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Protein

Regulator of G-protein signaling 12

Gene

Rgs12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 12
Short name:
RGS12
Gene namesi
Name:Rgs12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1918979 Rgs12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Nucleus, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004084741 – 1381Regulator of G-protein signaling 12Add BLAST1381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Cross-linki195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei524Omega-N-methylarginineBy similarity1
Modified residuei633Omega-N-methylarginineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Modified residuei850PhosphoserineCombined sources1
Modified residuei879PhosphoserineCombined sources1
Modified residuei943PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8CGE9
MaxQBiQ8CGE9
PaxDbiQ8CGE9
PRIDEiQ8CGE9

PTM databases

iPTMnetiQ8CGE9
PhosphoSitePlusiQ8CGE9

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Developmental stagei

Expressed in germinal vesicle oocyte, metaphase II oocyte and blastocyst (at protein level). Expressed in oocyte.1 Publication

Gene expression databases

BgeeiENSMUSG00000029101
ExpressionAtlasiQ8CGE9 baseline and differential
GenevisibleiQ8CGE9 MM

Interactioni

Subunit structurei

Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ8CGE9, 7 interactors
MINTiQ8CGE9
STRINGi10090.ENSMUSP00000030984

Structurei

3D structure databases

ProteinModelPortaliQ8CGE9
SMRiQ8CGE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 98PDZPROSITE-ProRule annotationAdd BLAST78
Domaini223 – 390PIDPROSITE-ProRule annotationAdd BLAST168
Domaini715 – 832RGSPROSITE-ProRule annotationAdd BLAST118
Domaini962 – 1032RBD 1PROSITE-ProRule annotationAdd BLAST71
Domaini1034 – 1104RBD 2PROSITE-ProRule annotationAdd BLAST71
Domaini1187 – 1209GoLocoPROSITE-ProRule annotationAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1362 – 1367Poly-Pro6

Domaini

The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000049112
HOVERGENiHBG063299
InParanoidiQ8CGE9
KOiK16449
TreeFamiTF328814

Family and domain databases

CDDicd08742 RGS_RGS12, 1 hit
Gene3Di1.10.196.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR037880 RGS12_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF02188 GoLoco, 1 hit
PF00595 PDZ, 1 hit
PF02196 RBD, 2 hits
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS01179 PID, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CGE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRAGEPGKR QPGPAPPRVR SVEVARGRAG YGFTLSGQAP CVLSCVMRGS
60 70 80 90 100
PADFVGLRAG DQILAINEIN VKKASHEDVV KLIGKCSGVL HMVIAEGTSH
110 120 130 140 150
VESCSSDEEG GLYEGKGWLR PKLDSKALGI NRAERVVEEV QSGGIFNMIF
160 170 180 190 200
ESSSLCASGP EPLKLKQRSL SESAALRLDA GQAGLCAPHP SMLSKEDISK
210 220 230 240 250
VINDDSVFTV GLDSHDDFGL DASILNVAMV VGYLGSIELP STSSNLEHDS
260 270 280 290 300
LQAIRGCMRR LRAEQKIHSL VTMKVMHDCV QLVTDRAGVV AEYPAEKLAF
310 320 330 340 350
SAVCPDDRRF FGLVTMQTND DGGLAQEDEG ALRTSCHVFM VDPDLFHHKI
360 370 380 390 400
HQGIARRFGF ACTADPDTSG CLEFPASSLP VLQFISVLYR DMGELIEGVR
410 420 430 440 450
ARAFLDGDAD AHQNNSTSSN SDSGIGNFNQ EEKSNRVLVV DLGGGSSRHG
460 470 480 490 500
QGSSPGWESG GGRGSQPWSA PWNGAFCHDS EAGSPLETSP NTDRFWDLTK
510 520 530 540 550
HSGPVSHMEV PPATLRSSIP PSKRGAAGSS CGFNQRWLPV HVLQEWQCGH
560 570 580 590 600
ASDQESYTDS TDGWSSVNCG TLPPPMSKIP ADRYRVEGSF AQAPLSTQKR
610 620 630 640 650
DWSRKAFGMQ NLFGPHRNVR KTKEDKKSSK LGRGVALAQT SQRTSARRSF
660 670 680 690 700
GRSRRFSITR SLDDLESATV SDGELTGADL KDCISNNSLS SNASLPSVQS
710 720 730 740 750
CRRLRERRVA SWAVSFERLL QDPVGVRYFS DFLRKEFSEE NILFWQACEC
760 770 780 790 800
FSHVPAHDKK ELSYRAREIF SKFLCSKATT PVNIDSQAQL ADDILNAPHP
810 820 830 840 850
DMFKEQQLQI FNLMKFDSYT RFLKSQLYQE CVLAEVEGRT LPDSQQVPSS
860 870 880 890 900
PASKHSISSD HSNVSTPKKL SGKSKSGRSL NEDVGEEDSE KKRRGAFFSW
910 920 930 940 950
SRSRSTGRSQ KKKDHGDHAH DAPHANGGLC RRESQGSVSS AGSLDLSEAC
960 970 980 990 1000
RTSALEKDKA AKHCCVHLPD GTSCVVAVKS GFSIKEILSG LCERHGINGA
1010 1020 1030 1040 1050
AVDLFLVGGD KPLVLHQDSS ILATRDLRLE KRTLFRLDLV PINRSVGLKA
1060 1070 1080 1090 1100
KPTKPVTEVL RPVVAKYGLD LGSLLVRLSG EKEPLDLGAP ISSLDGQRVI
1110 1120 1130 1140 1150
LEERDPSRGK VSTDKQKGAP VKQNSAVNSS PRNHLAMGEE RTLGKSNSIK
1160 1170 1180 1190 1200
IRGENGKSAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN
1210 1220 1230 1240 1250
RADDQRGLLR KEDLVLPEFL RLPAGSSELA LSSPPPVKGY SKRAVTGHGQ
1260 1270 1280 1290 1300
EGAAQTEESY SDSPATSPAS AQSPCSAYSP GSAHSPGSAH STPGPPGTTQ
1310 1320 1330 1340 1350
PGEKPTKPSC VSMVQEGTTQ AWRRLSPEME AGGIQTVEDE QVADLTLMGE
1360 1370 1380
GDISSPNSTL LPPPPTPQDT PGPPRPGTSR F
Length:1,381
Mass (Da):149,637
Last modified:July 27, 2011 - v2
Checksum:i8897CD1D249B66C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti536R → K in AAH40396 (PubMed:15489334).Curated1
Sequence conflicti1135L → S in AAH40396 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126447 Genomic DNA No translation available.
AC133204 Genomic DNA No translation available.
BC040396 mRNA Translation: AAH40396.1
CCDSiCCDS19222.1
RefSeqiNP_775578.2, NM_173402.2
UniGeneiMm.196208

Genome annotation databases

EnsembliENSMUST00000030984; ENSMUSP00000030984; ENSMUSG00000029101
GeneIDi71729
KEGGimmu:71729
UCSCiuc008xdg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRGS12_MOUSE
AccessioniPrimary (citable) accession number: Q8CGE9
Secondary accession number(s): E9PXX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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