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Protein

Uridine phosphorylase 2

Gene

Upp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity).By similarity

Catalytic activityi

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Enzyme regulationi

A conditional disulfide bridge can form within the protein that dislocates a critical phosphate-coordinating arginine Arg-100 away from the active site, disabling the enzyme.By similarity

Pathwayi

GO - Molecular functioni

  1. uridine phosphorylase activity Source: UniProtKB

GO - Biological processi

  1. nucleotide catabolic process Source: InterPro
  2. UMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_241108. Pyrimidine catabolism.
REACT_259385. Pyrimidine salvage reactions.
SABIO-RKQ8CGR7.
UniPathwayiUPA00574; UER00633.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine phosphorylase 2 (EC:2.4.2.3)
Short name:
UPase 2
Short name:
UrdPase 2
Alternative name(s):
Liver-specific uridine phosphorylase
Short name:
L-UrdPase
Gene namesi
Name:Upp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1923904. Upp2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
  2. type III intermediate filament Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Uridine phosphorylase 2PRO_0000063194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi95 ↔ 102Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ8CGR7.
PaxDbiQ8CGR7.
PRIDEiQ8CGR7.

PTM databases

PhosphoSiteiQ8CGR7.

Expressioni

Tissue specificityi

Liver specific.

Gene expression databases

BgeeiQ8CGR7.
CleanExiMM_UPP2.
ExpressionAtlasiQ8CGR7. baseline and differential.
GenevestigatoriQ8CGR7.

Structurei

3D structure databases

ProteinModelPortaliQ8CGR7.
SMRiQ8CGR7. Positions 22-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG2820.
GeneTreeiENSGT00390000004400.
HOGENOMiHOG000231747.
HOVERGENiHBG047725.
InParanoidiQ8CGR7.
KOiK00757.
TreeFamiTF314310.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01719. euk_UDPppase. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CGR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASILPASNR SMRPDKNTYE RKRSVYVKNP YLEGMDEDIL YHLDLGTKTH
60 70 80 90 100
NLPAMFGDVK FVCVGGSPNR MKAFAQFMHK ELRLEGDGED IEDICAGTDR
110 120 130 140 150
YCMFKTGPVL SVSHGMGIPS ISIMLHELIK LLHHAHCCDV TIIRIGTSGG
160 170 180 190 200
IGIAPGSVVI TDTAVDSFFK PRFEQVILDN VVTRSTELDK ELANDLFNCS
210 220 230 240 250
REIPNVPTLI GHTMCTYDFY EGQGRLDGAL CSFSREKKLD YLKRAYRAGV
260 270 280 290 300
RNIEMESTVF AAMCGLCGLR AAVVCVTLLD RLESDQINLS HDVLVEYQQR
310 320
PQLLISNFIK KQLGLCDQMS
Length:320
Mass (Da):35,755
Last modified:March 1, 2003 - v1
Checksum:iA8FEF664BF1A048C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152393 mRNA. Translation: AAO05705.1.
CCDSiCCDS16051.1.
RefSeqiNP_083968.1. NM_029692.3.
XP_006498472.1. XM_006498409.1.
XP_006498473.1. XM_006498410.1.
XP_006498474.1. XM_006498411.1.
UniGeneiMm.200370.
Mm.378432.

Genome annotation databases

EnsembliENSMUST00000102755; ENSMUSP00000099816; ENSMUSG00000026839.
GeneIDi76654.
KEGGimmu:76654.
UCSCiuc008jsw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152393 mRNA. Translation: AAO05705.1.
CCDSiCCDS16051.1.
RefSeqiNP_083968.1. NM_029692.3.
XP_006498472.1. XM_006498409.1.
XP_006498473.1. XM_006498410.1.
XP_006498474.1. XM_006498411.1.
UniGeneiMm.200370.
Mm.378432.

3D structure databases

ProteinModelPortaliQ8CGR7.
SMRiQ8CGR7. Positions 22-314.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8CGR7.

Proteomic databases

MaxQBiQ8CGR7.
PaxDbiQ8CGR7.
PRIDEiQ8CGR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102755; ENSMUSP00000099816; ENSMUSG00000026839.
GeneIDi76654.
KEGGimmu:76654.
UCSCiuc008jsw.1. mouse.

Organism-specific databases

CTDi151531.
MGIiMGI:1923904. Upp2.

Phylogenomic databases

eggNOGiCOG2820.
GeneTreeiENSGT00390000004400.
HOGENOMiHOG000231747.
HOVERGENiHBG047725.
InParanoidiQ8CGR7.
KOiK00757.
TreeFamiTF314310.

Enzyme and pathway databases

UniPathwayiUPA00574; UER00633.
ReactomeiREACT_241108. Pyrimidine catabolism.
REACT_259385. Pyrimidine salvage reactions.
SABIO-RKQ8CGR7.

Miscellaneous databases

NextBioi345565.
PROiQ8CGR7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CGR7.
CleanExiMM_UPP2.
ExpressionAtlasiQ8CGR7. baseline and differential.
GenevestigatoriQ8CGR7.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01719. euk_UDPppase. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors."
    Zhang Y., Repa J.J., Inoue Y., Hayhurst G.P., Gonzalez F.J., Mangelsdorf D.J.
    Mol. Endocrinol. 18:851-862(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X 129.

Entry informationi

Entry nameiUPP2_MOUSE
AccessioniPrimary (citable) accession number: Q8CGR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.