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Protein

Thiamine-triphosphatase

Gene

Thtpa

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolase highly specific for thiamine triphosphate (ThTP).By similarity

Catalytic activityi

Thiamine triphosphate + H2O = thiamine diphosphate + phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumBy similarity1
Metal bindingi9MagnesiumBy similarity1
Binding sitei11SubstrateBy similarity1
Binding sitei55SubstrateBy similarity1
Binding sitei57SubstrateBy similarity1
Binding sitei65SubstrateBy similarity1
Binding sitei125SubstrateBy similarity1
Metal bindingi145MagnesiumBy similarity1
Metal bindingi157MagnesiumBy similarity1
Binding sitei157SubstrateBy similarity1
Metal bindingi159MagnesiumBy similarity1
Binding sitei193SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.28 5301
ReactomeiR-RNO-196819 Vitamin B1 (thiamin) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine-triphosphatase (EC:3.6.1.28)
Short name:
ThTPase
Gene namesi
Name:Thtpa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi727917 Thtpa

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002214932 – 224Thiamine-triphosphataseAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ8CGV7
PRIDEiQ8CGV7

PTM databases

iPTMnetiQ8CGV7
PhosphoSitePlusiQ8CGV7

Expressioni

Gene expression databases

BgeeiENSRNOG00000018105
ExpressionAtlasiQ8CGV7 baseline and differential
GenevisibleiQ8CGV7 RN

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038507

Structurei

3D structure databases

ProteinModelPortaliQ8CGV7
SMRiQ8CGV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 201CYTHPROSITE-ProRule annotationAdd BLAST197

Sequence similaritiesi

Belongs to the ThTPase family.Curated

Phylogenomic databases

eggNOGiENOG410J0T6 Eukaryota
ENOG4111XGF LUCA
GeneTreeiENSGT00390000005996
HOGENOMiHOG000154571
HOVERGENiHBG057173
InParanoidiQ8CGV7
KOiK05307
PhylomeDBiQ8CGV7
TreeFamiTF333398

Family and domain databases

InterProiView protein in InterPro
IPR033469 CYTH-like_dom_sf
IPR023577 CYTH_domain
IPR012177 ThTPase
PfamiView protein in Pfam
PF01928 CYTH, 1 hit
PIRSFiPIRSF036561 ThTPase, 1 hit
SMARTiView protein in SMART
SM01118 CYTH, 1 hit
SUPFAMiSSF55154 SSF55154, 1 hit
PROSITEiView protein in PROSITE
PS51707 CYTH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CGV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGLIEVER KFTPGPDTEE RLQKLGATLE HRVTFRDTYY DTSELSLMLS
60 70 80 90 100
DHWLRQREGS GWEFKCPGVT GVSGPHNEYV EVTSESAIVT QLFELLGSGE
110 120 130 140 150
QETAGVAAVL GRLKLQEVAS FITTRSSWKL ALSGAHEEES LLTVDLDSTD
160 170 180 190 200
FGYAVGEVEA VVHEKAEVPA ALEKIISVSS MLGVPAQEKA PAKLLVYLQR
210 220
FRPQDYQRLL EADSSGEATG DSVP
Length:224
Mass (Da):24,544
Last modified:January 23, 2007 - v3
Checksum:i27013164E67F229B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081978 mRNA Translation: AAH81978.1
AY065967 mRNA Translation: AAL41027.1
RefSeqiNP_001007683.1, NM_001007682.1
UniGeneiRn.163276

Genome annotation databases

EnsembliENSRNOT00000034073; ENSRNOP00000038507; ENSRNOG00000018105
GeneIDi305889
KEGGirno:305889
UCSCiRGD:727917 rat

Similar proteinsi

Entry informationi

Entry nameiTHTPA_RAT
AccessioniPrimary (citable) accession number: Q8CGV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 107 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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