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Protein

BCL-6 corepressor

Gene

Bcor

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BCL-6 corepressor
Short name:
BCoR
Gene namesi
Name:Bcor
Synonyms:Kiaa1575
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1918708. Bcor.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • mitochondrion Source: MGI
  • nucleus Source: MGI
  • PcG protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669791 – 1759BCL-6 corepressorAdd BLAST1759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineBy similarity1
Modified residuei340PhosphoserineBy similarity1
Modified residuei365PhosphoserineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei392N6-acetyllysineBy similarity1
Modified residuei423PhosphoserineBy similarity1
Modified residuei1128PhosphothreonineCombined sources1
Modified residuei1131PhosphoserineCombined sources1
Modified residuei1143PhosphoserineCombined sources1
Modified residuei1293PhosphoserineBy similarity1
Modified residuei1348PhosphoserineCombined sources1
Modified residuei1413PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8CGN4.
PeptideAtlasiQ8CGN4.
PRIDEiQ8CGN4.

PTM databases

iPTMnetiQ8CGN4.
PhosphoSitePlusiQ8CGN4.

Expressioni

Tissue specificityi

Expressed in heart, liver, lung, skeletal muscle, spleen and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000040363.
CleanExiMM_BCOR.
ExpressionAtlasiQ8CGN4. baseline and differential.
GenevisibleiQ8CGN4. MM.

Interactioni

Subunit structurei

Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Isoform 1 may interact with MLLT3/AF9 (PubMed:12776190). Interacts with BCL6; the interaction is direct. Forms ternary complexes with BCL6 and SMRT/NCOR2 on selected target genes promoters; potently repress expression. Can interact with HDAC1, HDAC3 and HDAC5. Interacts with PCGF1; the interaction is direct. Interacts with KDM2B. Component of an approximative 800 kDa repressive BCOR complex at least composed of BCOR, RYBP, PCGF1, RING1, RNF2/RING2, KDM2B and SKP1 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Bcl6P411832EBI-1216174,EBI-6253762

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214722. 8 interactors.
DIPiDIP-29852N.
IntActiQ8CGN4. 5 interactors.
STRINGi10090.ENSMUSP00000111175.

Structurei

3D structure databases

ProteinModelPortaliQ8CGN4.
SMRiQ8CGN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1466 – 1499ANK 1Add BLAST34
Repeati1500 – 1529ANK 2Add BLAST30
Repeati1533 – 1562ANK 3Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni498 – 514Interaction with BCL6By similarityAdd BLAST17
Regioni1638 – 1752Necessary and sufficient for interaction with PCGF1By similarityAdd BLAST115

Sequence similaritiesi

Belongs to the BCOR family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IHDH. Eukaryota.
ENOG410YT00. LUCA.
GeneTreeiENSGT00760000119090.
HOVERGENiHBG050682.
InParanoidiQ8CGN4.
OMAiPGNIVYS.
OrthoDBiEOG091G0R1A.
PhylomeDBiQ8CGN4.
TreeFamiTF333317.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR031628. BCOR.
IPR032365. PUFD.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF15808. BCOR. 1 hit.
PF16553. PUFD. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CGN4-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSATPLYGN VHSWMNSERV RMCGTSEDRK IPVNDGDASK ARLELREETP
60 70 80 90 100
LSHSVVDTSG AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SGLCGLGSEK
110 120 130 140 150
GREATPSSLS GLGFSSERNP EMQFKPNTPE TVEASAVSGK PPNGFSAIYK
160 170 180 190 200
TPPGIQKSAV ATAESLGLDR PASDKQSPLN INGASYLRLP WVNPYMEGAT
210 220 230 240 250
PAIYPFLDSP NKYSLNMYKA LLPQQSYGLA QPLYSPVCTS GERFLYLPPP
260 270 280 290 300
HYVNPHIPSS LASPMRLSTP SASAAIPPLV HCSDKSLPWK MGVNPGNPVD
310 320 330 340 350
SHSYPHIQNS KQPRVTSAKA VNSGLPGDTA LLLPPSPRPS ARVHLPTQPA
360 370 380 390 400
AETYSEFHKH YPRISTSPSV TLTKPYMTAN SEFSTSRLSN GKYPKALDGG
410 420 430 440 450
DCAQSMPGHT RKTTVQDRKD GGSPPLLEKQ TVTKDVTDKP LDLSSKVVDA
460 470 480 490 500
DASKGDHMKK MAPTVLVHSR AASGLVLSGS EIPKETLSPP GNGCSIYRSE
510 520 530 540 550
IISTAPSSWV VPGPSPNEEN NGKSLSLKNK ALDWAIPQQR SSSCPRMGGT
560 570 580 590 600
DAVVTNVSGS VSSSGRPASA SPAPNANANA DGTKTSRSSV DTTPSVIQHV
610 620 630 640 650
GQPSSTPAKH GGSTSSKGAK ANPEPSFKAS ENGLPPTSIF LSPNEAFRSP
660 670 680 690 700
AIPYPRSYLP YAAPEGIALS PLSLHGKGPV YPHPVLLPNG SLFPGHLAPK
710 720 730 740 750
PGLPYGLHTS RPEFVTYQDA LGLGMVHPML IPHTPIEITK EEKPERRSRS
760 770 780 790 800
HERARYEDPT LRSRFSEMLE ASSTKLHPEV PTDKNLKPNS SWNQGKTGVK
810 820 830 840 850
SDKLVYVDLL REEADTKTDA GAPKAGLVAE NVGQDTEATK PSADPVIQQR
860 870 880 890 900
REFISLREEL GRITDFHESF TFKQASSQPV FSLGKDSGAA GTNKENLGVQ
910 920 930 940 950
VATPFLETAL GSEGPAVTFG KTQEDPKPFC VGGAPPNMDV TPAYTKEGTD
960 970 980 990 1000
EAESNDGKVL KPKPSKLAKR IANSAGYVGD RFKCVTTELY ADSSQLSREQ
1010 1020 1030 1040 1050
RALQMEGLQE DSILCLPAAY CERAMMRFSE LEMKEREGSH PATKDSEVCK
1060 1070 1080 1090 1100
FSPADWERLK GNQEKKPKSV TLEEAIADQN DSERCEYSTG NKHDLFEAPE
1110 1120 1130 1140 1150
DKDLPVEKYF LERPPVSEPP SDQGVVDTPH SPTLRLDRKR KLSGDSTHTE
1160 1170 1180 1190 1200
TAVEELAEDP LKAKRRRISK DDWPEREMTN SSSNHLEDPH CNELTNLKVC
1210 1220 1230 1240 1250
IELTGLHPKK QRHLLHLRER WEQQVSAAES KPGRQSRKEV AQAVQPEVTS
1260 1270 1280 1290 1300
QGTNITEEKP GRKKAEAKGN RGWSEESLKS CDNEQGLPVL SGSPPMKSLS
1310 1320 1330 1340 1350
STNASGKKQT QPSCTPASRL PAKQQKIKES QKTDVLCTGE DEDCQAASPL
1360 1370 1380 1390 1400
QKYTDNIEKP SGKRLCKTKH LIPQESRRSL QITGDYYVEN TDTKMTVRRF
1410 1420 1430 1440 1450
RKRPEPSSDY DLSPPAKQEP KPFDRLQQLL PATQATQLPR SNSPQETTQS
1460 1470 1480 1490 1500
RPMPPEARRL IVNKNAGETL LQRAARLGYE EVVLYCLENK VCDVNHRDNA
1510 1520 1530 1540 1550
GYCALHEACA RGWLNIVRHL LEYGADVNCS AQDGTRPLHD AVENDHLEIV
1560 1570 1580 1590 1600
RLLLSYGADP TLATYSGRTI MKMTHSELME KFLTDYLNDL QGRSEDDTSG
1610 1620 1630 1640 1650
AWEFYGSSVC EPDDESGYDV LANPPGPEDP DEEEDTYSDL FEFEFAESSL
1660 1670 1680 1690 1700
LPCYNIQVSV AQGPRNWLLL SDVLKKLKMS SRIFRSNFPN LEIVTIAEAE
1710 1720 1730 1740 1750
FYRQVSTSLL FSCPKDLEAF NPESKELLDL VEFTNELQTL LGSSVEWLHP

SDTGHENYW
Length:1,759
Mass (Da):192,631
Last modified:January 4, 2005 - v2
Checksum:iC7FF21CFB3C60D49
GO
Isoform 2 (identifier: Q8CGN4-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1005-1022: Missing.

Show »
Length:1,741
Mass (Da):190,664
Checksum:i6356F262D31FEB72
GO
Isoform 3 (identifier: Q8CGN4-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1171-1204: Missing.

Show »
Length:1,725
Mass (Da):188,678
Checksum:iBC1E474B524049F6
GO
Isoform 4 (identifier: Q8CGN4-4) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1005-1022: Missing.
     1171-1204: Missing.

Show »
Length:1,707
Mass (Da):186,710
Checksum:iEEDAB60D370F5520
GO

Sequence cautioni

The sequence BAC98208 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161A → V in AAN85318 (PubMed:12776190).Curated1
Sequence conflicti161A → V in AAN85319 (PubMed:12776190).Curated1
Sequence conflicti161A → V in AAN85320 (PubMed:12776190).Curated1
Sequence conflicti161A → V in AAN85321 (PubMed:12776190).Curated1
Sequence conflicti167G → S in AAN85318 (PubMed:12776190).Curated1
Sequence conflicti167G → S in AAN85319 (PubMed:12776190).Curated1
Sequence conflicti167G → S in AAN85320 (PubMed:12776190).Curated1
Sequence conflicti167G → S in AAN85321 (PubMed:12776190).Curated1
Sequence conflicti731I → V in AAN85318 (PubMed:12776190).Curated1
Sequence conflicti731I → V in AAN85319 (PubMed:12776190).Curated1
Sequence conflicti731I → V in AAN85320 (PubMed:12776190).Curated1
Sequence conflicti731I → V in AAN85321 (PubMed:12776190).Curated1
Sequence conflicti852E → D in BAC35338 (PubMed:16141072).Curated1
Sequence conflicti1424D → G in AAN85318 (PubMed:12776190).Curated1
Sequence conflicti1424D → G in AAN85319 (PubMed:12776190).Curated1
Sequence conflicti1424D → G in AAN85320 (PubMed:12776190).Curated1
Sequence conflicti1424D → G in AAN85321 (PubMed:12776190).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0125581005 – 1022Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_0125591171 – 1204Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161170 mRNA. Translation: AAN85318.1.
AY161171 mRNA. Translation: AAN85319.1.
AY161172 mRNA. Translation: AAN85320.1.
AY161173 mRNA. Translation: AAN85321.1.
AK129398 mRNA. Translation: BAC98208.1. Different initiation.
AL808012 Genomic DNA. Translation: CAM24722.1.
AL808012 Genomic DNA. Translation: CAM24723.1.
AL808012 Genomic DNA. Translation: CAM24724.1.
AL808012 Genomic DNA. Translation: CAM24725.1.
BC058656 mRNA. Translation: AAH58656.1.
AK053309 mRNA. Translation: BAC35338.1.
CCDSiCCDS30021.1. [Q8CGN4-3]
CCDS30022.1. [Q8CGN4-4]
CCDS40872.1. [Q8CGN4-2]
CCDS40873.1. [Q8CGN4-1]
RefSeqiNP_001161793.1. NM_001168321.1. [Q8CGN4-4]
NP_083786.2. NM_029510.3. [Q8CGN4-1]
NP_778209.2. NM_175044.3. [Q8CGN4-2]
NP_778210.2. NM_175045.3. [Q8CGN4-3]
NP_778211.2. NM_175046.3. [Q8CGN4-4]
XP_017174110.1. XM_017318621.1. [Q8CGN4-1]
XP_017174111.1. XM_017318622.1. [Q8CGN4-1]
XP_017174112.1. XM_017318623.1. [Q8CGN4-1]
XP_017174113.1. XM_017318624.1. [Q8CGN4-1]
UniGeneiMm.196328.
Mm.440386.
Mm.490017.

Genome annotation databases

EnsembliENSMUST00000043441; ENSMUSP00000048024; ENSMUSG00000040363. [Q8CGN4-4]
ENSMUST00000065143; ENSMUSP00000068618; ENSMUSG00000040363. [Q8CGN4-3]
ENSMUST00000115512; ENSMUSP00000111174; ENSMUSG00000040363. [Q8CGN4-2]
ENSMUST00000115513; ENSMUSP00000111175; ENSMUSG00000040363. [Q8CGN4-1]
ENSMUST00000124033; ENSMUSP00000116258; ENSMUSG00000040363. [Q8CGN4-4]
GeneIDi71458.
KEGGimmu:71458.
UCSCiuc009sqq.2. mouse. [Q8CGN4-1]
uc009sqr.2. mouse. [Q8CGN4-3]
uc009sqs.2. mouse. [Q8CGN4-2]
uc009sqt.2. mouse. [Q8CGN4-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161170 mRNA. Translation: AAN85318.1.
AY161171 mRNA. Translation: AAN85319.1.
AY161172 mRNA. Translation: AAN85320.1.
AY161173 mRNA. Translation: AAN85321.1.
AK129398 mRNA. Translation: BAC98208.1. Different initiation.
AL808012 Genomic DNA. Translation: CAM24722.1.
AL808012 Genomic DNA. Translation: CAM24723.1.
AL808012 Genomic DNA. Translation: CAM24724.1.
AL808012 Genomic DNA. Translation: CAM24725.1.
BC058656 mRNA. Translation: AAH58656.1.
AK053309 mRNA. Translation: BAC35338.1.
CCDSiCCDS30021.1. [Q8CGN4-3]
CCDS30022.1. [Q8CGN4-4]
CCDS40872.1. [Q8CGN4-2]
CCDS40873.1. [Q8CGN4-1]
RefSeqiNP_001161793.1. NM_001168321.1. [Q8CGN4-4]
NP_083786.2. NM_029510.3. [Q8CGN4-1]
NP_778209.2. NM_175044.3. [Q8CGN4-2]
NP_778210.2. NM_175045.3. [Q8CGN4-3]
NP_778211.2. NM_175046.3. [Q8CGN4-4]
XP_017174110.1. XM_017318621.1. [Q8CGN4-1]
XP_017174111.1. XM_017318622.1. [Q8CGN4-1]
XP_017174112.1. XM_017318623.1. [Q8CGN4-1]
XP_017174113.1. XM_017318624.1. [Q8CGN4-1]
UniGeneiMm.196328.
Mm.440386.
Mm.490017.

3D structure databases

ProteinModelPortaliQ8CGN4.
SMRiQ8CGN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214722. 8 interactors.
DIPiDIP-29852N.
IntActiQ8CGN4. 5 interactors.
STRINGi10090.ENSMUSP00000111175.

PTM databases

iPTMnetiQ8CGN4.
PhosphoSitePlusiQ8CGN4.

Proteomic databases

PaxDbiQ8CGN4.
PeptideAtlasiQ8CGN4.
PRIDEiQ8CGN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043441; ENSMUSP00000048024; ENSMUSG00000040363. [Q8CGN4-4]
ENSMUST00000065143; ENSMUSP00000068618; ENSMUSG00000040363. [Q8CGN4-3]
ENSMUST00000115512; ENSMUSP00000111174; ENSMUSG00000040363. [Q8CGN4-2]
ENSMUST00000115513; ENSMUSP00000111175; ENSMUSG00000040363. [Q8CGN4-1]
ENSMUST00000124033; ENSMUSP00000116258; ENSMUSG00000040363. [Q8CGN4-4]
GeneIDi71458.
KEGGimmu:71458.
UCSCiuc009sqq.2. mouse. [Q8CGN4-1]
uc009sqr.2. mouse. [Q8CGN4-3]
uc009sqs.2. mouse. [Q8CGN4-2]
uc009sqt.2. mouse. [Q8CGN4-4]

Organism-specific databases

CTDi54880.
MGIiMGI:1918708. Bcor.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IHDH. Eukaryota.
ENOG410YT00. LUCA.
GeneTreeiENSGT00760000119090.
HOVERGENiHBG050682.
InParanoidiQ8CGN4.
OMAiPGNIVYS.
OrthoDBiEOG091G0R1A.
PhylomeDBiQ8CGN4.
TreeFamiTF333317.

Miscellaneous databases

ChiTaRSiBcor. mouse.
PROiQ8CGN4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040363.
CleanExiMM_BCOR.
ExpressionAtlasiQ8CGN4. baseline and differential.
GenevisibleiQ8CGN4. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR031628. BCOR.
IPR032365. PUFD.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF15808. BCOR. 1 hit.
PF16553. PUFD. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCOR_MOUSE
AccessioniPrimary (citable) accession number: Q8CGN4
Secondary accession number(s): B1AXK3
, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.