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Q8CGK5

- INLR1_MOUSE

UniProt

Q8CGK5 - INLR1_MOUSE

Protein

Interferon lambda receptor 1

Gene

Ifnlr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.2 Publications

    GO - Molecular functioni

    1. cytokine receptor activity Source: MGI

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: GOC
    2. defense response to virus Source: UniProtKB
    3. mucosal immune response Source: UniProtKB
    4. regulation of defense response to virus by host Source: Ensembl
    5. response to type III interferon Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Antiviral defense

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon lambda receptor 1
    Short name:
    IFN-lambda R1
    Alternative name(s):
    Cytokine receptor class-II member 12
    Cytokine receptor family 2 member 12
    Short name:
    CRF2-12
    Interleukin-28 receptor subunit alpha
    Short name:
    IL-28 receptor subunit alpha
    Short name:
    IL-28R-alpha
    Short name:
    IL-28RA
    Gene namesi
    Name:Ifnlr1
    Synonyms:Il28ra
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2429859. Ifnlr1.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. interleukin-28 receptor complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    The mice are viable and appear to be of normal size, behavior and reproductive ability. There is no effect on the ability to combat vaginal viral infection, but antiviral response evoked by Toll-like reseptor (TLR) stimulation is reduced. Mice also display enhanced rotavirus susceptibility associated with epithelial vacuolization, villus deformation and epithelial cell disruption.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 535515Interferon lambda receptor 1PRO_0000011020Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi73 ↔ 81By similarity
    Disulfide bondi85 ↔ 149By similarity
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi194 ↔ 216By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8CGK5.
    PRIDEiQ8CGK5.

    PTM databases

    PhosphoSiteiQ8CGK5.

    Expressioni

    Gene expression databases

    BgeeiQ8CGK5.
    CleanExiMM_IL28RA.
    GenevestigatoriQ8CGK5.

    Interactioni

    Subunit structurei

    Heterodimer with IL10RB.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000074009.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CGK5.
    SMRiQ8CGK5. Positions 24-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 227207ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini249 – 535287CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 12196Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the type II cytokine receptor family.Curated
    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46166.
    GeneTreeiENSGT00510000048978.
    HOGENOMiHOG000112989.
    HOVERGENiHBG052069.
    InParanoidiQ8CGK5.
    KOiK05140.
    OMAiPWFQRAK.
    OrthoDBiEOG78H3T9.
    PhylomeDBiQ8CGK5.
    TreeFamiTF336003.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF01108. Tissue_fac. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CGK5-1 [UniParc]FASTAAdd to Basket

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    MWRADRWAPL LLFLLQSALG RPRLAPPRNV TLFSQNFTVY LTWLPGLGSP    50
    PNVTYFVTYQ SYIKTGWRPV EHCAGIKALV CPLMCLKKLN LYSKFKGRVQ 100
    AASAHGRSPR VESRYLEYLF DVELAPPTLV LTQMEKILRV NATYQLPPCM 150
    PSLELKYQVE FWKEGLGSKT LFPDTPYGQP VQIPLQQGAS RRHCLSARTV 200
    YTLIDIKYSQ FSEPSCIFLE APGDKRAVLA MPSLLLLLIA AVAAGVAWKI 250
    MKGNPWFQGV KTPRALDFSE YRYPVATFQP SGPEFSDDLI LCPQKELTIR 300
    NRPAPQVRNP ATLQAGPERD STEDEDEDTD YDDDGDSVQP YLERPLFISE 350
    KPRVMEHSET DESGVDSGGP WTSPVGSDGS SAWDSSDRSW SSTGDSSYKD 400
    EVGSSSCLDR KEPDQAPCGD WLQEALPCLE FSEDLGTVEE PLKDGLSGWR 450
    ISGSLSSKRD LAPVEPPVSL QTLTFCWVNN PEGEEEQEDE EEEEEEEEEE 500
    DWESEPKGSN AGCWGTSSVQ RTEVRGRMLG DYLVR 535
    Length:535
    Mass (Da):59,976
    Last modified:March 1, 2003 - v1
    Checksum:i32D12FA52B0BA17E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti105 – 1051H → Q in AAH57856. (PubMed:15489334)Curated
    Sequence conflicti231 – 2311M → L in AAH57856. (PubMed:15489334)Curated
    Sequence conflicti327 – 3271E → G in AAH57856. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY184376 mRNA. Translation: AAN86129.1.
    BC057856 mRNA. Translation: AAH57856.1.
    CCDSiCCDS18788.1.
    RefSeqiNP_777276.3. NM_174851.3.
    UniGeneiMm.259623.

    Genome annotation databases

    EnsembliENSMUST00000074408; ENSMUSP00000074009; ENSMUSG00000062157.
    GeneIDi242700.
    KEGGimmu:242700.
    UCSCiuc008vgw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY184376 mRNA. Translation: AAN86129.1 .
    BC057856 mRNA. Translation: AAH57856.1 .
    CCDSi CCDS18788.1.
    RefSeqi NP_777276.3. NM_174851.3.
    UniGenei Mm.259623.

    3D structure databases

    ProteinModelPortali Q8CGK5.
    SMRi Q8CGK5. Positions 24-222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000074009.

    PTM databases

    PhosphoSitei Q8CGK5.

    Proteomic databases

    PaxDbi Q8CGK5.
    PRIDEi Q8CGK5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074408 ; ENSMUSP00000074009 ; ENSMUSG00000062157 .
    GeneIDi 242700.
    KEGGi mmu:242700.
    UCSCi uc008vgw.2. mouse.

    Organism-specific databases

    CTDi 163702.
    MGIi MGI:2429859. Ifnlr1.

    Phylogenomic databases

    eggNOGi NOG46166.
    GeneTreei ENSGT00510000048978.
    HOGENOMi HOG000112989.
    HOVERGENi HBG052069.
    InParanoidi Q8CGK5.
    KOi K05140.
    OMAi PWFQRAK.
    OrthoDBi EOG78H3T9.
    PhylomeDBi Q8CGK5.
    TreeFami TF336003.

    Miscellaneous databases

    NextBioi 385500.
    PROi Q8CGK5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CGK5.
    CleanExi MM_IL28RA.
    Genevestigatori Q8CGK5.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF01108. Tissue_fac. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
      Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.
      Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.
    3. "An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity."
      Ank N., Iversen M.B., Bartholdy C., Staeheli P., Hartmann R., Jensen U.B., Dagnaes-Hansen F., Thomsen A.R., Chen Z., Haugen H., Klucher K., Paludan S.R.
      J. Immunol. 180:2474-2485(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    4. Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiINLR1_MOUSE
    AccessioniPrimary (citable) accession number: Q8CGK5
    Secondary accession number(s): Q6PEV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3