ID   TPH2_MOUSE              Reviewed;         488 AA.
AC   Q8CGV2;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 49.
DE   RecName: Full=Tryptophan 5-hydroxylase 2;
DE            EC=1.14.16.4;
DE   AltName: Full=Tryptophan 5-monooxygenase 2;
DE   AltName: Full=Neuronal tryptophan hydroxylase;
GN   Name=Tph2; Synonyms=Ntph;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=22400097; PubMed=12511643; DOI=10.1126/science.1078197;
RA   Walther D.J., Peter J.-U., Bashammakh S., Hortnagl H., Voits M.,
RA   Fink H., Bader M.;
RT   "Synthesis of serotonin by a second tryptophan hydroxylase isoform.";
RL   Science 299:76-76(2003).
CC   -!- CATALYTIC ACTIVITY: L-tryptophan + tetrahydrobiopterin + O(2) = 5-
CC       hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.
CC   -!- COFACTOR: Fe(2+) ion (By similarity).
CC   -!- PATHWAY: Aromatic compound metabolism; serotonin biosynthesis;
CC       serotonin from L-tryptophan: step 1/2.
CC   -!- TISSUE SPECIFICITY: Brain specific.
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family.
CC   -!- SIMILARITY: Contains 1 ACT domain.
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DR   EMBL; AY090565; AAM08923.1; -; mRNA.
DR   IPI; IPI00229583; -.
DR   UniGene; Mm.31597; -.
DR   HSSP; P04177; 1TOH.
DR   SMR; Q8CGV2; 149-437.
DR   PhosphoSite; Q8CGV2; -.
DR   Ensembl; ENSMUSG00000006764; Mus musculus.
DR   MGI; MGI:2651811; Tph2.
DR   HOGENOM; Q8CGV2; -.
DR   HOVERGEN; Q8CGV2; -.
DR   BRENDA; 1.14.16.4; 244.
DR   ArrayExpress; Q8CGV2; -.
DR   Bgee; Q8CGV2; -.
DR   CleanEx; MM_TPH2; -.
DR   GermOnline; ENSMUSG00000006764; Mus musculus.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004510; F:tryptophan 5-monooxygenase activity; IDA:MGI.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006587; P:serotonin biosynthetic process from tryptophan; IC:MGI.
DR   InterPro; IPR002912; ACT_bd.
DR   InterPro; IPR001273; ArAA_hydroxylase.
DR   InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR   InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR   InterPro; IPR005963; Trp_5_mOase.
DR   InterPro; IPR019773; Tyrosine_3-monooxygenase-like.
DR   Gene3D; G3DSA:1.10.800.10; Aaa_hydroxylase; 1.
DR   PANTHER; PTHR11473; Aaa_hydroxylase; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00351; Biopterin_H; 1.
DR   PIRSF; PIRSF000336; TH; 1.
DR   PRINTS; PR00372; FYWHYDRXLASE.
DR   ProDom; PD002559; Aaa_hydroxylase; 1.
DR   TIGRFAMs; TIGR01270; Trp_5_monoox; 1.
DR   PROSITE; PS00367; BIOPTERIN_HYDROXYL; 1.
PE   2: Evidence at transcript level;
KW   Iron; Metal-binding; Monooxygenase; Oxidoreductase; Phosphoprotein;
KW   Serotonin biosynthesis.
FT   CHAIN         1    488       Tryptophan 5-hydroxylase 2.
FT                                /FTId=PRO_0000205575.
FT   DOMAIN       62    134       ACT.
FT   METAL       316    316       Iron (By similarity).
FT   METAL       321    321       Iron (By similarity).
FT   METAL       361    361       Iron (By similarity).
FT   MOD_RES     380    380       Phosphoserine (By similarity).
FT   MOD_RES     390    390       Phosphoserine (By similarity).
SQ   SEQUENCE   488 AA;  55918 MW;  8769FB4DAEE80E4A CRC64;
     MQPAMMMFSS KYWARRGLSL DSAVPEDHQL LGSLTQNKAI KSEDKKSGKE PGKGDTTESS
     KTAVVFSLKN EVGGLVKALR LFQEKHVNML HIESRRSRRR SSEVEIFVDC ECGKTEFNEL
     IQLLKFQTTI VTLNPPESIW TEEEDLEDVP WFPRKISELD RCSHRVLMYG TELDADHPGF
     KDNVYRQRRK YFVDVAMGYK YGQPIPRVEY TEEETKTWGV VFRELSKLYP THACREYLKN
     LPLLTKYCGY REDNVPQLED VSMFLKERSG FTVRPVAGYL SPRDFLAGLA YRVFHCTQYV
     RHGSDPLYTP EPDTCHELLG HVPLLADPKF AQFSQEIGLA SLGASDEDVQ KLATCYFFTI
     EFGLCKQEGQ LRAYGAGLLS SIGELKHALS DKACVKSFDP KTTCLQECLI TTFQDAYFVS
     DSFEEAKEKM RDFAKSITRP FSVYFNRYTQ SIEILKDTRS IENVVQDLRS DLNTVCDALN
     KMNQYLGI
//