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Q8CGC3

- Q8CGC3_MOUSE

UniProt

Q8CGC3 - Q8CGC3_MOUSE

Protein
Submitted name:

Hdac6 protein

Gene

Hdac6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. beta-tubulin binding Source: MGI
    2. histone deacetylase activity Source: MGI
    3. protein binding Source: MGI
    4. tubulin deacetylase activity Source: MGI
    5. ubiquitin binding Source: MGI
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. aggresome assembly Source: MGI
    2. cellular response to hydrogen peroxide Source: Ensembl
    3. cellular response to misfolded protein Source: MGI
    4. Hsp90 deacetylation Source: MGI
    5. lysosome localization Source: Ensembl
    6. macroautophagy Source: Ensembl
    7. misfolded or incompletely synthesized protein catabolic process Source: Ensembl
    8. negative regulation of microtubule depolymerization Source: MGI
    9. negative regulation of proteolysis Source: Ensembl
    10. peptidyl-lysine deacetylation Source: Ensembl
    11. polyubiquitinated misfolded protein transport Source: Ensembl
    12. positive regulation of chaperone-mediated protein complex assembly Source: Ensembl
    13. positive regulation of epithelial cell migration Source: Ensembl
    14. positive regulation of hydrogen peroxide-mediated programmed cell death Source: Ensembl
    15. positive regulation of receptor biosynthetic process Source: Ensembl
    16. positive regulation of signal transduction Source: Ensembl
    17. protein complex disassembly Source: MGI
    18. protein deacetylation Source: MGI
    19. protein polyubiquitination Source: MGI
    20. regulation of establishment of protein localization Source: MGI
    21. regulation of fat cell differentiation Source: MGI
    22. regulation of receptor activity Source: Ensembl
    23. response to growth factor Source: Ensembl
    24. response to toxic substance Source: Ensembl
    25. tubulin deacetylation Source: MGI
    26. ubiquitin-dependent protein catabolic process Source: MGI
    27. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: MGI

    Keywords - Molecular functioni

    HydrolaseSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Hdac6 proteinImported
    Gene namesi
    Name:Hdac6Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1333752. Hdac6.

    Subcellular locationi

    GO - Cellular componenti

    1. aggresome Source: Ensembl
    2. caveola Source: Ensembl
    3. cell leading edge Source: Ensembl
    4. cytoplasm Source: MGI
    5. dynein complex Source: Ensembl
    6. histone deacetylase complex Source: Ensembl
    7. microtubule Source: Ensembl
    8. nucleus Source: MGI
    9. perinuclear region of cytoplasm Source: Ensembl
    10. protein complex Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8CGC3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8CGC3.
    BgeeiQ8CGC3.
    GenevestigatoriQ8CGC3.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UbcP6299112EBI-8319632,EBI-413074

    Protein-protein interaction databases

    IntActiQ8CGC3. 4 interactions.
    MINTiMINT-2840612.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CGC3.
    SMRiQ8CGC3. Positions 1045-1152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000004769.
    HOVERGENiHBG051894.
    InParanoidiQ8CGC3.
    PhylomeDBiQ8CGC3.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    3.40.800.20. 2 hits.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 2 hits.
    PF02148. zf-UBP. 1 hit.
    [Graphical view]
    PRINTSiPR01270. HDASUPER.
    SMARTiSM00290. ZnF_UBP. 1 hit.
    [Graphical view]
    PROSITEiPS50271. ZF_UBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CGC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSTGQDSST RQRKSRHNPQ SPLQESSATL KRGGKKCAVP HSSPNLAEVK     50
    KKGKMKKLSQ PAEEDLVVGL QGLDLNPETR VPVGTGLVFD EQLNDFHCLW 100
    DDSFPESPER LHAIREQLIL EGLLGRCVSF QARFAEKEEL MLVHSLEYID 150
    LMETTQYMNE GELRVLAETY DSVYLHPNSY SCACLATGSV LRLVDALMGA 200
    EIRNGMAVIR PPGHHAQHNL MDGYCMFNHL AVAARYAQKK HRIQRVLIVD 250
    WDVHHGQGTQ FIFDQDPSVL YFSIHRYEHG RFWPHLKASN WSTIGFGQGQ 300
    GYTINVPWNQ TGMRDADYIA AFLHILLPVA SEFQPQLVLV AAGFDALHGD 350
    PKSLQGEMAA TPAGFAHLTH LLMGLAGGKL ILSLEGGYNL RALAKGVSAS 400
    LHTLLGDPCP MLESCVVPCA SAQTSIYCTL EALEPFWEVL ERSVETQEED 450
    EVEEAVLEEE EEEGGWEATA LPMDTWPLLQ NRTGLVYDEK MMSHCNLWDN 500
    HHPETPQRIL RIMCHLEEVG LAARCLILPA RPALDSELLT CHSAEYVEHL 550
    RTTEKMKTRD LHREGANFDS IYICPSTFAC AKLATGAACR LVEAVLSGEV 600
    LNGIAVVRPP GHHAEPNAAC GFCFFNSVAV AARHAQIIAG RALRILIVDW 650
    DVHHGNGTQH IFEDDPSVLY VSLHRYDRGT FFPMGDEGAS SQVGRDAGIG 700
    FTVNVPWNGP RMGDADYLAA WHRLVLPIAY EFNPELVLIS AGFDAAQGDP 750
    LGGCQVTPEG YAHLTHLLMG LAGGRIILIL EGGYNLASIS ESMAACTHSL 800
    LGDPPPQLTL LRPPQSGALV SISEVIQVHR KYWRSLRLMK MEDKEECSSS 850
    RLVIKKLPPT ASPVSAKEMT TPKGKVPEES VRKTIAALPG KESTLGQAKS 900
    KMAKAVLAQG QSSEQAAKGT TLDLATSKET VGGATTDLWA SAAAPENFPN 950
    QTTSVEALGE TEPTPPASHT NKQTTGASPL QGVTAQQSLQ LGVLSTLELS 1000
    REAEEAHDSE EGLLGEAAGG QDMNSLMLTQ GFGDFNTQDV FYAVTPLSWC 1050
    PHLMAVCPIP AAGLDVSQPC KTCGTVQENW VCLTCYQVYC SRYVNAHMVC 1100
    HHEASEHPLV LSCVDLSTWC YVCQAYVHHE DLQDVKNAAH QNKFGEDMPH 1150
    SH 1152
    Length:1,152
    Mass (Da):126,115
    Last modified:March 1, 2003 - v1
    Checksum:i693F537190A9E011
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC041105 mRNA. Translation: AAH41105.1.
    UniGeneiMm.29854.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC041105 mRNA. Translation: AAH41105.1 .
    UniGenei Mm.29854.

    3D structure databases

    ProteinModelPortali Q8CGC3.
    SMRi Q8CGC3. Positions 1045-1152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CGC3. 4 interactions.
    MINTi MINT-2840612.

    Proteomic databases

    PRIDEi Q8CGC3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1333752. Hdac6.

    Phylogenomic databases

    HOGENOMi HOG000004769.
    HOVERGENi HBG051894.
    InParanoidi Q8CGC3.
    PhylomeDBi Q8CGC3.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8CGC3.
    Bgeei Q8CGC3.
    Genevestigatori Q8CGC3.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    3.40.800.20. 2 hits.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 2 hits.
    PF02148. zf-UBP. 1 hit.
    [Graphical view ]
    PRINTSi PR01270. HDASUPER.
    SMARTi SM00290. ZnF_UBP. 1 hit.
    [Graphical view ]
    PROSITEi PS50271. ZF_UBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: Mammary tumor. C3Imported.

    Entry informationi

    Entry nameiQ8CGC3_MOUSE
    AccessioniPrimary (citable) accession number: Q8CGC3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)