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Protein

Protein unc-45 homolog B

Gene

Unc45b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development (PubMed:12356907, PubMed:18326487, PubMed:18478096). Is necessary for normal early lens development (By similarity).By similarity3 Publications

GO - Molecular functioni

  • Hsp90 protein binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein unc-45 homolog B
Short name:
Unc-45B
Gene namesi
Name:Unc45b
Synonyms:Cmya4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2443377. Unc45b.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 931931Protein unc-45 homolog BPRO_0000249893Add
BLAST

Proteomic databases

MaxQBiQ8CGY6.
PaxDbiQ8CGY6.
PeptideAtlasiQ8CGY6.
PRIDEiQ8CGY6.

PTM databases

iPTMnetiQ8CGY6.
PhosphoSiteiQ8CGY6.

Expressioni

Tissue specificityi

Highly expressed in adult skeletal muscle and heart. Detected at intermediate levels in lung. Highly expressed in embryonic heart.1 Publication

Developmental stagei

Detected in fusing myoblasts during muscle cell differentiation. Highly expressed in young myotubes that are in the process of assembling and remodeling myofibrils. Subsequently, levels decrease during myotube maturation.

Gene expression databases

BgeeiENSMUSG00000018845.
CleanExiMM_UNC45B.
GenevisibleiQ8CGY6. MM.

Interactioni

Subunit structurei

Interacts with HSP90 in an ATP-independent manner.2 Publications

GO - Molecular functioni

  • Hsp90 protein binding Source: MGI

Protein-protein interaction databases

BioGridi229832. 2 interactions.
STRINGi10090.ENSMUSP00000018989.

Structurei

3D structure databases

ProteinModelPortaliQ8CGY6.
SMRiQ8CGY6. Positions 6-915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 3934TPR 1Add
BLAST
Repeati43 – 7634TPR 2Add
BLAST
Repeati77 – 11034TPR 3Add
BLAST
Repeati169 – 20840ARM 1Add
BLAST
Repeati211 – 25040ARM 2Add
BLAST
Repeati751 – 79040ARM 3Add
BLAST

Sequence similaritiesi

Contains 3 ARM repeats.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4151. Eukaryota.
ENOG410XQNT. LUCA.
GeneTreeiENSGT00840000129775.
HOGENOMiHOG000285994.
HOVERGENiHBG057344.
InParanoidiQ8CGY6.
OMAiCLYGVVT.
OrthoDBiEOG091G02FM.
PhylomeDBiQ8CGY6.
TreeFamiTF314096.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
1.25.40.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR024660. UCS_central_dom.
[Graphical view]
PfamiPF11701. UNC45-central. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 3 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CGY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAEAAQLK EEGNRHFQLQ DYKAATKSYS QALKLTKDKA LLATLYRNRA
60 70 80 90 100
ACGLKMESYA QAASDASRAI DINSADIKAL YRRCQALEHL GKLDQAFKDV
110 120 130 140 150
QRCATLEPRN QNFQETLRRL NTSIQEQLRV QFSTDSRVQT MFEILLNENS
160 170 180 190 200
EADKREKAAN NLIVLGREEA GAERIFQSNG VALLLQLMNT QRPELLLAAV
210 220 230 240 250
RTLSGMCSGH RARATAILHA VRIDRICSLM ALENEEMSLA VCNLLQAIID
260 270 280 290 300
SLSGEDKREH RGKEEALVLD TKKDLKQITS HLLDMLVSKK VSGQGRDQAL
310 320 330 340 350
NLLNKNVPRK DLSIHDNSRT IYVVDNGLRK ILKVVGQVPD LPSCLPLTDN
360 370 380 390 400
TRMLASILIN KLYDDLRCDP ERDHFRKICE EYITSKFDPQ DMDKNVNAIQ
410 420 430 440 450
TVSGILQGPF DLGNQLLGMK GVMEMMVALC GSEREADQLV AVEALIHAST
460 470 480 490 500
KLSRATFIIT NGVTLLKQIY KTTKNEKIKI RTLVGLCKLG SAGGSDYGLR
510 520 530 540 550
QFAEGSTEKL AKQCRKWLCN TAIDTRTRRW AVEGLAYLTL DADVKDDFVQ
560 570 580 590 600
DIPALQAMFE LAKARTSDKT ILYSVANTLV NCTNSYDVKE VVPELVQLAK
610 620 630 640 650
FSKQHVPEEH PKDKKDFVDL RVKRLLKAGV ISALACMVKA DSAILTDQTK
660 670 680 690 700
ELLARVFLAL CDNPKDRGTI VAQGGGKALI PLALEGTDVG KVKAAHGLAK
710 720 730 740 750
IAAVSNPDIA FPGERVYEVV RPLVSLLDTQ RDGLQNYEAL LGLTNLSGRS
760 770 780 790 800
DKLRQKIFKE KALPDIENYM FENHDQLRQA ATECMCNMVL NKEVQERFLA
810 820 830 840 850
DGNDRLKLVV LLCGEDDHKL QNAAAGALAM LTAAHKKLCL KMTEVTTQWL
860 870 880 890 900
EILQRLCLHD QLSVQHRGLV IAHNLLSADA ELARKLVESE LLEILTVVGK
910 920 930
QEPDEKRAAV VQTARECLIK CMDYGFIKPV S
Length:931
Mass (Da):103,638
Last modified:March 1, 2003 - v1
Checksum:i664CE68C55031578
GO
Isoform 2 (identifier: Q8CGY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     564-565: Missing.

Show »
Length:929
Mass (Da):103,411
Checksum:i324F10D558B266F5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti176 – 1761F → L in AAH84585 (PubMed:15489334).Curated
Sequence conflicti725 – 7251S → I in BAC34921 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei564 – 5652Missing in isoform 2. 3 PublicationsVSP_020588

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539793 mRNA. Translation: AAO13383.1.
AK052294 mRNA. Translation: BAC34921.1.
AK081821 mRNA. Translation: BAC38342.1.
AK084418 mRNA. Translation: BAC39178.1.
AL603745 Genomic DNA. Translation: CAI25496.1.
BC084585 mRNA. Translation: AAH84585.1.
CCDSiCCDS36251.1. [Q8CGY6-2]
RefSeqiNP_848795.3. NM_178680.4. [Q8CGY6-2]
UniGeneiMm.295205.

Genome annotation databases

EnsembliENSMUST00000018989; ENSMUSP00000018989; ENSMUSG00000018845. [Q8CGY6-2]
ENSMUST00000108160; ENSMUSP00000103795; ENSMUSG00000018845. [Q8CGY6-1]
ENSMUST00000164945; ENSMUSP00000129405; ENSMUSG00000018845. [Q8CGY6-1]
GeneIDi217012.
KEGGimmu:217012.
UCSCiuc007knu.2. mouse. [Q8CGY6-2]
uc007knw.1. mouse. [Q8CGY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539793 mRNA. Translation: AAO13383.1.
AK052294 mRNA. Translation: BAC34921.1.
AK081821 mRNA. Translation: BAC38342.1.
AK084418 mRNA. Translation: BAC39178.1.
AL603745 Genomic DNA. Translation: CAI25496.1.
BC084585 mRNA. Translation: AAH84585.1.
CCDSiCCDS36251.1. [Q8CGY6-2]
RefSeqiNP_848795.3. NM_178680.4. [Q8CGY6-2]
UniGeneiMm.295205.

3D structure databases

ProteinModelPortaliQ8CGY6.
SMRiQ8CGY6. Positions 6-915.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229832. 2 interactions.
STRINGi10090.ENSMUSP00000018989.

PTM databases

iPTMnetiQ8CGY6.
PhosphoSiteiQ8CGY6.

Proteomic databases

MaxQBiQ8CGY6.
PaxDbiQ8CGY6.
PeptideAtlasiQ8CGY6.
PRIDEiQ8CGY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018989; ENSMUSP00000018989; ENSMUSG00000018845. [Q8CGY6-2]
ENSMUST00000108160; ENSMUSP00000103795; ENSMUSG00000018845. [Q8CGY6-1]
ENSMUST00000164945; ENSMUSP00000129405; ENSMUSG00000018845. [Q8CGY6-1]
GeneIDi217012.
KEGGimmu:217012.
UCSCiuc007knu.2. mouse. [Q8CGY6-2]
uc007knw.1. mouse. [Q8CGY6-1]

Organism-specific databases

CTDi146862.
MGIiMGI:2443377. Unc45b.

Phylogenomic databases

eggNOGiKOG4151. Eukaryota.
ENOG410XQNT. LUCA.
GeneTreeiENSGT00840000129775.
HOGENOMiHOG000285994.
HOVERGENiHBG057344.
InParanoidiQ8CGY6.
OMAiCLYGVVT.
OrthoDBiEOG091G02FM.
PhylomeDBiQ8CGY6.
TreeFamiTF314096.

Miscellaneous databases

PROiQ8CGY6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018845.
CleanExiMM_UNC45B.
GenevisibleiQ8CGY6. MM.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
1.25.40.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR024660. UCS_central_dom.
[Graphical view]
PfamiPF11701. UNC45-central. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 3 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUN45B_MOUSE
AccessioniPrimary (citable) accession number: Q8CGY6
Secondary accession number(s): Q5XG72, Q8BHC5, Q8BWK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.