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Q8CGC3 (Q8CGC3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Interactions·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Hdac6 EMBL AAH41105.1 MGI 1333752
OrganismMus musculus (Mouse) EMBL AAH41105.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1152 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Keywords
   Molecular functionHydrolase SAAS SAAS000286
Gene Ontology (GO)
   Biological_processHsp90 deacetylation

Inferred from mutant phenotype PubMed 17785525. Source: MGI

aggresome assembly

Inferred from genetic interaction PubMed 16810319. Source: MGI

cellular response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

cellular response to misfolded protein

Inferred from mutant phenotype PubMed 17785525. Source: MGI

lysosome localization

Inferred from electronic annotation. Source: Ensembl

macroautophagy

Inferred from electronic annotation. Source: Ensembl

misfolded or incompletely synthesized protein catabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of microtubule depolymerization

Inferred from direct assay PubMed 12486003. Source: MGI

negative regulation of proteolysis

Inferred from electronic annotation. Source: Ensembl

peptidyl-lysine deacetylation

Inferred from electronic annotation. Source: Ensembl

polyubiquitinated misfolded protein transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of chaperone-mediated protein complex assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of hydrogen peroxide-mediated programmed cell death

Inferred from electronic annotation. Source: Ensembl

positive regulation of receptor biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of signal transduction

Inferred from electronic annotation. Source: Ensembl

protein complex disassembly

Inferred from genetic interaction PubMed 17785525. Source: MGI

protein deacetylation

Inferred from direct assay PubMed 12486003. Source: MGI

protein polyubiquitination

Inferred from direct assay PubMed 11689694. Source: MGI

regulation of establishment of protein localization

Inferred from mutant phenotype PubMed 22792322. Source: MGI

regulation of receptor activity

Inferred from electronic annotation. Source: Ensembl

response to growth factor

Inferred from electronic annotation. Source: Ensembl

response to toxic substance

Inferred from electronic annotation. Source: Ensembl

tubulin deacetylation

Inferred from mutant phenotype PubMed 12606581PubMed 16810319PubMed 17785525. Source: MGI

ubiquitin-dependent protein catabolic process

Inferred from mutant phenotype PubMed 16810319. Source: MGI

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Inferred from mutant phenotype PubMed 17785525. Source: MGI

   Cellular_componentaggresome

Inferred from electronic annotation. Source: Ensembl

caveola

Inferred from electronic annotation. Source: Ensembl

cell leading edge

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 11689694. Source: MGI

dynein complex

Inferred from electronic annotation. Source: Ensembl

histone deacetylase complex

Inferred from electronic annotation. Source: Ensembl

microtubule

Inferred from electronic annotation. Source: Ensembl

nucleus

Traceable author statement PubMed 12486003. Source: MGI

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

protein complex

Inferred from physical interaction PubMed 17785525. Source: MGI

   Molecular_functionbeta-tubulin binding

Inferred from direct assay PubMed 12606581. Source: MGI

histone deacetylase activity

Inferred from direct assay PubMed 11689694PubMed 9891014. Source: MGI

protein binding

Inferred from physical interaction PubMed 11689694PubMed 22792322. Source: MGI

tubulin deacetylase activity

Inferred from direct assay PubMed 12606581. Source: MGI

ubiquitin binding

Inferred from direct assay PubMed 16810319. Source: MGI

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

UbcP6299112EBI-8319632,EBI-413074

Sequences

Sequence LengthMass (Da)Tools
Q8CGC3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 693F537190A9E011

FASTA1,152126,115
        10         20         30         40         50         60 
MTSTGQDSST RQRKSRHNPQ SPLQESSATL KRGGKKCAVP HSSPNLAEVK KKGKMKKLSQ 

        70         80         90        100        110        120 
PAEEDLVVGL QGLDLNPETR VPVGTGLVFD EQLNDFHCLW DDSFPESPER LHAIREQLIL 

       130        140        150        160        170        180 
EGLLGRCVSF QARFAEKEEL MLVHSLEYID LMETTQYMNE GELRVLAETY DSVYLHPNSY 

       190        200        210        220        230        240 
SCACLATGSV LRLVDALMGA EIRNGMAVIR PPGHHAQHNL MDGYCMFNHL AVAARYAQKK 

       250        260        270        280        290        300 
HRIQRVLIVD WDVHHGQGTQ FIFDQDPSVL YFSIHRYEHG RFWPHLKASN WSTIGFGQGQ 

       310        320        330        340        350        360 
GYTINVPWNQ TGMRDADYIA AFLHILLPVA SEFQPQLVLV AAGFDALHGD PKSLQGEMAA 

       370        380        390        400        410        420 
TPAGFAHLTH LLMGLAGGKL ILSLEGGYNL RALAKGVSAS LHTLLGDPCP MLESCVVPCA 

       430        440        450        460        470        480 
SAQTSIYCTL EALEPFWEVL ERSVETQEED EVEEAVLEEE EEEGGWEATA LPMDTWPLLQ 

       490        500        510        520        530        540 
NRTGLVYDEK MMSHCNLWDN HHPETPQRIL RIMCHLEEVG LAARCLILPA RPALDSELLT 

       550        560        570        580        590        600 
CHSAEYVEHL RTTEKMKTRD LHREGANFDS IYICPSTFAC AKLATGAACR LVEAVLSGEV 

       610        620        630        640        650        660 
LNGIAVVRPP GHHAEPNAAC GFCFFNSVAV AARHAQIIAG RALRILIVDW DVHHGNGTQH 

       670        680        690        700        710        720 
IFEDDPSVLY VSLHRYDRGT FFPMGDEGAS SQVGRDAGIG FTVNVPWNGP RMGDADYLAA 

       730        740        750        760        770        780 
WHRLVLPIAY EFNPELVLIS AGFDAAQGDP LGGCQVTPEG YAHLTHLLMG LAGGRIILIL 

       790        800        810        820        830        840 
EGGYNLASIS ESMAACTHSL LGDPPPQLTL LRPPQSGALV SISEVIQVHR KYWRSLRLMK 

       850        860        870        880        890        900 
MEDKEECSSS RLVIKKLPPT ASPVSAKEMT TPKGKVPEES VRKTIAALPG KESTLGQAKS 

       910        920        930        940        950        960 
KMAKAVLAQG QSSEQAAKGT TLDLATSKET VGGATTDLWA SAAAPENFPN QTTSVEALGE 

       970        980        990       1000       1010       1020 
TEPTPPASHT NKQTTGASPL QGVTAQQSLQ LGVLSTLELS REAEEAHDSE EGLLGEAAGG 

      1030       1040       1050       1060       1070       1080 
QDMNSLMLTQ GFGDFNTQDV FYAVTPLSWC PHLMAVCPIP AAGLDVSQPC KTCGTVQENW 

      1090       1100       1110       1120       1130       1140 
VCLTCYQVYC SRYVNAHMVC HHEASEHPLV LSCVDLSTWC YVCQAYVHHE DLQDVKNAAH 

      1150 
QNKFGEDMPH SH 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N EMBL AAH41105.1.
Tissue: Mammary tumor. C3 EMBL AAH41105.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC041105 mRNA. Translation: AAH41105.1.
UniGeneMm.29854.

3D structure databases

ProteinModelPortalQ8CGC3.
SMRQ8CGC3. Positions 1045-1152.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8CGC3. 4 interactions.
MINTMINT-2840612.

Proteomic databases

PRIDEQ8CGC3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1333752. Hdac6.

Phylogenomic databases

HOGENOMHOG000004769.
HOVERGENHBG051894.
InParanoidQ8CGC3.
PhylomeDBQ8CGC3.

Gene expression databases

ArrayExpressQ8CGC3.
BgeeQ8CGC3.
GenevestigatorQ8CGC3.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSPR01270. HDASUPER.
SMARTSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEPS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ8CGC3_MOUSE
AccessionPrimary (citable) accession number: Q8CGC3
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)