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Protein

Thiamine-triphosphatase

Gene

Thtpa

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolase highly specific for thiamine triphosphate (ThTP).By similarity

Catalytic activityi

Thiamine triphosphate + H2O = thiamine diphosphate + phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumBy similarity1
Metal bindingi9MagnesiumBy similarity1
Binding sitei11SubstrateBy similarity1
Binding sitei55SubstrateBy similarity1
Binding sitei57SubstrateBy similarity1
Binding sitei65SubstrateBy similarity1
Binding sitei125SubstrateBy similarity1
Metal bindingi145MagnesiumBy similarity1
Metal bindingi157MagnesiumBy similarity1
Binding sitei157SubstrateBy similarity1
Metal bindingi159MagnesiumBy similarity1
Binding sitei193SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.28. 5301.
ReactomeiR-RNO-196819. Vitamin B1 (thiamin) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine-triphosphatase (EC:3.6.1.28)
Short name:
ThTPase
Gene namesi
Name:Thtpa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi727917. Thtpa.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002214932 – 224Thiamine-triphosphataseAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ8CGV7.
PRIDEiQ8CGV7.

PTM databases

iPTMnetiQ8CGV7.
PhosphoSitePlusiQ8CGV7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018105.
ExpressionAtlasiQ8CGV7. baseline and differential.
GenevisibleiQ8CGV7. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038507.

Structurei

3D structure databases

ProteinModelPortaliQ8CGV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 201CYTHPROSITE-ProRule annotationAdd BLAST197

Sequence similaritiesi

Belongs to the ThTPase family.Curated
Contains 1 CYTH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J0T6. Eukaryota.
ENOG4111XGF. LUCA.
GeneTreeiENSGT00390000005996.
HOGENOMiHOG000154571.
HOVERGENiHBG057173.
InParanoidiQ8CGV7.
KOiK05307.
PhylomeDBiQ8CGV7.
TreeFamiTF333398.

Family and domain databases

Gene3Di2.40.320.10. 1 hit.
InterProiIPR033469. CYTH-like_dom.
IPR023577. CYTH_domain.
IPR012177. ThTPase.
[Graphical view]
PfamiPF01928. CYTH. 1 hit.
[Graphical view]
PIRSFiPIRSF036561. ThTPase. 1 hit.
SMARTiSM01118. CYTH. 1 hit.
[Graphical view]
SUPFAMiSSF55154. SSF55154. 1 hit.
PROSITEiPS51707. CYTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CGV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGLIEVER KFTPGPDTEE RLQKLGATLE HRVTFRDTYY DTSELSLMLS
60 70 80 90 100
DHWLRQREGS GWEFKCPGVT GVSGPHNEYV EVTSESAIVT QLFELLGSGE
110 120 130 140 150
QETAGVAAVL GRLKLQEVAS FITTRSSWKL ALSGAHEEES LLTVDLDSTD
160 170 180 190 200
FGYAVGEVEA VVHEKAEVPA ALEKIISVSS MLGVPAQEKA PAKLLVYLQR
210 220
FRPQDYQRLL EADSSGEATG DSVP
Length:224
Mass (Da):24,544
Last modified:January 23, 2007 - v3
Checksum:i27013164E67F229B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081978 mRNA. Translation: AAH81978.1.
AY065967 mRNA. Translation: AAL41027.1.
RefSeqiNP_001007683.1. NM_001007682.1.
UniGeneiRn.163276.

Genome annotation databases

EnsembliENSRNOT00000034073; ENSRNOP00000038507; ENSRNOG00000018105.
GeneIDi305889.
KEGGirno:305889.
UCSCiRGD:727917. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081978 mRNA. Translation: AAH81978.1.
AY065967 mRNA. Translation: AAL41027.1.
RefSeqiNP_001007683.1. NM_001007682.1.
UniGeneiRn.163276.

3D structure databases

ProteinModelPortaliQ8CGV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038507.

PTM databases

iPTMnetiQ8CGV7.
PhosphoSitePlusiQ8CGV7.

Proteomic databases

PaxDbiQ8CGV7.
PRIDEiQ8CGV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034073; ENSRNOP00000038507; ENSRNOG00000018105.
GeneIDi305889.
KEGGirno:305889.
UCSCiRGD:727917. rat.

Organism-specific databases

CTDi79178.
RGDi727917. Thtpa.

Phylogenomic databases

eggNOGiENOG410J0T6. Eukaryota.
ENOG4111XGF. LUCA.
GeneTreeiENSGT00390000005996.
HOGENOMiHOG000154571.
HOVERGENiHBG057173.
InParanoidiQ8CGV7.
KOiK05307.
PhylomeDBiQ8CGV7.
TreeFamiTF333398.

Enzyme and pathway databases

BRENDAi3.6.1.28. 5301.
ReactomeiR-RNO-196819. Vitamin B1 (thiamin) metabolism.

Miscellaneous databases

PROiQ8CGV7.

Gene expression databases

BgeeiENSRNOG00000018105.
ExpressionAtlasiQ8CGV7. baseline and differential.
GenevisibleiQ8CGV7. RN.

Family and domain databases

Gene3Di2.40.320.10. 1 hit.
InterProiIPR033469. CYTH-like_dom.
IPR023577. CYTH_domain.
IPR012177. ThTPase.
[Graphical view]
PfamiPF01928. CYTH. 1 hit.
[Graphical view]
PIRSFiPIRSF036561. ThTPase. 1 hit.
SMARTiSM01118. CYTH. 1 hit.
[Graphical view]
SUPFAMiSSF55154. SSF55154. 1 hit.
PROSITEiPS51707. CYTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHTPA_RAT
AccessioniPrimary (citable) accession number: Q8CGV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.