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Q8CGB6

- TENC1_MOUSE

UniProt

Q8CGB6 - TENC1_MOUSE

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Protein

Tensin-like C1 domain-containing phosphatase

Gene
Tenc1, Tns2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei231 – 2311Phosphocysteine intermediate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri31 – 7949Phorbol-ester/DAG-typeAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular homeostasis Source: MGI
  2. collagen metabolic process Source: MGI
  3. intracellular signal transduction Source: InterPro
  4. kidney development Source: MGI
  5. multicellular organismal homeostasis Source: MGI
  6. multicellular organism growth Source: MGI
  7. negative regulation of cell proliferation Source: Ensembl
  8. response to muscle activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-like C1 domain-containing phosphatase (EC:3.1.3.-)
Alternative name(s):
C1 domain-containing phosphatase and tensin homolog
Short name:
C1-TEN
Tensin-2
Gene namesi
Name:Tenc1
Synonyms:Tns2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2387586. Tenc1.

Subcellular locationi

Cell junctionfocal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Note: Detected at the end of actin stress fibers By similarity.

GO - Cellular componenti

  1. focal adhesion Source: UniProtKB-SubCell
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14001400Tensin-like C1 domain-containing phosphatasePRO_0000292988Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei483 – 4831Phosphotyrosine1 Publication
Modified residuei1087 – 10871Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8CGB6.
PaxDbiQ8CGB6.
PRIDEiQ8CGB6.

PTM databases

PhosphoSiteiQ8CGB6.

Expressioni

Gene expression databases

BgeeiQ8CGB6.
CleanExiMM_TENC1.
GenevestigatoriQ8CGB6.

Interactioni

Subunit structurei

Interacts with AXL By similarity.

Protein-protein interaction databases

IntActiQ8CGB6. 1 interaction.
MINTiMINT-4115716.
STRINGi10090.ENSMUSP00000041087.

Structurei

3D structure databases

ProteinModelPortaliQ8CGB6.
SMRiQ8CGB6. Positions 126-467, 1126-1240, 1254-1400.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini122 – 294173Phosphatase tensin-typeAdd
BLAST
Domaini299 – 425127C2 tensin-typeAdd
BLAST
Domaini1131 – 1238108SH2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi502 – 5054Poly-Pro
Compositional biasi966 – 1113148Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain, Zinc-finger

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00620000087781.
HOGENOMiHOG000154544.
HOVERGENiHBG108559.
InParanoidiQ8CGB6.
KOiK18080.
OMAiRQGYREP.
OrthoDBiEOG7ZPNJ6.
PhylomeDBiQ8CGB6.
TreeFamiTF315996.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8CGB6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKSSGPVERL LRALGRRDSS RATSRPRKAE PHSFREKVFR KKTPVCAVCK     50
VTIDGTGVSC RVCKVATHRK CEAKVTSSCQ ALPPAELRRS TAPVRRIEHL 100
GSTKSLNHSK QRSTLPRSFS LDPLMERRWD LDLTYVTERI LAAAFPARPD 150
EQRHRGHLRE LAHVLQSKHR DKYLLFNLSE KRHDLTRLNP KVQDFGWPEL 200
HAPPLDKLCS ICKAMETWLS ADPQHVVVLY CKGSKGKLGV IVSAYMHYSK 250
ISAGADQALA TLTMRKFCED KVATELQPSQ RRYVSYFSGL LSGSIRMNSS 300
PLFLHYVFVP VLPAFEPNTG FQPFLKIYQS MQLVYTSGVY RIAGPGPQQL 350
CISLEPALLL KGDVMVTCYH KGGQGTDRTL VFRVQFHTCT IHGSRLTFPK 400
DQLDEAWADE RFPFQASVEF VFSSSPEKVK GNTPRNDPSV SVDYNTTEPA 450
VRWDSYENFN QHHEDSVDGA LAHTRGPLDG SPYAQVQRVP RQTPPAPSPE 500
LPPPPMLSVS SDSGHSSTLT TEHTAESPGR PPPTAAERQE LDRLLGGCGV 550
ASAGRGAGRE TAILDDEEQP SVGGGLHLGM YSGHRPGLSR RCSCRQGFRE 600
PCGVPNGSYY RPEGTLERRR PPYGGYEGHP QGYAEASVEK RRLCRSLSEG 650
PYPYAPELGK PANGDFGYRP AGYREVVILE DPGVPALCSC PACEEKLALP 700
TAALYGLRLE REAAEGWSSE VGKPLLHPVR PGHPLPLLVP ACGHHHAPMP 750
DYGCLKPPKV GEEGHEGCSY AVCSEGRYGH SGYPALVTYG YGGAVPSYCP 800
AYGRAPHSCG SPSEGRGYPS PGAHSPRAGS VSPGSPPYLQ PRKLGYEISA 850
EDGRDKYPLS GHLASTGPLA STESPEPSWR DGSSGHSTLP RSPRDPQCSA 900
SSELSGPSTP LHTSSPVQGK ESNRRQDTTR SPSLAPTQRL SPGEALPSVV 950
QGVAEKTPEL LTSSRPEQLD PSPFSQTSAP GSPNGWPQER SPGGHTNSAS 1000
PRSPVPTTLP GLRHAPWQGP RGTSDSPDGS PLTPVPTQMP WLVGSPEPPQ 1050
SSPTPAFPLA TSYDANGPIQ PPLPEKRHLP GSGQQPSPPA RSTNQHVTFA 1100
SPLPDVTQPP EHPLQENQSN VKFVQDTSKF WYKPHLSRDQ AIALLKDKDP 1150
GAFLIRDSHS FQGAYGLALK VATPPPSAQP WKGDPSEQLV RHFLIETGPK 1200
GVKIKGCPTE PYFGSLSALV SQHSISPISL PCCLRIPSKD PLEETPEAPV 1250
PTNMSTAADL LRQGAACSVL YLTSVETESL TGPQAVAKAS SAALSCSPVP 1300
VPAIVHFKVS AQGITLTDNQ RKLFFRRHYP VNSITFSSTD PQDRRWTNPD 1350
GATSKIFGFV AKKPGSPWEN VCHLFAELDP DQPASAIVTF ITKVLLGQRK 1400
Length:1,400
Mass (Da):152,013
Last modified:March 1, 2003 - v1
Checksum:i72CB109A17BB021C
GO
Isoform 2 (identifier: Q8CGB6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKSSGPVERLLRALGRRDSSRATSR → MK

Note: No experimental confirmation available.

Show »
Length:1,377
Mass (Da):149,503
Checksum:i54E6DD76352B9D7F
GO
Isoform 3 (identifier: Q8CGB6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     872-872: T → TELFPPVS

Note: No experimental confirmation available.

Show »
Length:1,407
Mass (Da):152,782
Checksum:i1051BA1D0437E506
GO
Isoform 4 (identifier: Q8CGB6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKSSGPVERLLRALGRRDSSRATSR → MGWSGGAPCCCPSSPRPRPSGRPPQ

Show »
Length:1,400
Mass (Da):151,794
Checksum:i4B813AFC267D06DF
GO

Sequence cautioni

The sequence BAE34316.1 differs from that shown. Reason: Frameshift at position 66.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2525MKSSG…RATSR → MK in isoform 2. VSP_026462Add
BLAST
Alternative sequencei1 – 2525MKSSG…RATSR → MGWSGGAPCCCPSSPRPRPS GRPPQ in isoform 4. VSP_026463Add
BLAST
Alternative sequencei872 – 8721T → TELFPPVS in isoform 3. VSP_026464

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541D → N in BAE28139. 1 Publication
Sequence conflicti195 – 1951F → L in BAE28139. 1 Publication
Sequence conflicti204 – 2041P → H in BAE28139. 1 Publication
Sequence conflicti1112 – 11143HPL → NPFVVQE in AAN32753. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF424789 mRNA. Translation: AAN32753.1.
BC025818 mRNA. Translation: AAH25818.1.
BC042190 mRNA. Translation: AAH42190.1.
AK147789 mRNA. Translation: BAE28139.1.
AK158009 mRNA. Translation: BAE34316.1. Frameshift.
CCDSiCCDS37224.1. [Q8CGB6-1]
RefSeqiNP_705761.2. NM_153533.2. [Q8CGB6-1]
XP_006520755.1. XM_006520692.1. [Q8CGB6-4]
XP_006520757.1. XM_006520694.1. [Q8CGB6-2]
UniGeneiMm.29389.

Genome annotation databases

EnsembliENSMUST00000046144; ENSMUSP00000041087; ENSMUSG00000037003. [Q8CGB6-3]
ENSMUST00000169627; ENSMUSP00000129146; ENSMUSG00000037003. [Q8CGB6-1]
GeneIDi209039.
KEGGimmu:209039.
UCSCiuc007xum.1. mouse. [Q8CGB6-4]
uc007xun.1. mouse. [Q8CGB6-2]
uc007xuo.1. mouse. [Q8CGB6-1]
uc011zzx.1. mouse. [Q8CGB6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF424789 mRNA. Translation: AAN32753.1 .
BC025818 mRNA. Translation: AAH25818.1 .
BC042190 mRNA. Translation: AAH42190.1 .
AK147789 mRNA. Translation: BAE28139.1 .
AK158009 mRNA. Translation: BAE34316.1 . Frameshift.
CCDSi CCDS37224.1. [Q8CGB6-1 ]
RefSeqi NP_705761.2. NM_153533.2. [Q8CGB6-1 ]
XP_006520755.1. XM_006520692.1. [Q8CGB6-4 ]
XP_006520757.1. XM_006520694.1. [Q8CGB6-2 ]
UniGenei Mm.29389.

3D structure databases

ProteinModelPortali Q8CGB6.
SMRi Q8CGB6. Positions 126-467, 1126-1240, 1254-1400.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CGB6. 1 interaction.
MINTi MINT-4115716.
STRINGi 10090.ENSMUSP00000041087.

PTM databases

PhosphoSitei Q8CGB6.

Proteomic databases

MaxQBi Q8CGB6.
PaxDbi Q8CGB6.
PRIDEi Q8CGB6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046144 ; ENSMUSP00000041087 ; ENSMUSG00000037003 . [Q8CGB6-3 ]
ENSMUST00000169627 ; ENSMUSP00000129146 ; ENSMUSG00000037003 . [Q8CGB6-1 ]
GeneIDi 209039.
KEGGi mmu:209039.
UCSCi uc007xum.1. mouse. [Q8CGB6-4 ]
uc007xun.1. mouse. [Q8CGB6-2 ]
uc007xuo.1. mouse. [Q8CGB6-1 ]
uc011zzx.1. mouse. [Q8CGB6-3 ]

Organism-specific databases

CTDi 23371.
MGIi MGI:2387586. Tenc1.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00620000087781.
HOGENOMi HOG000154544.
HOVERGENi HBG108559.
InParanoidi Q8CGB6.
KOi K18080.
OMAi RQGYREP.
OrthoDBi EOG7ZPNJ6.
PhylomeDBi Q8CGB6.
TreeFami TF315996.

Miscellaneous databases

NextBioi 372540.
PROi Q8CGB6.
SOURCEi Search...

Gene expression databases

Bgeei Q8CGB6.
CleanExi MM_TENC1.
Genevestigatori Q8CGB6.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR000008. C2_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
[Graphical view ]
Pfami PF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 1 hit.
SM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of mouse tensin 2."
    Lo S.H.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 753-1400 (ISOFORM 3).
    Strain: FVB/N.
    Tissue: Liver and Salivary gland.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-935 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-875 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Inner ear and Melanocyte.
  4. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-483 AND SER-1087, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiTENC1_MOUSE
AccessioniPrimary (citable) accession number: Q8CGB6
Secondary accession number(s): Q3TZ93
, Q3UGR8, Q8CJ95, Q8R122
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi