Ifnl3

Functionⁱ

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.4 Publications

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
receptor binding
Source: MGI
Inferred from sequence alignmentⁱ
- 12483210

Complete GO annotation...

GO - Biological processⁱ

defense response to virus Source: UniProtKB
innate immune response
Source: MGI
Inferred from direct assayⁱ
- 16751416
JAK-STAT cascade Source: InterPro
negative regulation of viral genome replication Source: UniProtKB
positive regulation of immune response Source: InterPro
regulation of T cell activation Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Antiviral defense

Enzyme and pathway databases

Reactomeⁱ	R-MMU-449836. Other interleukin signaling.

Reactomeⁱ

R-MMU-449836. Other interleukin signaling.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon lambda-3 Short name: IFN-lambda-3 Alternative name(s): Interleukin-28B Short name: IL-28B
Gene namesⁱ	Name:Ifnl3 Synonyms:Il28, Il28b
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:2450574. Ifnl3.

Subcellular locationⁱ

Secreted By similarity

GO - Cellular componentⁱ

extracellular space
Source: MGI
Inferred from direct assayⁱ
- 16751416
intracellular Source: GOC

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000015512	20 – 193	Interferon lambda-3Add BLAST		174

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	35 ↔ 132	By similarity
Disulfide bondⁱ	69 ↔ 166	By similarity
Disulfide bondⁱ	185 ↔ 192	By similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

EPDⁱ	Q8CGK6.
PaxDbⁱ	Q8CGK6.
PRIDEⁱ	Q8CGK6.

PTM databases

PhosphoSitePlusⁱ	Q8CGK6.

PhosphoSitePlusⁱ

Q8CGK6.

Expressionⁱ

Gene expression databases

CleanExⁱ	MM_IL28B.

CleanExⁱ

MM_IL28B.

Interactionⁱ

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
receptor binding
Source: MGI
Inferred from sequence alignmentⁱ
- 12483210

Complete GO annotation...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000077473.

STRINGⁱ

10090.ENSMUSP00000077473.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8CGK6.
SMRⁱ	Q8CGK6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the lambda interferon family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J0IH. Eukaryota. ENOG410ZDRD. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014310.
HOVERGENⁱ	HBG052108.
InParanoidⁱ	Q8CGK6.
KEGG Orthology (KO) More...KOⁱ	K05447.
OMAⁱ	KESLGCL.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RUH.
TreeFamⁱ	TF336172.

Family and domain databases

InterProⁱ	View protein in InterPro IPR029177. INF_lambda.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15177. IL28A. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q8CGK6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA 
        60         70         80         90        100
FKKAKGAIEK RLLEKDMRCS SHLISRAWDL KQLQVQERPK ALQAEVALTL 
       110        120        130        140        150
KVWENINDSA LTTILGQPLH TLSHIHSQLQ TCTQLQATAE PKPPSRRLSR 
       160        170        180        190 
WLHRLQEAQS KETPGCLEDS VTSNLFQLLL RDLKCVASGD QCV

Length:193

Mass (Da):21,664

Last modified:March 1, 2003 - v1

Checksum:ⁱ357A00AACAA9BC61

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	56	G → D in AAX58715 (PubMed:15914836).Curated		1
Sequence conflictⁱ	67	M → V in AAX58715 (PubMed:15914836).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY184375 mRNA. Translation: AAN86128.1. AY869696 mRNA. Translation: AAX58715.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21047.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_796370.1. NM_177396.1.
UniGeneⁱ	Mm.246799.

Genome annotation databases

Ensemblⁱ	ENSMUST00000078364; ENSMUSP00000077473; ENSMUSG00000060747.
GeneIDⁱ	338374.
KEGGⁱ	mmu:338374.
UCSC genome browser More...UCSCⁱ	uc009fze.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY184375 mRNA. Translation: AAN86128.1. AY869696 mRNA. Translation: AAX58715.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21047.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_796370.1. NM_177396.1.
UniGeneⁱ	Mm.246799.

3D structure databases

ProteinModelPortalⁱ	Q8CGK6.
SMRⁱ	Q8CGK6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000077473.

STRINGⁱ

10090.ENSMUSP00000077473.

PTM databases

PhosphoSitePlusⁱ	Q8CGK6.

PhosphoSitePlusⁱ

Q8CGK6.

Proteomic databases

EPDⁱ	Q8CGK6.
PaxDbⁱ	Q8CGK6.
PRIDEⁱ	Q8CGK6.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	338374.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000078364; ENSMUSP00000077473; ENSMUSG00000060747.
GeneIDⁱ	338374.
KEGGⁱ	mmu:338374.
UCSC genome browser More...UCSCⁱ	uc009fze.1. mouse.

Organism-specific databases

CTDⁱ	282617.
MGIⁱ	MGI:2450574. Ifnl3.

Phylogenomic databases

eggNOGⁱ	ENOG410J0IH. Eukaryota. ENOG410ZDRD. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014310.
HOVERGENⁱ	HBG052108.
InParanoidⁱ	Q8CGK6.
KEGG Orthology (KO) More...KOⁱ	K05447.
OMAⁱ	KESLGCL.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RUH.
TreeFamⁱ	TF336172.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-449836. Other interleukin signaling.

Reactomeⁱ

R-MMU-449836. Other interleukin signaling.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8CGK6.
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_IL28B.

CleanExⁱ

MM_IL28B.

Family and domain databases

InterProⁱ	View protein in InterPro IPR029177. INF_lambda.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15177. IL28A. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IFNL3_MOUSE
Accessionⁱ	Q8CGK6Primary (citable) accession number: Q8CGK6 Secondary accession number(s): Q4VK73
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
	Last sequence update:	March 1, 2003
	Last modified:	June 7, 2017
	This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8CGK6 (IFNL3_MOUSE)

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Interferon lambda-3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ