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Reviewed, UniProtKB/Swiss-Prot Q8CGV2 (TPH2_MOUSE)

Last modified February 9, 2010. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tryptophan 5-hydroxylase 2
    EC=1.14.16.4
Alternative name(s):
    Tryptophan 5-monooxygenase 2
    Neuronal tryptophan hydroxylase
Gene names
Name: Tph2
Synonyms: Ntph
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

Cofactor

Fe2+ ion By similarity.

Pathway

Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.

Tissue specificity

Brain specific.

Sequence similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Contains 1 ACT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Tryptophan 5-hydroxylase 2
PRO_0000205575

Regions

Domain62 – 13473ACT

Sites

Metal binding3161Iron By similarity
Metal binding3211Iron By similarity
Metal binding3611Iron By similarity

Amino acid modifications

Modified residue3801Phosphoserine By similarity
Modified residue3901Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CGV2-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 8769FB4DAEE80E4A

FASTA48855,918
        10         20         30         40         50         60 
MQPAMMMFSS KYWARRGLSL DSAVPEDHQL LGSLTQNKAI KSEDKKSGKE PGKGDTTESS 

        70         80         90        100        110        120 
KTAVVFSLKN EVGGLVKALR LFQEKHVNML HIESRRSRRR SSEVEIFVDC ECGKTEFNEL 

       130        140        150        160        170        180 
IQLLKFQTTI VTLNPPESIW TEEEDLEDVP WFPRKISELD RCSHRVLMYG TELDADHPGF 

       190        200        210        220        230        240 
KDNVYRQRRK YFVDVAMGYK YGQPIPRVEY TEEETKTWGV VFRELSKLYP THACREYLKN 

       250        260        270        280        290        300 
LPLLTKYCGY REDNVPQLED VSMFLKERSG FTVRPVAGYL SPRDFLAGLA YRVFHCTQYV 

       310        320        330        340        350        360 
RHGSDPLYTP EPDTCHELLG HVPLLADPKF AQFSQEIGLA SLGASDEDVQ KLATCYFFTI 

       370        380        390        400        410        420 
EFGLCKQEGQ LRAYGAGLLS SIGELKHALS DKACVKSFDP KTTCLQECLI TTFQDAYFVS 

       430        440        450        460        470        480 
DSFEEAKEKM RDFAKSITRP FSVYFNRYTQ SIEILKDTRS IENVVQDLRS DLNTVCDALN 


KMNQYLGI 

« Hide

References

[1]"Synthesis of serotonin by a second tryptophan hydroxylase isoform."
Walther D.J., Peter J.-U., Bashammakh S., Hortnagl H., Voits M., Fink H., Bader M.
Science 299:76-76(2003) [PubMed: 12511643] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY090565 mRNA. Translation: AAM08923.1.
IPIIPI00229583.
UniGeneMm.31597

3D structure databases

SMRQ8CGV2. Positions 57-127, 149-482.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8CGV2.

PTM databases

PhosphoSiteQ8CGV2.

Proteomic databases

PRIDEQ8CGV2.

Genome annotation databases

EnsemblENSMUST00000006949; ENSMUSP00000006949; ENSMUSG00000006764; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:2651811. Tph2.

Phylogenomic databases

HOGENOMHBG484724.
HOVERGENQ8CGV2.
InParanoidQ8CGV2.

Enzyme and pathway databases

BRENDA1.14.16.4. 244.

Gene expression databases

ArrayExpressQ8CGV2.
BgeeQ8CGV2.
CleanExMM_TPH2.
GenevestigatorQ8CGV2.
GermOnlineENSMUSG00000006764. Mus musculus.

Family and domain databases

InterProIPR002912. ACT_bd.
IPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005963. Trp_5_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
[Graphical view]
Gene3DG3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit.
PANTHERPTHR11473. Aaa_hydroxylase. 1 hit.
PfamPF01842. ACT. 1 hit.
PF00351. Biopterin_H. 1 hit.
[Graphical view]
PIRSFPIRSF000336. TH. 1 hit.
PRINTSPR00372. FYWHYDRXLASE.
TIGRFAMsTIGR01270. Trp_5_monoox. 1 hit.
PROSITEPS00367. BIOPTERIN_HYDROXYL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry nameTPH2_MOUSE
AccessionPrimary (citable) accession number: Q8CGV2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: March 1, 2003
Last modified: February 9, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents