ID Q8CGR6_MOUSE Unreviewed; 276 AA. AC Q8CGR6; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 27-MAR-2024, entry version 168. DE SubName: Full=Glandular kallikrein KLK13 {ECO:0000313|EMBL:AAN78420.1}; DE SubName: Full=Kallikrein l {ECO:0000313|EMBL:SFW93255.1}; DE SubName: Full=Kallikrein related-peptidase 13 {ECO:0000313|EMBL:BAQ21990.1, ECO:0000313|Ensembl:ENSMUSP00000065308.7}; GN Name=Klk13 {ECO:0000313|EMBL:BAQ21990.1, GN ECO:0000313|Ensembl:ENSMUSP00000065308.7, GN ECO:0000313|MGI:MGI:3615275}; GN Synonyms=Egfbp2 {ECO:0000313|MGI:MGI:3615275}, Klnl GN {ECO:0000313|EMBL:SFW93255.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAN78420.1}; RN [1] {ECO:0000313|EMBL:AAN78420.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12437987; DOI=10.1016/S0006-291X(02)02629-3; RA Olsson A.Y., Lundwall A.; RT "Organization and evolution of the glandular kallikrein locus in Mus RT musculus."; RL Biochem. Biophys. Res. Commun. 299:305-311(2002). RN [2] {ECO:0000313|EMBL:AAN78420.1} RP NUCLEOTIDE SEQUENCE. RA Adams M., Mural R.; RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSMUSP00000065308.7, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000065308.7, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000313|EMBL:BAQ21990.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=129X1/SvJ {ECO:0000313|EMBL:BAQ21990.1}; RA Murakami K., Tanaka T., Bando Y., Yoshida S.; RT "Differences of sequences of kallikrein-related peptidase mRNAs and KLK6 RT enzymatic activities among mouse strains."; RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:SFW93255.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28224083; DOI=10.1016/j.ymgmr.2017.01.009; RA Premzl M.; RT "Comparative genomic analysis of eutherian kallikrein genes."; RL Mol. Genet. Metab. Rep. 10:96-99(2017). RN [6] {ECO:0000313|EMBL:SFW93255.1} RP NUCLEOTIDE SEQUENCE. RX DOI=10.1016/j.genrep.2019.100414; RA Premzl M.; RT "Eutherian third-party data gene collections."; RL Gene Rep 16:100414-100414(2019). RN [7] {ECO:0000313|Ensembl:ENSMUSP00000065308.7} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000065308.7}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY152432; AAN78420.1; -; Genomic_DNA. DR EMBL; AB981045; BAQ21990.1; -; mRNA. DR EMBL; LT631608; SFW93255.1; -; Genomic_DNA. DR RefSeq; NP_001034131.2; NM_001039042.2. DR RefSeq; XP_006541118.1; XM_006541055.3. DR RefSeq; XP_006541119.1; XM_006541056.3. DR STRING; 10090.ENSMUSP00000065308; -. DR MEROPS; S01.306; -. DR PaxDb; 10090-ENSMUSP00000065308; -. DR ProteomicsDB; 334731; -. DR Antibodypedia; 18982; 314 antibodies from 31 providers. DR Ensembl; ENSMUST00000066834.8; ENSMUSP00000065308.7; ENSMUSG00000054046.8. DR GeneID; 626834; -. DR KEGG; mmu:626834; -. DR UCSC; uc009gnk.1; mouse. DR AGR; MGI:3615275; -. DR CTD; 26085; -. DR MGI; MGI:3615275; Klk13. DR VEuPathDB; HostDB:ENSMUSG00000054046; -. DR eggNOG; KOG3627; Eukaryota. DR GeneTree; ENSGT01030000234551; -. DR HOGENOM; CLU_006842_1_1_1; -. DR OMA; PAGTCCR; -. DR OrthoDB; 4629979at2759; -. DR TreeFam; TF331065; -. DR Reactome; R-MMU-6809371; Formation of the cornified envelope. DR BioGRID-ORCS; 626834; 2 hits in 77 CRISPR screens. DR Proteomes; UP000000589; Chromosome 7. DR Bgee; ENSMUSG00000054046; Expressed in esophagus and 44 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. DR GO; GO:0005615; C:extracellular space; IDA:MGI. DR GO; GO:0030141; C:secretory granule; IDA:MGI. DR GO; GO:0004175; F:endopeptidase activity; IDA:MGI. DR GO; GO:0016787; F:hydrolase activity; ISS:UniProtKB. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0016485; P:protein processing; IDA:MGI. DR CDD; cd00190; Tryp_SPc; 1. DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2. DR InterPro; IPR009003; Peptidase_S1_PA. DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin. DR InterPro; IPR001314; Peptidase_S1A. DR InterPro; IPR001254; Trypsin_dom. DR InterPro; IPR018114; TRYPSIN_HIS. DR InterPro; IPR033116; TRYPSIN_SER. DR PANTHER; PTHR24271:SF3; KALLIKREIN-13; 1. DR PANTHER; PTHR24271; KALLIKREIN-RELATED; 1. DR Pfam; PF00089; Trypsin; 1. DR PRINTS; PR00722; CHYMOTRYPSIN. DR SMART; SM00020; Tryp_SPc; 1. DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1. DR PROSITE; PS50240; TRYPSIN_DOM; 1. DR PROSITE; PS00134; TRYPSIN_HIS; 1. DR PROSITE; PS00135; TRYPSIN_SER; 1. PE 1: Evidence at protein level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Hydrolase {ECO:0000256|RuleBase:RU363034}; KW Protease {ECO:0000256|RuleBase:RU363034}; KW Proteomics identification {ECO:0007829|ProteomicsDB:Q8CGR6}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Serine protease {ECO:0000256|RuleBase:RU363034}; KW Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}. FT SIGNAL 1..18 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 19..276 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5015099072" FT DOMAIN 37..264 FT /note="Peptidase S1" FT /evidence="ECO:0000259|PROSITE:PS50240" SQ SEQUENCE 276 AA; 30360 MW; 33E189C67492FDCA CRC64; MWPLVATIAC LTLALSEGIS RDYPKILNGT NGTSGFLPGG YTCLPHSQPW QAALLIRGRL LCGGVLVHPK WVLTAAHCRK DGYTVHLGKH ALGRVENGEQ AMEVVRSIPH PEYQVTPTHL NHDHDIMLLE LKSPVQLSSH VRTLKLSADD CLPTGTCCRV SGWGTTTSPQ VNYPKTLQCA NIELRSDEEC RQVYPGKITA NMLCAGTKEG GKDSCEGDSG GPLICNGKLY GIISWGDFPC GQPNRPGVYT RVSKYLRWIR EIIRNTPEQR WTKGTQ //