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Q8CGB6 (TENC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tensin-like C1 domain-containing phosphatase

EC=3.1.3.-
Alternative name(s):
C1 domain-containing phosphatase and tensin homolog
Short name=C1-TEN
Tensin-2
Gene names
Name:Tenc1
Synonyms:Tns2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1400 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling By similarity.

Subunit structure

Interacts with AXL By similarity.

Subcellular location

Cell junctionfocal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Detected at the end of actin stress fibers By similarity.

Sequence similarities

Contains 1 C2 tensin-type domain.

Contains 1 phorbol-ester/DAG-type zinc finger.

Contains 1 phosphatase tensin-type domain.

Contains 1 SH2 domain.

Sequence caution

The sequence BAE34316.1 differs from that shown. Reason: Frameshift at position 66.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8CGB6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8CGB6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKSSGPVERLLRALGRRDSSRATSR → MK
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8CGB6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     872-872: T → TELFPPVS
Note: No experimental confirmation available.
Isoform 4 (identifier: Q8CGB6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKSSGPVERLLRALGRRDSSRATSR → MGWSGGAPCCCPSSPRPRPSGRPPQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14001400Tensin-like C1 domain-containing phosphatase
PRO_0000292988

Regions

Domain122 – 294173Phosphatase tensin-type
Domain299 – 425127C2 tensin-type
Domain1131 – 1238108SH2
Zinc finger31 – 7949Phorbol-ester/DAG-type
Compositional bias502 – 5054Poly-Pro
Compositional bias966 – 1113148Pro-rich

Sites

Active site2311Phosphocysteine intermediate By similarity

Amino acid modifications

Modified residue4831Phosphotyrosine Ref.6
Modified residue10871Phosphoserine Ref.6

Natural variations

Alternative sequence1 – 2525MKSSG…RATSR → MK in isoform 2.
VSP_026462
Alternative sequence1 – 2525MKSSG…RATSR → MGWSGGAPCCCPSSPRPRPS GRPPQ in isoform 4.
VSP_026463
Alternative sequence8721T → TELFPPVS in isoform 3.
VSP_026464

Experimental info

Sequence conflict541D → N in BAE28139. Ref.3
Sequence conflict1951F → L in BAE28139. Ref.3
Sequence conflict2041P → H in BAE28139. Ref.3
Sequence conflict1112 – 11143HPL → NPFVVQE in AAN32753. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 72CB109A17BB021C

FASTA1,400152,013
        10         20         30         40         50         60 
MKSSGPVERL LRALGRRDSS RATSRPRKAE PHSFREKVFR KKTPVCAVCK VTIDGTGVSC 

        70         80         90        100        110        120 
RVCKVATHRK CEAKVTSSCQ ALPPAELRRS TAPVRRIEHL GSTKSLNHSK QRSTLPRSFS 

       130        140        150        160        170        180 
LDPLMERRWD LDLTYVTERI LAAAFPARPD EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE 

       190        200        210        220        230        240 
KRHDLTRLNP KVQDFGWPEL HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGSKGKLGV 

       250        260        270        280        290        300 
IVSAYMHYSK ISAGADQALA TLTMRKFCED KVATELQPSQ RRYVSYFSGL LSGSIRMNSS 

       310        320        330        340        350        360 
PLFLHYVFVP VLPAFEPNTG FQPFLKIYQS MQLVYTSGVY RIAGPGPQQL CISLEPALLL 

       370        380        390        400        410        420 
KGDVMVTCYH KGGQGTDRTL VFRVQFHTCT IHGSRLTFPK DQLDEAWADE RFPFQASVEF 

       430        440        450        460        470        480 
VFSSSPEKVK GNTPRNDPSV SVDYNTTEPA VRWDSYENFN QHHEDSVDGA LAHTRGPLDG 

       490        500        510        520        530        540 
SPYAQVQRVP RQTPPAPSPE LPPPPMLSVS SDSGHSSTLT TEHTAESPGR PPPTAAERQE 

       550        560        570        580        590        600 
LDRLLGGCGV ASAGRGAGRE TAILDDEEQP SVGGGLHLGM YSGHRPGLSR RCSCRQGFRE 

       610        620        630        640        650        660 
PCGVPNGSYY RPEGTLERRR PPYGGYEGHP QGYAEASVEK RRLCRSLSEG PYPYAPELGK 

       670        680        690        700        710        720 
PANGDFGYRP AGYREVVILE DPGVPALCSC PACEEKLALP TAALYGLRLE REAAEGWSSE 

       730        740        750        760        770        780 
VGKPLLHPVR PGHPLPLLVP ACGHHHAPMP DYGCLKPPKV GEEGHEGCSY AVCSEGRYGH 

       790        800        810        820        830        840 
SGYPALVTYG YGGAVPSYCP AYGRAPHSCG SPSEGRGYPS PGAHSPRAGS VSPGSPPYLQ 

       850        860        870        880        890        900 
PRKLGYEISA EDGRDKYPLS GHLASTGPLA STESPEPSWR DGSSGHSTLP RSPRDPQCSA 

       910        920        930        940        950        960 
SSELSGPSTP LHTSSPVQGK ESNRRQDTTR SPSLAPTQRL SPGEALPSVV QGVAEKTPEL 

       970        980        990       1000       1010       1020 
LTSSRPEQLD PSPFSQTSAP GSPNGWPQER SPGGHTNSAS PRSPVPTTLP GLRHAPWQGP 

      1030       1040       1050       1060       1070       1080 
RGTSDSPDGS PLTPVPTQMP WLVGSPEPPQ SSPTPAFPLA TSYDANGPIQ PPLPEKRHLP 

      1090       1100       1110       1120       1130       1140 
GSGQQPSPPA RSTNQHVTFA SPLPDVTQPP EHPLQENQSN VKFVQDTSKF WYKPHLSRDQ 

      1150       1160       1170       1180       1190       1200 
AIALLKDKDP GAFLIRDSHS FQGAYGLALK VATPPPSAQP WKGDPSEQLV RHFLIETGPK 

      1210       1220       1230       1240       1250       1260 
GVKIKGCPTE PYFGSLSALV SQHSISPISL PCCLRIPSKD PLEETPEAPV PTNMSTAADL 

      1270       1280       1290       1300       1310       1320 
LRQGAACSVL YLTSVETESL TGPQAVAKAS SAALSCSPVP VPAIVHFKVS AQGITLTDNQ 

      1330       1340       1350       1360       1370       1380 
RKLFFRRHYP VNSITFSSTD PQDRRWTNPD GATSKIFGFV AKKPGSPWEN VCHLFAELDP 

      1390       1400 
DQPASAIVTF ITKVLLGQRK 

« Hide

Isoform 2 [UniParc].

Checksum: 54E6DD76352B9D7F
Show »

FASTA1,377149,503
Isoform 3 [UniParc].

Checksum: 1051BA1D0437E506
Show »

FASTA1,407152,782
Isoform 4 [UniParc].

Checksum: 4B813AFC267D06DF
Show »

FASTA1,400151,794

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of mouse tensin 2."
Lo S.H.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 753-1400 (ISOFORM 3).
Strain: FVB/N.
Tissue: Liver and Salivary gland.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-935 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-875 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Inner ear and Melanocyte.
[4]"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[6]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-483 AND SER-1087, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF424789 mRNA. Translation: AAN32753.1.
BC025818 mRNA. Translation: AAH25818.1.
BC042190 mRNA. Translation: AAH42190.1.
AK147789 mRNA. Translation: BAE28139.1.
AK158009 mRNA. Translation: BAE34316.1. Frameshift.
CCDSCCDS37224.1. [Q8CGB6-1]
RefSeqNP_705761.2. NM_153533.2. [Q8CGB6-1]
XP_006520755.1. XM_006520692.1. [Q8CGB6-4]
XP_006520757.1. XM_006520694.1. [Q8CGB6-2]
UniGeneMm.29389.

3D structure databases

ProteinModelPortalQ8CGB6.
SMRQ8CGB6. Positions 126-467, 1126-1240, 1254-1400.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8CGB6. 1 interaction.
MINTMINT-4115716.
STRING10090.ENSMUSP00000041087.

PTM databases

PhosphoSiteQ8CGB6.

Proteomic databases

MaxQBQ8CGB6.
PaxDbQ8CGB6.
PRIDEQ8CGB6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046144; ENSMUSP00000041087; ENSMUSG00000037003. [Q8CGB6-3]
ENSMUST00000169627; ENSMUSP00000129146; ENSMUSG00000037003. [Q8CGB6-1]
GeneID209039.
KEGGmmu:209039.
UCSCuc007xum.1. mouse. [Q8CGB6-4]
uc007xun.1. mouse. [Q8CGB6-2]
uc007xuo.1. mouse. [Q8CGB6-1]
uc011zzx.1. mouse. [Q8CGB6-3]

Organism-specific databases

CTD23371.
MGIMGI:2387586. Tenc1.

Phylogenomic databases

eggNOGCOG2453.
GeneTreeENSGT00620000087781.
HOGENOMHOG000154544.
HOVERGENHBG108559.
InParanoidQ8CGB6.
KOK18080.
OMARQGYREP.
OrthoDBEOG7ZPNJ6.
PhylomeDBQ8CGB6.
TreeFamTF315996.

Gene expression databases

BgeeQ8CGB6.
CleanExMM_TENC1.
GenevestigatorQ8CGB6.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProIPR000008. C2_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
[Graphical view]
PfamPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTSM00109. C1. 1 hit.
SM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio372540.
PROQ8CGB6.
SOURCESearch...

Entry information

Entry nameTENC1_MOUSE
AccessionPrimary (citable) accession number: Q8CGB6
Secondary accession number(s): Q3TZ93 expand/collapse secondary AC list , Q3UGR8, Q8CJ95, Q8R122
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot