGQGRDQAL
310 320 330 340 350
NLLNKNVPRK DLSIHDNSRT IYVVDNGLRK ILKVVGQVPD LPSCLPLTDN
360 370 380 390 400
TRMLASILIN KLYDDLRCDP ERDHFRKICE EYITSKFDPQ DMDKNVNAIQ
410 420 430 440 450
TVSGILQGPF DLGNQLLGMK GVMEMMVALC GSEREADQLV AVEALIHAST
460 470 480 490 500
KLSRATFIIT NGVTLLKQIY KTTKNEKIKI RTLVGLCKLG SAGGSDYGLR
510 520 530 540 550
QFAEGSTEKL AKQCRKWLCN TAIDTRTRRW AVEGLAYLTL DADVKDDFVQ
560 570 580 590 600
DIPALQAMFE LAKARTSDKT ILYSVANTLV NCTNSYDVKE VVPELVQLAK
610 620 630 640 650
FSKQHVPEEH PKDKKDFVDL RVKRLLKAGV ISALACMVKA DSAILTDQTK
660 670 680 690 700
ELLARVFLAL CDNPKDRGTI VAQGGGKALI PLALEGTDVG KVKAAHGLAK
710 720 730 740 750
IAAVSNPDIA FPGERVYEVV RPLVSLLDTQ RDGLQNYEAL LGLTNLSGRS
760 770 780 790 800
DKLRQKIFKE KALPDIENYM FENHDQLRQA ATECMCNMVL NKEVQERFLA
810 820 830 840 850
DGNDRLKLVV LLCGEDDHKL QNAAAGALAM LTAAHKKLCL KMTEVTTQWL
860 870 880 890 900
EILQRLCLHD QLSVQHRGLV IAHNLLSADA ELARKLVESE LLEILTVVGK
910 920 930
QEPDEKRAAV VQTARECLIK CMDYGFIKPV S
Length:931
Mass (Da):103,638
Last modified:March 1, 2003 - v1
Checksum:i664CE68C55031578
GO
Isoform 2 (identifier: Q8CGY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     564-565: Missing.

Show »
Length:929
Mass (Da):103,411
Checksum:i324F10D558B266F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176F → L in AAH84585 (PubMed:15489334).Curated1
Sequence conflicti725S → I in BAC34921 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020588564 – 565Missing in isoform 2. 3 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539793 mRNA Translation: AAO13383.1
AK052294 mRNA Translation: BAC34921.1
AK081821 mRNA Translation: BAC38342.1
AK084418 mRNA Translation: BAC39178.1
AL603745 Genomic DNA No translation available.
BC084585 mRNA Translation: AAH84585.1
CCDSiCCDS36251.1 [Q8CGY6-2]
RefSeqiNP_848795.3, NM_178680.4 [Q8CGY6-2]
UniGeneiMm.295205

Genome annotation databases

EnsembliENSMUST00000018989; ENSMUSP00000018989; ENSMUSG00000018845 [Q8CGY6-2]
ENSMUST00000108160; ENSMUSP00000103795; ENSMUSG00000018845 [Q8CGY6-1]
ENSMUST00000164945; ENSMUSP00000129405; ENSMUSG00000018845 [Q8CGY6-1]
GeneIDi217012
KEGGimmu:217012
UCSCiuc007knu.2 mouse [Q8CGY6-2]
uc007knw.1 mouse [Q8CGY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUN45B_MOUSE
AccessioniPrimary (citable) accession number: Q8CGY6
Secondary accession number(s): Q5XG72, Q8BHC5, Q8BWK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health