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Protein

Interferon lambda receptor 1

Gene

Ifnlr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.2 Publications

GO - Molecular functioni

  1. cytokine receptor activity Source: MGI

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: GO_Central
  2. defense response to virus Source: UniProtKB
  3. mucosal immune response Source: UniProtKB
  4. regulation of defense response to virus by host Source: MGI
  5. response to type III interferon Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon lambda receptor 1
Short name:
IFN-lambda R1
Alternative name(s):
Cytokine receptor class-II member 12
Cytokine receptor family 2 member 12
Short name:
CRF2-12
Interleukin-28 receptor subunit alpha
Short name:
IL-28 receptor subunit alpha
Short name:
IL-28R-alpha
Short name:
IL-28RA
Gene namesi
Name:Ifnlr1
Synonyms:Il28ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2429859. Ifnlr1.

Subcellular locationi

  1. Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 227207ExtracellularSequence AnalysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence AnalysisAdd
BLAST
Topological domaini249 – 535287CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. interleukin-28 receptor complex Source: MGI
  3. plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

The mice are viable and appear to be of normal size, behavior and reproductive ability. There is no effect on the ability to combat vaginal viral infection, but antiviral response evoked by Toll-like reseptor (TLR) stimulation is reduced. Mice also display enhanced rotavirus susceptibility associated with epithelial vacuolization, villus deformation and epithelial cell disruption.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 535515Interferon lambda receptor 1PRO_0000011020Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi73 ↔ 81By similarity
Disulfide bondi85 ↔ 149By similarity
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi194 ↔ 216By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8CGK5.
PRIDEiQ8CGK5.

PTM databases

PhosphoSiteiQ8CGK5.

Expressioni

Gene expression databases

BgeeiQ8CGK5.
CleanExiMM_IL28RA.
ExpressionAtlasiQ8CGK5. baseline and differential.
GenevestigatoriQ8CGK5.

Interactioni

Subunit structurei

Heterodimer with IL10RB.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074009.

Structurei

3D structure databases

ProteinModelPortaliQ8CGK5.
SMRiQ8CGK5. Positions 24-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 12196Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46166.
GeneTreeiENSGT00510000048978.
HOGENOMiHOG000112989.
HOVERGENiHBG052069.
InParanoidiQ8CGK5.
KOiK05140.
OMAiPWFQRAK.
OrthoDBiEOG78H3T9.
PhylomeDBiQ8CGK5.
TreeFamiTF336003.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF01108. Tissue_fac. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CGK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRADRWAPL LLFLLQSALG RPRLAPPRNV TLFSQNFTVY LTWLPGLGSP
60 70 80 90 100
PNVTYFVTYQ SYIKTGWRPV EHCAGIKALV CPLMCLKKLN LYSKFKGRVQ
110 120 130 140 150
AASAHGRSPR VESRYLEYLF DVELAPPTLV LTQMEKILRV NATYQLPPCM
160 170 180 190 200
PSLELKYQVE FWKEGLGSKT LFPDTPYGQP VQIPLQQGAS RRHCLSARTV
210 220 230 240 250
YTLIDIKYSQ FSEPSCIFLE APGDKRAVLA MPSLLLLLIA AVAAGVAWKI
260 270 280 290 300
MKGNPWFQGV KTPRALDFSE YRYPVATFQP SGPEFSDDLI LCPQKELTIR
310 320 330 340 350
NRPAPQVRNP ATLQAGPERD STEDEDEDTD YDDDGDSVQP YLERPLFISE
360 370 380 390 400
KPRVMEHSET DESGVDSGGP WTSPVGSDGS SAWDSSDRSW SSTGDSSYKD
410 420 430 440 450
EVGSSSCLDR KEPDQAPCGD WLQEALPCLE FSEDLGTVEE PLKDGLSGWR
460 470 480 490 500
ISGSLSSKRD LAPVEPPVSL QTLTFCWVNN PEGEEEQEDE EEEEEEEEEE
510 520 530
DWESEPKGSN AGCWGTSSVQ RTEVRGRMLG DYLVR
Length:535
Mass (Da):59,976
Last modified:March 1, 2003 - v1
Checksum:i32D12FA52B0BA17E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051H → Q in AAH57856 (PubMed:15489334).Curated
Sequence conflicti231 – 2311M → L in AAH57856 (PubMed:15489334).Curated
Sequence conflicti327 – 3271E → G in AAH57856 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184376 mRNA. Translation: AAN86129.1.
BC057856 mRNA. Translation: AAH57856.1.
CCDSiCCDS18788.1.
RefSeqiNP_777276.3. NM_174851.3.
UniGeneiMm.259623.

Genome annotation databases

EnsembliENSMUST00000074408; ENSMUSP00000074009; ENSMUSG00000062157.
GeneIDi242700.
KEGGimmu:242700.
UCSCiuc008vgw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY184376 mRNA. Translation: AAN86129.1.
BC057856 mRNA. Translation: AAH57856.1.
CCDSiCCDS18788.1.
RefSeqiNP_777276.3. NM_174851.3.
UniGeneiMm.259623.

3D structure databases

ProteinModelPortaliQ8CGK5.
SMRiQ8CGK5. Positions 24-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074009.

PTM databases

PhosphoSiteiQ8CGK5.

Proteomic databases

PaxDbiQ8CGK5.
PRIDEiQ8CGK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074408; ENSMUSP00000074009; ENSMUSG00000062157.
GeneIDi242700.
KEGGimmu:242700.
UCSCiuc008vgw.2. mouse.

Organism-specific databases

CTDi163702.
MGIiMGI:2429859. Ifnlr1.

Phylogenomic databases

eggNOGiNOG46166.
GeneTreeiENSGT00510000048978.
HOGENOMiHOG000112989.
HOVERGENiHBG052069.
InParanoidiQ8CGK5.
KOiK05140.
OMAiPWFQRAK.
OrthoDBiEOG78H3T9.
PhylomeDBiQ8CGK5.
TreeFamiTF336003.

Miscellaneous databases

NextBioi385500.
PROiQ8CGK5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CGK5.
CleanExiMM_IL28RA.
ExpressionAtlasiQ8CGK5. baseline and differential.
GenevestigatoriQ8CGK5.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF01108. Tissue_fac. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
    Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.
    Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.
  3. "An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity."
    Ank N., Iversen M.B., Bartholdy C., Staeheli P., Hartmann R., Jensen U.B., Dagnaes-Hansen F., Thomsen A.R., Chen Z., Haugen H., Klucher K., Paludan S.R.
    J. Immunol. 180:2474-2485(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiINLR1_MOUSE
AccessioniPrimary (citable) accession number: Q8CGK5
Secondary accession number(s): Q6PEV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.