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Protein

Interferon lambda-3

Gene

Ifnl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-MMU-449836. Other interleukin signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon lambda-3
Short name:
IFN-lambda-3
Alternative name(s):
Interleukin-28B
Short name:
IL-28B
Gene namesi
Name:Ifnl3
Synonyms:Il28, Il28b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2450574. Ifnl3.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
  • intracellular Source: GOC

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001551220 – 193Interferon lambda-3Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 132By similarity
Disulfide bondi69 ↔ 166By similarity
Disulfide bondi185 ↔ 192By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ8CGK6.
PaxDbiQ8CGK6.
PRIDEiQ8CGK6.

PTM databases

PhosphoSitePlusiQ8CGK6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060747.
CleanExiMM_IL28B.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077473.

Structurei

3D structure databases

ProteinModelPortaliQ8CGK6.
SMRiQ8CGK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lambda interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0IH. Eukaryota.
ENOG410ZDRD. LUCA.
GeneTreeiENSGT00390000014310.
HOVERGENiHBG052108.
InParanoidiQ8CGK6.
KOiK05447.
OMAiKESLGCL.
OrthoDBiEOG091G0RUH.
TreeFamiTF336172.

Family and domain databases

InterProiView protein in InterPro
IPR029177. INF_lambda.
PfamiView protein in Pfam
PF15177. IL28A. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CGK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA
60 70 80 90 100
FKKAKGAIEK RLLEKDMRCS SHLISRAWDL KQLQVQERPK ALQAEVALTL
110 120 130 140 150
KVWENINDSA LTTILGQPLH TLSHIHSQLQ TCTQLQATAE PKPPSRRLSR
160 170 180 190
WLHRLQEAQS KETPGCLEDS VTSNLFQLLL RDLKCVASGD QCV
Length:193
Mass (Da):21,664
Last modified:March 1, 2003 - v1
Checksum:i357A00AACAA9BC61
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56G → D in AAX58715 (PubMed:15914836).Curated1
Sequence conflicti67M → V in AAX58715 (PubMed:15914836).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184375 mRNA. Translation: AAN86128.1.
AY869696 mRNA. Translation: AAX58715.1.
CCDSiCCDS21047.1.
RefSeqiNP_796370.1. NM_177396.1.
UniGeneiMm.246799.

Genome annotation databases

EnsembliENSMUST00000078364; ENSMUSP00000077473; ENSMUSG00000060747.
GeneIDi338374.
KEGGimmu:338374.
UCSCiuc009fze.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiIFNL3_MOUSE
AccessioniPrimary (citable) accession number: Q8CGK6
Secondary accession number(s): Q4VK73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families