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Q8CGR5 (KLK14_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Kallikrein-14
EC=3.4.21.-
Alternative name(s):
Glandular kallikrein KLK14
Short name=mGK14
Kallikrein related-peptidase 14
Gene names
Name:Klk14
Synonyms:Gk14
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis By similarity.

Enzyme regulation

Inhibited by SERPINA1, SERPINC1, SERPINE1, SERPINF2, aprotinin, soybean, trypsin inhibitor and leupeptin. Inhibited by serine protease inhibitor SPINK5. Has an autoproteolytic activity which may have a regulatory effect. Activated by citrate and inhibited by zinc and to a lower extent by manganese By similarity.

Subcellular location

Secreted › extracellular space By similarity.

Post-translational modification

Proteolytic cleavage of the activation peptide produces the active enzyme By similarity.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Propeptide19 – 235Activation peptide By similarity
PRO_0000378340
Chain24 – 250227Kallikrein-14
PRO_0000378341

Regions

Domain24 – 248225Peptidase S1

Sites

Active site661Charge relay system By similarity
Active site1101Charge relay system By similarity
Active site2031Charge relay system By similarity

Amino acid modifications

Disulfide bond51 ↔ 67 By similarity
Disulfide bond142 ↔ 209 By similarity
Disulfide bond174 ↔ 188 By similarity
Disulfide bond199 ↔ 224 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CGR5 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: F62FEBF2290FEBE8

FASTA25027,016
        10         20         30         40         50         60 
MFLLLIILQA LAVAIAQSQG DHKIIGGYRC VRNSQPWQVA LQAGPGHRFL CGGVLLSDQW 

        70         80         90        100        110        120 
VITAAHCARP ILHVALGKHN IRRWEATQQV VRVARQVPHP QYQPQAHDND LMLLKLQKKV 

       130        140        150        160        170        180 
RLGRAVKTIS VASSCASPGT PCRVSGWGTI ASPIARYPTA LQCVNVNIMS EQACHRAYPG 

       190        200        210        220        230        240 
IITSGMVCAG VPEGGKDSCQ GDSGGPLVCG GQLQGLVSWG MERCAMPGYP GVYANLCNYH 

       250 
SWIQRTMQSN

« Hide

References

« Hide 'large scale' references
[1]"Organization and evolution of the glandular kallikrein locus in Mus musculus."
Olsson A.Y., Lundwall A.
Biochem. Biophys. Res. Commun. 299:305-311(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY152433 Genomic DNA. Translation: AAN78421.1.
BC128019 mRNA. Translation: AAI28020.1.
IPIIPI00229559.
RefSeqNP_777355.1. NM_174866.2.
UniGeneMm.247377.

3D structure databases

ProteinModelPortalQ8CGR5.
SMRQ8CGR5. Positions 24-250.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000056935.

Protein family/group databases

MEROPSS01.029.

Proteomic databases

PRIDEQ8CGR5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000056329; ENSMUSP00000056935; ENSMUSG00000044737.
GeneID317653.
KEGGmmu:317653.
UCSCuc009gni.2. mouse.

Organism-specific databases

CTD43847.
MGIMGI:2447564. Klk14.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00690000101721.
HOGENOMHOG000251820.
InParanoidQ8CGR5.
KOK09622.
OMANSLQCVN.
OrthoDBEOG43BMPJ.

Gene expression databases

GenevestigatorQ8CGR5.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. Pept_Ser_Cys. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKLK14. mouse.
NextBio394144.
SOURCESearch...

Entry information

Entry nameKLK14_MOUSE
AccessionPrimary (citable) accession number: Q8CGR5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: March 1, 2003
Last modified: May 29, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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