Q8CGC3 (Q8CGC3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hdac6 protein EMBL AAH41105.1

Gene names

Name:

Hdac6 EMBL AAH41105.1 MGI 1333752

Organism

Mus musculus (Mouse) EMBL AAH41105.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1152 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Hydrolase SAAS SAAS000286
Gene Ontology (GO)
Biological_process	Hsp90 deacetylation Inferred from mutant phenotype PubMed 17785525. Source: MGI aggresome assembly Inferred from genetic interaction PubMed 16810319. Source: MGI cellular response to hydrogen peroxide Inferred from electronic annotation. Source: Compara cellular response to misfolded protein Inferred from mutant phenotype PubMed 17785525. Source: MGI lysosome localization Inferred from electronic annotation. Source: Compara macroautophagy Inferred from electronic annotation. Source: Compara misfolded or incompletely synthesized protein catabolic process Inferred from electronic annotation. Source: Compara negative regulation of microtubule depolymerization Inferred from direct assay PubMed 12486003. Source: MGI negative regulation of proteolysis Inferred from electronic annotation. Source: Compara peptidyl-lysine deacetylation Inferred from electronic annotation. Source: Compara polyubiquitinated misfolded protein transport Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of chaperone-mediated protein complex assembly Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell migration Inferred from electronic annotation. Source: Compara positive regulation of receptor biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of signal transduction Inferred from electronic annotation. Source: Compara protein complex disassembly Inferred from genetic interaction PubMed 17785525. Source: MGI protein polyubiquitination Inferred from direct assay PubMed 11689694. Source: MGI regulation of establishment of protein localization Inferred from mutant phenotype PubMed 22792322. Source: MGI regulation of receptor activity Inferred from electronic annotation. Source: Compara response to growth factor stimulus Inferred from electronic annotation. Source: Compara response to toxin Inferred from electronic annotation. Source: Compara ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Inferred from mutant phenotype PubMed 17785525. Source: MGI
Cellular_component	aggresome Inferred from electronic annotation. Source: Compara caveola Inferred from electronic annotation. Source: Compara cell leading edge Inferred from electronic annotation. Source: Compara cytoplasmic microtubule Inferred from direct assay PubMed 12606581. Source: MGI dynein complex Inferred from electronic annotation. Source: Compara histone deacetylase complex Inferred from electronic annotation. Source: Compara nucleus Traceable author statement PubMed 12486003. Source: MGI perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara
Molecular_function	beta-tubulin binding Inferred from direct assay PubMed 12606581. Source: MGI histone deacetylase activity Inferred from direct assay PubMed 11689694PubMed 9891014. Source: MGI tubulin deacetylase activity Inferred from direct assay PubMed 12606581. Source: MGI ubiquitin binding Inferred from direct assay PubMed 16810319. Source: MGI zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8CGC3 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 693F537190A9E011	FASTA	1,152	126,115
	10 20 30 40 50 60 MTSTGQDSST RQRKSRHNPQ SPLQESSATL KRGGKKCAVP HSSPNLAEVK KKGKMKKLSQ 70 80 90 100 110 120 PAEEDLVVGL QGLDLNPETR VPVGTGLVFD EQLNDFHCLW DDSFPESPER LHAIREQLIL 130 140 150 160 170 180 EGLLGRCVSF QARFAEKEEL MLVHSLEYID LMETTQYMNE GELRVLAETY DSVYLHPNSY 190 200 210 220 230 240 SCACLATGSV LRLVDALMGA EIRNGMAVIR PPGHHAQHNL MDGYCMFNHL AVAARYAQKK 250 260 270 280 290 300 HRIQRVLIVD WDVHHGQGTQ FIFDQDPSVL YFSIHRYEHG RFWPHLKASN WSTIGFGQGQ 310 320 330 340 350 360 GYTINVPWNQ TGMRDADYIA AFLHILLPVA SEFQPQLVLV AAGFDALHGD PKSLQGEMAA 370 380 390 400 410 420 TPAGFAHLTH LLMGLAGGKL ILSLEGGYNL RALAKGVSAS LHTLLGDPCP MLESCVVPCA 430 440 450 460 470 480 SAQTSIYCTL EALEPFWEVL ERSVETQEED EVEEAVLEEE EEEGGWEATA LPMDTWPLLQ 490 500 510 520 530 540 NRTGLVYDEK MMSHCNLWDN HHPETPQRIL RIMCHLEEVG LAARCLILPA RPALDSELLT 550 560 570 580 590 600 CHSAEYVEHL RTTEKMKTRD LHREGANFDS IYICPSTFAC AKLATGAACR LVEAVLSGEV 610 620 630 640 650 660 LNGIAVVRPP GHHAEPNAAC GFCFFNSVAV AARHAQIIAG RALRILIVDW DVHHGNGTQH 670 680 690 700 710 720 IFEDDPSVLY VSLHRYDRGT FFPMGDEGAS SQVGRDAGIG FTVNVPWNGP RMGDADYLAA 730 740 750 760 770 780 WHRLVLPIAY EFNPELVLIS AGFDAAQGDP LGGCQVTPEG YAHLTHLLMG LAGGRIILIL 790 800 810 820 830 840 EGGYNLASIS ESMAACTHSL LGDPPPQLTL LRPPQSGALV SISEVIQVHR KYWRSLRLMK 850 860 870 880 890 900 MEDKEECSSS RLVIKKLPPT ASPVSAKEMT TPKGKVPEES VRKTIAALPG KESTLGQAKS 910 920 930 940 950 960 KMAKAVLAQG QSSEQAAKGT TLDLATSKET VGGATTDLWA SAAAPENFPN QTTSVEALGE 970 980 990 1000 1010 1020 TEPTPPASHT NKQTTGASPL QGVTAQQSLQ LGVLSTLELS REAEEAHDSE EGLLGEAAGG 1030 1040 1050 1060 1070 1080 QDMNSLMLTQ GFGDFNTQDV FYAVTPLSWC PHLMAVCPIP AAGLDVSQPC KTCGTVQENW 1090 1100 1110 1120 1130 1140 VCLTCYQVYC SRYVNAHMVC HHEASEHPLV LSCVDLSTWC YVCQAYVHHE DLQDVKNAAH 1150 QNKFGEDMPH SH

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N EMBL AAH41105.1. Tissue: Mammary tumor. C3 EMBL AAH41105.1.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC041105 mRNA. Translation: AAH41105.1.
IPI	IPI00323705.
UniGene	Mm.29854.
3D structure databases
ProteinModelPortal	Q8CGC3.
SMR	Q8CGC3. Positions 1045-1152.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-2840612.
STRING	Q8CGC3.
Proteomic databases
PRIDE	Q8CGC3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:1333752. Hdac6.
Phylogenomic databases
HOGENOM	HOG000004769.
HOVERGEN	HBG051894.
InParanoid	Q8CGC3.
Gene expression databases
ArrayExpress	Q8CGC3.
Bgee	Q8CGC3.
Genevestigator	Q8CGC3.
Family and domain databases
Gene3D	3.30.40.10. 1 hit. 3.40.800.20. 2 hits.
InterPro	IPR000286. His_deacetylse. IPR023801. His_deacetylse_dom. IPR013083. Znf_RING/FYVE/PHD. IPR001607. Znf_UBP. [Graphical view]
PANTHER	PTHR10625. PTHR10625. 1 hit.
Pfam	PF00850. Hist_deacetyl. 2 hits. PF02148. zf-UBP. 1 hit. [Graphical view]
PRINTS	PR01270. HDASUPER.
SMART	SM00290. ZnF_UBP. 1 hit. [Graphical view]
PROSITE	PS50271. ZF_UBP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q8CGC3_MOUSE

Accession

Primary (citable) accession number: Q8CGC3

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)