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Protein
Submitted name:

Hdac6 protein

Gene

Hdac6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Hdac6 proteinImported
Gene namesi
Name:Hdac6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1333752. Hdac6.

Subcellular locationi

GO - Cellular componenti

  • aggresome Source: MGI
  • caveola Source: MGI
  • cell leading edge Source: MGI
  • cytoplasm Source: MGI
  • dynein complex Source: Ensembl
  • histone deacetylase complex Source: MGI
  • inclusion body Source: MGI
  • microtubule Source: MGI
  • microtubule associated complex Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • perinuclear region of cytoplasm Source: MGI
  • protein complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8CGC3.

Expressioni

Gene expression databases

BgeeiQ8CGC3.
ExpressionAtlasiQ8CGC3. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UbcP6299112EBI-8319632,EBI-413074

Protein-protein interaction databases

IntActiQ8CGC3. 4 interactions.
MINTiMINT-2840612.
STRINGi10090.ENSMUSP00000033501.

Structurei

3D structure databases

ProteinModelPortaliQ8CGC3.
SMRiQ8CGC3. Positions 1045-1152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000004769.
HOVERGENiHBG051894.
PhylomeDBiQ8CGC3.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CGC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTGQDSST RQRKSRHNPQ SPLQESSATL KRGGKKCAVP HSSPNLAEVK
60 70 80 90 100
KKGKMKKLSQ PAEEDLVVGL QGLDLNPETR VPVGTGLVFD EQLNDFHCLW
110 120 130 140 150
DDSFPESPER LHAIREQLIL EGLLGRCVSF QARFAEKEEL MLVHSLEYID
160 170 180 190 200
LMETTQYMNE GELRVLAETY DSVYLHPNSY SCACLATGSV LRLVDALMGA
210 220 230 240 250
EIRNGMAVIR PPGHHAQHNL MDGYCMFNHL AVAARYAQKK HRIQRVLIVD
260 270 280 290 300
WDVHHGQGTQ FIFDQDPSVL YFSIHRYEHG RFWPHLKASN WSTIGFGQGQ
310 320 330 340 350
GYTINVPWNQ TGMRDADYIA AFLHILLPVA SEFQPQLVLV AAGFDALHGD
360 370 380 390 400
PKSLQGEMAA TPAGFAHLTH LLMGLAGGKL ILSLEGGYNL RALAKGVSAS
410 420 430 440 450
LHTLLGDPCP MLESCVVPCA SAQTSIYCTL EALEPFWEVL ERSVETQEED
460 470 480 490 500
EVEEAVLEEE EEEGGWEATA LPMDTWPLLQ NRTGLVYDEK MMSHCNLWDN
510 520 530 540 550
HHPETPQRIL RIMCHLEEVG LAARCLILPA RPALDSELLT CHSAEYVEHL
560 570 580 590 600
RTTEKMKTRD LHREGANFDS IYICPSTFAC AKLATGAACR LVEAVLSGEV
610 620 630 640 650
LNGIAVVRPP GHHAEPNAAC GFCFFNSVAV AARHAQIIAG RALRILIVDW
660 670 680 690 700
DVHHGNGTQH IFEDDPSVLY VSLHRYDRGT FFPMGDEGAS SQVGRDAGIG
710 720 730 740 750
FTVNVPWNGP RMGDADYLAA WHRLVLPIAY EFNPELVLIS AGFDAAQGDP
760 770 780 790 800
LGGCQVTPEG YAHLTHLLMG LAGGRIILIL EGGYNLASIS ESMAACTHSL
810 820 830 840 850
LGDPPPQLTL LRPPQSGALV SISEVIQVHR KYWRSLRLMK MEDKEECSSS
860 870 880 890 900
RLVIKKLPPT ASPVSAKEMT TPKGKVPEES VRKTIAALPG KESTLGQAKS
910 920 930 940 950
KMAKAVLAQG QSSEQAAKGT TLDLATSKET VGGATTDLWA SAAAPENFPN
960 970 980 990 1000
QTTSVEALGE TEPTPPASHT NKQTTGASPL QGVTAQQSLQ LGVLSTLELS
1010 1020 1030 1040 1050
REAEEAHDSE EGLLGEAAGG QDMNSLMLTQ GFGDFNTQDV FYAVTPLSWC
1060 1070 1080 1090 1100
PHLMAVCPIP AAGLDVSQPC KTCGTVQENW VCLTCYQVYC SRYVNAHMVC
1110 1120 1130 1140 1150
HHEASEHPLV LSCVDLSTWC YVCQAYVHHE DLQDVKNAAH QNKFGEDMPH

SH
Length:1,152
Mass (Da):126,115
Last modified:March 1, 2003 - v1
Checksum:i693F537190A9E011
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC041105 mRNA. Translation: AAH41105.1.
UniGeneiMm.29854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC041105 mRNA. Translation: AAH41105.1.
UniGeneiMm.29854.

3D structure databases

ProteinModelPortaliQ8CGC3.
SMRiQ8CGC3. Positions 1045-1152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CGC3. 4 interactions.
MINTiMINT-2840612.
STRINGi10090.ENSMUSP00000033501.

Proteomic databases

PRIDEiQ8CGC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1333752. Hdac6.

Phylogenomic databases

HOGENOMiHOG000004769.
HOVERGENiHBG051894.
PhylomeDBiQ8CGC3.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ8CGC3.
ExpressionAtlasiQ8CGC3. baseline and differential.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. C3Imported.

Entry informationi

Entry nameiQ8CGC3_MOUSE
AccessioniPrimary (citable) accession number: Q8CGC3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.