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Protein

Transcription factor SOX-30

Gene

Sox30

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi366 – 434HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-30
Gene namesi
Name:Sox30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1341157. Sox30.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487751 – 782Transcription factor SOX-30Add BLAST782

Proteomic databases

PaxDbiQ8CGW4.
PRIDEiQ8CGW4.

PTM databases

iPTMnetiQ8CGW4.
PhosphoSitePlusiQ8CGW4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040489.
CleanExiMM_SOX30.
GenevisibleiQ8CGW4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037519.

Structurei

3D structure databases

ProteinModelPortaliQ8CGW4.
SMRiQ8CGW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 36Pro-richAdd BLAST31
Compositional biasi31 – 126Ala-richAdd BLAST96
Compositional biasi490 – 675Pro-richAdd BLAST186

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410KD21. Eukaryota.
ENOG4112BUX. LUCA.
GeneTreeiENSGT00760000119274.
HOGENOMiHOG000070158.
HOVERGENiHBG057980.
InParanoidiQ8CGW4.
KOiK09271.
OMAiQPPKEYP.
OrthoDBiEOG091G0AGA.
PhylomeDBiQ8CGW4.
TreeFamiTF336594.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CGW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERARPEPPP PPPPPPRQPP RPTPPRPLRP APPAQPVEAA TFRAAAAERS
60 70 80 90 100
QSPSAQATAA MAAVASSCGE AAAAGAQAAG TRRLLQVKPE QVLLLPPGGP
110 120 130 140 150
GVPPAPDEGA AAAAAAAAAA ASSAQARLLQ LRPELLLLPP QSAADGGPCR
160 170 180 190 200
PELHPMQPRT LLVKAEKQEL GAGLDLSVGS RRTTEAGPRA SRAAKLDGTG
210 220 230 240 250
KALDGRRSDE KKAKLEAEEA PRDALKGGEG KSLLAIGEGV IKTEEPDRPR
260 270 280 290 300
DDCRLGTEAT SNGLVHSSKE AILAQPPSAF GPHQQDLRFP LTLHTVPPGA
310 320 330 340 350
RIQFQGPPPS ELIRLSKVPL TPVPIKMQSL LEPSVKIETK DVPLTVLPSD
360 370 380 390 400
AGIPDTPFSK DRNGHVKRPM NAFMVWARIH RPALAKANPA ANNAEISVQL
410 420 430 440 450
GLEWNKLSEE QKKPYYDEAQ KIKEKHREEF PGWVYQPRPG KRKRFPLSVS
460 470 480 490 500
NVFSGTTQNI ISTNPTTIYP YRSPTYSVVI PGLQNTITHP VGEAPPAIQL
510 520 530 540 550
PTPAVQRPSP ITLFQPSVSS TGPVAVPPPS LTPRPSLPPQ RFSGPSQTDI
560 570 580 590 600
HRLPSGSSRS VKRSTPGSLE STTRIPAGAS TAHARFATSP IQPPKEYASV
610 620 630 640 650
STCPRSTPIP PATPIPHSHV YQPPPLGHPA TLFGTPPRFS FHHPYFLPGP
660 670 680 690 700
HYFPSSTCPY SRPPFGYGNF PSSMPECLGY YEDRYQKHEA IFSALNRDYP
710 720 730 740 750
FRDYPDEHTH SEDSRSCESM DGPPYYSSHG HGGEEYLNAM PTLDIGALEN
760 770 780
VFTAPASAPS GVQQVNVTDS DEEEEEKVLR NL
Length:782
Mass (Da):83,938
Last modified:March 1, 2003 - v1
Checksum:i0D1EEBB17BCB4F41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY005801 mRNA. Translation: AAF99391.1.
CCDSiCCDS24570.1.
RefSeqiNP_775560.1. NM_173384.2.
UniGeneiMm.66708.

Genome annotation databases

EnsembliENSMUST00000049038; ENSMUSP00000037519; ENSMUSG00000040489.
GeneIDi214105.
KEGGimmu:214105.
UCSCiuc011xtj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY005801 mRNA. Translation: AAF99391.1.
CCDSiCCDS24570.1.
RefSeqiNP_775560.1. NM_173384.2.
UniGeneiMm.66708.

3D structure databases

ProteinModelPortaliQ8CGW4.
SMRiQ8CGW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037519.

PTM databases

iPTMnetiQ8CGW4.
PhosphoSitePlusiQ8CGW4.

Proteomic databases

PaxDbiQ8CGW4.
PRIDEiQ8CGW4.

Protocols and materials databases

DNASUi214105.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049038; ENSMUSP00000037519; ENSMUSG00000040489.
GeneIDi214105.
KEGGimmu:214105.
UCSCiuc011xtj.1. mouse.

Organism-specific databases

CTDi11063.
MGIiMGI:1341157. Sox30.

Phylogenomic databases

eggNOGiENOG410KD21. Eukaryota.
ENOG4112BUX. LUCA.
GeneTreeiENSGT00760000119274.
HOGENOMiHOG000070158.
HOVERGENiHBG057980.
InParanoidiQ8CGW4.
KOiK09271.
OMAiQPPKEYP.
OrthoDBiEOG091G0AGA.
PhylomeDBiQ8CGW4.
TreeFamiTF336594.

Miscellaneous databases

PROiQ8CGW4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040489.
CleanExiMM_SOX30.
GenevisibleiQ8CGW4. MM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOX30_MOUSE
AccessioniPrimary (citable) accession number: Q8CGW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.