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Protein

Kallikrein-14

Gene

Klk14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis (By similarity).By similarity

Enzyme regulationi

Inhibited by SERPINA1, SERPINC1, SERPINE1, SERPINF2, aprotinin, soybean, trypsin inhibitor and leupeptin. Inhibited by serine protease inhibitor SPINK5. Has an autoproteolytic activity which may have a regulatory effect. Activated by citrate and inhibited by zinc and to a lower extent by manganese (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Charge relay systemBy similarity
Active sitei110 – 1101Charge relay systemBy similarity
Active sitei203 – 2031Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.029.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-14 (EC:3.4.21.-)
Alternative name(s):
Glandular kallikrein KLK14
Short name:
mGK14
Kallikrein related-peptidase 14
Gene namesi
Name:Klk14
Synonyms:Gk14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2447564. Klk14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Propeptidei19 – 235Activation peptideBy similarityPRO_0000378340
Chaini24 – 250227Kallikrein-14PRO_0000378341Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 67PROSITE-ProRule annotation
Disulfide bondi142 ↔ 209PROSITE-ProRule annotation
Disulfide bondi174 ↔ 188PROSITE-ProRule annotation
Disulfide bondi199 ↔ 224PROSITE-ProRule annotation

Post-translational modificationi

Proteolytic cleavage of the activation peptide produces the active enzyme.By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

MaxQBiQ8CGR5.
PaxDbiQ8CGR5.
PRIDEiQ8CGR5.

PTM databases

PhosphoSiteiQ8CGR5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044737.
ExpressionAtlasiQ8CGR5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056935.

Structurei

3D structure databases

ProteinModelPortaliQ8CGR5.
SMRiQ8CGR5. Positions 24-250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 248225Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
InParanoidiQ8CGR5.
KOiK09622.
OMAiGMERCAM.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ8CGR5.
TreeFamiTF331065.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CGR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLLLIILQA LAVAIAQSQG DHKIIGGYRC VRNSQPWQVA LQAGPGHRFL
60 70 80 90 100
CGGVLLSDQW VITAAHCARP ILHVALGKHN IRRWEATQQV VRVARQVPHP
110 120 130 140 150
QYQPQAHDND LMLLKLQKKV RLGRAVKTIS VASSCASPGT PCRVSGWGTI
160 170 180 190 200
ASPIARYPTA LQCVNVNIMS EQACHRAYPG IITSGMVCAG VPEGGKDSCQ
210 220 230 240 250
GDSGGPLVCG GQLQGLVSWG MERCAMPGYP GVYANLCNYH SWIQRTMQSN
Length:250
Mass (Da):27,016
Last modified:March 1, 2003 - v1
Checksum:iF62FEBF2290FEBE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152433 Genomic DNA. Translation: AAN78421.1.
BC128019 mRNA. Translation: AAI28020.1.
CCDSiCCDS21180.1.
RefSeqiNP_777355.1. NM_174866.3.
XP_006541018.1. XM_006540955.2.
XP_011249172.1. XM_011250870.1.
UniGeneiMm.247377.

Genome annotation databases

EnsembliENSMUST00000056329; ENSMUSP00000056935; ENSMUSG00000044737.
GeneIDi317653.
KEGGimmu:317653.
UCSCiuc009gni.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152433 Genomic DNA. Translation: AAN78421.1.
BC128019 mRNA. Translation: AAI28020.1.
CCDSiCCDS21180.1.
RefSeqiNP_777355.1. NM_174866.3.
XP_006541018.1. XM_006540955.2.
XP_011249172.1. XM_011250870.1.
UniGeneiMm.247377.

3D structure databases

ProteinModelPortaliQ8CGR5.
SMRiQ8CGR5. Positions 24-250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056935.

Protein family/group databases

MEROPSiS01.029.

PTM databases

PhosphoSiteiQ8CGR5.

Proteomic databases

MaxQBiQ8CGR5.
PaxDbiQ8CGR5.
PRIDEiQ8CGR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056329; ENSMUSP00000056935; ENSMUSG00000044737.
GeneIDi317653.
KEGGimmu:317653.
UCSCiuc009gni.2. mouse.

Organism-specific databases

CTDi43847.
MGIiMGI:2447564. Klk14.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
InParanoidiQ8CGR5.
KOiK09622.
OMAiGMERCAM.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ8CGR5.
TreeFamiTF331065.

Miscellaneous databases

ChiTaRSiKlk14. mouse.
PROiQ8CGR5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044737.
ExpressionAtlasiQ8CGR5. baseline and differential.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLK14_MOUSE
AccessioniPrimary (citable) accession number: Q8CGR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.