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Protein

Doublesex- and mab-3-related transcription factor C2

Gene

Dmrtc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in sexual development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi42 – 89DMPROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

GO - Biological processi

  • male meiosis I Source: MGI
  • positive regulation of histone H3-K9 dimethylation Source: MGI
  • positive regulation of histone H3-K9 trimethylation Source: MGI
  • sex differentiation Source: GO_Central
  • spermatid nucleus elongation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Differentiation, Sexual differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Doublesex- and mab-3-related transcription factor C2
Alternative name(s):
Doublesex- and mab-3-related transcription factor 7
Gene namesi
Name:Dmrtc2
Synonyms:Dmrt7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1918491. Dmrtc2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: GO_Central
  • XY body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002441071 – 370Doublesex- and mab-3-related transcription factor C2Add BLAST370

Proteomic databases

PaxDbiQ8CGW9.
PRIDEiQ8CGW9.

PTM databases

PhosphoSitePlusiQ8CGW9.

Expressioni

Tissue specificityi

Expressed in testis. Highly expressed in ovary.

Developmental stagei

Expressed in gonads from E11.5.

Gene expression databases

BgeeiENSMUSG00000011349.
GenevisibleiQ8CGW9. MM.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi214575. 8 interactors.
STRINGi10090.ENSMUSP00000011493.

Structurei

3D structure databases

ProteinModelPortaliQ8CGW9.
SMRiQ8CGW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi123 – 352Pro-richAdd BLAST230

Sequence similaritiesi

Belongs to the DMRT family.Curated
Contains 1 DM DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3815. Eukaryota.
ENOG410XSK9. LUCA.
GeneTreeiENSGT00530000063957.
HOGENOMiHOG000231505.
HOVERGENiHBG081447.
InParanoidiQ8CGW9.
KOiK19493.
OMAiISRSPTC.
OrthoDBiEOG091G0K2L.
PhylomeDBiQ8CGW9.
TreeFamiTF340713.

Family and domain databases

Gene3Di4.10.1040.10. 1 hit.
InterProiIPR001275. DM_DNA-bd.
IPR031577. DMRT-C1/C2_C.
IPR026607. DMRT/dsx/mab-3.
[Graphical view]
PANTHERiPTHR12322. PTHR12322. 1 hit.
PfamiPF00751. DM. 1 hit.
PF15791. DMRT-like. 1 hit.
[Graphical view]
SMARTiSM00301. DM. 1 hit.
[Graphical view]
SUPFAMiSSF82927. SSF82927. 1 hit.
PROSITEiPS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CGW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSETAALH HCSADSSPAD EARVPQSTEL IPRRPVSRSP TCARCRNHGV
60 70 80 90 100
TAHLKGHKRL CLFQACECHK CVLILERRRV MAAQVALRRQ QEAQLKRHLA
110 120 130 140 150
QGLMKGATPL KAPLRVKKGA IRPGIPSGKE NIAPQPQSPH GAVPLVLTPP
160 170 180 190 200
GKENYGPLLL SRPPEALPLP WTPVPPGPWG PGHWLPPGLS MPPPVVCRLL
210 220 230 240 250
CQEPAVPLHP FPGFDPGTSL RLPTHGTLPT CPGSRSVLTA PLSGEPQGPP
260 270 280 290 300
NLPHTCSTLI LQSCGTPDSL LLQPQAPGAS CLAWTSGPSE RQLQREAAEA
310 320 330 340 350
LVGLKDSSQA PRLTPSVPPN PAWISLLHPC GPPAPPGGRG FQPVGPPLRP
360 370
SPGSSVSLHI GRLGSISLLS
Length:370
Mass (Da):39,095
Last modified:March 1, 2003 - v1
Checksum:iF4DFCB23C94C8A6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542046 mRNA. Translation: AAN77233.1.
BC100434 mRNA. Translation: AAI00435.1.
BC138203 mRNA. Translation: AAI38204.1.
BC145988 mRNA. Translation: AAI45989.1.
CCDSiCCDS20965.1.
RefSeqiNP_082008.1. NM_027732.2.
XP_006540422.1. XM_006540359.3.
UniGeneiMm.66855.

Genome annotation databases

EnsembliENSMUST00000011493; ENSMUSP00000011493; ENSMUSG00000011349.
GeneIDi71241.
KEGGimmu:71241.
UCSCiuc009fqp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542046 mRNA. Translation: AAN77233.1.
BC100434 mRNA. Translation: AAI00435.1.
BC138203 mRNA. Translation: AAI38204.1.
BC145988 mRNA. Translation: AAI45989.1.
CCDSiCCDS20965.1.
RefSeqiNP_082008.1. NM_027732.2.
XP_006540422.1. XM_006540359.3.
UniGeneiMm.66855.

3D structure databases

ProteinModelPortaliQ8CGW9.
SMRiQ8CGW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214575. 8 interactors.
STRINGi10090.ENSMUSP00000011493.

PTM databases

PhosphoSitePlusiQ8CGW9.

Proteomic databases

PaxDbiQ8CGW9.
PRIDEiQ8CGW9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000011493; ENSMUSP00000011493; ENSMUSG00000011349.
GeneIDi71241.
KEGGimmu:71241.
UCSCiuc009fqp.2. mouse.

Organism-specific databases

CTDi63946.
MGIiMGI:1918491. Dmrtc2.

Phylogenomic databases

eggNOGiKOG3815. Eukaryota.
ENOG410XSK9. LUCA.
GeneTreeiENSGT00530000063957.
HOGENOMiHOG000231505.
HOVERGENiHBG081447.
InParanoidiQ8CGW9.
KOiK19493.
OMAiISRSPTC.
OrthoDBiEOG091G0K2L.
PhylomeDBiQ8CGW9.
TreeFamiTF340713.

Miscellaneous databases

PROiQ8CGW9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000011349.
GenevisibleiQ8CGW9. MM.

Family and domain databases

Gene3Di4.10.1040.10. 1 hit.
InterProiIPR001275. DM_DNA-bd.
IPR031577. DMRT-C1/C2_C.
IPR026607. DMRT/dsx/mab-3.
[Graphical view]
PANTHERiPTHR12322. PTHR12322. 1 hit.
PfamiPF00751. DM. 1 hit.
PF15791. DMRT-like. 1 hit.
[Graphical view]
SMARTiSM00301. DM. 1 hit.
[Graphical view]
SUPFAMiSSF82927. SSF82927. 1 hit.
PROSITEiPS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDMRTD_MOUSE
AccessioniPrimary (citable) accession number: Q8CGW9
Secondary accession number(s): A6H6T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.