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Q8CGR7

- UPP2_MOUSE

UniProt

Q8CGR7 - UPP2_MOUSE

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Protein

Uridine phosphorylase 2

Gene

Upp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.By similarity

Catalytic activityi

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Enzyme regulationi

A conditional disulfide bridge can form within the protein that dislocates a critical phosphate-coordinating arginine Arg-100 away from the active site, disabling the enzyme.By similarity

Pathwayi

GO - Molecular functioni

  1. uridine phosphorylase activity Source: UniProtKB

GO - Biological processi

  1. nucleotide catabolic process Source: InterPro
  2. UMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

SABIO-RKQ8CGR7.
UniPathwayiUPA00574; UER00633.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine phosphorylase 2 (EC:2.4.2.3)
Short name:
UPase 2
Short name:
UrdPase 2
Alternative name(s):
Liver-specific uridine phosphorylase
Short name:
L-UrdPase
Gene namesi
Name:Upp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1923904. Upp2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
  2. type III intermediate filament Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Uridine phosphorylase 2PRO_0000063194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi95 ↔ 102Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ8CGR7.
PaxDbiQ8CGR7.
PRIDEiQ8CGR7.

PTM databases

PhosphoSiteiQ8CGR7.

Expressioni

Tissue specificityi

Liver specific.

Gene expression databases

BgeeiQ8CGR7.
CleanExiMM_UPP2.
ExpressionAtlasiQ8CGR7. baseline and differential.
GenevestigatoriQ8CGR7.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ8CGR7.
SMRiQ8CGR7. Positions 22-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG2820.
GeneTreeiENSGT00390000004400.
HOGENOMiHOG000231747.
HOVERGENiHBG047725.
InParanoidiQ8CGR7.
KOiK00757.
TreeFamiTF314310.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01719. euk_UDPppase. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CGR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASILPASNR SMRPDKNTYE RKRSVYVKNP YLEGMDEDIL YHLDLGTKTH
60 70 80 90 100
NLPAMFGDVK FVCVGGSPNR MKAFAQFMHK ELRLEGDGED IEDICAGTDR
110 120 130 140 150
YCMFKTGPVL SVSHGMGIPS ISIMLHELIK LLHHAHCCDV TIIRIGTSGG
160 170 180 190 200
IGIAPGSVVI TDTAVDSFFK PRFEQVILDN VVTRSTELDK ELANDLFNCS
210 220 230 240 250
REIPNVPTLI GHTMCTYDFY EGQGRLDGAL CSFSREKKLD YLKRAYRAGV
260 270 280 290 300
RNIEMESTVF AAMCGLCGLR AAVVCVTLLD RLESDQINLS HDVLVEYQQR
310 320
PQLLISNFIK KQLGLCDQMS
Length:320
Mass (Da):35,755
Last modified:March 1, 2003 - v1
Checksum:iA8FEF664BF1A048C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY152393 mRNA. Translation: AAO05705.1.
CCDSiCCDS16051.1.
RefSeqiNP_083968.1. NM_029692.3.
XP_006498472.1. XM_006498409.1.
XP_006498473.1. XM_006498410.1.
XP_006498474.1. XM_006498411.1.
UniGeneiMm.200370.
Mm.378432.

Genome annotation databases

EnsembliENSMUST00000102755; ENSMUSP00000099816; ENSMUSG00000026839.
GeneIDi76654.
KEGGimmu:76654.
UCSCiuc008jsw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY152393 mRNA. Translation: AAO05705.1 .
CCDSi CCDS16051.1.
RefSeqi NP_083968.1. NM_029692.3.
XP_006498472.1. XM_006498409.1.
XP_006498473.1. XM_006498410.1.
XP_006498474.1. XM_006498411.1.
UniGenei Mm.200370.
Mm.378432.

3D structure databases

ProteinModelPortali Q8CGR7.
SMRi Q8CGR7. Positions 22-314.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q8CGR7.

PTM databases

PhosphoSitei Q8CGR7.

Proteomic databases

MaxQBi Q8CGR7.
PaxDbi Q8CGR7.
PRIDEi Q8CGR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102755 ; ENSMUSP00000099816 ; ENSMUSG00000026839 .
GeneIDi 76654.
KEGGi mmu:76654.
UCSCi uc008jsw.1. mouse.

Organism-specific databases

CTDi 151531.
MGIi MGI:1923904. Upp2.

Phylogenomic databases

eggNOGi COG2820.
GeneTreei ENSGT00390000004400.
HOGENOMi HOG000231747.
HOVERGENi HBG047725.
InParanoidi Q8CGR7.
KOi K00757.
TreeFami TF314310.

Enzyme and pathway databases

UniPathwayi UPA00574 ; UER00633 .
SABIO-RK Q8CGR7.

Miscellaneous databases

NextBioi 345565.
PROi Q8CGR7.
SOURCEi Search...

Gene expression databases

Bgeei Q8CGR7.
CleanExi MM_UPP2.
ExpressionAtlasi Q8CGR7. baseline and differential.
Genevestigatori Q8CGR7.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
InterProi IPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view ]
PANTHERi PTHR21234. PTHR21234. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01719. euk_UDPppase. 1 hit.
PROSITEi PS01232. PNP_UDP_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors."
    Zhang Y., Repa J.J., Inoue Y., Hayhurst G.P., Gonzalez F.J., Mangelsdorf D.J.
    Mol. Endocrinol. 18:851-862(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X 129.

Entry informationi

Entry nameiUPP2_MOUSE
AccessioniPrimary (citable) accession number: Q8CGR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3