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Q8CGR7 (UPP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uridine phosphorylase 2

Short name=UPase 2
Short name=UrdPase 2
EC=2.4.2.3
Alternative name(s):
Liver-specific uridine phosphorylase
Short name=L-UrdPase
Gene names
Name:Upp2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.

Catalytic activity

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Enzyme regulation

A conditional disulfide bridge can form within the protein that dislocates a critical phosphate-coordinating arginine Arg-100 away from the active site, disabling the enzyme By similarity.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.

Tissue specificity

Liver specific.

Sequence similarities

Belongs to the PNP/UDP phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Uridine phosphorylase 2
PRO_0000063194

Amino acid modifications

Disulfide bond95 ↔ 102Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CGR7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: A8FEF664BF1A048C

FASTA32035,755
        10         20         30         40         50         60 
MASILPASNR SMRPDKNTYE RKRSVYVKNP YLEGMDEDIL YHLDLGTKTH NLPAMFGDVK 

        70         80         90        100        110        120 
FVCVGGSPNR MKAFAQFMHK ELRLEGDGED IEDICAGTDR YCMFKTGPVL SVSHGMGIPS 

       130        140        150        160        170        180 
ISIMLHELIK LLHHAHCCDV TIIRIGTSGG IGIAPGSVVI TDTAVDSFFK PRFEQVILDN 

       190        200        210        220        230        240 
VVTRSTELDK ELANDLFNCS REIPNVPTLI GHTMCTYDFY EGQGRLDGAL CSFSREKKLD 

       250        260        270        280        290        300 
YLKRAYRAGV RNIEMESTVF AAMCGLCGLR AAVVCVTLLD RLESDQINLS HDVLVEYQQR 

       310        320 
PQLLISNFIK KQLGLCDQMS 

« Hide

References

[1]"Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors."
Zhang Y., Repa J.J., Inoue Y., Hayhurst G.P., Gonzalez F.J., Mangelsdorf D.J.
Mol. Endocrinol. 18:851-862(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X 129.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY152393 mRNA. Translation: AAO05705.1.
CCDSCCDS16051.1.
RefSeqNP_083968.1. NM_029692.3.
XP_006498472.1. XM_006498409.1.
XP_006498473.1. XM_006498410.1.
XP_006498474.1. XM_006498411.1.
UniGeneMm.200370.
Mm.378432.

3D structure databases

ProteinModelPortalQ8CGR7.
SMRQ8CGR7. Positions 22-314.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ8CGR7.

PTM databases

PhosphoSiteQ8CGR7.

Proteomic databases

PaxDbQ8CGR7.
PRIDEQ8CGR7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000102755; ENSMUSP00000099816; ENSMUSG00000026839.
GeneID76654.
KEGGmmu:76654.
UCSCuc008jsw.1. mouse.

Organism-specific databases

CTD151531.
MGIMGI:1923904. Upp2.

Phylogenomic databases

eggNOGCOG2820.
GeneTreeENSGT00390000004400.
HOGENOMHOG000231747.
HOVERGENHBG047725.
KOK00757.
TreeFamTF314310.

Enzyme and pathway databases

SABIO-RKQ8CGR7.
UniPathwayUPA00574; UER00633.

Gene expression databases

BgeeQ8CGR7.
CleanExMM_UPP2.
GenevestigatorQ8CGR7.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
InterProIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view]
PANTHERPTHR21234. PTHR21234. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01719. euk_UDPppase. 1 hit.
PROSITEPS01232. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio345565.
PROQ8CGR7.
SOURCESearch...

Entry information

Entry nameUPP2_MOUSE
AccessionPrimary (citable) accession number: Q8CGR7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot