Q8CGV7 (THTPA_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiamine-triphosphatase
Short name=ThTPase
EC=3.6.1.28

Gene names

Name:

Thtpa

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Hydrolase highly specific for thiamine triphosphate (ThTP) By similarity.
Catalytic activity	Thiamine triphosphate + H2O = thiamine diphosphate + phosphate.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ThTPase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	thiamine metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thiamin-triphosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 224	223	Thiamine-triphosphatase		PRO_0000221493
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CGV7 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 27013164E67F229B	FASTA	224	24,544
	10 20 30 40 50 60 MAQGLIEVER KFTPGPDTEE RLQKLGATLE HRVTFRDTYY DTSELSLMLS DHWLRQREGS 70 80 90 100 110 120 GWEFKCPGVT GVSGPHNEYV EVTSESAIVT QLFELLGSGE QETAGVAAVL GRLKLQEVAS 130 140 150 160 170 180 FITTRSSWKL ALSGAHEEES LLTVDLDSTD FGYAVGEVEA VVHEKAEVPA ALEKIISVSS 190 200 210 220 MLGVPAQEKA PAKLLVYLQR FRPQDYQRLL EADSSGEATG DSVP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[2]	"Isolation and characterization of the rat ThTPase cDNA." Lakaye B.B., Coumans B.B., Makarchikov A.A., Grisar T.T., Bettendorff L.L. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 93-224. Strain: Wistar.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC081978 mRNA. Translation: AAH81978.1. AY065967 mRNA. Translation: AAL41027.1.
IPI	IPI00372679.
RefSeq	NP_001007683.1. NM_001007682.1.
UniGene	Rn.163276.
3D structure databases
ProteinModelPortal	Q8CGV7.
SMR	Q8CGV7. Positions 2-222.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CGV7.
Proteomic databases
PRIDE	Q8CGV7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000034073; ENSRNOP00000038507; ENSRNOG00000018105.
GeneID	305889.
KEGG	rno:305889.
UCSC	NM_001007682. rat.
Organism-specific databases
CTD	79178.
RGD	727917. Thtpa.
Phylogenomic databases
eggNOG	roNOG08037.
GeneTree	ENSGT00390000005996.
HOVERGEN	HBG057173.
InParanoid	Q8CGV7.
OMA	QREGSGW.
OrthoDB	EOG4Z62PN.
PhylomeDB	Q8CGV7.
Gene expression databases
ArrayExpress	Q8CGV7.
Genevestigator	Q8CGV7.
GermOnline	ENSRNOG00000018105. Rattus norvegicus.
Family and domain databases
InterPro	IPR023577. CYTH-like_domain. IPR008172. CYTH_domain. IPR012177. ThTPase. [Graphical view]
Gene3D	G3DSA:2.40.320.10. G3DSA:2.40.320.10. 1 hit.
KO	K05307.
PANTHER	PTHR14586. ThTPase. 1 hit.
Pfam	PF01928. CYTH. 1 hit. [Graphical view]
PIRSF	PIRSF036561. ThTPase. 1 hit.
SUPFAM	SSF55154. mRNA_capping_enz_bsu. 1 hit.
ProtoNet	Search...
Other
NextBio	655197.

Entry information

Entry name

THTPA_RAT

Accession

Primary (citable) accession number: Q8CGV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 67 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program