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Q8CGK7

- GNAL_MOUSE

UniProt

Q8CGK7 - GNAL_MOUSE

Protein

Guanine nucleotide-binding protein G(olf) subunit alpha

Gene

Gnal

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi56 – 561MagnesiumBy similarity
    Metal bindingi191 – 1911MagnesiumBy similarity
    Binding sitei353 – 3531GTP; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi49 – 568GTPBy similarity
    Nucleotide bindingi185 – 1917GTPBy similarity
    Nucleotide bindingi210 – 2145GTPBy similarity
    Nucleotide bindingi279 – 2824GTPBy similarity

    GO - Molecular functioni

    1. G-protein beta/gamma-subunit complex binding Source: RefGenome
    2. G-protein coupled receptor binding Source: RefGenome
    3. GTPase activity Source: MGI
    4. GTP binding Source: UniProtKB-KW
    5. metal ion binding Source: UniProtKB-KW
    6. signal transducer activity Source: RefGenome

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: MGI
    2. adenylate cyclase-activating dopamine receptor signaling pathway Source: MGI
    3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
    4. G-protein coupled receptor signaling pathway Source: MGI
    5. response to amphetamine Source: MGI
    6. response to caffeine Source: MGI
    7. sensory perception of smell Source: MGI

    Keywords - Molecular functioni

    Transducer

    Keywords - Ligandi

    GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_222824. Adenylate cyclase inhibitory pathway.
    REACT_224974. Adenylate cyclase activating pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(olf) subunit alpha
    Alternative name(s):
    Adenylate cyclase-stimulating G alpha protein, olfactory type
    Gene namesi
    Name:Gnal
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:95774. Gnal.

    Subcellular locationi

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Guanine nucleotide-binding protein G(olf) subunit alphaPRO_0000203733Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-palmitoyl glycineBy similarity
    Lipidationi3 – 31S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiQ8CGK7.
    PaxDbiQ8CGK7.
    PRIDEiQ8CGK7.

    PTM databases

    PhosphoSiteiQ8CGK7.

    Expressioni

    Gene expression databases

    BgeeiQ8CGK7.
    GenevestigatoriQ8CGK7.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CGK7.
    SMRiQ8CGK7. Positions 12-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-alpha family. G(s) subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG325092.
    GeneTreeiENSGT00690000102066.
    HOGENOMiHOG000038729.
    HOVERGENiHBG063184.
    KOiK04633.
    OMAiDYSQEFF.
    PhylomeDBiQ8CGK7.

    Family and domain databases

    Gene3Di1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR000367. Gprotein_alpha_S.
    IPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10218. PTHR10218. 1 hit.
    PfamiPF00503. G-alpha. 1 hit.
    [Graphical view]
    PRINTSiPR00318. GPROTEINA.
    PR00443. GPROTEINAS.
    SMARTiSM00275. G_alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.
    ProtoNetiSearch...

    Sequencei

    Sequence statusi: Complete.

    Q8CGK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCLGNSSKT AEDQGVDEKE RREANKKIEK QLQKERLAYK ATHRLLLLGA    50
    GESGKSTIVK QMRILHVNGF NPEEKKQKIL DIRKNVKDAI VTIVSAMSTI 100
    IPPVPLANPE NQFRSDYIKS IAPITDFEYS QEFFDHVKKL WDDEGVKACF 150
    ERSNEYQLID CAQYFLERID SVSLVDYTPT DQDLLRCRVL TSGIFETRFQ 200
    VDKVNFHMFD VGGQRDERRK WIQCFNDVTA IIYVAACSSY NMVIREDNNT 250
    NRLRESLDLF ESIWNNRWLR TISIILFLNK QDMLAEKVLA GKSKIEDYFP 300
    EYANYTVPED ATPDAGEDPK VTRAKFFIRD LFLRISTATG DGKHYCYPHF 350
    TCAVDTENIR RVFNDCRDII QRMHLKQYEL L 381
    Length:381
    Mass (Da):44,308
    Last modified:March 1, 2003 - v1
    Checksum:iF707E668EC279033
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY179169 mRNA. Translation: AAO03564.1.
    U38503 mRNA. Translation: AAB01734.1.
    M57635 mRNA. Translation: AAA63300.1.
    CCDSiCCDS29318.1.
    PIRiA33833.
    RefSeqiNP_034437.1. NM_010307.3.
    UniGeneiMm.440746.

    Genome annotation databases

    EnsembliENSMUST00000076605; ENSMUSP00000075908; ENSMUSG00000024524.
    GeneIDi14680.
    KEGGimmu:14680.
    UCSCiuc008flt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY179169 mRNA. Translation: AAO03564.1 .
    U38503 mRNA. Translation: AAB01734.1 .
    M57635 mRNA. Translation: AAA63300.1 .
    CCDSi CCDS29318.1.
    PIRi A33833.
    RefSeqi NP_034437.1. NM_010307.3.
    UniGenei Mm.440746.

    3D structure databases

    ProteinModelPortali Q8CGK7.
    SMRi Q8CGK7. Positions 12-381.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8CGK7.

    Proteomic databases

    MaxQBi Q8CGK7.
    PaxDbi Q8CGK7.
    PRIDEi Q8CGK7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000076605 ; ENSMUSP00000075908 ; ENSMUSG00000024524 .
    GeneIDi 14680.
    KEGGi mmu:14680.
    UCSCi uc008flt.1. mouse.

    Organism-specific databases

    CTDi 2774.
    MGIi MGI:95774. Gnal.

    Phylogenomic databases

    eggNOGi NOG325092.
    GeneTreei ENSGT00690000102066.
    HOGENOMi HOG000038729.
    HOVERGENi HBG063184.
    KOi K04633.
    OMAi DYSQEFF.
    PhylomeDBi Q8CGK7.

    Enzyme and pathway databases

    Reactomei REACT_222824. Adenylate cyclase inhibitory pathway.
    REACT_224974. Adenylate cyclase activating pathway.

    Miscellaneous databases

    ChiTaRSi GNAL. mouse.
    NextBioi 286586.
    PROi Q8CGK7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CGK7.
    Genevestigatori Q8CGK7.

    Family and domain databases

    Gene3Di 1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR000367. Gprotein_alpha_S.
    IPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10218. PTHR10218. 1 hit.
    Pfami PF00503. G-alpha. 1 hit.
    [Graphical view ]
    PRINTSi PR00318. GPROTEINA.
    PR00443. GPROTEINAS.
    SMARTi SM00275. G_alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The mouse G protein Golf alpha subunit full length coding sequence."
      Von Dannecker L.E.C., Malnic B.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 45-55, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    3. "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
      Williams C.J., Schultz R.M., Kopf G.S.
      Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 209-373.
      Strain: CF-1 / Harlan.
      Tissue: Brain.
    4. "Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse."
      Strathmann M., Wilkie T.M., Simon M.I.
      Proc. Natl. Acad. Sci. U.S.A. 86:7407-7409(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 216-276.
      Tissue: Brain.

    Entry informationi

    Entry nameiGNAL_MOUSE
    AccessioniPrimary (citable) accession number: Q8CGK7
    Secondary accession number(s): Q61020, Q61589
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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