UniProtKB - Q8CGK6 (IFNL3_MOUSE)
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Protein
Interferon lambda-3
Gene
Ifnl3
Organism
Mus musculus (Mouse)
Status
Functioni
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.4 Publications
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- receptor binding Source: MGI
GO - Biological processi
- defense response to virus Source: UniProtKB
- innate immune response Source: MGI
- JAK-STAT cascade Source: InterPro
- negative regulation of viral genome replication Source: UniProtKB
- positive regulation of immune response Source: InterPro
- regulation of T cell activation Source: GO_Central
Keywordsi
Molecular function | Cytokine |
Biological process | Antiviral defense |
Enzyme and pathway databases
Reactomei | R-MMU-8854691. Interleukin-20 family signaling. |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon lambda-3Short name: IFN-lambda-3 Alternative name(s): Interleukin-28B Short name: IL-28B |
Gene namesi | Name:Ifnl3 Synonyms:Il28, Il28b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2450574. Ifnl3. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000015512 | 20 – 193 | Interferon lambda-3Add BLAST | 174 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 35 ↔ 132 | By similarity | ||
Disulfide bondi | 69 ↔ 166 | By similarity | ||
Disulfide bondi | 185 ↔ 192 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
EPDi | Q8CGK6. |
PaxDbi | Q8CGK6. |
PRIDEi | Q8CGK6. |
PTM databases
PhosphoSitePlusi | Q8CGK6. |
Interactioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- receptor binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000077473. |
Structurei
3D structure databases
ProteinModelPortali | Q8CGK6. |
SMRi | Q8CGK6. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the lambda interferon family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410J0IH. Eukaryota. ENOG410ZDRD. LUCA. |
GeneTreei | ENSGT00390000014310. |
HOVERGENi | HBG052108. |
InParanoidi | Q8CGK6. |
KOi | K05447. |
OMAi | KESLGCL. |
OrthoDBi | EOG091G0RUH. |
TreeFami | TF336172. |
Family and domain databases
Gene3Di | 1.20.1250.60. 1 hit. |
InterProi | View protein in InterPro IPR038326. IFN-lambda_sf. IPR029177. INF_lambda. |
PANTHERi | PTHR31943. PTHR31943. 1 hit. |
Pfami | View protein in Pfam PF15177. IL28A. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8CGK6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA
60 70 80 90 100
FKKAKGAIEK RLLEKDMRCS SHLISRAWDL KQLQVQERPK ALQAEVALTL
110 120 130 140 150
KVWENINDSA LTTILGQPLH TLSHIHSQLQ TCTQLQATAE PKPPSRRLSR
160 170 180 190
WLHRLQEAQS KETPGCLEDS VTSNLFQLLL RDLKCVASGD QCV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 56 | G → D in AAX58715 (PubMed:15914836).Curated | 1 | |
Sequence conflicti | 67 | M → V in AAX58715 (PubMed:15914836).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY184375 mRNA. Translation: AAN86128.1. AY869696 mRNA. Translation: AAX58715.1. |
CCDSi | CCDS21047.1. |
RefSeqi | NP_796370.1. NM_177396.1. |
UniGenei | Mm.246799. |
Genome annotation databases
Ensembli | ENSMUST00000078364; ENSMUSP00000077473; ENSMUSG00000060747. |
GeneIDi | 338374. |
KEGGi | mmu:338374. |
UCSCi | uc009fze.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | IFNL3_MOUSE | |
Accessioni | Q8CGK6Primary (citable) accession number: Q8CGK6 Secondary accession number(s): Q4VK73 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | March 28, 2018 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |