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Protein

WD repeat-containing protein 47

Gene

Wdr47

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 47
Alternative name(s):
Neuronal enriched MAP interacting protein
Short name:
Nemitin
Gene namesi
Name:Wdr47
Synonyms:Kiaa0893
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2139593. Wdr47.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 920920WD repeat-containing protein 47PRO_0000051398Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei285 – 2851PhosphothreonineCombined sources
Modified residuei289 – 2891PhosphoserineCombined sources
Modified residuei292 – 2921PhosphoserineCombined sources
Modified residuei297 – 2971PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CGF6.
MaxQBiQ8CGF6.
PaxDbiQ8CGF6.
PRIDEiQ8CGF6.

PTM databases

iPTMnetiQ8CGF6.
PhosphoSiteiQ8CGF6.

Expressioni

Tissue specificityi

Enriched in the nervous system (at protein level).1 Publication

Developmental stagei

First detected in whole embryos at E11, strong and increasing protein levels are observed in the brain from E14 to early postnatal development. Expression continues into adulthood, though at a substantially decreased level.1 Publication

Gene expression databases

BgeeiQ8CGF6.
CleanExiMM_WDR47.
ExpressionAtlasiQ8CGF6. baseline and differential.
GenevisibleiQ8CGF6. MM.

Interactioni

Subunit structurei

Interacts with MAP1S (via WD repeats).1 Publication

Protein-protein interaction databases

DIPiDIP-58945N.
IntActiQ8CGF6. 1 interaction.
MINTiMINT-4140349.
STRINGi10090.ENSMUSP00000057482.

Structurei

3D structure databases

ProteinModelPortaliQ8CGF6.
SMRiQ8CGF6. Positions 11-233, 602-920.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 4233LisHPROSITE-ProRule annotationAdd
BLAST
Domaini45 – 10258CTLHPROSITE-ProRule annotationAdd
BLAST
Repeati605 – 64440WD 1Add
BLAST
Repeati660 – 69940WD 2Add
BLAST
Repeati707 – 74943WD 3Add
BLAST
Repeati754 – 79239WD 4Add
BLAST
Repeati799 – 83840WD 5Add
BLAST
Repeati841 – 88040WD 6Add
BLAST
Repeati887 – 91933WD 7Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi426 – 47550Gln-richAdd
BLAST

Sequence similaritiesi

Contains 1 CTLH domain.PROSITE-ProRule annotation
Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0641. Eukaryota.
ENOG410YF9K. LUCA.
GeneTreeiENSGT00760000119239.
HOGENOMiHOG000231412.
HOVERGENiHBG058798.
InParanoidiQ8CGF6.
OMAiIDPSAHD.
OrthoDBiEOG7F24T0.
TreeFamiTF312810.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR006595. CTLH_C.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CGF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAEETVNVK EVEIIKLILD FLNSKKLHIS MLALEKESGV INGLFSDDML
60 70 80 90 100
FLRQLILDGQ WDEVLQFIQP LECMEKFDKK RFRYIILKQK FLEALCVNNA
110 120 130 140 150
MSAEDEPQHL EFTMQEAVQC LHALEEYCPS KDDYSKLCLL LTLPRLTNHA
160 170 180 190 200
EFKDWNPSTA RVHCFEEVCV MVAEFIPADR KLSEAGFKAS NNRLFQLVMK
210 220 230 240 250
GLLYECCVEF CQSKATGEEI TESEVLLGID LLCGNGCDDL DLSLLSWLQN
260 270 280 290 300
LPSSVFSCAF EQKMLNIHVD KLLKPTKAAY ADLLTPLISK LSPYPSSPMR
310 320 330 340 350
RPQSADAYMT RSLNPALDGL TCGLTSHDKR ISDLGNKTSP MSHSFANFHY
360 370 380 390 400
PGVQNLSRSL MLENTECHSI YEESPERSDT PVEAQQPVSS EAMCQGSGLE
410 420 430 440 450
KEPANGAQNP VPAKQEKNEL RDSTEQFQEY YRQRLRYQQH LEQKEQQRQM
460 470 480 490 500
YQQMLLEGGV NQEDGPDQQQ NLTEQFLNRS IQKLGELNIG MDSLGNEVPV
510 520 530 540 550
LNQQCSGSKN NGSNNSSVTS FSTPPQDSSQ RLIHDTANIH TSTPRNPGST
560 570 580 590 600
NHIPFHEDSP CGSQNSSEHS VIKPSPGDSS GNLSRSKGEE DDKSKKQFVC
610 620 630 640 650
INTLEDTQAV RAVAFHPSGS LYAVGSNSKT LRVCAYPEKM DASAHDNPKQ
660 670 680 690 700
PVVRFKRNKH HKGSIYCVAW SPCGQLLATG SNDKYVKVLP FNAETCNATG
710 720 730 740 750
PDLEFSMHDG TIRDLAFMEG PESGGAILIS AGAGDCNIYT TDCQRGQGLH
760 770 780 790 800
ALSGHTGHIL ALYTWSGWMI ASGSQDKTVR FWDLRVPSCV RVVGTTFHGT
810 820 830 840 850
GSAVASVAVD PSGRLLATGQ EDSSCMLYDI RGGRMVQSYH PHSSDVRSVR
860 870 880 890 900
FSPGAHYLLT GSYDMKIKVT DLQGDLTKQL PLMVVGEHKD KVIQCRWHTQ
910 920
DLSFLSSSAD RTVTLWTYSG
Length:920
Mass (Da):102,312
Last modified:July 27, 2011 - v2
Checksum:i401F22FFC00951AA
GO

Sequence cautioni

The sequence BAC65679.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti450 – 4501M → I in AAH40337 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122397 mRNA. Translation: BAC65679.1. Different initiation.
AL683823 Genomic DNA. Translation: CAM14496.1.
CH466607 Genomic DNA. Translation: EDL01977.1.
BC040337 mRNA. Translation: AAH40337.1.
CCDSiCCDS17765.1.
RefSeqiNP_852065.2. NM_181400.3.
UniGeneiMm.285968.

Genome annotation databases

EnsembliENSMUST00000051145; ENSMUSP00000057482; ENSMUSG00000040389.
GeneIDi99512.
KEGGimmu:99512.
UCSCiuc008qzj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122397 mRNA. Translation: BAC65679.1. Different initiation.
AL683823 Genomic DNA. Translation: CAM14496.1.
CH466607 Genomic DNA. Translation: EDL01977.1.
BC040337 mRNA. Translation: AAH40337.1.
CCDSiCCDS17765.1.
RefSeqiNP_852065.2. NM_181400.3.
UniGeneiMm.285968.

3D structure databases

ProteinModelPortaliQ8CGF6.
SMRiQ8CGF6. Positions 11-233, 602-920.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-58945N.
IntActiQ8CGF6. 1 interaction.
MINTiMINT-4140349.
STRINGi10090.ENSMUSP00000057482.

PTM databases

iPTMnetiQ8CGF6.
PhosphoSiteiQ8CGF6.

Proteomic databases

EPDiQ8CGF6.
MaxQBiQ8CGF6.
PaxDbiQ8CGF6.
PRIDEiQ8CGF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051145; ENSMUSP00000057482; ENSMUSG00000040389.
GeneIDi99512.
KEGGimmu:99512.
UCSCiuc008qzj.2. mouse.

Organism-specific databases

CTDi22911.
MGIiMGI:2139593. Wdr47.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0641. Eukaryota.
ENOG410YF9K. LUCA.
GeneTreeiENSGT00760000119239.
HOGENOMiHOG000231412.
HOVERGENiHBG058798.
InParanoidiQ8CGF6.
OMAiIDPSAHD.
OrthoDBiEOG7F24T0.
TreeFamiTF312810.

Miscellaneous databases

PROiQ8CGF6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CGF6.
CleanExiMM_WDR47.
ExpressionAtlasiQ8CGF6. baseline and differential.
GenevisibleiQ8CGF6. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR006595. CTLH_C.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-285; SER-289 AND SER-292, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.
  6. Cited for: INTERACTION WITH MAP1S, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiWDR47_MOUSE
AccessioniPrimary (citable) accession number: Q8CGF6
Secondary accession number(s): A2AGC7, Q80TP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.