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Q8CGU9

- TPH2_RAT

UniProt

Q8CGU9 - TPH2_RAT

Protein

Tryptophan 5-hydroxylase 2

Gene

Tph2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

    Cofactori

    Fe2+ ion.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi313 – 3131IronBy similarity
    Metal bindingi318 – 3181IronBy similarity
    Metal bindingi358 – 3581IronBy similarity

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. tryptophan 5-monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aromatic amino acid family metabolic process Source: InterPro
    2. cellular response to lithium ion Source: RGD
    3. circadian rhythm Source: RGD
    4. response to activity Source: RGD
    5. response to calcium ion Source: RGD
    6. response to estrogen Source: RGD
    7. response to glucocorticoid Source: RGD
    8. response to nutrient levels Source: RGD
    9. serotonin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Serotonin biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    SABIO-RKQ8CGU9.
    UniPathwayiUPA00846; UER00799.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan 5-hydroxylase 2 (EC:1.14.16.4)
    Alternative name(s):
    Neuronal tryptophan hydroxylase
    Tryptophan 5-monooxygenase 2
    Gene namesi
    Name:Tph2
    Synonyms:Ntph
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi631332. Tph2.

    Subcellular locationi

    GO - Cellular componenti

    1. neuron projection Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 485485Tryptophan 5-hydroxylase 2PRO_0000205576Add
    BLAST

    Proteomic databases

    PRIDEiQ8CGU9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8CGU9.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8CGU9. 1 interaction.
    MINTiMINT-7997028.
    STRINGi10116.ENSRNOP00000005157.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CGU9.
    SMRiQ8CGU9. Positions 146-479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 13576ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ACT domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG3186.
    GeneTreeiENSGT00390000010268.
    HOGENOMiHOG000233373.
    HOVERGENiHBG006841.
    InParanoidiQ8CGU9.
    KOiK00502.
    OMAiEDVSMFL.
    OrthoDBiEOG7KM5T1.
    PhylomeDBiQ8CGU9.
    TreeFamiTF313327.

    Family and domain databases

    Gene3Di1.10.800.10. 1 hit.
    InterProiIPR002912. ACT_dom.
    IPR001273. ArAA_hydroxylase.
    IPR018301. ArAA_hydroxylase_Fe/CU_BS.
    IPR019774. Aromatic-AA_hydroxylase_C.
    IPR005963. Trp_5_mOase.
    IPR019773. Tyrosine_3-monooxygenase-like.
    [Graphical view]
    PANTHERiPTHR11473. PTHR11473. 1 hit.
    PfamiPF01842. ACT. 1 hit.
    PF00351. Biopterin_H. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000336. TH. 1 hit.
    PRINTSiPR00372. FYWHYDRXLASE.
    SUPFAMiSSF56534. SSF56534. 1 hit.
    TIGRFAMsiTIGR01270. Trp_5_monoox. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
    PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CGU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPAMMMFSS KYWARRGLSL DSAVPEEHQI LGGLTQNKAT ASKSEDKRSG    50
    KDTSESSKTA VVFSLKNEVG GLVRALRLFQ EKHVNMLHIE SRRSRRRSSE 100
    VEIFVDCECG KTEFNELIQL LKFQTTIVTL NPPDNIWTEE EELEDVPWFP 150
    RKISELDRCS HRVLMYGTEL DADHPGFKDN VYRQRRKYFV DVAMGYKYGQ 200
    PIPRVEYTEE ETKTWGVVFR ELSKLYPTHA CREYLKNFPL LTKYCGYRED 250
    NVPQLEDVSM FLKERSGFTV RPVAGYLSPR DFLAGLAYRV FHCTQYVRHG 300
    SDPLYTPEPD TCHELLGHVP LLADPKFAQF SQEIGLASLG ASDEDVQKLA 350
    TCYFFTIEFG LCKQEGQLRA YGAGLLSSIG ELKHALSDKA CVKAFDPKTT 400
    CLQECLITTF QDAYFVSESF EEAKEKMRDF AKSITRPFSV YFNPYTQSIE 450
    ILKDTRSIEN VVQDLRSDLN TVCDALNKMN QYLGI 485
    Length:485
    Mass (Da):55,621
    Last modified:March 1, 2003 - v1
    Checksum:iC859B87C04BE743D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY098915 mRNA. Translation: AAM28947.1.
    RefSeqiNP_776211.1. NM_173839.2.
    UniGeneiRn.28510.

    Genome annotation databases

    EnsembliENSRNOT00000005157; ENSRNOP00000005157; ENSRNOG00000003880.
    GeneIDi317675.
    KEGGirno:317675.
    UCSCiRGD:631332. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY098915 mRNA. Translation: AAM28947.1 .
    RefSeqi NP_776211.1. NM_173839.2.
    UniGenei Rn.28510.

    3D structure databases

    ProteinModelPortali Q8CGU9.
    SMRi Q8CGU9. Positions 146-479.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CGU9. 1 interaction.
    MINTi MINT-7997028.
    STRINGi 10116.ENSRNOP00000005157.

    Proteomic databases

    PRIDEi Q8CGU9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005157 ; ENSRNOP00000005157 ; ENSRNOG00000003880 .
    GeneIDi 317675.
    KEGGi rno:317675.
    UCSCi RGD:631332. rat.

    Organism-specific databases

    CTDi 121278.
    RGDi 631332. Tph2.

    Phylogenomic databases

    eggNOGi COG3186.
    GeneTreei ENSGT00390000010268.
    HOGENOMi HOG000233373.
    HOVERGENi HBG006841.
    InParanoidi Q8CGU9.
    KOi K00502.
    OMAi EDVSMFL.
    OrthoDBi EOG7KM5T1.
    PhylomeDBi Q8CGU9.
    TreeFami TF313327.

    Enzyme and pathway databases

    UniPathwayi UPA00846 ; UER00799 .
    SABIO-RK Q8CGU9.

    Miscellaneous databases

    NextBioi 672069.

    Gene expression databases

    Genevestigatori Q8CGU9.

    Family and domain databases

    Gene3Di 1.10.800.10. 1 hit.
    InterProi IPR002912. ACT_dom.
    IPR001273. ArAA_hydroxylase.
    IPR018301. ArAA_hydroxylase_Fe/CU_BS.
    IPR019774. Aromatic-AA_hydroxylase_C.
    IPR005963. Trp_5_mOase.
    IPR019773. Tyrosine_3-monooxygenase-like.
    [Graphical view ]
    PANTHERi PTHR11473. PTHR11473. 1 hit.
    Pfami PF01842. ACT. 1 hit.
    PF00351. Biopterin_H. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000336. TH. 1 hit.
    PRINTSi PR00372. FYWHYDRXLASE.
    SUPFAMi SSF56534. SSF56534. 1 hit.
    TIGRFAMsi TIGR01270. Trp_5_monoox. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
    PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Synthesis of serotonin by a second tryptophan hydroxylase isoform."
      Walther D.J., Peter J.-U., Bashammakh S., Hortnagl H., Voits M., Fink H., Bader M.
      Science 299:76-76(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTPH2_RAT
    AccessioniPrimary (citable) accession number: Q8CGU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3