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Q8CGU9 (TPH2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan 5-hydroxylase 2

EC=1.14.16.4
Alternative name(s):
Neuronal tryptophan hydroxylase
Tryptophan 5-monooxygenase 2
Gene names
Name:Tph2
Synonyms:Ntph
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

Cofactor

Fe2+ ion By similarity.

Pathway

Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.

Sequence similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Contains 1 ACT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485Tryptophan 5-hydroxylase 2
PRO_0000205576

Regions

Domain60 – 13576ACT

Sites

Metal binding3131Iron By similarity
Metal binding3181Iron By similarity
Metal binding3581Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CGU9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: C859B87C04BE743D

FASTA48555,621
        10         20         30         40         50         60 
MQPAMMMFSS KYWARRGLSL DSAVPEEHQI LGGLTQNKAT ASKSEDKRSG KDTSESSKTA 

        70         80         90        100        110        120 
VVFSLKNEVG GLVRALRLFQ EKHVNMLHIE SRRSRRRSSE VEIFVDCECG KTEFNELIQL 

       130        140        150        160        170        180 
LKFQTTIVTL NPPDNIWTEE EELEDVPWFP RKISELDRCS HRVLMYGTEL DADHPGFKDN 

       190        200        210        220        230        240 
VYRQRRKYFV DVAMGYKYGQ PIPRVEYTEE ETKTWGVVFR ELSKLYPTHA CREYLKNFPL 

       250        260        270        280        290        300 
LTKYCGYRED NVPQLEDVSM FLKERSGFTV RPVAGYLSPR DFLAGLAYRV FHCTQYVRHG 

       310        320        330        340        350        360 
SDPLYTPEPD TCHELLGHVP LLADPKFAQF SQEIGLASLG ASDEDVQKLA TCYFFTIEFG 

       370        380        390        400        410        420 
LCKQEGQLRA YGAGLLSSIG ELKHALSDKA CVKAFDPKTT CLQECLITTF QDAYFVSESF 

       430        440        450        460        470        480 
EEAKEKMRDF AKSITRPFSV YFNPYTQSIE ILKDTRSIEN VVQDLRSDLN TVCDALNKMN 


QYLGI 

« Hide

References

[1]"Synthesis of serotonin by a second tryptophan hydroxylase isoform."
Walther D.J., Peter J.-U., Bashammakh S., Hortnagl H., Voits M., Fink H., Bader M.
Science 299:76-76(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY098915 mRNA. Translation: AAM28947.1.
RefSeqNP_776211.1. NM_173839.2.
UniGeneRn.28510.

3D structure databases

ProteinModelPortalQ8CGU9.
SMRQ8CGU9. Positions 146-479.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8CGU9. 1 interaction.
MINTMINT-7997028.
STRING10116.ENSRNOP00000005157.

Proteomic databases

PRIDEQ8CGU9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000005157; ENSRNOP00000005157; ENSRNOG00000003880.
GeneID317675.
KEGGrno:317675.
UCSCRGD:631332. rat.

Organism-specific databases

CTD121278.
RGD631332. Tph2.

Phylogenomic databases

eggNOGCOG3186.
GeneTreeENSGT00390000010268.
HOGENOMHOG000233373.
HOVERGENHBG006841.
InParanoidQ8CGU9.
KOK00502.
OMAEDVSMFL.
OrthoDBEOG7KM5T1.
PhylomeDBQ8CGU9.
TreeFamTF313327.

Enzyme and pathway databases

SABIO-RKQ8CGU9.
UniPathwayUPA00846; UER00799.

Gene expression databases

GenevestigatorQ8CGU9.

Family and domain databases

Gene3D1.10.800.10. 1 hit.
InterProIPR002912. ACT_dom.
IPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005963. Trp_5_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
[Graphical view]
PANTHERPTHR11473. PTHR11473. 1 hit.
PfamPF01842. ACT. 1 hit.
PF00351. Biopterin_H. 1 hit.
[Graphical view]
PIRSFPIRSF000336. TH. 1 hit.
PRINTSPR00372. FYWHYDRXLASE.
SUPFAMSSF56534. SSF56534. 1 hit.
TIGRFAMsTIGR01270. Trp_5_monoox. 1 hit.
PROSITEPS51671. ACT. 1 hit.
PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio672069.

Entry information

Entry nameTPH2_RAT
AccessionPrimary (citable) accession number: Q8CGU9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways