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Protein

Zinc phosphodiesterase ELAC protein 2

Gene

Elac2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.

Cofactori

Zn2+Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc phosphodiesterase ELAC protein 2 (EC:3.1.26.11)
Alternative name(s):
ElaC homolog protein 2
Ribonuclease Z 2
Short name:
RNase Z 2
tRNA 3 endonuclease 2
tRNase Z 2
Gene namesi
Name:Elac2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628882 Elac2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionSequence analysisAdd BLAST16
ChainiPRO_000015583217 – 827Zinc phosphodiesterase ELAC protein 2Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193PhosphoserineBy similarity1
Modified residuei197PhosphoserineBy similarity1
Modified residuei202PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei617PhosphoserineBy similarity1
Modified residuei735PhosphoserineBy similarity1
Modified residuei795PhosphothreonineBy similarity1
Modified residuei800PhosphoserineBy similarity1
Modified residuei818PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CGS5
PRIDEiQ8CGS5

PTM databases

iPTMnetiQ8CGS5
PhosphoSitePlusiQ8CGS5

Interactioni

Subunit structurei

Homodimer. Interacts with PTCD1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004722

Structurei

3D structure databases

ProteinModelPortaliQ8CGS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2121 Eukaryota
COG1234 LUCA
HOGENOMiHOG000007499
HOVERGENiHBG050042
InParanoidiQ8CGS5
KOiK00784
PhylomeDBiQ8CGS5

Family and domain databases

Gene3Di3.60.15.101 hit
InterProiView protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR027794 tRNase_Z_dom
PfamiView protein in Pfam
PF12706 Lactamase_B_2, 1 hit
PF13691 Lactamase_B_4, 1 hit
SUPFAMiSSF56281 SSF56281, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CGS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWALRSLLRP LGLRTMSQGS ARRPRPPKDP LRHLRTREKR GPGWGPGGPN
60 70 80 90 100
TVYLQVVAAG GRDAAAALYV FSEYNRYLFN CGEGVQRLMQ EHKLKVARLD
110 120 130 140 150
NIFLTRMHWS NVGGLCGMIL TLKETGLPKC VLSGPPQLEK YLEAIKIFSG
160 170 180 190 200
PLKGIDLAVR PHSAPEYKDE TMTVYQVPIH SERRCGEQEP SRSPKRSPNR
210 220 230 240 250
LSPKQSSSDP GSAENGQCLP EGSSAGVNGK AWGRDPSLVV AFVCKLHLRK
260 270 280 290 300
GNFLVLKAKE LGLPVGTAAI APIIAAVKDG KSITYEGREI AAEELCTPPD
310 320 330 340 350
PGLVFIVVEC PDEGFIQPIC ENDTFQRYQG EADAPVAVVV HIAPESVLID
360 370 380 390 400
SRYQQWMERF GPDTQHLILN ENCPSVHNLR SHKIQTQLSL IHPDIFPQLT
410 420 430 440 450
SFHSKEEGST FSLPTVRGEC LLKYHVRPKR EWQRDTTLDC NTDEFIAEAL
460 470 480 490 500
ELPNFQESVE EYRKNMQASP APAEKRSQYP EIVFLGTGSA IPMKIRNVSS
510 520 530 540 550
TLVNLSPDKS VLLDCGEGTF GQLCRHYGQQ IDRVLCNLTA VFVSHLHADH
560 570 580 590 600
HTGLLNILLQ REHALASLGK PFQPLLVVAP TQLRAWLQQY HNQCQEILHH
610 620 630 640 650
ISMIPAKCLQ KGAEVPSPPV ERLISLLLET CDLQEFQTCL VRHCKHAFGC
660 670 680 690 700
ALVHSSGWKV VYSGDTMPCE ALVQMGKDAT LLIHEATLED GLEEEAVEKT
710 720 730 740 750
HSTTSQAIGV GMRMNAEFIM LNHFSQRYAK IPLFSPDFNE KVGIAFDHMK
760 770 780 790 800
VCFGDFPTVP KLIPPLKALF ADDIEEMVER REKRELRLVR AALLTQQADS
810 820
SEDREPHQKR AHSEEPHSPQ SKKVRAQ
Length:827
Mass (Da):92,340
Last modified:March 1, 2003 - v1
Checksum:i0D4D391BA0A581A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149902 mRNA Translation: AAN75376.1
RefSeqiNP_758829.1, NM_172326.1
UniGeneiRn.163124
Rn.229872

Genome annotation databases

GeneIDi282826
KEGGirno:282826
UCSCiRGD:628882 rat

Similar proteinsi

Entry informationi

Entry nameiRNZ2_RAT
AccessioniPrimary (citable) accession number: Q8CGS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome