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Q8CGN5

- PLIN1_MOUSE

UniProt

Q8CGN5 - PLIN1_MOUSE

Protein

Perilipin-1

Gene

Plin1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness By similarity. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. lipid catabolic process Source: MGI

    Keywords - Biological processi

    Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Perilipin-1
    Alternative name(s):
    Lipid droplet-associated protein
    Perilipin A
    Gene namesi
    Name:Plin1
    Synonyms:Peri, Plin
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1890505. Plin1.

    Subcellular locationi

    Endoplasmic reticulum By similarity. Lipid droplet 1 Publication
    Note: Lipid droplet surface-associated.

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. endoplasmic reticulum Source: UniProtKB-SubCell
    3. lipid particle Source: MGI

    Keywords - Cellular componenti

    Endoplasmic reticulum, Lipid droplet

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 517517Perilipin-1PRO_0000099885Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei410 – 4101Phosphoserine1 Publication
    Modified residuei460 – 4601Phosphoserine1 Publication

    Post-translational modificationi

    Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8CGN5.
    PaxDbiQ8CGN5.
    PRIDEiQ8CGN5.

    PTM databases

    PhosphoSiteiQ8CGN5.

    Expressioni

    Gene expression databases

    BgeeiQ8CGN5.
    CleanExiMM_PLIN.
    GenevestigatoriQ8CGN5.

    Interactioni

    Subunit structurei

    Interacts with ABHD5. Interacts with CIDEC.2 Publications

    Protein-protein interaction databases

    BioGridi222244. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CGN5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni290 – 32132Required for interaction with CIDECAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi308 – 31912Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the perilipin family.Curated

    Phylogenomic databases

    eggNOGiNOG75006.
    GeneTreeiENSGT00500000044795.
    HOGENOMiHOG000261608.
    InParanoidiQ4V9U2.
    KOiK08768.
    OMAiASVCNAY.
    OrthoDBiEOG7SN8CD.
    PhylomeDBiQ8CGN5.
    TreeFamiTF325901.

    Family and domain databases

    InterProiIPR004279. Perilipin.
    [Graphical view]
    PANTHERiPTHR14024. PTHR14024. 1 hit.
    PfamiPF03036. Perilipin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036881. PAT. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8CGN5-1) [UniParc]FASTAAdd to Basket

    Also known as: Peri A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSMNKGPTLL DGDLPEQENV LQRVLQLPVV SGTCECFQKT YNSTKEAHPL    50
    VASVCNAYEK GVQGASNLAA WSMEPVVRRL STQFTAANEL ACRGLDHLEE 100
    KIPALQYPPE KIASELKGTI STRLRSARNS ISVPIASTSD KVLGATLAGC 150
    ELALGMAKET AEYAANTRVG RLASGGADLA LGSIEKVVEF LLPPDKESAP 200
    SSGRQRTQKA PKAKPSLVRR VSTLANTLSR HTMQTTAWAL KQGHSLAMWI 250
    PGVAPLSSLA QWGASAAMQV VSRRQSEVRV PWLHNLAASQ DESHDDQTDT 300
    EGEETDDEEE EEESEAEENV LREVTALPNP RGLLGGVVHT VQNTLRNTIS 350
    AVTWAPAAVL GTVGRILHLT PAQAVSSTKG RAMSLSDALK GVTDNVVDTV 400
    VHYVPLPRLS LMEPESEFRD IDNPSAEAER KGSGARPASP ESTPRPGQPR 450
    GSLRSVRGLS APSCPGLDDK TEASARPGFL AMPREKPARR VSDSFFRPSV 500
    MEPILGRAQY SQLRKKS 517
    Length:517
    Mass (Da):55,596
    Last modified:October 13, 2009 - v2
    Checksum:i906AE1CC5AFD65AE
    GO
    Isoform 2 (identifier: Q8CGN5-2) [UniParc]FASTAAdd to Basket

    Also known as: Peri B

    The sequence of this isoform differs from the canonical sequence as follows:
         406-421: LPRLSLMEPESEFRDI → VSPAPGAPSDSQGFRD
         422-517: Missing.

    Show »
    Length:421
    Mass (Da):44,936
    Checksum:iD095B9EBBA5F2A33
    GO
    Isoform 3 (identifier: Q8CGN5-3) [UniParc]FASTAAdd to Basket

    Also known as: Peri C

    The sequence of this isoform differs from the canonical sequence as follows:
         326-347: ALPNPRGLLGGVVHTVQNTLRN → KTESPRPHSPRLGGEKEGNGIE
         348-517: Missing.

    Show »
    Length:347
    Mass (Da):37,489
    Checksum:i1F196F6ADD7BC77F
    GO
    Isoform 4 (identifier: Q8CGN5-4) [UniParc]FASTAAdd to Basket

    Also known as: Peri D

    The sequence of this isoform differs from the canonical sequence as follows:
         199-244: APSSGRQRTQ...TTAWALKQGH → GICHPDWLAI...GYPSASSGNS
         245-517: Missing.

    Show »
    Length:244
    Mass (Da):25,934
    Checksum:i3F65AEC4A4C9D796
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31M → I in AAN77870. 1 PublicationCurated
    Sequence conflicti317 – 3171E → D in BAC27409. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei199 – 24446APSSG…LKQGH → GICHPDWLAILGARWPLSTR GSVGGIQVLLALLWDRGYPS ASSGNS in isoform 4. 1 PublicationVSP_038204Add
    BLAST
    Alternative sequencei245 – 517273Missing in isoform 4. 1 PublicationVSP_038205Add
    BLAST
    Alternative sequencei326 – 34722ALPNP…NTLRN → KTESPRPHSPRLGGEKEGNG IE in isoform 3. 1 PublicationVSP_038206Add
    BLAST
    Alternative sequencei348 – 517170Missing in isoform 3. 1 PublicationVSP_038207Add
    BLAST
    Alternative sequencei406 – 42116LPRLS…EFRDI → VSPAPGAPSDSQGFRD in isoform 2. 1 PublicationVSP_038208Add
    BLAST
    Alternative sequencei422 – 51796Missing in isoform 2. 1 PublicationVSP_038209Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY161165 mRNA. Translation: AAN77870.1.
    AK031445 mRNA. Translation: BAC27409.1.
    CH466543 Genomic DNA. Translation: EDL07055.1.
    BC096685 mRNA. Translation: AAH96685.1.
    CCDSiCCDS21385.1. [Q8CGN5-1]
    RefSeqiNP_001106942.1. NM_001113471.1. [Q8CGN5-1]
    NP_783571.2. NM_175640.2. [Q8CGN5-1]
    UniGeneiMm.254917.

    Genome annotation databases

    EnsembliENSMUST00000032762; ENSMUSP00000032762; ENSMUSG00000030546. [Q8CGN5-1]
    ENSMUST00000178257; ENSMUSP00000136996; ENSMUSG00000030546. [Q8CGN5-1]
    GeneIDi103968.
    KEGGimmu:103968.
    UCSCiuc009hyu.2. mouse. [Q8CGN5-1]
    uc009hyw.1. mouse. [Q8CGN5-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Fat, wonderful fat - Issue 10 of May 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY161165 mRNA. Translation: AAN77870.1 .
    AK031445 mRNA. Translation: BAC27409.1 .
    CH466543 Genomic DNA. Translation: EDL07055.1 .
    BC096685 mRNA. Translation: AAH96685.1 .
    CCDSi CCDS21385.1. [Q8CGN5-1 ]
    RefSeqi NP_001106942.1. NM_001113471.1. [Q8CGN5-1 ]
    NP_783571.2. NM_175640.2. [Q8CGN5-1 ]
    UniGenei Mm.254917.

    3D structure databases

    ProteinModelPortali Q8CGN5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 222244. 1 interaction.

    PTM databases

    PhosphoSitei Q8CGN5.

    Proteomic databases

    MaxQBi Q8CGN5.
    PaxDbi Q8CGN5.
    PRIDEi Q8CGN5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032762 ; ENSMUSP00000032762 ; ENSMUSG00000030546 . [Q8CGN5-1 ]
    ENSMUST00000178257 ; ENSMUSP00000136996 ; ENSMUSG00000030546 . [Q8CGN5-1 ]
    GeneIDi 103968.
    KEGGi mmu:103968.
    UCSCi uc009hyu.2. mouse. [Q8CGN5-1 ]
    uc009hyw.1. mouse. [Q8CGN5-3 ]

    Organism-specific databases

    CTDi 5346.
    MGIi MGI:1890505. Plin1.

    Phylogenomic databases

    eggNOGi NOG75006.
    GeneTreei ENSGT00500000044795.
    HOGENOMi HOG000261608.
    InParanoidi Q4V9U2.
    KOi K08768.
    OMAi ASVCNAY.
    OrthoDBi EOG7SN8CD.
    PhylomeDBi Q8CGN5.
    TreeFami TF325901.

    Miscellaneous databases

    NextBioi 356265.
    PROi Q8CGN5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CGN5.
    CleanExi MM_PLIN.
    Genevestigatori Q8CGN5.

    Family and domain databases

    InterProi IPR004279. Perilipin.
    [Graphical view ]
    PANTHERi PTHR14024. PTHR14024. 1 hit.
    Pfami PF03036. Perilipin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036881. PAT. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The murine perilipin gene: the lipid droplet-associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin."
      Lu X., Gruia-Gray J., Copeland N.G., Gilbert D.J., Jenkins N.A., Londos C., Kimmel A.R.
      Mamm. Genome 12:741-749(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
    2. "Mouse perilipin."
      Tansey J.T., Lu X., Londos C., Kimmel A.R.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Testis.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    6. "Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes."
      Subramanian V., Rothenberg A., Gomez C., Cohen A.W., Garcia A., Bhattacharyya S., Shapiro L., Dolios G., Wang R., Lisanti M.P., Brasaemle D.L.
      J. Biol. Chem. 279:42062-42071(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ABHD5.
    7. "The stoichiometry of protein phosphorylation in adipocyte lipid droplets: analysis by N-terminal isotope tagging and enzymatic dephosphorylation."
      Kanshin E., Wang S., Ashmarina L., Fedjaev M., Nifant'ev I., Mitchell G.A., Pshezhetsky A.V.
      Proteomics 9:5067-5077(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-410 AND SER-460.
    8. "Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes."
      Sun Z., Gong J., Wu H., Xu W., Wu L., Xu D., Gao J., Wu J.W., Yang H., Yang M., Li P.
      Nat. Commun. 4:1594-1594(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN UNILOCULAR LIPID DROPLET FORMATION AND LIPOLYSIS, INTERACTION WITH CIDEC, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiPLIN1_MOUSE
    AccessioniPrimary (citable) accession number: Q8CGN5
    Secondary accession number(s): Q4V9U2, Q8C0F5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3