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Q8CGV2

- TPH2_MOUSE

UniProt

Q8CGV2 - TPH2_MOUSE

Protein

Tryptophan 5-hydroxylase 2

Gene

Tph2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

    Cofactori

    Fe2+ ion.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi316 – 3161IronBy similarity
    Metal bindingi321 – 3211IronBy similarity
    Metal bindingi361 – 3611IronBy similarity

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. tryptophan 5-monooxygenase activity Source: MGI

    GO - Biological processi

    1. cellular response to lithium ion Source: Ensembl
    2. circadian rhythm Source: Ensembl
    3. response to activity Source: Ensembl
    4. response to calcium ion Source: Ensembl
    5. response to estrogen Source: Ensembl
    6. response to glucocorticoid Source: Ensembl
    7. response to nutrient levels Source: Ensembl
    8. serotonin biosynthetic process from tryptophan Source: MGI

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Serotonin biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BRENDAi1.14.16.4. 3474.
    ReactomeiREACT_218437. Serotonin and melatonin biosynthesis.
    UniPathwayiUPA00846; UER00799.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan 5-hydroxylase 2 (EC:1.14.16.4)
    Alternative name(s):
    Neuronal tryptophan hydroxylase
    Tryptophan 5-monooxygenase 2
    Gene namesi
    Name:Tph2
    Synonyms:Ntph
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:2651811. Tph2.

    Subcellular locationi

    GO - Cellular componenti

    1. neuron projection Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Tryptophan 5-hydroxylase 2PRO_0000205575Add
    BLAST

    Proteomic databases

    MaxQBiQ8CGV2.
    PaxDbiQ8CGV2.
    PRIDEiQ8CGV2.

    PTM databases

    PhosphoSiteiQ8CGV2.

    Expressioni

    Tissue specificityi

    Brain specific.

    Gene expression databases

    BgeeiQ8CGV2.
    CleanExiMM_TPH2.
    GenevestigatoriQ8CGV2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000006949.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CGV2.
    SMRiQ8CGV2. Positions 55-482.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 13876ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ACT domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG3186.
    GeneTreeiENSGT00390000010268.
    HOGENOMiHOG000233373.
    HOVERGENiHBG006841.
    InParanoidiQ0VBT4.
    KOiK00502.
    OMAiEDVSMFL.
    OrthoDBiEOG7KM5T1.
    TreeFamiTF313327.

    Family and domain databases

    Gene3Di1.10.800.10. 1 hit.
    InterProiIPR002912. ACT_dom.
    IPR001273. ArAA_hydroxylase.
    IPR018301. ArAA_hydroxylase_Fe/CU_BS.
    IPR019774. Aromatic-AA_hydroxylase_C.
    IPR005963. Trp_5_mOase.
    IPR019773. Tyrosine_3-monooxygenase-like.
    [Graphical view]
    PANTHERiPTHR11473. PTHR11473. 1 hit.
    PfamiPF01842. ACT. 1 hit.
    PF00351. Biopterin_H. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000336. TH. 1 hit.
    PRINTSiPR00372. FYWHYDRXLASE.
    SUPFAMiSSF56534. SSF56534. 1 hit.
    TIGRFAMsiTIGR01270. Trp_5_monoox. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
    PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CGV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPAMMMFSS KYWARRGLSL DSAVPEDHQL LGSLTQNKAI KSEDKKSGKE    50
    PGKGDTTESS KTAVVFSLKN EVGGLVKALR LFQEKHVNML HIESRRSRRR 100
    SSEVEIFVDC ECGKTEFNEL IQLLKFQTTI VTLNPPESIW TEEEDLEDVP 150
    WFPRKISELD RCSHRVLMYG TELDADHPGF KDNVYRQRRK YFVDVAMGYK 200
    YGQPIPRVEY TEEETKTWGV VFRELSKLYP THACREYLKN LPLLTKYCGY 250
    REDNVPQLED VSMFLKERSG FTVRPVAGYL SPRDFLAGLA YRVFHCTQYV 300
    RHGSDPLYTP EPDTCHELLG HVPLLADPKF AQFSQEIGLA SLGASDEDVQ 350
    KLATCYFFTI EFGLCKQEGQ LRAYGAGLLS SIGELKHALS DKACVKSFDP 400
    KTTCLQECLI TTFQDAYFVS DSFEEAKEKM RDFAKSITRP FSVYFNPYTQ 450
    SIEILKDTRS IENVVQDLRS DLNTVCDALN KMNQYLGI 488
    Length:488
    Mass (Da):55,859
    Last modified:July 27, 2011 - v2
    Checksum:i876B59C784E80E4A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti447 – 4471P → R in AAM08923. (PubMed:12511643)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY090565 mRNA. Translation: AAM08923.1.
    BC120514 mRNA. Translation: AAI20515.1.
    BC125430 mRNA. Translation: AAI25431.1.
    CCDSiCCDS36061.1.
    RefSeqiNP_775567.2. NM_173391.3.
    UniGeneiMm.31597.

    Genome annotation databases

    EnsembliENSMUST00000006949; ENSMUSP00000006949; ENSMUSG00000006764.
    GeneIDi216343.
    KEGGimmu:216343.
    UCSCiuc007haw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY090565 mRNA. Translation: AAM08923.1 .
    BC120514 mRNA. Translation: AAI20515.1 .
    BC125430 mRNA. Translation: AAI25431.1 .
    CCDSi CCDS36061.1.
    RefSeqi NP_775567.2. NM_173391.3.
    UniGenei Mm.31597.

    3D structure databases

    ProteinModelPortali Q8CGV2.
    SMRi Q8CGV2. Positions 55-482.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000006949.

    PTM databases

    PhosphoSitei Q8CGV2.

    Proteomic databases

    MaxQBi Q8CGV2.
    PaxDbi Q8CGV2.
    PRIDEi Q8CGV2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006949 ; ENSMUSP00000006949 ; ENSMUSG00000006764 .
    GeneIDi 216343.
    KEGGi mmu:216343.
    UCSCi uc007haw.2. mouse.

    Organism-specific databases

    CTDi 121278.
    MGIi MGI:2651811. Tph2.

    Phylogenomic databases

    eggNOGi COG3186.
    GeneTreei ENSGT00390000010268.
    HOGENOMi HOG000233373.
    HOVERGENi HBG006841.
    InParanoidi Q0VBT4.
    KOi K00502.
    OMAi EDVSMFL.
    OrthoDBi EOG7KM5T1.
    TreeFami TF313327.

    Enzyme and pathway databases

    UniPathwayi UPA00846 ; UER00799 .
    BRENDAi 1.14.16.4. 3474.
    Reactomei REACT_218437. Serotonin and melatonin biosynthesis.

    Miscellaneous databases

    NextBioi 375107.
    PROi Q8CGV2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CGV2.
    CleanExi MM_TPH2.
    Genevestigatori Q8CGV2.

    Family and domain databases

    Gene3Di 1.10.800.10. 1 hit.
    InterProi IPR002912. ACT_dom.
    IPR001273. ArAA_hydroxylase.
    IPR018301. ArAA_hydroxylase_Fe/CU_BS.
    IPR019774. Aromatic-AA_hydroxylase_C.
    IPR005963. Trp_5_mOase.
    IPR019773. Tyrosine_3-monooxygenase-like.
    [Graphical view ]
    PANTHERi PTHR11473. PTHR11473. 1 hit.
    Pfami PF01842. ACT. 1 hit.
    PF00351. Biopterin_H. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000336. TH. 1 hit.
    PRINTSi PR00372. FYWHYDRXLASE.
    SUPFAMi SSF56534. SSF56534. 1 hit.
    TIGRFAMsi TIGR01270. Trp_5_monoox. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
    PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Synthesis of serotonin by a second tryptophan hydroxylase isoform."
      Walther D.J., Peter J.-U., Bashammakh S., Hortnagl H., Voits M., Fink H., Bader M.
      Science 299:76-76(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiTPH2_MOUSE
    AccessioniPrimary (citable) accession number: Q8CGV2
    Secondary accession number(s): Q0VBT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3