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Q8CGN4 (BCOR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BCL-6 corepressor

Short name=BCoR
Gene names
Name:Bcor
Synonyms:Kiaa1575
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1759 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) By similarity. Ref.1

Subunit structure

Interacts with BCL6; the interaction is direct. Forms ternary complexes with BCL6 and SMRT/NCOR2 on selected target genes promoters; potently repress expression. Can interact with HDAC1, HDAC3 and HDAC5. Interacts with PCGF1; the interaction is direct. Interacts with KDM2B. Component of an approximative 800 kDa repressive BCOR complex at least composed of BCOR, RYBP, PCGF1, RING1, RNF2/RING2, KDM2B and SKP1. Isoform 1 may interact with MLLT3/AF9. Ref.1

Subcellular location

Nucleus Ref.1.

Tissue specificity

Expressed in heart, liver, lung, skeletal muscle, spleen and testis. Ref.1

Sequence similarities

Belongs to the BCOR family.

Contains 3 ANK repeats.

Sequence caution

The sequence BAC98208.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainANK repeat
Repeat
   Molecular functionChromatin regulator
Repressor
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processheart development

Inferred from electronic annotation. Source: Ensembl

histone H2A monoubiquitination

Inferred from electronic annotation. Source: Ensembl

negative regulation of bone mineralization

Inferred from electronic annotation. Source: Ensembl

negative regulation of histone H3-K36 methylation

Inferred from electronic annotation. Source: Ensembl

negative regulation of histone H3-K4 methylation

Inferred from electronic annotation. Source: Ensembl

negative regulation of tooth mineralization

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay Ref.1. Source: MGI

odontogenesis

Inferred from electronic annotation. Source: Ensembl

palate development

Inferred from electronic annotation. Source: Ensembl

specification of axis polarity

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentPcG protein complex

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay Ref.1. Source: MGI

   Molecular_functiontranscription corepressor activity

Inferred from physical interaction Ref.1. Source: MGI

transcription regulatory region DNA binding

Inferred from electronic annotation. Source: Ensembl

ubiquitin-protein ligase activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8CGN4-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8CGN4-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1005-1022: Missing.
Isoform 3 (identifier: Q8CGN4-3)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     1171-1204: Missing.
Isoform 4 (identifier: Q8CGN4-4)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     1005-1022: Missing.
     1171-1204: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 17591759BCL-6 corepressor
PRO_0000066979

Regions

Repeat1466 – 149934ANK 1
Repeat1500 – 152930ANK 2
Repeat1533 – 156230ANK 3
Region498 – 51417Interaction with BCL6 By similarity
Region1638 – 1752115Necessary and sufficient for interaction with PCGF1 By similarity

Amino acid modifications

Modified residue3361Phosphoserine By similarity
Modified residue3401Phosphoserine By similarity
Modified residue3651Phosphoserine By similarity
Modified residue3671Phosphoserine By similarity
Modified residue3921N6-acetyllysine By similarity
Modified residue4231Phosphoserine By similarity
Modified residue11431Phosphoserine By similarity
Modified residue14131Phosphoserine By similarity

Natural variations

Alternative sequence1005 – 102218Missing in isoform 2 and isoform 4.
VSP_012558
Alternative sequence1171 – 120434Missing in isoform 3 and isoform 4.
VSP_012559

Experimental info

Sequence conflict1611A → V in AAN85318. Ref.1
Sequence conflict1611A → V in AAN85319. Ref.1
Sequence conflict1611A → V in AAN85320. Ref.1
Sequence conflict1611A → V in AAN85321. Ref.1
Sequence conflict1671G → S in AAN85318. Ref.1
Sequence conflict1671G → S in AAN85319. Ref.1
Sequence conflict1671G → S in AAN85320. Ref.1
Sequence conflict1671G → S in AAN85321. Ref.1
Sequence conflict7311I → V in AAN85318. Ref.1
Sequence conflict7311I → V in AAN85319. Ref.1
Sequence conflict7311I → V in AAN85320. Ref.1
Sequence conflict7311I → V in AAN85321. Ref.1
Sequence conflict8521E → D in BAC35338. Ref.5
Sequence conflict14241D → G in AAN85318. Ref.1
Sequence conflict14241D → G in AAN85319. Ref.1
Sequence conflict14241D → G in AAN85320. Ref.1
Sequence conflict14241D → G in AAN85321. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A) [UniParc].

Last modified January 4, 2005. Version 2.
Checksum: C7FF21CFB3C60D49

FASTA1,759192,631
        10         20         30         40         50         60 
MLSATPLYGN VHSWMNSERV RMCGTSEDRK IPVNDGDASK ARLELREETP LSHSVVDTSG 

        70         80         90        100        110        120 
AHRIDGLAAL SMDRTGLIRE GLRVPGNIVY SGLCGLGSEK GREATPSSLS GLGFSSERNP 

       130        140        150        160        170        180 
EMQFKPNTPE TVEASAVSGK PPNGFSAIYK TPPGIQKSAV ATAESLGLDR PASDKQSPLN 

       190        200        210        220        230        240 
INGASYLRLP WVNPYMEGAT PAIYPFLDSP NKYSLNMYKA LLPQQSYGLA QPLYSPVCTS 

       250        260        270        280        290        300 
GERFLYLPPP HYVNPHIPSS LASPMRLSTP SASAAIPPLV HCSDKSLPWK MGVNPGNPVD 

       310        320        330        340        350        360 
SHSYPHIQNS KQPRVTSAKA VNSGLPGDTA LLLPPSPRPS ARVHLPTQPA AETYSEFHKH 

       370        380        390        400        410        420 
YPRISTSPSV TLTKPYMTAN SEFSTSRLSN GKYPKALDGG DCAQSMPGHT RKTTVQDRKD 

       430        440        450        460        470        480 
GGSPPLLEKQ TVTKDVTDKP LDLSSKVVDA DASKGDHMKK MAPTVLVHSR AASGLVLSGS 

       490        500        510        520        530        540 
EIPKETLSPP GNGCSIYRSE IISTAPSSWV VPGPSPNEEN NGKSLSLKNK ALDWAIPQQR 

       550        560        570        580        590        600 
SSSCPRMGGT DAVVTNVSGS VSSSGRPASA SPAPNANANA DGTKTSRSSV DTTPSVIQHV 

       610        620        630        640        650        660 
GQPSSTPAKH GGSTSSKGAK ANPEPSFKAS ENGLPPTSIF LSPNEAFRSP AIPYPRSYLP 

       670        680        690        700        710        720 
YAAPEGIALS PLSLHGKGPV YPHPVLLPNG SLFPGHLAPK PGLPYGLHTS RPEFVTYQDA 

       730        740        750        760        770        780 
LGLGMVHPML IPHTPIEITK EEKPERRSRS HERARYEDPT LRSRFSEMLE ASSTKLHPEV 

       790        800        810        820        830        840 
PTDKNLKPNS SWNQGKTGVK SDKLVYVDLL REEADTKTDA GAPKAGLVAE NVGQDTEATK 

       850        860        870        880        890        900 
PSADPVIQQR REFISLREEL GRITDFHESF TFKQASSQPV FSLGKDSGAA GTNKENLGVQ 

       910        920        930        940        950        960 
VATPFLETAL GSEGPAVTFG KTQEDPKPFC VGGAPPNMDV TPAYTKEGTD EAESNDGKVL 

       970        980        990       1000       1010       1020 
KPKPSKLAKR IANSAGYVGD RFKCVTTELY ADSSQLSREQ RALQMEGLQE DSILCLPAAY 

      1030       1040       1050       1060       1070       1080 
CERAMMRFSE LEMKEREGSH PATKDSEVCK FSPADWERLK GNQEKKPKSV TLEEAIADQN 

      1090       1100       1110       1120       1130       1140 
DSERCEYSTG NKHDLFEAPE DKDLPVEKYF LERPPVSEPP SDQGVVDTPH SPTLRLDRKR 

      1150       1160       1170       1180       1190       1200 
KLSGDSTHTE TAVEELAEDP LKAKRRRISK DDWPEREMTN SSSNHLEDPH CNELTNLKVC 

      1210       1220       1230       1240       1250       1260 
IELTGLHPKK QRHLLHLRER WEQQVSAAES KPGRQSRKEV AQAVQPEVTS QGTNITEEKP 

      1270       1280       1290       1300       1310       1320 
GRKKAEAKGN RGWSEESLKS CDNEQGLPVL SGSPPMKSLS STNASGKKQT QPSCTPASRL 

      1330       1340       1350       1360       1370       1380 
PAKQQKIKES QKTDVLCTGE DEDCQAASPL QKYTDNIEKP SGKRLCKTKH LIPQESRRSL 

      1390       1400       1410       1420       1430       1440 
QITGDYYVEN TDTKMTVRRF RKRPEPSSDY DLSPPAKQEP KPFDRLQQLL PATQATQLPR 

      1450       1460       1470       1480       1490       1500 
SNSPQETTQS RPMPPEARRL IVNKNAGETL LQRAARLGYE EVVLYCLENK VCDVNHRDNA 

      1510       1520       1530       1540       1550       1560 
GYCALHEACA RGWLNIVRHL LEYGADVNCS AQDGTRPLHD AVENDHLEIV RLLLSYGADP 

      1570       1580       1590       1600       1610       1620 
TLATYSGRTI MKMTHSELME KFLTDYLNDL QGRSEDDTSG AWEFYGSSVC EPDDESGYDV 

      1630       1640       1650       1660       1670       1680 
LANPPGPEDP DEEEDTYSDL FEFEFAESSL LPCYNIQVSV AQGPRNWLLL SDVLKKLKMS 

      1690       1700       1710       1720       1730       1740 
SRIFRSNFPN LEIVTIAEAE FYRQVSTSLL FSCPKDLEAF NPESKELLDL VEFTNELQTL 

      1750 
LGSSVEWLHP SDTGHENYW 

« Hide

Isoform 2 (B) [UniParc].

Checksum: 6356F262D31FEB72
Show »

FASTA1,741190,664
Isoform 3 (C) [UniParc].

Checksum: BC1E474B524049F6
Show »

FASTA1,725188,678
Isoform 4 (D) [UniParc].

Checksum: EEDAB60D370F5520
Show »

FASTA1,707186,710

References

« Hide 'large scale' references
[1]"The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor."
Srinivasan R.S., de Erkenez A.C., Hemenway C.S.
Oncogene 22:3395-3406(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), FUNCTION, INTERACTION WITH MLLT3, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: Swiss Webster / NIH.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Embryonic tail.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: C57BL/6.
Tissue: Brain.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-945.
Strain: C57BL/6J.
Tissue: Eye.
[6]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY161170 mRNA. Translation: AAN85318.1.
AY161171 mRNA. Translation: AAN85319.1.
AY161172 mRNA. Translation: AAN85320.1.
AY161173 mRNA. Translation: AAN85321.1.
AK129398 mRNA. Translation: BAC98208.1. Different initiation.
AL808012 Genomic DNA. Translation: CAM24722.1.
AL808012 Genomic DNA. Translation: CAM24723.1.
AL808012 Genomic DNA. Translation: CAM24724.1.
AL808012 Genomic DNA. Translation: CAM24725.1.
BC058656 mRNA. Translation: AAH58656.1.
AK053309 mRNA. Translation: BAC35338.1.
RefSeqNP_001161793.1. NM_001168321.1.
NP_083786.2. NM_029510.3.
NP_778209.2. NM_175044.3.
NP_778210.2. NM_175045.3.
NP_778211.2. NM_175046.3.
UniGeneMm.196328.

3D structure databases

ProteinModelPortalQ8CGN4.
SMRQ8CGN4. Positions 1467-1621, 1640-1752.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid214722. 8 interactions.
DIPDIP-29852N.
IntActQ8CGN4. 3 interactions.

PTM databases

PhosphoSiteQ8CGN4.

Proteomic databases

PaxDbQ8CGN4.
PRIDEQ8CGN4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000043441; ENSMUSP00000048024; ENSMUSG00000040363. [Q8CGN4-4]
ENSMUST00000065143; ENSMUSP00000068618; ENSMUSG00000040363. [Q8CGN4-3]
ENSMUST00000115512; ENSMUSP00000111174; ENSMUSG00000040363. [Q8CGN4-2]
ENSMUST00000115513; ENSMUSP00000111175; ENSMUSG00000040363. [Q8CGN4-1]
ENSMUST00000124033; ENSMUSP00000116258; ENSMUSG00000040363. [Q8CGN4-4]
GeneID71458.
KEGGmmu:71458.
UCSCuc009sqq.2. mouse. [Q8CGN4-1]
uc009sqr.2. mouse. [Q8CGN4-3]
uc009sqs.2. mouse. [Q8CGN4-2]
uc009sqt.2. mouse. [Q8CGN4-4]

Organism-specific databases

CTD54880.
MGIMGI:1918708. Bcor.
RougeSearch...

Phylogenomic databases

eggNOGCOG0666.
GeneTreeENSGT00740000115210.
HOVERGENHBG050682.
InParanoidB1AXK3.
OMASSCPRMG.
OrthoDBEOG7KWSGQ.
PhylomeDBQ8CGN4.
TreeFamTF333317.

Gene expression databases

ArrayExpressQ8CGN4.
BgeeQ8CGN4.
CleanExMM_BCOR.
GenevestigatorQ8CGN4.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBCOR. mouse.
NextBio333823.
PROQ8CGN4.
SOURCESearch...

Entry information

Entry nameBCOR_MOUSE
AccessionPrimary (citable) accession number: Q8CGN4
Secondary accession number(s): B1AXK3 expand/collapse secondary AC list , B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot