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Q8CGU9

- TPH2_RAT

UniProt

Q8CGU9 - TPH2_RAT

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Protein

Tryptophan 5-hydroxylase 2

Gene
Tph2, Ntph
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

Cofactori

Fe2+ ion By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi313 – 3131Iron By similarity
Metal bindingi318 – 3181Iron By similarity
Metal bindingi358 – 3581Iron By similarity

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. tryptophan 5-monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic amino acid family metabolic process Source: InterPro
  2. cellular response to lithium ion Source: RGD
  3. circadian rhythm Source: RGD
  4. response to activity Source: RGD
  5. response to calcium ion Source: RGD
  6. response to estrogen Source: RGD
  7. response to glucocorticoid Source: RGD
  8. response to nutrient levels Source: RGD
  9. serotonin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Serotonin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKQ8CGU9.
UniPathwayiUPA00846; UER00799.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan 5-hydroxylase 2 (EC:1.14.16.4)
Alternative name(s):
Neuronal tryptophan hydroxylase
Tryptophan 5-monooxygenase 2
Gene namesi
Name:Tph2
Synonyms:Ntph
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi631332. Tph2.

Subcellular locationi

GO - Cellular componenti

  1. neuron projection Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Tryptophan 5-hydroxylase 2PRO_0000205576Add
BLAST

Proteomic databases

PRIDEiQ8CGU9.

Expressioni

Gene expression databases

GenevestigatoriQ8CGU9.

Interactioni

Protein-protein interaction databases

IntActiQ8CGU9. 1 interaction.
MINTiMINT-7997028.
STRINGi10116.ENSRNOP00000005157.

Structurei

3D structure databases

ProteinModelPortaliQ8CGU9.
SMRiQ8CGU9. Positions 146-479.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 13576ACTAdd
BLAST

Sequence similaritiesi

Contains 1 ACT domain.

Phylogenomic databases

eggNOGiCOG3186.
GeneTreeiENSGT00390000010268.
HOGENOMiHOG000233373.
HOVERGENiHBG006841.
InParanoidiQ8CGU9.
KOiK00502.
OMAiEDVSMFL.
OrthoDBiEOG7KM5T1.
PhylomeDBiQ8CGU9.
TreeFamiTF313327.

Family and domain databases

Gene3Di1.10.800.10. 1 hit.
InterProiIPR002912. ACT_dom.
IPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005963. Trp_5_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
[Graphical view]
PANTHERiPTHR11473. PTHR11473. 1 hit.
PfamiPF01842. ACT. 1 hit.
PF00351. Biopterin_H. 1 hit.
[Graphical view]
PIRSFiPIRSF000336. TH. 1 hit.
PRINTSiPR00372. FYWHYDRXLASE.
SUPFAMiSSF56534. SSF56534. 1 hit.
TIGRFAMsiTIGR01270. Trp_5_monoox. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CGU9-1 [UniParc]FASTAAdd to Basket

« Hide

MQPAMMMFSS KYWARRGLSL DSAVPEEHQI LGGLTQNKAT ASKSEDKRSG    50
KDTSESSKTA VVFSLKNEVG GLVRALRLFQ EKHVNMLHIE SRRSRRRSSE 100
VEIFVDCECG KTEFNELIQL LKFQTTIVTL NPPDNIWTEE EELEDVPWFP 150
RKISELDRCS HRVLMYGTEL DADHPGFKDN VYRQRRKYFV DVAMGYKYGQ 200
PIPRVEYTEE ETKTWGVVFR ELSKLYPTHA CREYLKNFPL LTKYCGYRED 250
NVPQLEDVSM FLKERSGFTV RPVAGYLSPR DFLAGLAYRV FHCTQYVRHG 300
SDPLYTPEPD TCHELLGHVP LLADPKFAQF SQEIGLASLG ASDEDVQKLA 350
TCYFFTIEFG LCKQEGQLRA YGAGLLSSIG ELKHALSDKA CVKAFDPKTT 400
CLQECLITTF QDAYFVSESF EEAKEKMRDF AKSITRPFSV YFNPYTQSIE 450
ILKDTRSIEN VVQDLRSDLN TVCDALNKMN QYLGI 485
Length:485
Mass (Da):55,621
Last modified:March 1, 2003 - v1
Checksum:iC859B87C04BE743D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY098915 mRNA. Translation: AAM28947.1.
RefSeqiNP_776211.1. NM_173839.2.
UniGeneiRn.28510.

Genome annotation databases

EnsembliENSRNOT00000005157; ENSRNOP00000005157; ENSRNOG00000003880.
GeneIDi317675.
KEGGirno:317675.
UCSCiRGD:631332. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY098915 mRNA. Translation: AAM28947.1 .
RefSeqi NP_776211.1. NM_173839.2.
UniGenei Rn.28510.

3D structure databases

ProteinModelPortali Q8CGU9.
SMRi Q8CGU9. Positions 146-479.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CGU9. 1 interaction.
MINTi MINT-7997028.
STRINGi 10116.ENSRNOP00000005157.

Proteomic databases

PRIDEi Q8CGU9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005157 ; ENSRNOP00000005157 ; ENSRNOG00000003880 .
GeneIDi 317675.
KEGGi rno:317675.
UCSCi RGD:631332. rat.

Organism-specific databases

CTDi 121278.
RGDi 631332. Tph2.

Phylogenomic databases

eggNOGi COG3186.
GeneTreei ENSGT00390000010268.
HOGENOMi HOG000233373.
HOVERGENi HBG006841.
InParanoidi Q8CGU9.
KOi K00502.
OMAi EDVSMFL.
OrthoDBi EOG7KM5T1.
PhylomeDBi Q8CGU9.
TreeFami TF313327.

Enzyme and pathway databases

UniPathwayi UPA00846 ; UER00799 .
SABIO-RK Q8CGU9.

Miscellaneous databases

NextBioi 672069.

Gene expression databases

Genevestigatori Q8CGU9.

Family and domain databases

Gene3Di 1.10.800.10. 1 hit.
InterProi IPR002912. ACT_dom.
IPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005963. Trp_5_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
[Graphical view ]
PANTHERi PTHR11473. PTHR11473. 1 hit.
Pfami PF01842. ACT. 1 hit.
PF00351. Biopterin_H. 1 hit.
[Graphical view ]
PIRSFi PIRSF000336. TH. 1 hit.
PRINTSi PR00372. FYWHYDRXLASE.
SUPFAMi SSF56534. SSF56534. 1 hit.
TIGRFAMsi TIGR01270. Trp_5_monoox. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Synthesis of serotonin by a second tryptophan hydroxylase isoform."
    Walther D.J., Peter J.-U., Bashammakh S., Hortnagl H., Voits M., Fink H., Bader M.
    Science 299:76-76(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTPH2_RAT
AccessioniPrimary (citable) accession number: Q8CGU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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