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Q8CGK6 (IFNL3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon lambda-3

Short name=IFN-lambda-3
Alternative name(s):
Interleukin-28B
Short name=IL-28B
Gene names
Name:Ifnl3
Synonyms:Il28, Il28b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Ref.2 Ref.3 Ref.4 Ref.5

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the lambda interferon family.

Ontologies

Keywords
   Biological processAntiviral defense
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to virus

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from direct assay PubMed 16751416. Source: MGI

   Cellular_componentextracellular space

Inferred from direct assay PubMed 16751416. Source: MGI

   Molecular_functionreceptor binding

Inferred from sequence alignment Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 193174Interferon lambda-3
PRO_0000015512

Amino acid modifications

Disulfide bond35 ↔ 132 By similarity
Disulfide bond69 ↔ 166 By similarity
Disulfide bond185 ↔ 192 By similarity

Experimental info

Sequence conflict561G → D in AAX58715. Ref.2
Sequence conflict671M → V in AAX58715. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8CGK6 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 357A00AACAA9BC61

FASTA19321,664
        10         20         30         40         50         60 
MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA FKKAKGAIEK 

        70         80         90        100        110        120 
RLLEKDMRCS SHLISRAWDL KQLQVQERPK ALQAEVALTL KVWENINDSA LTTILGQPLH 

       130        140        150        160        170        180 
TLSHIHSQLQ TCTQLQATAE PKPPSRRLSR WLHRLQEAQS KETPGCLEDS VTSNLFQLLL 

       190 
RDLKCVASGD QCV 

« Hide

References

[1]"IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.
Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model."
Bartlett N.W., Buttigieg K., Kotenko S.V., Smith G.L.
J. Gen. Virol. 86:1589-1596(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: 129/Sv.
[3]"Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma."
Lasfar A., Lewis-Antes A., Smirnov S.V., Anantha S., Abushahba W., Tian B., Reuhl K., Dickensheets H., Sheikh F., Donnelly R.P., Raveche E., Kotenko S.V.
Cancer Res. 66:4468-4477(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity."
Ank N., Iversen M.B., Bartholdy C., Staeheli P., Hartmann R., Jensen U.B., Dagnaes-Hansen F., Thomsen A.R., Chen Z., Haugen H., Klucher K., Paludan S.R.
J. Immunol. 180:2474-2485(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"IFN-lambda determines the intestinal epithelial antiviral host defense."
Pott J., Mahlakoiv T., Mordstein M., Duerr C.U., Michiels T., Stockinger S., Staeheli P., Hornef M.W.
Proc. Natl. Acad. Sci. U.S.A. 108:7944-7949(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY184375 mRNA. Translation: AAN86128.1.
AY869696 mRNA. Translation: AAX58715.1.
RefSeqNP_796370.1. NM_177396.1.
UniGeneMm.246799.

3D structure databases

ProteinModelPortalQ8CGK6.
SMRQ8CGK6. Positions 35-193.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8CGK6.

Protocols and materials databases

DNASU338374.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000078364; ENSMUSP00000077473; ENSMUSG00000060747.
GeneID338374.
KEGGmmu:338374.
UCSCuc009fze.1. mouse.

Organism-specific databases

CTD282617.
MGIMGI:2450574. Ifnl3.

Phylogenomic databases

eggNOGNOG40189.
GeneTreeENSGT00390000014310.
HOVERGENHBG052108.
InParanoidQ8CGK6.
KOK05447.
OMAAWERPVA.
OrthoDBEOG7F24V6.
TreeFamTF336172.

Gene expression databases

CleanExMM_IL28B.
GenevestigatorQ8CGK6.

Family and domain databases

ProtoNetSearch...

Other

NextBio400191.
PROQ8CGK6.
SOURCESearch...

Entry information

Entry nameIFNL3_MOUSE
AccessionPrimary (citable) accession number: Q8CGK6
Secondary accession number(s): Q4VK73
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot