Reviewed, UniProtKB/Swiss-Prot Q8CGV7 (THTPA_RAT)

Names and origin

Protein names

Recommended name:
    Thiamine-triphosphatase
      Short name=ThTPase
    EC=3.6.1.28

Gene names

Name:

Thtpa

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolase highly specific for thiamine triphosphate (ThTP) By similarity.
Catalytic activity	Thiamine triphosphate + H2O = thiamine diphosphate + phosphate.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ThTPase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
PTM	Acetylation
Gene Ontology (GO)
Biological process	cAMP biosynthetic process Inferred from electronic annotation. Source: InterPro thiamin metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenylate cyclase activity Inferred from electronic annotation. Source: InterPro thiamin-triphosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 224	223	Thiamine-triphosphatase		PRO_0000221493
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CGV7-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 27013164E67F229B	FASTA	224	24,544
	10 20 30 40 50 60 MAQGLIEVER KFTPGPDTEE RLQKLGATLE HRVTFRDTYY DTSELSLMLS DHWLRQREGS 70 80 90 100 110 120 GWEFKCPGVT GVSGPHNEYV EVTSESAIVT QLFELLGSGE QETAGVAAVL GRLKLQEVAS 130 140 150 160 170 180 FITTRSSWKL ALSGAHEEES LLTVDLDSTD FGYAVGEVEA VVHEKAEVPA ALEKIISVSS 190 200 210 220 MLGVPAQEKA PAKLLVYLQR FRPQDYQRLL EADSSGEATG DSVP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[2]	"Isolation and characterization of the rat ThTPase cDNA." Lakaye B.B., Coumans B.B., Makarchikov A.A., Grisar T.T., Bettendorff L.L. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 93-224. Strain: Wistar.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC081978 mRNA. Translation: AAH81978.1. AY065967 mRNA. Translation: AAL41027.1.
IPI	IPI00372679.
RefSeq	NP_001007683.1.
UniGene	Rn.163276
3D structure databases
SMR	Q8CGV7. Positions 2-222.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000018105. Rattus norvegicus. [Contig view]
GeneID	305889.
KEGG	rno:305889.
Organism-specific databases
RGD	727917. Thtpa.
Phylogenomic databases
HOVERGEN	Q8CGV7.
OMA	Q8CGV7. EVERKFV.
Enzyme and pathway databases
BRENDA	3.6.1.28. 248.
Gene expression databases
ArrayExpress	Q8CGV7.
GermOnline	ENSRNOG00000018105. Rattus norvegicus.
Family and domain databases
InterPro	IPR008172. Adenylate_cyclase. IPR012177. ThTPase. [Graphical view]
PANTHER	PTHR14586. ThTPase. 1 hit.
Pfam	PF01928. CYTH. 1 hit. [Graphical view]
PIRSF	PIRSF036561. ThTPase. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	655197.

Entry information

Entry name

THTPA_RAT

Accession

Primary (citable) accession number: Q8CGV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 46 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)