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Q8CGR7

- UPP2_MOUSE

UniProt

Q8CGR7 - UPP2_MOUSE

Protein

Uridine phosphorylase 2

Gene

Upp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.By similarity

    Catalytic activityi

    Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

    Enzyme regulationi

    A conditional disulfide bridge can form within the protein that dislocates a critical phosphate-coordinating arginine Arg-100 away from the active site, disabling the enzyme.By similarity

    Pathwayi

    GO - Molecular functioni

    1. uridine phosphorylase activity Source: UniProtKB

    GO - Biological processi

    1. nucleotide catabolic process Source: InterPro
    2. UMP salvage Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    SABIO-RKQ8CGR7.
    UniPathwayiUPA00574; UER00633.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uridine phosphorylase 2 (EC:2.4.2.3)
    Short name:
    UPase 2
    Short name:
    UrdPase 2
    Alternative name(s):
    Liver-specific uridine phosphorylase
    Short name:
    L-UrdPase
    Gene namesi
    Name:Upp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1923904. Upp2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    2. type III intermediate filament Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Uridine phosphorylase 2PRO_0000063194Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi95 ↔ 102Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ8CGR7.
    PRIDEiQ8CGR7.

    PTM databases

    PhosphoSiteiQ8CGR7.

    Expressioni

    Tissue specificityi

    Liver specific.

    Gene expression databases

    BgeeiQ8CGR7.
    CleanExiMM_UPP2.
    GenevestigatoriQ8CGR7.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CGR7.
    SMRiQ8CGR7. Positions 22-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PNP/UDP phosphorylase family.Curated

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG2820.
    GeneTreeiENSGT00390000004400.
    HOGENOMiHOG000231747.
    HOVERGENiHBG047725.
    KOiK00757.
    TreeFamiTF314310.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    InterProiIPR018017. Nucleoside_phosphorylase.
    IPR018016. Nucleoside_phosphorylase_CS.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR010059. Uridine_phosphorylase_euk.
    [Graphical view]
    PANTHERiPTHR21234. PTHR21234. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01719. euk_UDPppase. 1 hit.
    PROSITEiPS01232. PNP_UDP_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CGR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASILPASNR SMRPDKNTYE RKRSVYVKNP YLEGMDEDIL YHLDLGTKTH    50
    NLPAMFGDVK FVCVGGSPNR MKAFAQFMHK ELRLEGDGED IEDICAGTDR 100
    YCMFKTGPVL SVSHGMGIPS ISIMLHELIK LLHHAHCCDV TIIRIGTSGG 150
    IGIAPGSVVI TDTAVDSFFK PRFEQVILDN VVTRSTELDK ELANDLFNCS 200
    REIPNVPTLI GHTMCTYDFY EGQGRLDGAL CSFSREKKLD YLKRAYRAGV 250
    RNIEMESTVF AAMCGLCGLR AAVVCVTLLD RLESDQINLS HDVLVEYQQR 300
    PQLLISNFIK KQLGLCDQMS 320
    Length:320
    Mass (Da):35,755
    Last modified:March 1, 2003 - v1
    Checksum:iA8FEF664BF1A048C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY152393 mRNA. Translation: AAO05705.1.
    CCDSiCCDS16051.1.
    RefSeqiNP_083968.1. NM_029692.3.
    XP_006498472.1. XM_006498409.1.
    XP_006498473.1. XM_006498410.1.
    XP_006498474.1. XM_006498411.1.
    UniGeneiMm.200370.
    Mm.378432.

    Genome annotation databases

    EnsembliENSMUST00000102755; ENSMUSP00000099816; ENSMUSG00000026839.
    GeneIDi76654.
    KEGGimmu:76654.
    UCSCiuc008jsw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY152393 mRNA. Translation: AAO05705.1 .
    CCDSi CCDS16051.1.
    RefSeqi NP_083968.1. NM_029692.3.
    XP_006498472.1. XM_006498409.1.
    XP_006498473.1. XM_006498410.1.
    XP_006498474.1. XM_006498411.1.
    UniGenei Mm.200370.
    Mm.378432.

    3D structure databases

    ProteinModelPortali Q8CGR7.
    SMRi Q8CGR7. Positions 22-314.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q8CGR7.

    PTM databases

    PhosphoSitei Q8CGR7.

    Proteomic databases

    PaxDbi Q8CGR7.
    PRIDEi Q8CGR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102755 ; ENSMUSP00000099816 ; ENSMUSG00000026839 .
    GeneIDi 76654.
    KEGGi mmu:76654.
    UCSCi uc008jsw.1. mouse.

    Organism-specific databases

    CTDi 151531.
    MGIi MGI:1923904. Upp2.

    Phylogenomic databases

    eggNOGi COG2820.
    GeneTreei ENSGT00390000004400.
    HOGENOMi HOG000231747.
    HOVERGENi HBG047725.
    KOi K00757.
    TreeFami TF314310.

    Enzyme and pathway databases

    UniPathwayi UPA00574 ; UER00633 .
    SABIO-RK Q8CGR7.

    Miscellaneous databases

    NextBioi 345565.
    PROi Q8CGR7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CGR7.
    CleanExi MM_UPP2.
    Genevestigatori Q8CGR7.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    InterProi IPR018017. Nucleoside_phosphorylase.
    IPR018016. Nucleoside_phosphorylase_CS.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR010059. Uridine_phosphorylase_euk.
    [Graphical view ]
    PANTHERi PTHR21234. PTHR21234. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01719. euk_UDPppase. 1 hit.
    PROSITEi PS01232. PNP_UDP_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors."
      Zhang Y., Repa J.J., Inoue Y., Hayhurst G.P., Gonzalez F.J., Mangelsdorf D.J.
      Mol. Endocrinol. 18:851-862(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X 129.

    Entry informationi

    Entry nameiUPP2_MOUSE
    AccessioniPrimary (citable) accession number: Q8CGR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3