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Q8CGC3

- Q8CGC3_MOUSE

UniProt

Q8CGC3 - Q8CGC3_MOUSE

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Protein
Submitted name:

Hdac6 protein

Gene

Hdac6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. beta-tubulin binding Source: MGI
  2. histone deacetylase activity Source: MGI
  3. tubulin deacetylase activity Source: MGI
  4. ubiquitin binding Source: MGI
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. aggresome assembly Source: MGI
  2. cellular response to hydrogen peroxide Source: Ensembl
  3. cellular response to misfolded protein Source: MGI
  4. histone deacetylation Source: GOC
  5. Hsp90 deacetylation Source: MGI
  6. lysosome localization Source: Ensembl
  7. macroautophagy Source: Ensembl
  8. misfolded or incompletely synthesized protein catabolic process Source: Ensembl
  9. negative regulation of microtubule depolymerization Source: MGI
  10. negative regulation of proteolysis Source: Ensembl
  11. peptidyl-lysine deacetylation Source: Ensembl
  12. polyubiquitinated misfolded protein transport Source: Ensembl
  13. positive regulation of chaperone-mediated protein complex assembly Source: Ensembl
  14. positive regulation of epithelial cell migration Source: Ensembl
  15. positive regulation of hydrogen peroxide-mediated programmed cell death Source: Ensembl
  16. positive regulation of receptor biosynthetic process Source: Ensembl
  17. positive regulation of signal transduction Source: Ensembl
  18. protein complex disassembly Source: MGI
  19. protein deacetylation Source: MGI
  20. protein polyubiquitination Source: MGI
  21. regulation of establishment of protein localization Source: MGI
  22. regulation of fat cell differentiation Source: MGI
  23. regulation of receptor activity Source: Ensembl
  24. response to growth factor Source: Ensembl
  25. response to toxic substance Source: Ensembl
  26. tubulin deacetylation Source: MGI
  27. ubiquitin-dependent protein catabolic process Source: MGI
  28. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Hdac6 proteinImported
Gene namesi
Name:Hdac6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1333752. Hdac6.

Subcellular locationi

GO - Cellular componenti

  1. aggresome Source: Ensembl
  2. caveola Source: Ensembl
  3. cell leading edge Source: Ensembl
  4. cytoplasm Source: MGI
  5. dynein complex Source: Ensembl
  6. histone deacetylase complex Source: Ensembl
  7. microtubule Source: Ensembl
  8. nucleus Source: MGI
  9. perinuclear region of cytoplasm Source: Ensembl
  10. protein complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8CGC3.

Expressioni

Gene expression databases

BgeeiQ8CGC3.
ExpressionAtlasiQ8CGC3. baseline and differential.
GenevestigatoriQ8CGC3.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UbcP6299112EBI-8319632,EBI-413074

Protein-protein interaction databases

IntActiQ8CGC3. 4 interactions.
MINTiMINT-2840612.

Structurei

3D structure databases

ProteinModelPortaliQ8CGC3.
SMRiQ8CGC3. Positions 1045-1152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000004769.
HOVERGENiHBG051894.
PhylomeDBiQ8CGC3.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CGC3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSTGQDSST RQRKSRHNPQ SPLQESSATL KRGGKKCAVP HSSPNLAEVK
60 70 80 90 100
KKGKMKKLSQ PAEEDLVVGL QGLDLNPETR VPVGTGLVFD EQLNDFHCLW
110 120 130 140 150
DDSFPESPER LHAIREQLIL EGLLGRCVSF QARFAEKEEL MLVHSLEYID
160 170 180 190 200
LMETTQYMNE GELRVLAETY DSVYLHPNSY SCACLATGSV LRLVDALMGA
210 220 230 240 250
EIRNGMAVIR PPGHHAQHNL MDGYCMFNHL AVAARYAQKK HRIQRVLIVD
260 270 280 290 300
WDVHHGQGTQ FIFDQDPSVL YFSIHRYEHG RFWPHLKASN WSTIGFGQGQ
310 320 330 340 350
GYTINVPWNQ TGMRDADYIA AFLHILLPVA SEFQPQLVLV AAGFDALHGD
360 370 380 390 400
PKSLQGEMAA TPAGFAHLTH LLMGLAGGKL ILSLEGGYNL RALAKGVSAS
410 420 430 440 450
LHTLLGDPCP MLESCVVPCA SAQTSIYCTL EALEPFWEVL ERSVETQEED
460 470 480 490 500
EVEEAVLEEE EEEGGWEATA LPMDTWPLLQ NRTGLVYDEK MMSHCNLWDN
510 520 530 540 550
HHPETPQRIL RIMCHLEEVG LAARCLILPA RPALDSELLT CHSAEYVEHL
560 570 580 590 600
RTTEKMKTRD LHREGANFDS IYICPSTFAC AKLATGAACR LVEAVLSGEV
610 620 630 640 650
LNGIAVVRPP GHHAEPNAAC GFCFFNSVAV AARHAQIIAG RALRILIVDW
660 670 680 690 700
DVHHGNGTQH IFEDDPSVLY VSLHRYDRGT FFPMGDEGAS SQVGRDAGIG
710 720 730 740 750
FTVNVPWNGP RMGDADYLAA WHRLVLPIAY EFNPELVLIS AGFDAAQGDP
760 770 780 790 800
LGGCQVTPEG YAHLTHLLMG LAGGRIILIL EGGYNLASIS ESMAACTHSL
810 820 830 840 850
LGDPPPQLTL LRPPQSGALV SISEVIQVHR KYWRSLRLMK MEDKEECSSS
860 870 880 890 900
RLVIKKLPPT ASPVSAKEMT TPKGKVPEES VRKTIAALPG KESTLGQAKS
910 920 930 940 950
KMAKAVLAQG QSSEQAAKGT TLDLATSKET VGGATTDLWA SAAAPENFPN
960 970 980 990 1000
QTTSVEALGE TEPTPPASHT NKQTTGASPL QGVTAQQSLQ LGVLSTLELS
1010 1020 1030 1040 1050
REAEEAHDSE EGLLGEAAGG QDMNSLMLTQ GFGDFNTQDV FYAVTPLSWC
1060 1070 1080 1090 1100
PHLMAVCPIP AAGLDVSQPC KTCGTVQENW VCLTCYQVYC SRYVNAHMVC
1110 1120 1130 1140 1150
HHEASEHPLV LSCVDLSTWC YVCQAYVHHE DLQDVKNAAH QNKFGEDMPH

SH
Length:1,152
Mass (Da):126,115
Last modified:March 1, 2003 - v1
Checksum:i693F537190A9E011
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC041105 mRNA. Translation: AAH41105.1.
UniGeneiMm.29854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC041105 mRNA. Translation: AAH41105.1 .
UniGenei Mm.29854.

3D structure databases

ProteinModelPortali Q8CGC3.
SMRi Q8CGC3. Positions 1045-1152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CGC3. 4 interactions.
MINTi MINT-2840612.

Proteomic databases

PRIDEi Q8CGC3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1333752. Hdac6.

Phylogenomic databases

HOGENOMi HOG000004769.
HOVERGENi HBG051894.
PhylomeDBi Q8CGC3.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Bgeei Q8CGC3.
ExpressionAtlasi Q8CGC3. baseline and differential.
Genevestigatori Q8CGC3.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
SMARTi SM00290. ZnF_UBP. 1 hit.
[Graphical view ]
PROSITEi PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. C3Imported.

Entry informationi

Entry nameiQ8CGC3_MOUSE
AccessioniPrimary (citable) accession number: Q8CGC3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)