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Q8CGM1 (BAI2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brain-specific angiogenesis inhibitor 2
Gene names
Name:Bai2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1561 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Might be involved in angiogenesis inhibition. Ref.1

Subunit structure

Interacts with GABPB2. Ref.5

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Specifically expressed in the brain. The peak level in the brain is observed 10 days after birth. Ref.1

Developmental stage

Ubiquitous in embryonic tissues, but expression is acutely down-regulated after birth, except in the brain, to a level that is maintained throughout adulthood. Ref.1

Induction

Down-regulated after hypoxia.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 1 GPS domain.

Contains 4 TSP type-1 domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GABPB1Q065473EBI-8014984,EBI-618165From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8CGM1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8CGM1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     299-353: Missing.
Isoform 3 (identifier: Q8CGM1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1113-1145: SERCPWASLLLPCSACGAVPSPLLSSASARNAM → RLSWNLWGYGSQLCLFPKLPR

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 15611541Brain-specific angiogenesis inhibitor 2
PRO_0000245613

Regions

Topological domain21 – 930910Extracellular Potential
Transmembrane931 – 95121Helical; Name=1; Potential
Topological domain952 – 9598Cytoplasmic Potential
Transmembrane960 – 98021Helical; Name=2; Potential
Topological domain981 – 9888Extracellular Potential
Transmembrane989 – 100921Helical; Name=3; Potential
Topological domain1010 – 103021Cytoplasmic Potential
Transmembrane1031 – 105121Helical; Name=4; Potential
Topological domain1052 – 107221Extracellular Potential
Transmembrane1073 – 109321Helical; Name=5; Potential
Topological domain1094 – 111522Cytoplasmic Potential
Transmembrane1116 – 113621Helical; Name=6; Potential
Topological domain1137 – 114711Extracellular Potential
Transmembrane1148 – 116821Helical; Name=7; Potential
Topological domain1169 – 1561393Cytoplasmic Potential
Domain300 – 35354TSP type-1 1
Domain355 – 40854TSP type-1 2
Domain410 – 46354TSP type-1 3
Domain466 – 51954TSP type-1 4
Domain865 – 91753GPS
Compositional bias117 – 1226Poly-Glu
Compositional bias123 – 1275Poly-Ala
Compositional bias180 – 1834Poly-Asn
Compositional bias1309 – 13124Poly-Pro
Compositional bias1358 – 13614Poly-Gly
Compositional bias1419 – 14246Poly-Pro

Amino acid modifications

Modified residue13451Phosphotyrosine Ref.6
Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation1821N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation3471N-linked (GlcNAc...) Potential
Glycosylation4281N-linked (GlcNAc...) Potential
Glycosylation5511N-linked (GlcNAc...) Potential
Glycosylation6361N-linked (GlcNAc...) Potential
Glycosylation8611N-linked (GlcNAc...) Potential
Disulfide bond312 ↔ 346 By similarity
Disulfide bond316 ↔ 352 By similarity
Disulfide bond327 ↔ 336 By similarity
Disulfide bond367 ↔ 402 By similarity
Disulfide bond371 ↔ 407 By similarity
Disulfide bond382 ↔ 392 By similarity
Disulfide bond422 ↔ 457 By similarity
Disulfide bond426 ↔ 462 By similarity
Disulfide bond437 ↔ 447 By similarity
Disulfide bond478 ↔ 513 By similarity
Disulfide bond482 ↔ 518 By similarity
Disulfide bond493 ↔ 503 By similarity
Disulfide bond525 ↔ 560 By similarity
Disulfide bond548 ↔ 578 By similarity
Disulfide bond868 ↔ 900 By similarity
Disulfide bond888 ↔ 902 By similarity

Natural variations

Alternative sequence299 – 35355Missing in isoform 2.
VSP_019762
Alternative sequence1113 – 114533SERCP…ARNAM → RLSWNLWGYGSQLCLFPKLP R in isoform 3.
VSP_019763

Experimental info

Sequence conflict1161P → L in AAN86965. Ref.1
Sequence conflict1221Missing in AAN86965. Ref.1
Sequence conflict3861Q → K in AAN86965. Ref.1
Sequence conflict5261R → G in BAE34635. Ref.2
Sequence conflict6741D → G in BAE34635. Ref.2
Sequence conflict11791A → V in BAE34635. Ref.2
Sequence conflict13161N → D in BAE25937. Ref.2
Sequence conflict14671Missing in BAE25937. Ref.2
Sequence conflict14671Missing in BAE25805. Ref.2
Sequence conflict15501T → P in AAN86965. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 11, 2006. Version 2.
Checksum: 3B3EB731F619CBA3

FASTA1,561169,863
        10         20         30         40         50         60 
MTPACPLLLS VILSLRLATA FDPAPSACSA LASGVLYGAF SLQDLFPTIA SGCSWTLENP 

        70         80         90        100        110        120 
DPTKYSLYLR FNRQEQVCTH FAPRLLPLDH YLVNFTCLRP GPEEATARAE SEVGRPEEEE 

       130        140        150        160        170        180 
EEAAAAASGL ELCGGSGPFT FLHFDKNFVQ LCLSAEPSEA PRLLAPAALA FRFVEVLLIN 

       190        200        210        220        230        240 
NNNSSQFTCG VLCRWSEECG RAAGRACGFA QPGCSCPGEA GANPATTTSP GPPVAHTLSN 

       250        260        270        280        290        300 
ALVPGGPAPP AEADLHSGSS NDLFTTEMRY GEEPEEEPKV KTQWPRSADE PGLYMAQTGD 

       310        320        330        340        350        360 
PAAEEWSPWS VCSLTCGQGL QVRTRSCVSS PYGTLCSGPL RETRPCNNSA TCPVHGVWEE 

       370        380        390        400        410        420 
WGSWSLCSRS CGRGSRSRMR TCVPPQHGGK ACEGPELQTK LCSMAACPVE GQWLEWGPWG 

       430        440        450        460        470        480 
PCSSSCANGT QQRSRKCSVA GPAWATCAGA LTDTRECSNL DCPATDGKWG PWNAWSLCSK 

       490        500        510        520        530        540 
TCDTGWQRRF RMCQASGTQG YPCEGTGEEV KPCSEKRCPA FHEMCRDEYV MLMTWKRAAA 

       550        560        570        580        590        600 
GEIIYNKCPP NASGSASRRC LLSAQGVAYW GLPSFARCIS HEYRYLYLSL REHLAKGQRM 

       610        620        630        640        650        660 
LAGEGMSQVV RSLQELLARR TYYSGDLLFS VDILRNVTDT FKRATYVPSA DDVQRFFQVV 

       670        680        690        700        710        720 
SFMVDSENKD KWDDAQQVSP GSVHLLRVVE DFIHLVGDAL KAFQSSLIVT DNLVISIQRE 

       730        740        750        760        770        780 
PISAVSSDIT FPMRGRRGMK DWVRHSEDRL FLPKEVLSLS SPGKPATPGA ATAGSPGRGR 

       790        800        810        820        830        840 
GPGTVPPGPG HAHQRLLPAD PEESSSYFVI GAVLYRTLGL ILPPPRPPLA VTSRVMTVTV 

       850        860        870        880        890        900 
RPPTQPPAEP LITVELSYII NGTTDPHCAS WDYSRADTNS GDWNTESCQT LETQAAHTRC 

       910        920        930        940        950        960 
QCQHLSTFAV LAQPPKDLTL ELAGAPSVPL VIGCAVSCMA LLTLLAIYAA FWRFIKSERS 

       970        980        990       1000       1010       1020 
IILLNFCLSI LASNILILVG QSRVLSKGVC TMTAAFLHFF FLSSFCWVLT EAWQSYLAVI 

      1030       1040       1050       1060       1070       1080 
GRMRTRLVRK RFLCLGWGLP ALVVAVSVGF TRTKGYGTSS YCWLSLEGGL LYAFVGPAAV 

      1090       1100       1110       1120       1130       1140 
IVLVNMLIGI IVFNKLMARD GVSDKSKKQR AGSERCPWAS LLLPCSACGA VPSPLLSSAS 

      1150       1160       1170       1180       1190       1200 
ARNAMASLWS SCVVLPLLAL TWMSAVLAMT DRRSVLFQAL FAVFNSAQGF VITAVHCFLR 

      1210       1220       1230       1240       1250       1260 
REVQDVVKCQ MGVCRADESE DSPDSCKNGQ LQILSDFEKD VDLACQTVLF KEVNTCNPST 

      1270       1280       1290       1300       1310       1320 
ITGTLSRLSL DEDEEPKSCL VGPEGGLSFS PLPGNILVPM AASPGLGEPP PPQETNPVYM 

      1330       1340       1350       1360       1370       1380 
CGEGGLRQLD LTWIRQSEPG SEGDYMVLPR RTLSLQPGGG GTAGEEAPRA RPEGTPRRAA 

      1390       1400       1410       1420       1430       1440 
KTVAHTEGYP SFLSVEHSGL GLGPAYGSLQ NPYGMTFQPP PPTPSARQVP EPGERSRTMP 

      1450       1460       1470       1480       1490       1500 
RTVPGSTMKL GSLERKKLRY SDLDFEKVMH TRKRHSELYH ELNQKFHTFD RYRSQSSAKE 

      1510       1520       1530       1540       1550       1560 
KPSPPGGRPG LSQHRRHQSW STFKSMTLGS LPPKPRERLA LHRTAAWEPT EPPDGDFQTE 


V 

« Hide

Isoform 2 [UniParc].

Checksum: 6164F02425F64DC1
Show »

FASTA1,506164,063
Isoform 3 [UniParc].

Checksum: 7051D25C930EA7C5
Show »

FASTA1,549169,051

References

« Hide 'large scale' references
[1]"Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis."
Kee H.J., Koh J.T., Kim M.Y., Ahn K.Y., Kim J.K., Bae C.S., Park S.S., Kim K.K.
J. Cereb. Blood Flow Metab. 22:1054-1067(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, FUNCTION.
Strain: ICR.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Diencephalon and Visual cortex.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: C57BL/6.
Tissue: Brain.
[5]"Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor."
Jeong B.C., Kim M.Y., Lee J.H., Kee H.J., Kho D.H., Han K.E., Qian Y.R., Kim J.K., Kim K.K.
FEBS Lett. 580:669-676(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GABPB2.
[6]"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1345, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY168407 mRNA. Translation: AAN86965.1.
AK144268 mRNA. Translation: BAE25805.1.
AK144559 mRNA. Translation: BAE25937.1.
AK158735 mRNA. Translation: BAE34635.1.
AL626774 Genomic DNA. Translation: CAM17272.1.
AL626774 Genomic DNA. Translation: CAM17273.1.
AL626774 Genomic DNA. Translation: CAQ52064.1.
BC056926 mRNA. Translation: AAH56926.1.
CCDSCCDS51309.1. [Q8CGM1-3]
CCDS57300.1. [Q8CGM1-2]
RefSeqNP_001186625.1. NM_001199696.1. [Q8CGM1-2]
NP_001277643.1. NM_001290714.1.
NP_001277644.1. NM_001290715.1. [Q8CGM1-1]
NP_775094.2. NM_173071.3. [Q8CGM1-3]
XP_006503113.1. XM_006503050.1. [Q8CGM1-1]
UniGeneMm.262241.

3D structure databases

ProteinModelPortalQ8CGM1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8CGM1. 1 interaction.
MINTMINT-1504097.

Protein family/group databases

MEROPSS63.032.
GPCRDBSearch...

PTM databases

PhosphoSiteQ8CGM1.

Proteomic databases

PaxDbQ8CGM1.
PRIDEQ8CGM1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000106015; ENSMUSP00000101636; ENSMUSG00000028782. [Q8CGM1-1]
ENSMUST00000106017; ENSMUSP00000101638; ENSMUSG00000028782. [Q8CGM1-3]
ENSMUST00000121049; ENSMUSP00000112869; ENSMUSG00000028782. [Q8CGM1-2]
GeneID230775.
KEGGmmu:230775.
UCSCuc008uym.2. mouse. [Q8CGM1-3]
uc008uyn.2. mouse. [Q8CGM1-2]
uc008uyp.1. mouse. [Q8CGM1-1]

Organism-specific databases

CTD576.
MGIMGI:2451244. Bai2.

Phylogenomic databases

eggNOGNOG146816.
GeneTreeENSGT00690000101769.
HOVERGENHBG004813.
InParanoidB1ASB7.
KOK04597.
PhylomeDBQ8CGM1.
TreeFamTF331634.

Gene expression databases

BgeeQ8CGM1.
CleanExMM_BAI2.
GenevestigatorQ8CGM1.

Family and domain databases

InterProIPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR008077. GPCR_2_brain-spec_angio_inhib.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF01825. GPS. 1 hit.
PF00090. TSP_1. 4 hits.
[Graphical view]
PRINTSPR01694. BAIPRECURSOR.
PR00249. GPCRSECRETIN.
SMARTSM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00209. TSP1. 4 hits.
[Graphical view]
SUPFAMSSF82895. SSF82895. 4 hits.
PROSITEPS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBAI2. mouse.
NextBio380140.
PROQ8CGM1.
SOURCESearch...

Entry information

Entry nameBAI2_MOUSE
AccessionPrimary (citable) accession number: Q8CGM1
Secondary accession number(s): B1ASB7 expand/collapse secondary AC list , B1ASB8, B2FDE3, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries