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Protein

Tensin-2

Gene

Tns2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei231Phosphocysteine intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri31 – 79Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST49

GO - Molecular functioni

GO - Biological processi

  • cellular homeostasis Source: MGI
  • collagen metabolic process Source: MGI
  • intracellular signal transduction Source: InterPro
  • kidney development Source: MGI
  • multicellular organismal homeostasis Source: MGI
  • multicellular organism growth Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • response to muscle activity Source: MGI

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-2 (EC:3.1.3.-)
Alternative name(s):
C1 domain-containing phosphatase and tensin homolog
Short name:
C1-TEN
Tensin-like C1 domain-containing phosphatase
Gene namesi
Name:Tns2
Synonyms:Tenc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2387586 Tns2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002929881 – 1400Tensin-2Add BLAST1400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphothreonineBy similarity1
Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei455PhosphoserineCombined sources1
Modified residuei456PhosphotyrosineBy similarity1
Modified residuei466PhosphoserineCombined sources1
Modified residuei474PhosphothreonineBy similarity1
Modified residuei481PhosphoserineCombined sources1
Modified residuei483PhosphotyrosineCombined sources1
Modified residuei555Omega-N-methylarginineCombined sources1
Modified residuei820PhosphoserineBy similarity1
Modified residuei825PhosphoserineBy similarity1
Modified residuei830PhosphoserineCombined sources1
Modified residuei832PhosphoserineCombined sources1
Modified residuei835PhosphoserineCombined sources1
Modified residuei909PhosphothreonineCombined sources1
Modified residuei931PhosphoserineBy similarity1
Modified residuei941PhosphoserineCombined sources1
Modified residuei972PhosphoserineBy similarity1
Modified residuei977PhosphothreonineBy similarity1
Modified residuei991PhosphoserineBy similarity1
Modified residuei1003PhosphoserineBy similarity1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1173PhosphothreonineBy similarity1
Modified residuei1238PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ8CGB6
PeptideAtlasiQ8CGB6
PRIDEiQ8CGB6

PTM databases

iPTMnetiQ8CGB6
PhosphoSitePlusiQ8CGB6
SwissPalmiQ8CGB6

Expressioni

Gene expression databases

BgeeiENSMUSG00000037003
CleanExiMM_TENC1
GenevisibleiQ8CGB6 MM

Interactioni

Subunit structurei

Interacts with AXL. Interacts with SYK; leading to its phosphorylation (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ8CGB6
IntActiQ8CGB6, 1 interactor
MINTiQ8CGB6
STRINGi10090.ENSMUSP00000129146

Structurei

3D structure databases

ProteinModelPortaliQ8CGB6
SMRiQ8CGB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 294Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST173
Domaini299 – 425C2 tensin-typePROSITE-ProRule annotationAdd BLAST127
Domaini1131 – 1238SH2PROSITE-ProRule annotationAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi502 – 505Poly-Pro4
Compositional biasi966 – 1113Pro-richAdd BLAST148

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri31 – 79Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

SH2 domain, Zinc-finger

Phylogenomic databases

eggNOGiKOG1930 Eukaryota
KOG2283 Eukaryota
ENOG410YFRV LUCA
GeneTreeiENSGT00760000119113
HOGENOMiHOG000154544
HOVERGENiHBG108559
InParanoidiQ8CGB6
KOiK18080
OMAiYYRPEGT
OrthoDBiEOG091G00II
PhylomeDBiQ8CGB6
TreeFamiTF315996

Family and domain databases

CDDicd00029 C1, 1 hit
cd01213 PTB_tensin, 1 hit
cd09927 SH2_Tensin_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR014020 Tensin_C2-dom
IPR035012 Tensin_like_SH2
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF10409 PTEN_C2, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00462 PTB, 1 hit
SM01326 PTEN_C2, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50001 SH2, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CGB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSSGPVERL LRALGRRDSS RATSRPRKAE PHSFREKVFR KKTPVCAVCK
60 70 80 90 100
VTIDGTGVSC RVCKVATHRK CEAKVTSSCQ ALPPAELRRS TAPVRRIEHL
110 120 130 140 150
GSTKSLNHSK QRSTLPRSFS LDPLMERRWD LDLTYVTERI LAAAFPARPD
160 170 180 190 200
EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE KRHDLTRLNP KVQDFGWPEL
210 220 230 240 250
HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGSKGKLGV IVSAYMHYSK
260 270 280 290 300
ISAGADQALA TLTMRKFCED KVATELQPSQ RRYVSYFSGL LSGSIRMNSS
310 320 330 340 350
PLFLHYVFVP VLPAFEPNTG FQPFLKIYQS MQLVYTSGVY RIAGPGPQQL
360 370 380 390 400
CISLEPALLL KGDVMVTCYH KGGQGTDRTL VFRVQFHTCT IHGSRLTFPK
410 420 430 440 450
DQLDEAWADE RFPFQASVEF VFSSSPEKVK GNTPRNDPSV SVDYNTTEPA
460 470 480 490 500
VRWDSYENFN QHHEDSVDGA LAHTRGPLDG SPYAQVQRVP RQTPPAPSPE
510 520 530 540 550
LPPPPMLSVS SDSGHSSTLT TEHTAESPGR PPPTAAERQE LDRLLGGCGV
560 570 580 590 600
ASAGRGAGRE TAILDDEEQP SVGGGLHLGM YSGHRPGLSR RCSCRQGFRE
610 620 630 640 650
PCGVPNGSYY RPEGTLERRR PPYGGYEGHP QGYAEASVEK RRLCRSLSEG
660 670 680 690 700
PYPYAPELGK PANGDFGYRP AGYREVVILE DPGVPALCSC PACEEKLALP
710 720 730 740 750
TAALYGLRLE REAAEGWSSE VGKPLLHPVR PGHPLPLLVP ACGHHHAPMP
760 770 780 790 800
DYGCLKPPKV GEEGHEGCSY AVCSEGRYGH SGYPALVTYG YGGAVPSYCP
810 820 830 840 850
AYGRAPHSCG SPSEGRGYPS PGAHSPRAGS VSPGSPPYLQ PRKLGYEISA
860 870 880 890 900
EDGRDKYPLS GHLASTGPLA STESPEPSWR DGSSGHSTLP RSPRDPQCSA
910 920 930 940 950
SSELSGPSTP LHTSSPVQGK ESNRRQDTTR SPSLAPTQRL SPGEALPSVV
960 970 980 990 1000
QGVAEKTPEL LTSSRPEQLD PSPFSQTSAP GSPNGWPQER SPGGHTNSAS
1010 1020 1030 1040 1050
PRSPVPTTLP GLRHAPWQGP RGTSDSPDGS PLTPVPTQMP WLVGSPEPPQ
1060 1070 1080 1090 1100
SSPTPAFPLA TSYDANGPIQ PPLPEKRHLP GSGQQPSPPA RSTNQHVTFA
1110 1120 1130 1140 1150
SPLPDVTQPP EHPLQENQSN VKFVQDTSKF WYKPHLSRDQ AIALLKDKDP
1160 1170 1180 1190 1200
GAFLIRDSHS FQGAYGLALK VATPPPSAQP WKGDPSEQLV RHFLIETGPK
1210 1220 1230 1240 1250
GVKIKGCPTE PYFGSLSALV SQHSISPISL PCCLRIPSKD PLEETPEAPV
1260 1270 1280 1290 1300
PTNMSTAADL LRQGAACSVL YLTSVETESL TGPQAVAKAS SAALSCSPVP
1310 1320 1330 1340 1350
VPAIVHFKVS AQGITLTDNQ RKLFFRRHYP VNSITFSSTD PQDRRWTNPD
1360 1370 1380 1390 1400
GATSKIFGFV AKKPGSPWEN VCHLFAELDP DQPASAIVTF ITKVLLGQRK
Length:1,400
Mass (Da):152,013
Last modified:March 1, 2003 - v1
Checksum:i72CB109A17BB021C
GO
Isoform 2 (identifier: Q8CGB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKSSGPVERLLRALGRRDSSRATSR → MK

Note: No experimental confirmation available.
Show »
Length:1,377
Mass (Da):149,503
Checksum:i54E6DD76352B9D7F
GO
Isoform 3 (identifier: Q8CGB6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     872-872: T → TELFPPVS

Note: No experimental confirmation available.
Show »
Length:1,407
Mass (Da):152,782
Checksum:i1051BA1D0437E506
GO
Isoform 4 (identifier: Q8CGB6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKSSGPVERLLRALGRRDSSRATSR → MGWSGGAPCCCPSSPRPRPSGRPPQ

Show »
Length:1,400
Mass (Da):151,794
Checksum:i4B813AFC267D06DF
GO

Sequence cautioni

The sequence BAE34316 differs from that shown. Reason: Frameshift at position 66.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54D → N in BAE28139 (PubMed:16141072).Curated1
Sequence conflicti195F → L in BAE28139 (PubMed:16141072).Curated1
Sequence conflicti204P → H in BAE28139 (PubMed:16141072).Curated1
Sequence conflicti1112 – 1114HPL → NPFVVQE in AAN32753 (Ref. 1) Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0264621 – 25MKSSG…RATSR → MK in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0264631 – 25MKSSG…RATSR → MGWSGGAPCCCPSSPRPRPS GRPPQ in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_026464872T → TELFPPVS in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424789 mRNA Translation: AAN32753.1
BC025818 mRNA Translation: AAH25818.1
BC042190 mRNA Translation: AAH42190.1
AK147789 mRNA Translation: BAE28139.1
AK158009 mRNA Translation: BAE34316.1 Frameshift.
CCDSiCCDS37224.1 [Q8CGB6-1]
RefSeqiNP_705761.2, NM_153533.2 [Q8CGB6-1]
XP_006520755.1, XM_006520692.2 [Q8CGB6-4]
XP_006520757.1, XM_006520694.2 [Q8CGB6-2]
XP_011243839.1, XM_011245537.2
UniGeneiMm.29389

Genome annotation databases

EnsembliENSMUST00000046144; ENSMUSP00000041087; ENSMUSG00000037003 [Q8CGB6-3]
ENSMUST00000169627; ENSMUSP00000129146; ENSMUSG00000037003 [Q8CGB6-1]
ENSMUST00000228958; ENSMUSP00000155830; ENSMUSG00000037003 [Q8CGB6-4]
GeneIDi209039
KEGGimmu:209039
UCSCiuc007xum.1 mouse [Q8CGB6-4]
uc007xun.1 mouse [Q8CGB6-2]
uc007xuo.1 mouse [Q8CGB6-1]
uc011zzx.1 mouse [Q8CGB6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTNS2_MOUSE
AccessioniPrimary (citable) accession number: Q8CGB6
Secondary accession number(s): Q3TZ93
, Q3UGR8, Q8CJ95, Q8R122
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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