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Q8CGC3

- Q8CGC3_MOUSE

UniProt

Q8CGC3 - Q8CGC3_MOUSE

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Protein
Submitted name: Hdac6 protein
Gene
Hdac6
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. beta-tubulin binding Source: MGI
  2. histone deacetylase activity Source: MGI
  3. protein binding Source: MGI
  4. tubulin deacetylase activity Source: MGI
  5. ubiquitin binding Source: MGI
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. Hsp90 deacetylation Source: MGI
  2. aggresome assembly Source: MGI
  3. cellular response to hydrogen peroxide Source: Ensembl
  4. cellular response to misfolded protein Source: MGI
  5. lysosome localization Source: Ensembl
  6. macroautophagy Source: Ensembl
  7. misfolded or incompletely synthesized protein catabolic process Source: Ensembl
  8. negative regulation of microtubule depolymerization Source: MGI
  9. negative regulation of proteolysis Source: Ensembl
  10. peptidyl-lysine deacetylation Source: Ensembl
  11. polyubiquitinated misfolded protein transport Source: Ensembl
  12. positive regulation of chaperone-mediated protein complex assembly Source: Ensembl
  13. positive regulation of epithelial cell migration Source: Ensembl
  14. positive regulation of hydrogen peroxide-mediated programmed cell death Source: Ensembl
  15. positive regulation of receptor biosynthetic process Source: Ensembl
  16. positive regulation of signal transduction Source: Ensembl
  17. protein complex disassembly Source: MGI
  18. protein deacetylation Source: MGI
  19. protein polyubiquitination Source: MGI
  20. regulation of establishment of protein localization Source: MGI
  21. regulation of receptor activity Source: Ensembl
  22. response to growth factor Source: Ensembl
  23. response to toxic substance Source: Ensembl
  24. tubulin deacetylation Source: MGI
  25. ubiquitin-dependent protein catabolic process Source: MGI
  26. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Hdac6 proteinImported
Gene namesi
Name:Hdac6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1333752. Hdac6.

Subcellular locationi

GO - Cellular componenti

  1. aggresome Source: Ensembl
  2. caveola Source: Ensembl
  3. cell leading edge Source: Ensembl
  4. cytoplasm Source: MGI
  5. dynein complex Source: Ensembl
  6. histone deacetylase complex Source: Ensembl
  7. microtubule Source: Ensembl
  8. nucleus Source: MGI
  9. perinuclear region of cytoplasm Source: Ensembl
  10. protein complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8CGC3.

Expressioni

Gene expression databases

ArrayExpressiQ8CGC3.
BgeeiQ8CGC3.
GenevestigatoriQ8CGC3.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UbcP6299112EBI-8319632,EBI-413074

Protein-protein interaction databases

IntActiQ8CGC3. 4 interactions.
MINTiMINT-2840612.

Structurei

3D structure databases

ProteinModelPortaliQ8CGC3.
SMRiQ8CGC3. Positions 1045-1152.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000004769.
HOVERGENiHBG051894.
InParanoidiQ8CGC3.
PhylomeDBiQ8CGC3.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CGC3-1 [UniParc]FASTAAdd to Basket

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MTSTGQDSST RQRKSRHNPQ SPLQESSATL KRGGKKCAVP HSSPNLAEVK     50
KKGKMKKLSQ PAEEDLVVGL QGLDLNPETR VPVGTGLVFD EQLNDFHCLW 100
DDSFPESPER LHAIREQLIL EGLLGRCVSF QARFAEKEEL MLVHSLEYID 150
LMETTQYMNE GELRVLAETY DSVYLHPNSY SCACLATGSV LRLVDALMGA 200
EIRNGMAVIR PPGHHAQHNL MDGYCMFNHL AVAARYAQKK HRIQRVLIVD 250
WDVHHGQGTQ FIFDQDPSVL YFSIHRYEHG RFWPHLKASN WSTIGFGQGQ 300
GYTINVPWNQ TGMRDADYIA AFLHILLPVA SEFQPQLVLV AAGFDALHGD 350
PKSLQGEMAA TPAGFAHLTH LLMGLAGGKL ILSLEGGYNL RALAKGVSAS 400
LHTLLGDPCP MLESCVVPCA SAQTSIYCTL EALEPFWEVL ERSVETQEED 450
EVEEAVLEEE EEEGGWEATA LPMDTWPLLQ NRTGLVYDEK MMSHCNLWDN 500
HHPETPQRIL RIMCHLEEVG LAARCLILPA RPALDSELLT CHSAEYVEHL 550
RTTEKMKTRD LHREGANFDS IYICPSTFAC AKLATGAACR LVEAVLSGEV 600
LNGIAVVRPP GHHAEPNAAC GFCFFNSVAV AARHAQIIAG RALRILIVDW 650
DVHHGNGTQH IFEDDPSVLY VSLHRYDRGT FFPMGDEGAS SQVGRDAGIG 700
FTVNVPWNGP RMGDADYLAA WHRLVLPIAY EFNPELVLIS AGFDAAQGDP 750
LGGCQVTPEG YAHLTHLLMG LAGGRIILIL EGGYNLASIS ESMAACTHSL 800
LGDPPPQLTL LRPPQSGALV SISEVIQVHR KYWRSLRLMK MEDKEECSSS 850
RLVIKKLPPT ASPVSAKEMT TPKGKVPEES VRKTIAALPG KESTLGQAKS 900
KMAKAVLAQG QSSEQAAKGT TLDLATSKET VGGATTDLWA SAAAPENFPN 950
QTTSVEALGE TEPTPPASHT NKQTTGASPL QGVTAQQSLQ LGVLSTLELS 1000
REAEEAHDSE EGLLGEAAGG QDMNSLMLTQ GFGDFNTQDV FYAVTPLSWC 1050
PHLMAVCPIP AAGLDVSQPC KTCGTVQENW VCLTCYQVYC SRYVNAHMVC 1100
HHEASEHPLV LSCVDLSTWC YVCQAYVHHE DLQDVKNAAH QNKFGEDMPH 1150
SH 1152
Length:1,152
Mass (Da):126,115
Last modified:March 1, 2003 - v1
Checksum:i693F537190A9E011
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC041105 mRNA. Translation: AAH41105.1.
UniGeneiMm.29854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC041105 mRNA. Translation: AAH41105.1 .
UniGenei Mm.29854.

3D structure databases

ProteinModelPortali Q8CGC3.
SMRi Q8CGC3. Positions 1045-1152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CGC3. 4 interactions.
MINTi MINT-2840612.

Proteomic databases

PRIDEi Q8CGC3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1333752. Hdac6.

Phylogenomic databases

HOGENOMi HOG000004769.
HOVERGENi HBG051894.
InParanoidi Q8CGC3.
PhylomeDBi Q8CGC3.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

ArrayExpressi Q8CGC3.
Bgeei Q8CGC3.
Genevestigatori Q8CGC3.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
SMARTi SM00290. ZnF_UBP. 1 hit.
[Graphical view ]
PROSITEi PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. C3Imported.

Entry informationi

Entry nameiQ8CGC3_MOUSE
AccessioniPrimary (citable) accession number: Q8CGC3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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