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Protein

Transcription elongation regulator 1

Gene

Tcerg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation regulator 1
Alternative name(s):
Formin-binding protein 28
Short name:
FBP 28
TATA box-binding protein-associated factor 2S
Transcription factor CA150
p144
Gene namesi
Name:Tcerg1
Synonyms:Taf2s
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1926421. Tcerg1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11001100Transcription elongation regulator 1PRO_0000076064Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki505 – 505Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8CGF7.
MaxQBiQ8CGF7.
PaxDbiQ8CGF7.
PRIDEiQ8CGF7.

PTM databases

iPTMnetiQ8CGF7.
PhosphoSiteiQ8CGF7.

Expressioni

Gene expression databases

BgeeiQ8CGF7.
CleanExiMM_TCERG1.
ExpressionAtlasiQ8CGF7. baseline and differential.
GenevisibleiQ8CGF7. MM.

Interactioni

Subunit structurei

Binds RNA polymerase II, HD and SF1 (By similarity). Binds formin. Interacts (via the second WW domain) with TREX1 (via proline-rich region).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207801. 5 interactions.
IntActiQ8CGF7. 2 interactions.
MINTiMINT-1867177.
STRINGi10090.ENSMUSP00000025375.

Structurei

Secondary structure

1
1100
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi136 – 1416Combined sources
Beta strandi147 – 1515Combined sources
Turni152 – 1543Combined sources
Beta strandi157 – 1604Combined sources
Beta strandi432 – 4343Combined sources
Beta strandi438 – 4414Combined sources
Turni443 – 4453Combined sources
Beta strandi447 – 4515Combined sources
Turni452 – 4554Combined sources
Beta strandi456 – 4605Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E0LNMR-A430-466[»]
2JUPNMR-W430-466[»]
2RLYNMR-W430-466[»]
2RM0NMR-W430-466[»]
2YSINMR-A133-165[»]
ProteinModelPortaliQ8CGF7.
SMRiQ8CGF7. Positions 126-165, 430-466, 519-581, 652-855, 897-1082.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8CGF7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 16434WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini431 – 46434WW 2PROSITE-ProRule annotationAdd
BLAST
Domaini530 – 56334WW 3PROSITE-ProRule annotationAdd
BLAST
Domaini661 – 71454FF 1Add
BLAST
Domaini727 – 78155FF 2Add
BLAST
Domaini793 – 84856FF 3Add
BLAST
Domaini898 – 95457FF 4Add
BLAST
Domaini956 – 101257FF 5Add
BLAST
Domaini1014 – 107966FF 6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili184 – 25471Sequence analysisAdd
BLAST
Coiled coili607 – 65751Sequence analysisAdd
BLAST
Coiled coili846 – 90863Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi628 – 6325Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 132101Pro-richAdd
BLAST
Compositional biasi169 – 25789Ala/Gln-richAdd
BLAST
Compositional biasi262 – 32867Thr-richAdd
BLAST
Compositional biasi324 – 39168Pro-richAdd
BLAST
Compositional biasi456 – 51762Glu-richAdd
BLAST
Compositional biasi1085 – 10895Poly-Pro

Domaini

The FF domains preferentially binds peptides with the consensus sequence [DE](2-5)-[FWY]-[DE]2-5 and mediate interaction with HTATSF1 and probably bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II.1 Publication
The WW domains bind Pro-rich domains.1 Publication

Sequence similaritiesi

Contains 6 FF domains.Curated
Contains 3 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0155. Eukaryota.
ENOG410XPZW. LUCA.
GeneTreeiENSGT00820000127014.
HOGENOMiHOG000008544.
HOVERGENiHBG062908.
InParanoidiQ8CGF7.
KOiK12824.
OMAiNPRTTFS.
OrthoDBiEOG7DC24V.
PhylomeDBiQ8CGF7.
TreeFamiTF317748.

Family and domain databases

Gene3Di1.10.10.440. 5 hits.
InterProiIPR002713. FF_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF01846. FF. 6 hits.
PF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00441. FF. 6 hits.
SM00456. WW. 3 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 3 hits.
SSF81698. SSF81698. 5 hits.
PROSITEiPS51676. FF. 6 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CGF7-1) [UniParc]FASTAAdd to basket

Also known as: CA150a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAERGGDGGE GERFNPGELR MAQQQALRFR GPAPPPNAVM RGPPPLMRPP
60 70 80 90 100
PPFGMMRGPP PPPRPPFGRP PFDPNMPPMP PPGGIPPPMG PPHLQRPPFM
110 120 130 140 150
PPPMGAMPPP PGMMFPPGMP PGTAPGAPAL PPTEEIWVEN KTPDGKVYYY
160 170 180 190 200
NARTRESAWT KPDGVKVIQQ SELTPMLAAQ AQVQAQAQAQ AQAQAQAQAQ
210 220 230 240 250
AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ AQAQAQAQAQ
260 270 280 290 300
AQVQAQAVGA PTPTTSSPAP AVSTSTPTST PSSTTATTTT ATSVAQTVST
310 320 330 340 350
PTTQDQTPSS AVSVATPTVS VSAPAPTATP VQTVPQPHPQ TLPPAVPHSV
360 370 380 390 400
PQPAAAIPAF PPVMVPPFRV PLPGMPIPLP GVAMMQIVSC PYVKTVATTK
410 420 430 440 450
TGVLPGMAPP IVPMIHPQVA IAASPATLAG ATAVSEWTEY KTADGKTYYY
460 470 480 490 500
NNRTLESTWE KPQELKEKEK LDEKIKEPIK EASEEPLPME TEEEDPKEEP
510 520 530 540 550
VKEIKEEPKE EEMTEEEKAA QKAKPVATTP IPGTPWCVVW TGDERVFFYN
560 570 580 590 600
PTTRLSMWDR PDDLIGRADV DKIIQEPPHK KGLEDMKKLR HPAPTMLSIQ
610 620 630 640 650
KWQFSMSAIK EEQELMEEMN EDEPIKAKKR KRDDNKDIDS EKEAAMEAEI
660 670 680 690 700
KAARERAIVP LEARMKQFKD MLLERGVSAF STWEKELHKI VFDPRYLLLN
710 720 730 740 750
PKERKQVFDQ YVKTRAEEER REKKNKIMQA KEDFKKMMEE AKFNPRATFS
760 770 780 790 800
EFAAKHAKDS RFKAIEKMKD REALFNEFVA AARKKEKEDS KTRGEKIKSD
810 820 830 840 850
FFELLSNHHL DSQSRWSKVK DKVESDPRYK AVDSSSMRED LFKQYIEKIA
860 870 880 890 900
KNLDSEKEKE LERQARIEAS LREREREVQK ARSEQTKEID REREQHKREE
910 920 930 940 950
AIQNFKALLS DMVRSSDVSW SDTRRTLRKD HRWESGSLLE REEKEKLFNE
960 970 980 990 1000
HIEALTKKKR EHFRQLLDET SAITLTSTWK EVKKIIKEDP RCIKFSSSDR
1010 1020 1030 1040 1050
KKQREFEEYI RDKYITAKAD FRTLLKETKF ITYRSKKLIQ ESDQHLKDVE
1060 1070 1080 1090 1100
KILQNDKRYL VLDCVPEERR KLIVAYVDDL DRRGPPPPPT ASEPTRRSTK
Length:1,100
Mass (Da):123,788
Last modified:September 27, 2004 - v2
Checksum:i54E73FD2381CA38B
GO
Isoform 2 (identifier: Q8CGF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-401: Missing.

Show »
Length:1,079
Mass (Da):121,577
Checksum:iF919AFEFAE3CAE3B
GO
Isoform 3 (identifier: Q8CGF7-3) [UniParc]FASTAAdd to basket

Also known as: CA150b

The sequence of this isoform differs from the canonical sequence as follows:
     1034-1034: R → S
     1035-1100: Missing.

Show »
Length:1,034
Mass (Da):116,054
Checksum:i464F8E1F0FB2E9C7
GO

Sequence cautioni

The sequence AAH39185.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41R → H in BAA86392 (PubMed:10578054).Curated
Sequence conflicti30 – 301R → G in BAA86392 (PubMed:10578054).Curated
Sequence conflicti48 – 481R → I in AAH39185 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti184 – 1852Missing .1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei381 – 40121Missing in isoform 2. 1 PublicationVSP_011655Add
BLAST
Alternative sequencei1034 – 10341R → S in isoform 3. 1 PublicationVSP_011656
Alternative sequencei1035 – 110066Missing in isoform 3. 1 PublicationVSP_011657Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC039185 mRNA. Translation: AAH39185.1. Different initiation.
BC040284 mRNA. Translation: AAH40284.1.
AB023485 mRNA. Translation: BAA86392.1.
U40749 mRNA. Translation: AAC52477.1.
AK082750 mRNA. Translation: BAC38600.1.
CCDSiCCDS29214.1. [Q8CGF7-1]
PIRiS64716.
RefSeqiNP_001034563.1. NM_001039474.1. [Q8CGF7-1]
NP_001276455.1. NM_001289526.1.
XP_006526178.1. XM_006526115.2. [Q8CGF7-2]
UniGeneiMm.270511.

Genome annotation databases

EnsembliENSMUST00000025375; ENSMUSP00000025375; ENSMUSG00000024498. [Q8CGF7-1]
ENSMUST00000173642; ENSMUSP00000134458; ENSMUSG00000024498. [Q8CGF7-3]
GeneIDi56070.
KEGGimmu:56070.
UCSCiuc008etw.2. mouse. [Q8CGF7-2]
uc008etx.1. mouse. [Q8CGF7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC039185 mRNA. Translation: AAH39185.1. Different initiation.
BC040284 mRNA. Translation: AAH40284.1.
AB023485 mRNA. Translation: BAA86392.1.
U40749 mRNA. Translation: AAC52477.1.
AK082750 mRNA. Translation: BAC38600.1.
CCDSiCCDS29214.1. [Q8CGF7-1]
PIRiS64716.
RefSeqiNP_001034563.1. NM_001039474.1. [Q8CGF7-1]
NP_001276455.1. NM_001289526.1.
XP_006526178.1. XM_006526115.2. [Q8CGF7-2]
UniGeneiMm.270511.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E0LNMR-A430-466[»]
2JUPNMR-W430-466[»]
2RLYNMR-W430-466[»]
2RM0NMR-W430-466[»]
2YSINMR-A133-165[»]
ProteinModelPortaliQ8CGF7.
SMRiQ8CGF7. Positions 126-165, 430-466, 519-581, 652-855, 897-1082.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207801. 5 interactions.
IntActiQ8CGF7. 2 interactions.
MINTiMINT-1867177.
STRINGi10090.ENSMUSP00000025375.

PTM databases

iPTMnetiQ8CGF7.
PhosphoSiteiQ8CGF7.

Proteomic databases

EPDiQ8CGF7.
MaxQBiQ8CGF7.
PaxDbiQ8CGF7.
PRIDEiQ8CGF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025375; ENSMUSP00000025375; ENSMUSG00000024498. [Q8CGF7-1]
ENSMUST00000173642; ENSMUSP00000134458; ENSMUSG00000024498. [Q8CGF7-3]
GeneIDi56070.
KEGGimmu:56070.
UCSCiuc008etw.2. mouse. [Q8CGF7-2]
uc008etx.1. mouse. [Q8CGF7-1]

Organism-specific databases

CTDi10915.
MGIiMGI:1926421. Tcerg1.

Phylogenomic databases

eggNOGiKOG0155. Eukaryota.
ENOG410XPZW. LUCA.
GeneTreeiENSGT00820000127014.
HOGENOMiHOG000008544.
HOVERGENiHBG062908.
InParanoidiQ8CGF7.
KOiK12824.
OMAiNPRTTFS.
OrthoDBiEOG7DC24V.
PhylomeDBiQ8CGF7.
TreeFamiTF317748.

Miscellaneous databases

EvolutionaryTraceiQ8CGF7.
PROiQ8CGF7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CGF7.
CleanExiMM_TCERG1.
ExpressionAtlasiQ8CGF7. baseline and differential.
GenevisibleiQ8CGF7. MM.

Family and domain databases

Gene3Di1.10.10.440. 5 hits.
InterProiIPR002713. FF_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF01846. FF. 6 hits.
PF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00441. FF. 6 hits.
SM00456. WW. 3 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 3 hits.
SSF81698. SSF81698. 5 hits.
PROSITEiPS51676. FF. 6 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and splicing isoforms of mouse p144, a homologue of CA150."
    Simada M., Saito M., Katakai T., Shimizu A., Ichimura T., Omata S., Horigome T.
    J. Biochem. 126:1033-1042(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), ALTERNATIVE SPLICING.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT 184-GLN-ALA-185 DEL.
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains."
    Chan D.C., Bedford M.T., Leder P.
    EMBO J. 15:1045-1054(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 437-462, INTERACTION WITH FORMIN.
    Strain: FVB/NJ.
    Tissue: Embryo.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 827-1100 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell.
  5. "FF domains of CA150 bind transcription and splicing factors through multiple weak interactions."
    Smith M.J., Kulkarni S., Pawson T.
    Mol. Cell. Biol. 24:9274-9285(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTATSF1, DOMAIN.
  6. "Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains."
    Brucet M., Querol-Audi J., Serra M., Ramirez-Espain X., Bertlik K., Ruiz L., Lloberas J., Macias M.J., Fita I., Celada A.
    J. Biol. Chem. 282:14547-14557(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TREX1.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  8. "Structural analysis of WW domains and design of a WW prototype."
    Macias M.J., Gervais V., Civera C., Oschkinat H.
    Nat. Struct. Biol. 7:375-379(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 437-462.

Entry informationi

Entry nameiTCRG1_MOUSE
AccessioniPrimary (citable) accession number: Q8CGF7
Secondary accession number(s): Q61051
, Q8C490, Q8CHT8, Q9R0R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: June 8, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.