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Q8CGV2

- TPH2_MOUSE

UniProt

Q8CGV2 - TPH2_MOUSE

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Protein

Tryptophan 5-hydroxylase 2

Gene
Tph2, Ntph
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

Cofactori

Fe2+ ion By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi316 – 3161Iron By similarity
Metal bindingi321 – 3211Iron By similarity
Metal bindingi361 – 3611Iron By similarity

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. tryptophan 5-monooxygenase activity Source: MGI

GO - Biological processi

  1. cellular response to lithium ion Source: Ensembl
  2. circadian rhythm Source: Ensembl
  3. response to activity Source: Ensembl
  4. response to calcium ion Source: Ensembl
  5. response to estrogen Source: Ensembl
  6. response to glucocorticoid Source: Ensembl
  7. response to nutrient levels Source: Ensembl
  8. serotonin biosynthetic process from tryptophan Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Serotonin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.16.4. 3474.
ReactomeiREACT_218437. Serotonin and melatonin biosynthesis.
UniPathwayiUPA00846; UER00799.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan 5-hydroxylase 2 (EC:1.14.16.4)
Alternative name(s):
Neuronal tryptophan hydroxylase
Tryptophan 5-monooxygenase 2
Gene namesi
Name:Tph2
Synonyms:Ntph
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:2651811. Tph2.

Subcellular locationi

GO - Cellular componenti

  1. neuron projection Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Tryptophan 5-hydroxylase 2PRO_0000205575Add
BLAST

Proteomic databases

MaxQBiQ8CGV2.
PaxDbiQ8CGV2.
PRIDEiQ8CGV2.

PTM databases

PhosphoSiteiQ8CGV2.

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

BgeeiQ8CGV2.
CleanExiMM_TPH2.
GenevestigatoriQ8CGV2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006949.

Structurei

3D structure databases

ProteinModelPortaliQ8CGV2.
SMRiQ8CGV2. Positions 55-482.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 13876ACTAdd
BLAST

Sequence similaritiesi

Contains 1 ACT domain.

Phylogenomic databases

eggNOGiCOG3186.
GeneTreeiENSGT00390000010268.
HOGENOMiHOG000233373.
HOVERGENiHBG006841.
InParanoidiQ0VBT4.
KOiK00502.
OMAiEDVSMFL.
OrthoDBiEOG7KM5T1.
TreeFamiTF313327.

Family and domain databases

Gene3Di1.10.800.10. 1 hit.
InterProiIPR002912. ACT_dom.
IPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005963. Trp_5_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
[Graphical view]
PANTHERiPTHR11473. PTHR11473. 1 hit.
PfamiPF01842. ACT. 1 hit.
PF00351. Biopterin_H. 1 hit.
[Graphical view]
PIRSFiPIRSF000336. TH. 1 hit.
PRINTSiPR00372. FYWHYDRXLASE.
SUPFAMiSSF56534. SSF56534. 1 hit.
TIGRFAMsiTIGR01270. Trp_5_monoox. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CGV2-1 [UniParc]FASTAAdd to Basket

« Hide

MQPAMMMFSS KYWARRGLSL DSAVPEDHQL LGSLTQNKAI KSEDKKSGKE    50
PGKGDTTESS KTAVVFSLKN EVGGLVKALR LFQEKHVNML HIESRRSRRR 100
SSEVEIFVDC ECGKTEFNEL IQLLKFQTTI VTLNPPESIW TEEEDLEDVP 150
WFPRKISELD RCSHRVLMYG TELDADHPGF KDNVYRQRRK YFVDVAMGYK 200
YGQPIPRVEY TEEETKTWGV VFRELSKLYP THACREYLKN LPLLTKYCGY 250
REDNVPQLED VSMFLKERSG FTVRPVAGYL SPRDFLAGLA YRVFHCTQYV 300
RHGSDPLYTP EPDTCHELLG HVPLLADPKF AQFSQEIGLA SLGASDEDVQ 350
KLATCYFFTI EFGLCKQEGQ LRAYGAGLLS SIGELKHALS DKACVKSFDP 400
KTTCLQECLI TTFQDAYFVS DSFEEAKEKM RDFAKSITRP FSVYFNPYTQ 450
SIEILKDTRS IENVVQDLRS DLNTVCDALN KMNQYLGI 488
Length:488
Mass (Da):55,859
Last modified:July 27, 2011 - v2
Checksum:i876B59C784E80E4A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti447 – 4471P → R in AAM08923. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY090565 mRNA. Translation: AAM08923.1.
BC120514 mRNA. Translation: AAI20515.1.
BC125430 mRNA. Translation: AAI25431.1.
CCDSiCCDS36061.1.
RefSeqiNP_775567.2. NM_173391.3.
UniGeneiMm.31597.

Genome annotation databases

EnsembliENSMUST00000006949; ENSMUSP00000006949; ENSMUSG00000006764.
GeneIDi216343.
KEGGimmu:216343.
UCSCiuc007haw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY090565 mRNA. Translation: AAM08923.1 .
BC120514 mRNA. Translation: AAI20515.1 .
BC125430 mRNA. Translation: AAI25431.1 .
CCDSi CCDS36061.1.
RefSeqi NP_775567.2. NM_173391.3.
UniGenei Mm.31597.

3D structure databases

ProteinModelPortali Q8CGV2.
SMRi Q8CGV2. Positions 55-482.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000006949.

PTM databases

PhosphoSitei Q8CGV2.

Proteomic databases

MaxQBi Q8CGV2.
PaxDbi Q8CGV2.
PRIDEi Q8CGV2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006949 ; ENSMUSP00000006949 ; ENSMUSG00000006764 .
GeneIDi 216343.
KEGGi mmu:216343.
UCSCi uc007haw.2. mouse.

Organism-specific databases

CTDi 121278.
MGIi MGI:2651811. Tph2.

Phylogenomic databases

eggNOGi COG3186.
GeneTreei ENSGT00390000010268.
HOGENOMi HOG000233373.
HOVERGENi HBG006841.
InParanoidi Q0VBT4.
KOi K00502.
OMAi EDVSMFL.
OrthoDBi EOG7KM5T1.
TreeFami TF313327.

Enzyme and pathway databases

UniPathwayi UPA00846 ; UER00799 .
BRENDAi 1.14.16.4. 3474.
Reactomei REACT_218437. Serotonin and melatonin biosynthesis.

Miscellaneous databases

NextBioi 375107.
PROi Q8CGV2.
SOURCEi Search...

Gene expression databases

Bgeei Q8CGV2.
CleanExi MM_TPH2.
Genevestigatori Q8CGV2.

Family and domain databases

Gene3Di 1.10.800.10. 1 hit.
InterProi IPR002912. ACT_dom.
IPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005963. Trp_5_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
[Graphical view ]
PANTHERi PTHR11473. PTHR11473. 1 hit.
Pfami PF01842. ACT. 1 hit.
PF00351. Biopterin_H. 1 hit.
[Graphical view ]
PIRSFi PIRSF000336. TH. 1 hit.
PRINTSi PR00372. FYWHYDRXLASE.
SUPFAMi SSF56534. SSF56534. 1 hit.
TIGRFAMsi TIGR01270. Trp_5_monoox. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Synthesis of serotonin by a second tryptophan hydroxylase isoform."
    Walther D.J., Peter J.-U., Bashammakh S., Hortnagl H., Voits M., Fink H., Bader M.
    Science 299:76-76(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTPH2_MOUSE
AccessioniPrimary (citable) accession number: Q8CGV2
Secondary accession number(s): Q0VBT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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