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Protein
Submitted name:

Epidermal growth factor-binding protein type B

Gene

Klk13

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. endopeptidase activity Source: MGI
  2. hydrolase activity Source: UniProtKB
  3. serine-type endopeptidase activity Source: GO_Central

GO - Biological processi

  1. protein processing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotation

Protein family/group databases

MEROPSiS01.306.

Names & Taxonomyi

Protein namesi
Submitted name:
Epidermal growth factor-binding protein type BImported
Submitted name:
Glandular kallikrein KLK13Imported
Submitted name:
Kallikrein related-peptidase 13Imported
Gene namesi
Name:Klk13Imported
Synonyms:Egfbp2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3615275. Klk13.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular space Source: MGI
  3. extracellular vesicular exosome Source: MGI
  4. secretory granule Source: MGI
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ8CGR6.
PaxDbiQ8CGR6.
PRIDEiQ8CGR6.

Expressioni

Gene expression databases

BgeeiQ8CGR6.
GenevestigatoriQ8CGR6.

Structurei

3D structure databases

ProteinModelPortaliQ8CGR6.
SMRiQ8CGR6. Positions 40-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ8CGR6.
KOiK09463.
OMAiIRNTPEQ.
OrthoDBiEOG75B84T.
PhylomeDBiQ8CGR6.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CGR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPLVATIAC LTLALSEGIS RDYPKILNGT NGTSGFLPGG YTCLPHSQPW
60 70 80 90 100
QAALLIRGRL LCGGVLVHPK WVLTAAHCRK DGYTVHLGKH ALGRVENGEQ
110 120 130 140 150
AMEVVRSIPH PEYQVTPTHL NHDHDIMLLE LKSPVQLSSH VRTLKLSADD
160 170 180 190 200
CLPTGTCCRV SGWGTTTSPQ VNYPKTLQCA NIELRSDEEC RQVYPGKITA
210 220 230 240 250
NMLCAGTKEG GKDSCEGDSG GPLICNGKLY GIISWGDFPC GQPNRPGVYT
260 270
RVSKYLRWIR EIIRNTPEQR WTKGTQ
Length:276
Mass (Da):30,360
Last modified:March 1, 2003 - v1
Checksum:i33E189C67492FDCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151989 Genomic DNA. No translation available.
AY152432 Genomic DNA. Translation: AAN78420.1.
AB981045 mRNA. Translation: BAQ21990.1.
RefSeqiNP_001034131.2. NM_001039042.2.
XP_006541118.1. XM_006541055.2.
XP_006541119.1. XM_006541056.2.
UniGeneiMm.389891.

Genome annotation databases

EnsembliENSMUST00000066834; ENSMUSP00000065308; ENSMUSG00000054046.
GeneIDi626834.
KEGGimmu:626834.
UCSCiuc009gnk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151989 Genomic DNA. No translation available.
AY152432 Genomic DNA. Translation: AAN78420.1.
AB981045 mRNA. Translation: BAQ21990.1.
RefSeqiNP_001034131.2. NM_001039042.2.
XP_006541118.1. XM_006541055.2.
XP_006541119.1. XM_006541056.2.
UniGeneiMm.389891.

3D structure databases

ProteinModelPortaliQ8CGR6.
SMRiQ8CGR6. Positions 40-264.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.306.

Proteomic databases

MaxQBiQ8CGR6.
PaxDbiQ8CGR6.
PRIDEiQ8CGR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066834; ENSMUSP00000065308; ENSMUSG00000054046.
GeneIDi626834.
KEGGimmu:626834.
UCSCiuc009gnk.1. mouse.

Organism-specific databases

CTDi26085.
MGIiMGI:3615275. Klk13.

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ8CGR6.
KOiK09463.
OMAiIRNTPEQ.
OrthoDBiEOG75B84T.
PhylomeDBiQ8CGR6.
TreeFamiTF331065.

Miscellaneous databases

NextBioi419122.
PROiQ8CGR6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CGR6.
GenevestigatoriQ8CGR6.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organization and evolution of the glandular kallikrein locus in Mus musculus."
    Olsson A.Y., Lundwall A.
    Biochem. Biophys. Res. Commun. 299:305-311(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Adams M., Mural R.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  5. "Differences of sequences of kallikrein-related peptidase mRNAs and KLK6 enzymatic activities among mouse strains."
    Murakami K., Tanaka T., Bando Y., Yoshida S.
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129X1/SvJImported.

Entry informationi

Entry nameiQ8CGR6_MOUSE
AccessioniPrimary (citable) accession number: Q8CGR6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 1, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.