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Protein

Tensin-2

Gene

Tns2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei231Phosphocysteine intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri31 – 79Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST49

GO - Molecular functioni

GO - Biological processi

  • cellular homeostasis Source: MGI
  • collagen metabolic process Source: MGI
  • intracellular signal transduction Source: InterPro
  • kidney development Source: MGI
  • multicellular organismal homeostasis Source: MGI
  • multicellular organism growth Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • response to muscle activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-2 (EC:3.1.3.-)
Alternative name(s):
C1 domain-containing phosphatase and tensin homolog
Short name:
C1-TEN
Tensin-like C1 domain-containing phosphatase
Gene namesi
Name:Tns2
Synonyms:Tenc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2387586. Tns2.

Subcellular locationi

  • Cell junctionfocal adhesion By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

  • Note: Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002929881 – 1400Tensin-2Add BLAST1400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphothreonineBy similarity1
Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei455PhosphoserineCombined sources1
Modified residuei456PhosphotyrosineBy similarity1
Modified residuei466PhosphoserineCombined sources1
Modified residuei474PhosphothreonineBy similarity1
Modified residuei481PhosphoserineCombined sources1
Modified residuei483PhosphotyrosineCombined sources1
Modified residuei555Omega-N-methylarginineCombined sources1
Modified residuei820PhosphoserineBy similarity1
Modified residuei825PhosphoserineBy similarity1
Modified residuei830PhosphoserineCombined sources1
Modified residuei832PhosphoserineCombined sources1
Modified residuei835PhosphoserineCombined sources1
Modified residuei909PhosphothreonineCombined sources1
Modified residuei931PhosphoserineBy similarity1
Modified residuei941PhosphoserineCombined sources1
Modified residuei972PhosphoserineBy similarity1
Modified residuei977PhosphothreonineBy similarity1
Modified residuei991PhosphoserineBy similarity1
Modified residuei1003PhosphoserineBy similarity1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1173PhosphothreonineBy similarity1
Modified residuei1238PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ8CGB6.
PeptideAtlasiQ8CGB6.
PRIDEiQ8CGB6.

PTM databases

iPTMnetiQ8CGB6.
PhosphoSitePlusiQ8CGB6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037003.
CleanExiMM_TENC1.
GenevisibleiQ8CGB6. MM.

Interactioni

Subunit structurei

Interacts with AXL. Interacts with SYK; leading to its phosphorylation (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8CGB6. 1 interactor.
MINTiMINT-4115716.
STRINGi10090.ENSMUSP00000129146.

Structurei

3D structure databases

ProteinModelPortaliQ8CGB6.
SMRiQ8CGB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 294Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST173
Domaini299 – 425C2 tensin-typePROSITE-ProRule annotationAdd BLAST127
Domaini1131 – 1238SH2PROSITE-ProRule annotationAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi502 – 505Poly-Pro4
Compositional biasi966 – 1113Pro-richAdd BLAST148

Sequence similaritiesi

Contains 1 C2 tensin-type domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 phosphatase tensin-type domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri31 – 79Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

SH2 domain, Zinc-finger

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
ENOG410YFRV. LUCA.
GeneTreeiENSGT00760000119113.
HOGENOMiHOG000154544.
HOVERGENiHBG108559.
InParanoidiQ8CGB6.
KOiK18080.
OMAiRQGYREP.
OrthoDBiEOG091G00II.
PhylomeDBiQ8CGB6.
TreeFamiTF315996.

Family and domain databases

CDDicd00029. C1. 1 hit.
cd01213. PTB_tensin. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR033929. Tensin_PTB.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CGB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSSGPVERL LRALGRRDSS RATSRPRKAE PHSFREKVFR KKTPVCAVCK
60 70 80 90 100
VTIDGTGVSC RVCKVATHRK CEAKVTSSCQ ALPPAELRRS TAPVRRIEHL
110 120 130 140 150
GSTKSLNHSK QRSTLPRSFS LDPLMERRWD LDLTYVTERI LAAAFPARPD
160 170 180 190 200
EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE KRHDLTRLNP KVQDFGWPEL
210 220 230 240 250
HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGSKGKLGV IVSAYMHYSK
260 270 280 290 300
ISAGADQALA TLTMRKFCED KVATELQPSQ RRYVSYFSGL LSGSIRMNSS
310 320 330 340 350
PLFLHYVFVP VLPAFEPNTG FQPFLKIYQS MQLVYTSGVY RIAGPGPQQL
360 370 380 390 400
CISLEPALLL KGDVMVTCYH KGGQGTDRTL VFRVQFHTCT IHGSRLTFPK
410 420 430 440 450
DQLDEAWADE RFPFQASVEF VFSSSPEKVK GNTPRNDPSV SVDYNTTEPA
460 470 480 490 500
VRWDSYENFN QHHEDSVDGA LAHTRGPLDG SPYAQVQRVP RQTPPAPSPE
510 520 530 540 550
LPPPPMLSVS SDSGHSSTLT TEHTAESPGR PPPTAAERQE LDRLLGGCGV
560 570 580 590 600
ASAGRGAGRE TAILDDEEQP SVGGGLHLGM YSGHRPGLSR RCSCRQGFRE
610 620 630 640 650
PCGVPNGSYY RPEGTLERRR PPYGGYEGHP QGYAEASVEK RRLCRSLSEG
660 670 680 690 700
PYPYAPELGK PANGDFGYRP AGYREVVILE DPGVPALCSC PACEEKLALP
710 720 730 740 750
TAALYGLRLE REAAEGWSSE VGKPLLHPVR PGHPLPLLVP ACGHHHAPMP
760 770 780 790 800
DYGCLKPPKV GEEGHEGCSY AVCSEGRYGH SGYPALVTYG YGGAVPSYCP
810 820 830 840 850
AYGRAPHSCG SPSEGRGYPS PGAHSPRAGS VSPGSPPYLQ PRKLGYEISA
860 870 880 890 900
EDGRDKYPLS GHLASTGPLA STESPEPSWR DGSSGHSTLP RSPRDPQCSA
910 920 930 940 950
SSELSGPSTP LHTSSPVQGK ESNRRQDTTR SPSLAPTQRL SPGEALPSVV
960 970 980 990 1000
QGVAEKTPEL LTSSRPEQLD PSPFSQTSAP GSPNGWPQER SPGGHTNSAS
1010 1020 1030 1040 1050
PRSPVPTTLP GLRHAPWQGP RGTSDSPDGS PLTPVPTQMP WLVGSPEPPQ
1060 1070 1080 1090 1100
SSPTPAFPLA TSYDANGPIQ PPLPEKRHLP GSGQQPSPPA RSTNQHVTFA
1110 1120 1130 1140 1150
SPLPDVTQPP EHPLQENQSN VKFVQDTSKF WYKPHLSRDQ AIALLKDKDP
1160 1170 1180 1190 1200
GAFLIRDSHS FQGAYGLALK VATPPPSAQP WKGDPSEQLV RHFLIETGPK
1210 1220 1230 1240 1250
GVKIKGCPTE PYFGSLSALV SQHSISPISL PCCLRIPSKD PLEETPEAPV
1260 1270 1280 1290 1300
PTNMSTAADL LRQGAACSVL YLTSVETESL TGPQAVAKAS SAALSCSPVP
1310 1320 1330 1340 1350
VPAIVHFKVS AQGITLTDNQ RKLFFRRHYP VNSITFSSTD PQDRRWTNPD
1360 1370 1380 1390 1400
GATSKIFGFV AKKPGSPWEN VCHLFAELDP DQPASAIVTF ITKVLLGQRK
Length:1,400
Mass (Da):152,013
Last modified:March 1, 2003 - v1
Checksum:i72CB109A17BB021C
GO
Isoform 2 (identifier: Q8CGB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKSSGPVERLLRALGRRDSSRATSR → MK

Note: No experimental confirmation available.
Show »
Length:1,377
Mass (Da):149,503
Checksum:i54E6DD76352B9D7F
GO
Isoform 3 (identifier: Q8CGB6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     872-872: T → TELFPPVS

Note: No experimental confirmation available.
Show »
Length:1,407
Mass (Da):152,782
Checksum:i1051BA1D0437E506
GO
Isoform 4 (identifier: Q8CGB6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKSSGPVERLLRALGRRDSSRATSR → MGWSGGAPCCCPSSPRPRPSGRPPQ

Show »
Length:1,400
Mass (Da):151,794
Checksum:i4B813AFC267D06DF
GO

Sequence cautioni

The sequence BAE34316 differs from that shown. Reason: Frameshift at position 66.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54D → N in BAE28139 (PubMed:16141072).Curated1
Sequence conflicti195F → L in BAE28139 (PubMed:16141072).Curated1
Sequence conflicti204P → H in BAE28139 (PubMed:16141072).Curated1
Sequence conflicti1112 – 1114HPL → NPFVVQE in AAN32753 (Ref. 1) Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0264621 – 25MKSSG…RATSR → MK in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0264631 – 25MKSSG…RATSR → MGWSGGAPCCCPSSPRPRPS GRPPQ in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_026464872T → TELFPPVS in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424789 mRNA. Translation: AAN32753.1.
BC025818 mRNA. Translation: AAH25818.1.
BC042190 mRNA. Translation: AAH42190.1.
AK147789 mRNA. Translation: BAE28139.1.
AK158009 mRNA. Translation: BAE34316.1. Frameshift.
CCDSiCCDS37224.1. [Q8CGB6-1]
RefSeqiNP_705761.2. NM_153533.2. [Q8CGB6-1]
XP_006520755.1. XM_006520692.2. [Q8CGB6-4]
XP_006520757.1. XM_006520694.2. [Q8CGB6-2]
XP_011243839.1. XM_011245537.2. [Q8CGB6-3]
UniGeneiMm.29389.

Genome annotation databases

EnsembliENSMUST00000046144; ENSMUSP00000041087; ENSMUSG00000037003. [Q8CGB6-3]
ENSMUST00000169627; ENSMUSP00000129146; ENSMUSG00000037003. [Q8CGB6-1]
GeneIDi209039.
KEGGimmu:209039.
UCSCiuc007xum.1. mouse. [Q8CGB6-4]
uc007xun.1. mouse. [Q8CGB6-2]
uc007xuo.1. mouse. [Q8CGB6-1]
uc011zzx.1. mouse. [Q8CGB6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424789 mRNA. Translation: AAN32753.1.
BC025818 mRNA. Translation: AAH25818.1.
BC042190 mRNA. Translation: AAH42190.1.
AK147789 mRNA. Translation: BAE28139.1.
AK158009 mRNA. Translation: BAE34316.1. Frameshift.
CCDSiCCDS37224.1. [Q8CGB6-1]
RefSeqiNP_705761.2. NM_153533.2. [Q8CGB6-1]
XP_006520755.1. XM_006520692.2. [Q8CGB6-4]
XP_006520757.1. XM_006520694.2. [Q8CGB6-2]
XP_011243839.1. XM_011245537.2. [Q8CGB6-3]
UniGeneiMm.29389.

3D structure databases

ProteinModelPortaliQ8CGB6.
SMRiQ8CGB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CGB6. 1 interactor.
MINTiMINT-4115716.
STRINGi10090.ENSMUSP00000129146.

PTM databases

iPTMnetiQ8CGB6.
PhosphoSitePlusiQ8CGB6.

Proteomic databases

PaxDbiQ8CGB6.
PeptideAtlasiQ8CGB6.
PRIDEiQ8CGB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046144; ENSMUSP00000041087; ENSMUSG00000037003. [Q8CGB6-3]
ENSMUST00000169627; ENSMUSP00000129146; ENSMUSG00000037003. [Q8CGB6-1]
GeneIDi209039.
KEGGimmu:209039.
UCSCiuc007xum.1. mouse. [Q8CGB6-4]
uc007xun.1. mouse. [Q8CGB6-2]
uc007xuo.1. mouse. [Q8CGB6-1]
uc011zzx.1. mouse. [Q8CGB6-3]

Organism-specific databases

CTDi23371.
MGIiMGI:2387586. Tns2.

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
ENOG410YFRV. LUCA.
GeneTreeiENSGT00760000119113.
HOGENOMiHOG000154544.
HOVERGENiHBG108559.
InParanoidiQ8CGB6.
KOiK18080.
OMAiRQGYREP.
OrthoDBiEOG091G00II.
PhylomeDBiQ8CGB6.
TreeFamiTF315996.

Miscellaneous databases

PROiQ8CGB6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037003.
CleanExiMM_TENC1.
GenevisibleiQ8CGB6. MM.

Family and domain databases

CDDicd00029. C1. 1 hit.
cd01213. PTB_tensin. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR033929. Tensin_PTB.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNS2_MOUSE
AccessioniPrimary (citable) accession number: Q8CGB6
Secondary accession number(s): Q3TZ93
, Q3UGR8, Q8CJ95, Q8R122
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.