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Q8CGK6

- IFNL3_MOUSE

UniProt

Q8CGK6 - IFNL3_MOUSE

Protein

Interferon lambda-3

Gene

Ifnl3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.4 Publications

    GO - Molecular functioni

    1. receptor binding Source: MGI

    GO - Biological processi

    1. defense response to virus Source: UniProtKB
    2. innate immune response Source: MGI
    3. JAK-STAT cascade Source: InterPro
    4. negative regulation of viral genome replication Source: UniProtKB
    5. positive regulation of immune response Source: InterPro

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon lambda-3
    Short name:
    IFN-lambda-3
    Alternative name(s):
    Interleukin-28B
    Short name:
    IL-28B
    Gene namesi
    Name:Ifnl3
    Synonyms:Il28, Il28b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2450574. Ifnl3.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 193174Interferon lambda-3PRO_0000015512Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi35 ↔ 132By similarity
    Disulfide bondi69 ↔ 166By similarity
    Disulfide bondi185 ↔ 192By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ8CGK6.

    Expressioni

    Gene expression databases

    CleanExiMM_IL28B.
    GenevestigatoriQ8CGK6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CGK6.
    SMRiQ8CGK6. Positions 35-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the lambda interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40189.
    GeneTreeiENSGT00390000014310.
    HOVERGENiHBG052108.
    InParanoidiQ8CGK6.
    KOiK05447.
    OMAiAWERPVA.
    OrthoDBiEOG7F24V6.
    TreeFamiTF336172.

    Family and domain databases

    InterProiIPR029177. INF_lambda.
    [Graphical view]
    PfamiPF15177. IL28A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CGK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA    50
    FKKAKGAIEK RLLEKDMRCS SHLISRAWDL KQLQVQERPK ALQAEVALTL 100
    KVWENINDSA LTTILGQPLH TLSHIHSQLQ TCTQLQATAE PKPPSRRLSR 150
    WLHRLQEAQS KETPGCLEDS VTSNLFQLLL RDLKCVASGD QCV 193
    Length:193
    Mass (Da):21,664
    Last modified:March 1, 2003 - v1
    Checksum:i357A00AACAA9BC61
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561G → D in AAX58715. (PubMed:15914836)Curated
    Sequence conflicti67 – 671M → V in AAX58715. (PubMed:15914836)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY184375 mRNA. Translation: AAN86128.1.
    AY869696 mRNA. Translation: AAX58715.1.
    CCDSiCCDS21047.1.
    RefSeqiNP_796370.1. NM_177396.1.
    UniGeneiMm.246799.

    Genome annotation databases

    EnsembliENSMUST00000078364; ENSMUSP00000077473; ENSMUSG00000060747.
    GeneIDi338374.
    KEGGimmu:338374.
    UCSCiuc009fze.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY184375 mRNA. Translation: AAN86128.1 .
    AY869696 mRNA. Translation: AAX58715.1 .
    CCDSi CCDS21047.1.
    RefSeqi NP_796370.1. NM_177396.1.
    UniGenei Mm.246799.

    3D structure databases

    ProteinModelPortali Q8CGK6.
    SMRi Q8CGK6. Positions 35-193.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8CGK6.

    Protocols and materials databases

    DNASUi 338374.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000078364 ; ENSMUSP00000077473 ; ENSMUSG00000060747 .
    GeneIDi 338374.
    KEGGi mmu:338374.
    UCSCi uc009fze.1. mouse.

    Organism-specific databases

    CTDi 282617.
    MGIi MGI:2450574. Ifnl3.

    Phylogenomic databases

    eggNOGi NOG40189.
    GeneTreei ENSGT00390000014310.
    HOVERGENi HBG052108.
    InParanoidi Q8CGK6.
    KOi K05447.
    OMAi AWERPVA.
    OrthoDBi EOG7F24V6.
    TreeFami TF336172.

    Miscellaneous databases

    NextBioi 400191.
    PROi Q8CGK6.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_IL28B.
    Genevestigatori Q8CGK6.

    Family and domain databases

    InterProi IPR029177. INF_lambda.
    [Graphical view ]
    Pfami PF15177. IL28A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
      Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.
      Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model."
      Bartlett N.W., Buttigieg K., Kotenko S.V., Smith G.L.
      J. Gen. Virol. 86:1589-1596(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: 129/Sv.
    3. "Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma."
      Lasfar A., Lewis-Antes A., Smirnov S.V., Anantha S., Abushahba W., Tian B., Reuhl K., Dickensheets H., Sheikh F., Donnelly R.P., Raveche E., Kotenko S.V.
      Cancer Res. 66:4468-4477(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity."
      Ank N., Iversen M.B., Bartholdy C., Staeheli P., Hartmann R., Jensen U.B., Dagnaes-Hansen F., Thomsen A.R., Chen Z., Haugen H., Klucher K., Paludan S.R.
      J. Immunol. 180:2474-2485(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Interferon-lambda: a new addition to an old family."
      Donnelly R.P., Kotenko S.V.
      J. Interferon Cytokine Res. 30:555-564(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    6. Cited for: FUNCTION.
    7. "Interferon-lambda in the context of viral infections: production, response and therapeutic implications."
      Hermant P., Michiels T.
      J. Innate Immun. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiIFNL3_MOUSE
    AccessioniPrimary (citable) accession number: Q8CGK6
    Secondary accession number(s): Q4VK73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3