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Q8CGV2 (TPH2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan 5-hydroxylase 2
EC=1.14.16.4
Alternative name(s):
Neuronal tryptophan hydroxylase
Tryptophan 5-monooxygenase 2
Gene names
Name:Tph2
Synonyms:Ntph
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

Cofactor

Fe2+ ion By similarity.

Pathway

Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.

Tissue specificity

Brain specific.

Sequence similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Contains 1 ACT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Tryptophan 5-hydroxylase 2
PRO_0000205575

Regions

Domain62 – 13473ACT

Sites

Metal binding3161Iron By similarity
Metal binding3211Iron By similarity
Metal binding3611Iron By similarity

Experimental info

Sequence conflict4471P → R in AAM08923. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8CGV2 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 876B59C784E80E4A

FASTA48855,859
        10         20         30         40         50         60 
MQPAMMMFSS KYWARRGLSL DSAVPEDHQL LGSLTQNKAI KSEDKKSGKE PGKGDTTESS 

        70         80         90        100        110        120 
KTAVVFSLKN EVGGLVKALR LFQEKHVNML HIESRRSRRR SSEVEIFVDC ECGKTEFNEL 

       130        140        150        160        170        180 
IQLLKFQTTI VTLNPPESIW TEEEDLEDVP WFPRKISELD RCSHRVLMYG TELDADHPGF 

       190        200        210        220        230        240 
KDNVYRQRRK YFVDVAMGYK YGQPIPRVEY TEEETKTWGV VFRELSKLYP THACREYLKN 

       250        260        270        280        290        300 
LPLLTKYCGY REDNVPQLED VSMFLKERSG FTVRPVAGYL SPRDFLAGLA YRVFHCTQYV 

       310        320        330        340        350        360 
RHGSDPLYTP EPDTCHELLG HVPLLADPKF AQFSQEIGLA SLGASDEDVQ KLATCYFFTI 

       370        380        390        400        410        420 
EFGLCKQEGQ LRAYGAGLLS SIGELKHALS DKACVKSFDP KTTCLQECLI TTFQDAYFVS 

       430        440        450        460        470        480 
DSFEEAKEKM RDFAKSITRP FSVYFNPYTQ SIEILKDTRS IENVVQDLRS DLNTVCDALN 


KMNQYLGI

« Hide

References

« Hide 'large scale' references
[1]"Synthesis of serotonin by a second tryptophan hydroxylase isoform."
Walther D.J., Peter J.-U., Bashammakh S., Hortnagl H., Voits M., Fink H., Bader M.
Science 299:76-76(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY090565 mRNA. Translation: AAM08923.1.
BC120514 mRNA. Translation: AAI20515.1.
BC125430 mRNA. Translation: AAI25431.1.
IPIIPI00229583.
RefSeqNP_775567.2. NM_173391.3.
UniGeneMm.31597.

3D structure databases

ProteinModelPortalQ8CGV2.
SMRQ8CGV2. Positions 55-482.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000006949.

PTM databases

PhosphoSiteQ8CGV2.

Proteomic databases

PaxDbQ8CGV2.
PRIDEQ8CGV2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006949; ENSMUSP00000006949; ENSMUSG00000006764.
GeneID216343.
KEGGmmu:216343.

Organism-specific databases

CTD121278.
MGIMGI:2651811. Tph2.

Phylogenomic databases

eggNOGCOG3186.
GeneTreeENSGT00390000010268.
HOGENOMHOG000233373.
HOVERGENHBG006841.
InParanoidQ0VBT4.
KOK00502.
OMALEDVSMF.
OrthoDBEOG4S7JPZ.

Enzyme and pathway databases

BRENDA1.14.16.4. 3474.
UniPathwayUPA00846; UER00799.

Gene expression databases

BgeeQ8CGV2.
CleanExMM_TPH2.
GenevestigatorQ8CGV2.
GermOnlineENSMUSG00000006764. Mus musculus.

Family and domain databases

Gene3D1.10.800.10. 1 hit.
InterProIPR002912. ACT_dom.
IPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005963. Trp_5_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
[Graphical view]
PANTHERPTHR11473. PTHR11473. 1 hit.
PfamPF01842. ACT. 1 hit.
PF00351. Biopterin_H. 1 hit.
[Graphical view]
PIRSFPIRSF000336. TH. 1 hit.
PRINTSPR00372. FYWHYDRXLASE.
SUPFAMSSF56534. Aaa_hydroxylase. 1 hit.
TIGRFAMsTIGR01270. Trp_5_monoox. 1 hit.
PROSITEPS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio375107.
SOURCESearch...

Entry information

Entry nameTPH2_MOUSE
AccessionPrimary (citable) accession number: Q8CGV2
Secondary accession number(s): Q0VBT4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: July 27, 2011
Last modified: May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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