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Protein

Zinc phosphodiesterase ELAC protein 2

Gene

Elac2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.

Cofactori

Zn2+Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc phosphodiesterase ELAC protein 2 (EC:3.1.26.11)
Alternative name(s):
ElaC homolog protein 2
Ribonuclease Z 2
Short name:
RNase Z 2
tRNA 3 endonuclease 2
tRNase Z 2
Gene namesi
Name:Elac2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628882. Elac2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionSequence analysisAdd BLAST16
ChainiPRO_000015583217 – 827Zinc phosphodiesterase ELAC protein 2Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193PhosphoserineBy similarity1
Modified residuei197PhosphoserineBy similarity1
Modified residuei202PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei617PhosphoserineBy similarity1
Modified residuei735PhosphoserineBy similarity1
Modified residuei795PhosphothreonineBy similarity1
Modified residuei800PhosphoserineBy similarity1
Modified residuei818PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CGS5.
PRIDEiQ8CGS5.

PTM databases

iPTMnetiQ8CGS5.
PhosphoSitePlusiQ8CGS5.

Interactioni

Subunit structurei

Homodimer. Interacts with PTCD1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004722.

Structurei

3D structure databases

ProteinModelPortaliQ8CGS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2121. Eukaryota.
COG1234. LUCA.
HOGENOMiHOG000007499.
HOVERGENiHBG050042.
InParanoidiQ8CGS5.
KOiK00784.
PhylomeDBiQ8CGS5.

Family and domain databases

Gene3Di3.60.15.10. 3 hits.
InterProiIPR001279. Metallo-B-lactamas.
IPR027794. tRNase_Z_dom.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 1 hit.
PF13691. Lactamase_B_4. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CGS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWALRSLLRP LGLRTMSQGS ARRPRPPKDP LRHLRTREKR GPGWGPGGPN
60 70 80 90 100
TVYLQVVAAG GRDAAAALYV FSEYNRYLFN CGEGVQRLMQ EHKLKVARLD
110 120 130 140 150
NIFLTRMHWS NVGGLCGMIL TLKETGLPKC VLSGPPQLEK YLEAIKIFSG
160 170 180 190 200
PLKGIDLAVR PHSAPEYKDE TMTVYQVPIH SERRCGEQEP SRSPKRSPNR
210 220 230 240 250
LSPKQSSSDP GSAENGQCLP EGSSAGVNGK AWGRDPSLVV AFVCKLHLRK
260 270 280 290 300
GNFLVLKAKE LGLPVGTAAI APIIAAVKDG KSITYEGREI AAEELCTPPD
310 320 330 340 350
PGLVFIVVEC PDEGFIQPIC ENDTFQRYQG EADAPVAVVV HIAPESVLID
360 370 380 390 400
SRYQQWMERF GPDTQHLILN ENCPSVHNLR SHKIQTQLSL IHPDIFPQLT
410 420 430 440 450
SFHSKEEGST FSLPTVRGEC LLKYHVRPKR EWQRDTTLDC NTDEFIAEAL
460 470 480 490 500
ELPNFQESVE EYRKNMQASP APAEKRSQYP EIVFLGTGSA IPMKIRNVSS
510 520 530 540 550
TLVNLSPDKS VLLDCGEGTF GQLCRHYGQQ IDRVLCNLTA VFVSHLHADH
560 570 580 590 600
HTGLLNILLQ REHALASLGK PFQPLLVVAP TQLRAWLQQY HNQCQEILHH
610 620 630 640 650
ISMIPAKCLQ KGAEVPSPPV ERLISLLLET CDLQEFQTCL VRHCKHAFGC
660 670 680 690 700
ALVHSSGWKV VYSGDTMPCE ALVQMGKDAT LLIHEATLED GLEEEAVEKT
710 720 730 740 750
HSTTSQAIGV GMRMNAEFIM LNHFSQRYAK IPLFSPDFNE KVGIAFDHMK
760 770 780 790 800
VCFGDFPTVP KLIPPLKALF ADDIEEMVER REKRELRLVR AALLTQQADS
810 820
SEDREPHQKR AHSEEPHSPQ SKKVRAQ
Length:827
Mass (Da):92,340
Last modified:March 1, 2003 - v1
Checksum:i0D4D391BA0A581A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149902 mRNA. Translation: AAN75376.1.
RefSeqiNP_758829.1. NM_172326.1.
UniGeneiRn.163124.
Rn.229872.

Genome annotation databases

GeneIDi282826.
KEGGirno:282826.
UCSCiRGD:628882. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149902 mRNA. Translation: AAN75376.1.
RefSeqiNP_758829.1. NM_172326.1.
UniGeneiRn.163124.
Rn.229872.

3D structure databases

ProteinModelPortaliQ8CGS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004722.

PTM databases

iPTMnetiQ8CGS5.
PhosphoSitePlusiQ8CGS5.

Proteomic databases

PaxDbiQ8CGS5.
PRIDEiQ8CGS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282826.
KEGGirno:282826.
UCSCiRGD:628882. rat.

Organism-specific databases

CTDi60528.
RGDi628882. Elac2.

Phylogenomic databases

eggNOGiKOG2121. Eukaryota.
COG1234. LUCA.
HOGENOMiHOG000007499.
HOVERGENiHBG050042.
InParanoidiQ8CGS5.
KOiK00784.
PhylomeDBiQ8CGS5.

Miscellaneous databases

PROiQ8CGS5.

Family and domain databases

Gene3Di3.60.15.10. 3 hits.
InterProiIPR001279. Metallo-B-lactamas.
IPR027794. tRNase_Z_dom.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 1 hit.
PF13691. Lactamase_B_4. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRNZ2_RAT
AccessioniPrimary (citable) accession number: Q8CGS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.