Q8CGB6 (TENC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tensin-like C1 domain-containing phosphatase
EC=3.1.3.-

Alternative name(s):
C1 domain-containing phosphatase and tensin homolog
Short name=C1-TEN
Tensin-2

Gene names

Name:	Tenc1
Synonyms:	Tns2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1400 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling By similarity.
Subunit structure	Interacts with AXL By similarity.
Subcellular location	Cell junction › focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Detected at the end of actin stress fibers By similarity.
Sequence similarities	Contains 1 C2 tensin-type domain. Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 phosphatase tensin-type domain. Contains 1 SH2 domain.
Sequence caution	The sequence BAE34316.1 differs from that shown. Reason: Frameshift at position 66.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	SH2 domain Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular homeostasis Inferred from mutant phenotype PubMed 10823724. Source: MGI collagen metabolic process Inferred from mutant phenotype PubMed 10823724. Source: MGI intracellular signal transduction Inferred from electronic annotation. Source: InterPro kidney development Inferred from mutant phenotype PubMed 10823724. Source: MGI multicellular organism growth Inferred from mutant phenotype PubMed 10823724. Source: MGI multicellular organismal homeostasis Inferred from mutant phenotype PubMed 10823724. Source: MGI negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara response to muscle activity Inferred from mutant phenotype PubMed 10823724. Source: MGI
Cellular_component	focal adhesion Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8CGB6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8CGB6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKSSGPVERLLRALGRRDSSRATSR → MK

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8CGB6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     872-872: T → TELFPPVS

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8CGB6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKSSGPVERLLRALGRRDSSRATSR → MGWSGGAPCCCPSSPRPRPSGRPPQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1400	1400	Tensin-like C1 domain-containing phosphatase		PRO_0000292988
Regions
	Domain	122 – 294	173	Phosphatase tensin-type
	Domain	299 – 425	127	C2 tensin-type
	Domain	1131 – 1238	108	SH2
	Zinc finger	31 – 79	49	Phorbol-ester/DAG-type
	Compositional bias	502 – 505	4	Poly-Pro
	Compositional bias	966 – 1113	148	Pro-rich
Sites
	Active site	231	1	Phosphocysteine intermediate By similarity
Amino acid modifications
	Modified residue	455	1	Phosphoserine Ref.5
	Modified residue	466	1	Phosphoserine Ref.5
	Modified residue	481	1	Phosphoserine Ref.5
	Modified residue	483	1	Phosphotyrosine Ref.4 Ref.5 Ref.6
	Modified residue	832	1	Phosphoserine Ref.5
	Modified residue	835	1	Phosphoserine Ref.5
	Modified residue	913	1	Phosphothreonine Ref.5
	Modified residue	1087	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1 – 25	25	MKSSG…RATSR → MK in isoform 2.		VSP_026462
	Alternative sequence	1 – 25	25	MKSSG…RATSR → MGWSGGAPCCCPSSPRPRPS GRPPQ in isoform 4.		VSP_026463
	Alternative sequence	872	1	T → TELFPPVS in isoform 3.		VSP_026464
Experimental info
	Sequence conflict	54	1	D → N in BAE28139. Ref.3
	Sequence conflict	195	1	F → L in BAE28139. Ref.3
	Sequence conflict	204	1	P → H in BAE28139. Ref.3
	Sequence conflict	1112 – 1114	3	HPL → NPFVVQE in AAN32753. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 72CB109A17BB021C	FASTA	1,400	152,013
	10 20 30 40 50 60 MKSSGPVERL LRALGRRDSS RATSRPRKAE PHSFREKVFR KKTPVCAVCK VTIDGTGVSC 70 80 90 100 110 120 RVCKVATHRK CEAKVTSSCQ ALPPAELRRS TAPVRRIEHL GSTKSLNHSK QRSTLPRSFS 130 140 150 160 170 180 LDPLMERRWD LDLTYVTERI LAAAFPARPD EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE 190 200 210 220 230 240 KRHDLTRLNP KVQDFGWPEL HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGSKGKLGV 250 260 270 280 290 300 IVSAYMHYSK ISAGADQALA TLTMRKFCED KVATELQPSQ RRYVSYFSGL LSGSIRMNSS 310 320 330 340 350 360 PLFLHYVFVP VLPAFEPNTG FQPFLKIYQS MQLVYTSGVY RIAGPGPQQL CISLEPALLL 370 380 390 400 410 420 KGDVMVTCYH KGGQGTDRTL VFRVQFHTCT IHGSRLTFPK DQLDEAWADE RFPFQASVEF 430 440 450 460 470 480 VFSSSPEKVK GNTPRNDPSV SVDYNTTEPA VRWDSYENFN QHHEDSVDGA LAHTRGPLDG 490 500 510 520 530 540 SPYAQVQRVP RQTPPAPSPE LPPPPMLSVS SDSGHSSTLT TEHTAESPGR PPPTAAERQE 550 560 570 580 590 600 LDRLLGGCGV ASAGRGAGRE TAILDDEEQP SVGGGLHLGM YSGHRPGLSR RCSCRQGFRE 610 620 630 640 650 660 PCGVPNGSYY RPEGTLERRR PPYGGYEGHP QGYAEASVEK RRLCRSLSEG PYPYAPELGK 670 680 690 700 710 720 PANGDFGYRP AGYREVVILE DPGVPALCSC PACEEKLALP TAALYGLRLE REAAEGWSSE 730 740 750 760 770 780 VGKPLLHPVR PGHPLPLLVP ACGHHHAPMP DYGCLKPPKV GEEGHEGCSY AVCSEGRYGH 790 800 810 820 830 840 SGYPALVTYG YGGAVPSYCP AYGRAPHSCG SPSEGRGYPS PGAHSPRAGS VSPGSPPYLQ 850 860 870 880 890 900 PRKLGYEISA EDGRDKYPLS GHLASTGPLA STESPEPSWR DGSSGHSTLP RSPRDPQCSA 910 920 930 940 950 960 SSELSGPSTP LHTSSPVQGK ESNRRQDTTR SPSLAPTQRL SPGEALPSVV QGVAEKTPEL 970 980 990 1000 1010 1020 LTSSRPEQLD PSPFSQTSAP GSPNGWPQER SPGGHTNSAS PRSPVPTTLP GLRHAPWQGP 1030 1040 1050 1060 1070 1080 RGTSDSPDGS PLTPVPTQMP WLVGSPEPPQ SSPTPAFPLA TSYDANGPIQ PPLPEKRHLP 1090 1100 1110 1120 1130 1140 GSGQQPSPPA RSTNQHVTFA SPLPDVTQPP EHPLQENQSN VKFVQDTSKF WYKPHLSRDQ 1150 1160 1170 1180 1190 1200 AIALLKDKDP GAFLIRDSHS FQGAYGLALK VATPPPSAQP WKGDPSEQLV RHFLIETGPK 1210 1220 1230 1240 1250 1260 GVKIKGCPTE PYFGSLSALV SQHSISPISL PCCLRIPSKD PLEETPEAPV PTNMSTAADL 1270 1280 1290 1300 1310 1320 LRQGAACSVL YLTSVETESL TGPQAVAKAS SAALSCSPVP VPAIVHFKVS AQGITLTDNQ 1330 1340 1350 1360 1370 1380 RKLFFRRHYP VNSITFSSTD PQDRRWTNPD GATSKIFGFV AKKPGSPWEN VCHLFAELDP 1390 1400 DQPASAIVTF ITKVLLGQRK
	Isoform 2 [UniParc]. Checksum: 54E6DD76352B9D7F	FASTA	1,377	149,503
	10 20 30 40 50 60 MKPRKAEPHS FREKVFRKKT PVCAVCKVTI DGTGVSCRVC KVATHRKCEA KVTSSCQALP 70 80 90 100 110 120 PAELRRSTAP VRRIEHLGST KSLNHSKQRS TLPRSFSLDP LMERRWDLDL TYVTERILAA 130 140 150 160 170 180 AFPARPDEQR HRGHLRELAH VLQSKHRDKY LLFNLSEKRH DLTRLNPKVQ DFGWPELHAP 190 200 210 220 230 240 PLDKLCSICK AMETWLSADP QHVVVLYCKG SKGKLGVIVS AYMHYSKISA GADQALATLT 250 260 270 280 290 300 MRKFCEDKVA TELQPSQRRY VSYFSGLLSG SIRMNSSPLF LHYVFVPVLP AFEPNTGFQP 310 320 330 340 350 360 FLKIYQSMQL VYTSGVYRIA GPGPQQLCIS LEPALLLKGD VMVTCYHKGG QGTDRTLVFR 370 380 390 400 410 420 VQFHTCTIHG SRLTFPKDQL DEAWADERFP FQASVEFVFS SSPEKVKGNT PRNDPSVSVD 430 440 450 460 470 480 YNTTEPAVRW DSYENFNQHH EDSVDGALAH TRGPLDGSPY AQVQRVPRQT PPAPSPELPP 490 500 510 520 530 540 PPMLSVSSDS GHSSTLTTEH TAESPGRPPP TAAERQELDR LLGGCGVASA GRGAGRETAI 550 560 570 580 590 600 LDDEEQPSVG GGLHLGMYSG HRPGLSRRCS CRQGFREPCG VPNGSYYRPE GTLERRRPPY 610 620 630 640 650 660 GGYEGHPQGY AEASVEKRRL CRSLSEGPYP YAPELGKPAN GDFGYRPAGY REVVILEDPG 670 680 690 700 710 720 VPALCSCPAC EEKLALPTAA LYGLRLEREA AEGWSSEVGK PLLHPVRPGH PLPLLVPACG 730 740 750 760 770 780 HHHAPMPDYG CLKPPKVGEE GHEGCSYAVC SEGRYGHSGY PALVTYGYGG AVPSYCPAYG 790 800 810 820 830 840 RAPHSCGSPS EGRGYPSPGA HSPRAGSVSP GSPPYLQPRK LGYEISAEDG RDKYPLSGHL 850 860 870 880 890 900 ASTGPLASTE SPEPSWRDGS SGHSTLPRSP RDPQCSASSE LSGPSTPLHT SSPVQGKESN 910 920 930 940 950 960 RRQDTTRSPS LAPTQRLSPG EALPSVVQGV AEKTPELLTS SRPEQLDPSP FSQTSAPGSP 970 980 990 1000 1010 1020 NGWPQERSPG GHTNSASPRS PVPTTLPGLR HAPWQGPRGT SDSPDGSPLT PVPTQMPWLV 1030 1040 1050 1060 1070 1080 GSPEPPQSSP TPAFPLATSY DANGPIQPPL PEKRHLPGSG QQPSPPARST NQHVTFASPL 1090 1100 1110 1120 1130 1140 PDVTQPPEHP LQENQSNVKF VQDTSKFWYK PHLSRDQAIA LLKDKDPGAF LIRDSHSFQG 1150 1160 1170 1180 1190 1200 AYGLALKVAT PPPSAQPWKG DPSEQLVRHF LIETGPKGVK IKGCPTEPYF GSLSALVSQH 1210 1220 1230 1240 1250 1260 SISPISLPCC LRIPSKDPLE ETPEAPVPTN MSTAADLLRQ GAACSVLYLT SVETESLTGP 1270 1280 1290 1300 1310 1320 QAVAKASSAA LSCSPVPVPA IVHFKVSAQG ITLTDNQRKL FFRRHYPVNS ITFSSTDPQD 1330 1340 1350 1360 1370 RRWTNPDGAT SKIFGFVAKK PGSPWENVCH LFAELDPDQP ASAIVTFITK VLLGQRK
	Isoform 3 [UniParc]. Checksum: 1051BA1D0437E506	FASTA	1,407	152,782
	10 20 30 40 50 60 MKSSGPVERL LRALGRRDSS RATSRPRKAE PHSFREKVFR KKTPVCAVCK VTIDGTGVSC 70 80 90 100 110 120 RVCKVATHRK CEAKVTSSCQ ALPPAELRRS TAPVRRIEHL GSTKSLNHSK QRSTLPRSFS 130 140 150 160 170 180 LDPLMERRWD LDLTYVTERI LAAAFPARPD EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE 190 200 210 220 230 240 KRHDLTRLNP KVQDFGWPEL HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGSKGKLGV 250 260 270 280 290 300 IVSAYMHYSK ISAGADQALA TLTMRKFCED KVATELQPSQ RRYVSYFSGL LSGSIRMNSS 310 320 330 340 350 360 PLFLHYVFVP VLPAFEPNTG FQPFLKIYQS MQLVYTSGVY RIAGPGPQQL CISLEPALLL 370 380 390 400 410 420 KGDVMVTCYH KGGQGTDRTL VFRVQFHTCT IHGSRLTFPK DQLDEAWADE RFPFQASVEF 430 440 450 460 470 480 VFSSSPEKVK GNTPRNDPSV SVDYNTTEPA VRWDSYENFN QHHEDSVDGA LAHTRGPLDG 490 500 510 520 530 540 SPYAQVQRVP RQTPPAPSPE LPPPPMLSVS SDSGHSSTLT TEHTAESPGR PPPTAAERQE 550 560 570 580 590 600 LDRLLGGCGV ASAGRGAGRE TAILDDEEQP SVGGGLHLGM YSGHRPGLSR RCSCRQGFRE 610 620 630 640 650 660 PCGVPNGSYY RPEGTLERRR PPYGGYEGHP QGYAEASVEK RRLCRSLSEG PYPYAPELGK 670 680 690 700 710 720 PANGDFGYRP AGYREVVILE DPGVPALCSC PACEEKLALP TAALYGLRLE REAAEGWSSE 730 740 750 760 770 780 VGKPLLHPVR PGHPLPLLVP ACGHHHAPMP DYGCLKPPKV GEEGHEGCSY AVCSEGRYGH 790 800 810 820 830 840 SGYPALVTYG YGGAVPSYCP AYGRAPHSCG SPSEGRGYPS PGAHSPRAGS VSPGSPPYLQ 850 860 870 880 890 900 PRKLGYEISA EDGRDKYPLS GHLASTGPLA STELFPPVSE SPEPSWRDGS SGHSTLPRSP 910 920 930 940 950 960 RDPQCSASSE LSGPSTPLHT SSPVQGKESN RRQDTTRSPS LAPTQRLSPG EALPSVVQGV 970 980 990 1000 1010 1020 AEKTPELLTS SRPEQLDPSP FSQTSAPGSP NGWPQERSPG GHTNSASPRS PVPTTLPGLR 1030 1040 1050 1060 1070 1080 HAPWQGPRGT SDSPDGSPLT PVPTQMPWLV GSPEPPQSSP TPAFPLATSY DANGPIQPPL 1090 1100 1110 1120 1130 1140 PEKRHLPGSG QQPSPPARST NQHVTFASPL PDVTQPPEHP LQENQSNVKF VQDTSKFWYK 1150 1160 1170 1180 1190 1200 PHLSRDQAIA LLKDKDPGAF LIRDSHSFQG AYGLALKVAT PPPSAQPWKG DPSEQLVRHF 1210 1220 1230 1240 1250 1260 LIETGPKGVK IKGCPTEPYF GSLSALVSQH SISPISLPCC LRIPSKDPLE ETPEAPVPTN 1270 1280 1290 1300 1310 1320 MSTAADLLRQ GAACSVLYLT SVETESLTGP QAVAKASSAA LSCSPVPVPA IVHFKVSAQG 1330 1340 1350 1360 1370 1380 ITLTDNQRKL FFRRHYPVNS ITFSSTDPQD RRWTNPDGAT SKIFGFVAKK PGSPWENVCH 1390 1400 LFAELDPDQP ASAIVTFITK VLLGQRK
	Isoform 4 [UniParc]. Checksum: 4B813AFC267D06DF	FASTA	1,400	151,794
	10 20 30 40 50 60 MGWSGGAPCC CPSSPRPRPS GRPPQPRKAE PHSFREKVFR KKTPVCAVCK VTIDGTGVSC 70 80 90 100 110 120 RVCKVATHRK CEAKVTSSCQ ALPPAELRRS TAPVRRIEHL GSTKSLNHSK QRSTLPRSFS 130 140 150 160 170 180 LDPLMERRWD LDLTYVTERI LAAAFPARPD EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE 190 200 210 220 230 240 KRHDLTRLNP KVQDFGWPEL HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGSKGKLGV 250 260 270 280 290 300 IVSAYMHYSK ISAGADQALA TLTMRKFCED KVATELQPSQ RRYVSYFSGL LSGSIRMNSS 310 320 330 340 350 360 PLFLHYVFVP VLPAFEPNTG FQPFLKIYQS MQLVYTSGVY RIAGPGPQQL CISLEPALLL 370 380 390 400 410 420 KGDVMVTCYH KGGQGTDRTL VFRVQFHTCT IHGSRLTFPK DQLDEAWADE RFPFQASVEF 430 440 450 460 470 480 VFSSSPEKVK GNTPRNDPSV SVDYNTTEPA VRWDSYENFN QHHEDSVDGA LAHTRGPLDG 490 500 510 520 530 540 SPYAQVQRVP RQTPPAPSPE LPPPPMLSVS SDSGHSSTLT TEHTAESPGR PPPTAAERQE 550 560 570 580 590 600 LDRLLGGCGV ASAGRGAGRE TAILDDEEQP SVGGGLHLGM YSGHRPGLSR RCSCRQGFRE 610 620 630 640 650 660 PCGVPNGSYY RPEGTLERRR PPYGGYEGHP QGYAEASVEK RRLCRSLSEG PYPYAPELGK 670 680 690 700 710 720 PANGDFGYRP AGYREVVILE DPGVPALCSC PACEEKLALP TAALYGLRLE REAAEGWSSE 730 740 750 760 770 780 VGKPLLHPVR PGHPLPLLVP ACGHHHAPMP DYGCLKPPKV GEEGHEGCSY AVCSEGRYGH 790 800 810 820 830 840 SGYPALVTYG YGGAVPSYCP AYGRAPHSCG SPSEGRGYPS PGAHSPRAGS VSPGSPPYLQ 850 860 870 880 890 900 PRKLGYEISA EDGRDKYPLS GHLASTGPLA STESPEPSWR DGSSGHSTLP RSPRDPQCSA 910 920 930 940 950 960 SSELSGPSTP LHTSSPVQGK ESNRRQDTTR SPSLAPTQRL SPGEALPSVV QGVAEKTPEL 970 980 990 1000 1010 1020 LTSSRPEQLD PSPFSQTSAP GSPNGWPQER SPGGHTNSAS PRSPVPTTLP GLRHAPWQGP 1030 1040 1050 1060 1070 1080 RGTSDSPDGS PLTPVPTQMP WLVGSPEPPQ SSPTPAFPLA TSYDANGPIQ PPLPEKRHLP 1090 1100 1110 1120 1130 1140 GSGQQPSPPA RSTNQHVTFA SPLPDVTQPP EHPLQENQSN VKFVQDTSKF WYKPHLSRDQ 1150 1160 1170 1180 1190 1200 AIALLKDKDP GAFLIRDSHS FQGAYGLALK VATPPPSAQP WKGDPSEQLV RHFLIETGPK 1210 1220 1230 1240 1250 1260 GVKIKGCPTE PYFGSLSALV SQHSISPISL PCCLRIPSKD PLEETPEAPV PTNMSTAADL 1270 1280 1290 1300 1310 1320 LRQGAACSVL YLTSVETESL TGPQAVAKAS SAALSCSPVP VPAIVHFKVS AQGITLTDNQ 1330 1340 1350 1360 1370 1380 RKLFFRRHYP VNSITFSSTD PQDRRWTNPD GATSKIFGFV AKKPGSPWEN VCHLFAELDP 1390 1400 DQPASAIVTF ITKVLLGQRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of mouse tensin 2." Lo S.H. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 753-1400 (ISOFORM 3). Strain: FVB/N. Tissue: Liver and Salivary gland.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-935 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-875 (ISOFORM 1). Strain: C57BL/6J. Tissue: Inner ear and Melanocyte.
[4]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-483, MASS SPECTROMETRY. Tissue: Brain.
[5]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455; SER-466; SER-481; TYR-483; SER-832; SER-835 AND THR-913, MASS SPECTROMETRY. Tissue: Liver.
[6]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-483 AND SER-1087, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF424789 mRNA. Translation: AAN32753.1. BC025818 mRNA. Translation: AAH25818.1. BC042190 mRNA. Translation: AAH42190.1. AK147789 mRNA. Translation: BAE28139.1. AK158009 mRNA. Translation: BAE34316.1. Frameshift.
IPI	IPI00762785. IPI00816969. IPI00848476. IPI00848939.
RefSeq	NP_705761.2. NM_153533.2.
UniGene	Mm.29389.
3D structure databases
ProteinModelPortal	Q8CGB6.
SMR	Q8CGB6. Positions 32-79, 126-467, 1126-1240, 1254-1400.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4115716.
STRING	10090.ENSMUSP00000041087.
PTM databases
PhosphoSite	Q8CGB6.
Proteomic databases
PaxDb	Q8CGB6.
PRIDE	Q8CGB6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000046144; ENSMUSP00000041087; ENSMUSG00000037003. ENSMUST00000169627; ENSMUSP00000129146; ENSMUSG00000037003.
GeneID	209039.
KEGG	mmu:209039.
UCSC	uc007xum.1. mouse. uc007xun.1. mouse. uc007xuo.1. mouse. uc011zzx.1. mouse.
Organism-specific databases
CTD	23371.
MGI	MGI:2387586. Tenc1.
Phylogenomic databases
eggNOG	COG2453.
GeneTree	ENSGT00620000087781.
HOGENOM	HOG000154544.
HOVERGEN	HBG108559.
InParanoid	Q8CGB6.
OMA	HAPWQGP.
OrthoDB	EOG4MW858.
Gene expression databases
Bgee	Q8CGB6.
CleanEx	MM_TENC1.
Genevestigator	Q8CGB6.
Family and domain databases
Gene3D	2.30.29.30. 1 hit. 3.30.505.10. 1 hit.
InterPro	IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR011993. PH_like_dom. IPR014019. Phosphatase_tensin-typ. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. IPR013625. PTB. IPR006020. PTyr_interaction_dom. IPR000980. SH2. IPR014020. Tensin_phosphatase_C2-dom. [Graphical view]
Pfam	PF08416. PTB. 1 hit. PF10409. PTEN_C2. 1 hit. PF00017. SH2. 1 hit. [Graphical view]
SMART	SM00109. C1. 1 hit. SM00462. PTB. 1 hit. SM00252. SH2. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit.
PROSITE	PS51182. C2_TENSIN. 1 hit. PS51181. PPASE_TENSIN. 1 hit. PS50001. SH2. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	372540.
SOURCE	Search...

Entry information

Entry name

TENC1_MOUSE

Accession

Primary (citable) accession number: Q8CGB6
Secondary accession number(s): Q3TZ93 , Q3UGR8, Q8CJ95, Q8R122

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program