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Q8CGK6

- IFNL3_MOUSE

UniProt

Q8CGK6 - IFNL3_MOUSE

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Protein
Interferon lambda-3
Gene
Ifnl3, Il28, Il28b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

GO - Molecular functioni

  1. receptor binding Source: MGI

GO - Biological processi

  1. JAK-STAT cascade Source: InterPro
  2. defense response to virus Source: UniProtKB
  3. innate immune response Source: MGI
  4. negative regulation of viral genome replication Source: UniProtKB
  5. positive regulation of immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon lambda-3
Short name:
IFN-lambda-3
Alternative name(s):
Interleukin-28B
Short name:
IL-28B
Gene namesi
Name:Ifnl3
Synonyms:Il28, Il28b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2450574. Ifnl3.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 193174Interferon lambda-3
PRO_0000015512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 132 By similarity
Disulfide bondi69 ↔ 166 By similarity
Disulfide bondi185 ↔ 192 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8CGK6.

Expressioni

Gene expression databases

CleanExiMM_IL28B.
GenevestigatoriQ8CGK6.

Structurei

3D structure databases

ProteinModelPortaliQ8CGK6.
SMRiQ8CGK6. Positions 35-193.

Family & Domainsi

Sequence similaritiesi

Belongs to the lambda interferon family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40189.
GeneTreeiENSGT00390000014310.
HOVERGENiHBG052108.
InParanoidiQ8CGK6.
KOiK05447.
OMAiAWERPVA.
OrthoDBiEOG7F24V6.
TreeFamiTF336172.

Family and domain databases

InterProiIPR029177. INF_lambda.
[Graphical view]
PfamiPF15177. IL28A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CGK6-1 [UniParc]FASTAAdd to Basket

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MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA    50
FKKAKGAIEK RLLEKDMRCS SHLISRAWDL KQLQVQERPK ALQAEVALTL 100
KVWENINDSA LTTILGQPLH TLSHIHSQLQ TCTQLQATAE PKPPSRRLSR 150
WLHRLQEAQS KETPGCLEDS VTSNLFQLLL RDLKCVASGD QCV 193
Length:193
Mass (Da):21,664
Last modified:March 1, 2003 - v1
Checksum:i357A00AACAA9BC61
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561G → D in AAX58715. 1 Publication
Sequence conflicti67 – 671M → V in AAX58715. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY184375 mRNA. Translation: AAN86128.1.
AY869696 mRNA. Translation: AAX58715.1.
CCDSiCCDS21047.1.
RefSeqiNP_796370.1. NM_177396.1.
UniGeneiMm.246799.

Genome annotation databases

EnsembliENSMUST00000078364; ENSMUSP00000077473; ENSMUSG00000060747.
GeneIDi338374.
KEGGimmu:338374.
UCSCiuc009fze.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY184375 mRNA. Translation: AAN86128.1 .
AY869696 mRNA. Translation: AAX58715.1 .
CCDSi CCDS21047.1.
RefSeqi NP_796370.1. NM_177396.1.
UniGenei Mm.246799.

3D structure databases

ProteinModelPortali Q8CGK6.
SMRi Q8CGK6. Positions 35-193.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8CGK6.

Protocols and materials databases

DNASUi 338374.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000078364 ; ENSMUSP00000077473 ; ENSMUSG00000060747 .
GeneIDi 338374.
KEGGi mmu:338374.
UCSCi uc009fze.1. mouse.

Organism-specific databases

CTDi 282617.
MGIi MGI:2450574. Ifnl3.

Phylogenomic databases

eggNOGi NOG40189.
GeneTreei ENSGT00390000014310.
HOVERGENi HBG052108.
InParanoidi Q8CGK6.
KOi K05447.
OMAi AWERPVA.
OrthoDBi EOG7F24V6.
TreeFami TF336172.

Miscellaneous databases

NextBioi 400191.
PROi Q8CGK6.
SOURCEi Search...

Gene expression databases

CleanExi MM_IL28B.
Genevestigatori Q8CGK6.

Family and domain databases

InterProi IPR029177. INF_lambda.
[Graphical view ]
Pfami PF15177. IL28A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
    Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.
    Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model."
    Bartlett N.W., Buttigieg K., Kotenko S.V., Smith G.L.
    J. Gen. Virol. 86:1589-1596(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: 129/Sv.
  3. "Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma."
    Lasfar A., Lewis-Antes A., Smirnov S.V., Anantha S., Abushahba W., Tian B., Reuhl K., Dickensheets H., Sheikh F., Donnelly R.P., Raveche E., Kotenko S.V.
    Cancer Res. 66:4468-4477(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity."
    Ank N., Iversen M.B., Bartholdy C., Staeheli P., Hartmann R., Jensen U.B., Dagnaes-Hansen F., Thomsen A.R., Chen Z., Haugen H., Klucher K., Paludan S.R.
    J. Immunol. 180:2474-2485(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Interferon-lambda: a new addition to an old family."
    Donnelly R.P., Kotenko S.V.
    J. Interferon Cytokine Res. 30:555-564(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  6. Cited for: FUNCTION.
  7. "Interferon-lambda in the context of viral infections: production, response and therapeutic implications."
    Hermant P., Michiels T.
    J. Innate Immun. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiIFNL3_MOUSE
AccessioniPrimary (citable) accession number: Q8CGK6
Secondary accession number(s): Q4VK73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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