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Protein

Retinitis pigmentosa 1-like 1 protein

Gene

Rp1l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors.1 Publication

GO - Biological processi

  • axoneme assembly Source: GO_Central
  • intracellular signal transduction Source: InterPro
  • photoreceptor cell development Source: UniProtKB
  • photoreceptor cell maintenance Source: UniProtKB
  • retina development in camera-type eye Source: GO_Central
  • visual perception Source: UniProtKB-KW

Keywordsi

Biological processCilium biogenesis/degradation, Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Retinitis pigmentosa 1-like 1 protein
Alternative name(s):
Retinitis pigmentosa 1-like protein 1
Gene namesi
Name:Rp1l1
Synonyms:Rp1hl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2384303. Rp1l1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Mice display scattered outer segment disorganization, reduced electroretinogram amplitudes, and progressive photoreceptor degeneration. In single rods defective cells photosensitivity is reduced. Rp1 and Rp1l1 double heterozygotes exhibits abnormal outer segment morphology and reduced single rod photosensitivity and dark currents, while individual heterozygotes are normal.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000974071 – 1859Retinitis pigmentosa 1-like 1 proteinAdd BLAST1859

Proteomic databases

PaxDbiQ8CGM2.
PRIDEiQ8CGM2.

PTM databases

iPTMnetiQ8CGM2.
PhosphoSitePlusiQ8CGM2.

Expressioni

Tissue specificityi

Retinal-specific; expressed in photoreceptor.

Developmental stagei

Detected in retina at birth but not at prenatal stages.

Gene expression databases

BgeeiENSMUSG00000046049.
CleanExiMM_RP1L1.
ExpressionAtlasiQ8CGM2. baseline and differential.

Interactioni

Subunit structurei

Interacts with RP1; has a synergistic effect with RP1 in photoreceptor differentiation.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055449.

Structurei

3D structure databases

ProteinModelPortaliQ8CGM2.
SMRiQ8CGM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 126Doublecortin 1PROSITE-ProRule annotationAdd BLAST85
Domaini160 – 239Doublecortin 2PROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1484 – 1487Poly-Arg4

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3757. Eukaryota.
ENOG410ZE6Q. LUCA.
GeneTreeiENSGT00880000138001.
HOGENOMiHOG000220862.
HOVERGENiHBG079142.
InParanoidiQ8CGM2.
KOiK19538.
OMAiEEFCPCE.
OrthoDBiEOG091G00UF.
PhylomeDBiQ8CGM2.
TreeFamiTF318770.

Family and domain databases

CDDicd01617. DCX. 1 hit.
Gene3Di3.10.20.230. 2 hits.
InterProiView protein in InterPro
IPR003533. Doublecortin_dom.
IPR036572. Doublecortin_dom_sf.
PfamiView protein in Pfam
PF03607. DCX. 2 hits.
SMARTiView protein in SMART
SM00537. DCX. 2 hits.
SUPFAMiSSF89837. SSF89837. 2 hits.
PROSITEiView protein in PROSITE
PS50309. DC. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8CGM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTPGDTRD APAPSHPAPS HRQCLLPSVA HTPSVTEVTP AKKITFLKRG
60 70 80 90 100
DPQFAGVRLA VHQRTFKTFS SLMDELSQRM PLSFGVRSVT TPRGLHGLSA
110 120 130 140 150
LEQLQDGGCY LCSDRKPPKT SREPGRLQRK SPSAGQAQVF QGGHEAPETS
160 170 180 190 200
YSWKGPVAPR RLTLVKNGDP RRQQTVVLSH KNTRSLAAFL GKASELLRFP
210 220 230 240 250
VKQVYTTRGK KVDSLQTLLD GPSVLVCAGN EAFRCLEMEN DRGNRTRKLS
260 270 280 290 300
SVTARSERGC WGPNAKQSVI HSRGRSGGKL RQVSLTSERS GLSDHPASGH
310 320 330 340 350
RAWAGPALDR CPQDMPVPPG SLVAADDVEK KVCMNEDGSL SVEMKVRFQL
360 370 380 390 400
LGEDTLRWSQ RVGQASVFTA ASGKGQDPRE ADRFCCRQEG YPWGILKPGA
410 420 430 440 450
QGLGSYDGGC QEAFDVGQKS QPSYDIWRNP LATPEGTGPT PRRRWGLAKL
460 470 480 490 500
SGCKSHWRQE ANHRKGHDKD NLSRVSTPRH PRSVQPGSCC PWTPDGDTGS
510 520 530 540 550
DTLHPVSSAS SHNETDLESG EGLCLEDTGP HGSRPETQST ERALSDTSVS
560 570 580 590 600
AKSREESSEG GGQLHRSSSQ ARVMASREQV TKGDNPCIST QSHLPLNHMG
610 620 630 640 650
LQTEKYRQGT RGWEVSGEPE LRLALVPGHS GSQDTQRDAL PAPACAPAQW
660 670 680 690 700
RQRKQKRPAS VECLPSVSVP YQVAQKGHAR QDHYYRDTQS SLDTALQMPM
710 720 730 740 750
PQEREQACPG SPAPQSPSNS PSAGNQASED LRSPFSSSLD LQEPQATSKA
760 770 780 790 800
TTIAVSGSDC VCHSTRSVEP AGDTKCQAHS STPTPAHRGE LGCLWDKAGT
810 820 830 840 850
TPEPFSFSVL LDRCPEADDP RTYHDCCCLQ AVPSSPLAAP SGQTQTSISE
860 870 880 890 900
ACLGGSSFCP TPPKEQTCFG RESASNGSTS SGHSRADGFA GPRRTLLVKS
910 920 930 940 950
PGVRGSLEER EADGGVTPSA LPYASPDAVV REWLGNIPEK PVLMTYEMAD
960 970 980 990 1000
ENTEVPSDGP EGPKEDSLKV LGEPSQAKQQ PPEGATNEHP EPAGVLSGPG
1010 1020 1030 1040 1050
SVCCRLGGDL HPDATSGERL KAPAEAGIGE GARVDHGVSL CALPTKVAAS
1060 1070 1080 1090 1100
TQIMKALLGS KPGRPSSLPE VSSTVAQRLS SSAGAFIACL ARLHFFDESL
1110 1120 1130 1140 1150
GPLDGKVRLE ESPKYQEMLR LFQTLWPGSE LWQGQLDFSL RKLTSHQALL
1160 1170 1180 1190 1200
GTEDFTPTSS SGVDVSSGSG GSGESSVPCV MDNTLAPEKR DLPLKIPSQR
1210 1220 1230 1240 1250
PDSRNQGYPE LVGHSTVSSV SQVRACATGG EETGKGGRKQ TWGNAPEQSV
1260 1270 1280 1290 1300
HSTMLEGDAL SEETEGRVRE RLQENSVHGK GLPEEGVRVC SQEMLAAGSQ
1310 1320 1330 1340 1350
DGAGSPEDTR VPTDEAGADA ASGGLWPLDG REEPTESPQH FSESNSRVRE
1360 1370 1380 1390 1400
HQSAHKLELG LEEVSRLDAR GCKQACIKAS SGTMAHKGSL DPDPIWVSKL
1410 1420 1430 1440 1450
LKKIEKAFMA HLADATAELR ARWDLHDNHL LDQMVTELEQ DVGRRLQAST
1460 1470 1480 1490 1500
VMEVRKIQSR AGRMVPEPPR EALRGQASLQ TEQRRRRLQG LRNFSAVPGQ
1510 1520 1530 1540 1550
GPLSLTLEDG PTLKTALGTK SGAEPAEDEF CPCEICLKKK RTPRFPKDAA
1560 1570 1580 1590 1600
TVSGAPVRKA FDLQQILQSK KGGSSNREAM EVAPQRTGRM LSQEDLGTVQ
1610 1620 1630 1640 1650
GADEKQGLGV AEGEEGEGKQ RLRAEEDPEI LKTEGSGCCA PEEDEATEED
1660 1670 1680 1690 1700
GEICIGTAQE SQQLEGTEMG KEGTLPQSFR DGGTLEAPAR QGTHSVEIQE
1710 1720 1730 1740 1750
ASRERQQEVE GRHQDVKEDS PWVSSGESQG RVGSENTSLD QEGRLLNHHQ
1760 1770 1780 1790 1800
RPGPQSHHTA CSSRALSLDN SSQVSQKGSD GDLTSGDLKC TKAKNSRVLH
1810 1820 1830 1840 1850
AEKKVPVMYP ERSSSEQEVP SSPRLPKQGK GEDEGSAGSL ACTQVGGKVD

GFGQDDLDF
Length:1,859
Mass (Da):199,686
Last modified:March 1, 2003 - v1
Checksum:iED885DA0FAF6E6E9
GO

Sequence cautioni

The sequence AAH31365 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY168340 mRNA. Translation: AAN86958.1.
AJ491325 mRNA. Translation: CAD36958.1.
BC031365 mRNA. Translation: AAH31365.1. Different initiation.
CCDSiCCDS36951.1.
RefSeqiNP_666358.2. NM_146246.3.
UniGeneiMm.300655.

Genome annotation databases

EnsembliENSMUST00000058229; ENSMUSP00000055449; ENSMUSG00000046049.
GeneIDi271209.
KEGGimmu:271209.
UCSCiuc007uia.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiRP1L1_MOUSE
AccessioniPrimary (citable) accession number: Q8CGM2
Secondary accession number(s): Q8K0I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2003
Last modified: January 31, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot