Q8CGB3 (UACA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uveal autoantigen with coiled-coil domains and ankyrin repeats

Alternative name(s):
Nuclear membrane-binding protein
Short name=Nucling

Gene names

Name:	Uaca
Synonyms:	Kiaa1561

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1411 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1. Ref.5 Ref.6 Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury By similarity. Ref.5 Ref.6
Subunit structure	Component of the apoptosome complex, composed of APAF1, pro-caspase-9 and UACA. In the complex, it probably interacts directly with APAF1. Interacts with LGALS3, ARF6 and ACTB. Ref.5 Ref.6
Subcellular location	Nucleus. Cytoplasm. Cytoplasm › cytoskeleton. Note: Expressed diffusely in cytoplasm. Ref.1
Tissue specificity	Highly expressed in heart, liver, kidney and testis. Weakly expressed in lung and skeletal muscle. Not expressed in brain and spleen. Ref.1
Developmental stage	First detected at the E9.5 stage in heart at the edge of both sides of the common ventricular chamber and is then progressively increased and restricted to the myocardial wall of left common ventricular chamber of heart. Ref.1
Induction	Up-regulated during cardiomyogenic differentiation. By apoptotic stress in a dose-dependent manner. Ref.1
Disruption phenotype	Mice show a high incidence of inflammatory lesions in preputial glands. Cells around the lesions showed resistance to apoptosis. Ref.6
Sequence similarities	Contains 6 ANK repeats.
Sequence caution	The sequence BAC78213.1 differs from that shown. Reason: Erroneous initiation. The sequence BAD32481.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Nucleus
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Coiled coil Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intrinsic apoptotic signaling pathway in response to DNA damage Inferred from mutant phenotype Ref.5. Source: MGI intrinsic apoptotic signaling pathway in response to oxidative stress Inferred from mutant phenotype Ref.5. Source: MGI negative regulation of NF-kappaB import into nucleus Inferred from mutant phenotype Ref.6. Source: MGI negative regulation of inflammatory response Inferred from mutant phenotype Ref.6. Source: MGI positive regulation of apoptotic process Inferred from direct assay Ref.5. Source: MGI positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from direct assay Ref.5. Source: MGI positive regulation of protein import into nucleus Inferred from mutant phenotype Ref.5. Source: MGI response to UV Inferred from mutant phenotype Ref.5. Source: MGI
Cellular_component	apoptosome Inferred from direct assay Ref.5. Source: MGI cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from direct assay Ref.1. Source: MGI mitochondrion Inferred from electronic annotation. Source: Compara nuclear envelope Inferred from direct assay Ref.1Ref.6. Source: MGI perinuclear region of cytoplasm Inferred from direct assay Ref.5. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8CGB3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8CGB3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-398: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8CGB3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     264-264: G → GGG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1411	1411	Uveal autoantigen with coiled-coil domains and ankyrin repeats		PRO_0000231651
Regions
	Repeat	69 – 98	30	ANK 1
	Repeat	102 – 131	30	ANK 2
	Repeat	135 – 164	30	ANK 3
	Repeat	168 – 197	30	ANK 4
	Repeat	201 – 230	30	ANK 5
	Repeat	234 – 263	30	ANK 6
	Coiled coil	299 – 379	81	Potential
	Coiled coil	442 – 624	183	Potential
	Coiled coil	652 – 1380	729	Potential
Amino acid modifications
	Modified residue	280	1	Phosphoserine Ref.8
	Modified residue	453	1	Phosphothreonine Ref.7
Natural variations
	Alternative sequence	1 – 398	398	Missing in isoform 2.		VSP_017874
	Alternative sequence	264	1	G → GGG in isoform 3.		VSP_017875
Experimental info
	Sequence conflict	144	1	V → A in AAH42415. Ref.3
	Sequence conflict	353	1	P → L in AAH42415. Ref.3
	Sequence conflict	757	1	R → K in AAH42415. Ref.3
	Sequence conflict	778	1	A → T in AAH42415. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 4, 2006. Version 2. Checksum: 0809D2DE9732F879	FASTA	1,411	160,813
	10 20 30 40 50 60 MKSLKSRLWK QDAPGPTSPS SPTAVASTQS AEWNKYDDRL MKAAERGDVE KVSSILAKKG 70 80 90 100 110 120 VHPGKLDVEG RSAFHVVASK GNLECLNAIL THGIDVATRD SAGRNALHLA AKYGHALCLQ 130 140 150 160 170 180 KLLQYNCPTE HVDLQGRTAL HDAVMADCPS SIQLLCDHGA SVNAKDIDGR TPLVLATQMC 190 200 210 220 230 240 RPTICQLLID RGADVNSRDK QNRTALMLGC EYGCRDAVEV LVKNGADLTL LDALGHDSSY 250 260 270 280 290 300 YARIGDNLDI LNLLKTASEN TNKGRELWRK GPPLQQRNLS HTQDEGSVKS TQREQREPHS 310 320 330 340 350 360 FQDLEIENED LREKLRKIQQ EQRILLDKVN GLQLQLNEEV MVADDLESER EKPKSLLAAK 370 380 390 400 410 420 EKQHEESLRT IEALKNRFKY FESDHPGPGS YPSNRKEDML HKQGQMYTTE PQCASPGIPP 430 440 450 460 470 480 HMHSRSMLRP LELSLPSQTS YSENEILKKE LETLRTYYDS AKQDRLKFQN ELAHKVAECK 490 500 510 520 530 540 ALALECERVK EDSDEQIKQL EDALKDVQKR MYESEGKVKQ MQTHFLALKE HLTNEAATGS 550 560 570 580 590 600 HRIIEELREQ LKDLKGKYEG ASAEVGKLRS QIKQSEMLVG EFKRDEGRLV EENKRLQKEC 610 620 630 640 650 660 GTCEVELERR GRRVVELEGQ LKELGAKLAL SVPTEKFESM KSSLSNDINE KVKRLAEVGR 670 680 690 700 710 720 DYESAQGEIR QLKRDLESVR AQHIRPEEHE QLRSRLEQKS GELGKKVSEL TLKNQTLQKD 730 740 750 760 770 780 VEKLHADNKL LNQQVHSLTV EMKTRYVPLR VSEEMKRSHD VNVEDLNKKL SEATQRYAEK 790 800 810 820 830 840 KQEAERLLAE NDKLTKNVSR LEAVFVAPEK HEKELMGLKS NIAELKKQLS ELNKKCGEGQ 850 860 870 880 890 900 EKIRALMSEN SSLKKTLSSQ YVPAKTHEEV KASLNSTVEK TNRALLEAKK RFDDTSQEVS 910 920 930 940 950 960 KLRDENEVLR RNLENVQNQM KADYVSLEEH SRRMSTVSQS LKEAQEANAA ILADHRQGQE 970 980 990 1000 1010 1020 EIVSLHAEIK AQKKELDTIQ ECIKLKYAPL ARLEECERKF KATEKGLKEQ LSEQTHKCRQ 1030 1040 1050 1060 1070 1080 RDEEVKKGKQ ENERLRADLA ALQKELQDRN ALAEEAREAE RALSGKADEL SKQLKDLSQK 1090 1100 1110 1120 1130 1140 YSDVKSEREK LVEEKAKQAS EILAAQNLLQ KQPVPLEQVE ALKKSLNGTI EQLKEELRSK 1150 1160 1170 1180 1190 1200 QRCLEREQQT VSQLQQLLEN QKNSSVTLAE HLKLKEALEK EVGIMKASLR EKEEESQKKT 1210 1220 1230 1240 1250 1260 KEVSKLQTEV QTTKQALKNL ETREVVDMSK YKATKNDLET QISNLNDKLA SLNRKYDQAC 1270 1280 1290 1300 1310 1320 EEKVSAKDEK ELLHLSIEQE IRDQKERCDK SLTTIMELQQ RIQESAKQIE AKDNKITELL 1330 1340 1350 1360 1370 1380 NDVERLKQAL NGLSQLTYSS GSPTKRQSQL VDTLQQRVRD LQQQLADADR QHQEVIAIYR 1390 1400 1410 THLLSAAQGH MDEDVQAALL QIIQMRQGLV C
	Isoform 2 [UniParc]. Checksum: 13DDD2313B8FED0F	FASTA	1,013	116,517
	10 20 30 40 50 60 MLHKQGQMYT TEPQCASPGI PPHMHSRSML RPLELSLPSQ TSYSENEILK KELETLRTYY 70 80 90 100 110 120 DSAKQDRLKF QNELAHKVAE CKALALECER VKEDSDEQIK QLEDALKDVQ KRMYESEGKV 130 140 150 160 170 180 KQMQTHFLAL KEHLTNEAAT GSHRIIEELR EQLKDLKGKY EGASAEVGKL RSQIKQSEML 190 200 210 220 230 240 VGEFKRDEGR LVEENKRLQK ECGTCEVELE RRGRRVVELE GQLKELGAKL ALSVPTEKFE 250 260 270 280 290 300 SMKSSLSNDI NEKVKRLAEV GRDYESAQGE IRQLKRDLES VRAQHIRPEE HEQLRSRLEQ 310 320 330 340 350 360 KSGELGKKVS ELTLKNQTLQ KDVEKLHADN KLLNQQVHSL TVEMKTRYVP LRVSEEMKRS 370 380 390 400 410 420 HDVNVEDLNK KLSEATQRYA EKKQEAERLL AENDKLTKNV SRLEAVFVAP EKHEKELMGL 430 440 450 460 470 480 KSNIAELKKQ LSELNKKCGE GQEKIRALMS ENSSLKKTLS SQYVPAKTHE EVKASLNSTV 490 500 510 520 530 540 EKTNRALLEA KKRFDDTSQE VSKLRDENEV LRRNLENVQN QMKADYVSLE EHSRRMSTVS 550 560 570 580 590 600 QSLKEAQEAN AAILADHRQG QEEIVSLHAE IKAQKKELDT IQECIKLKYA PLARLEECER 610 620 630 640 650 660 KFKATEKGLK EQLSEQTHKC RQRDEEVKKG KQENERLRAD LAALQKELQD RNALAEEARE 670 680 690 700 710 720 AERALSGKAD ELSKQLKDLS QKYSDVKSER EKLVEEKAKQ ASEILAAQNL LQKQPVPLEQ 730 740 750 760 770 780 VEALKKSLNG TIEQLKEELR SKQRCLEREQ QTVSQLQQLL ENQKNSSVTL AEHLKLKEAL 790 800 810 820 830 840 EKEVGIMKAS LREKEEESQK KTKEVSKLQT EVQTTKQALK NLETREVVDM SKYKATKNDL 850 860 870 880 890 900 ETQISNLNDK LASLNRKYDQ ACEEKVSAKD EKELLHLSIE QEIRDQKERC DKSLTTIMEL 910 920 930 940 950 960 QQRIQESAKQ IEAKDNKITE LLNDVERLKQ ALNGLSQLTY SSGSPTKRQS QLVDTLQQRV 970 980 990 1000 1010 RDLQQQLADA DRQHQEVIAI YRTHLLSAAQ GHMDEDVQAA LLQIIQMRQG LVC
	Isoform 3 [UniParc]. Checksum: 89FA7474FDE59D5C	FASTA	1,413	160,927
	10 20 30 40 50 60 MKSLKSRLWK QDAPGPTSPS SPTAVASTQS AEWNKYDDRL MKAAERGDVE KVSSILAKKG 70 80 90 100 110 120 VHPGKLDVEG RSAFHVVASK GNLECLNAIL THGIDVATRD SAGRNALHLA AKYGHALCLQ 130 140 150 160 170 180 KLLQYNCPTE HVDLQGRTAL HDAVMADCPS SIQLLCDHGA SVNAKDIDGR TPLVLATQMC 190 200 210 220 230 240 RPTICQLLID RGADVNSRDK QNRTALMLGC EYGCRDAVEV LVKNGADLTL LDALGHDSSY 250 260 270 280 290 300 YARIGDNLDI LNLLKTASEN TNKGGGRELW RKGPPLQQRN LSHTQDEGSV KSTQREQREP 310 320 330 340 350 360 HSFQDLEIEN EDLREKLRKI QQEQRILLDK VNGLQLQLNE EVMVADDLES EREKPKSLLA 370 380 390 400 410 420 AKEKQHEESL RTIEALKNRF KYFESDHPGP GSYPSNRKED MLHKQGQMYT TEPQCASPGI 430 440 450 460 470 480 PPHMHSRSML RPLELSLPSQ TSYSENEILK KELETLRTYY DSAKQDRLKF QNELAHKVAE 490 500 510 520 530 540 CKALALECER VKEDSDEQIK QLEDALKDVQ KRMYESEGKV KQMQTHFLAL KEHLTNEAAT 550 560 570 580 590 600 GSHRIIEELR EQLKDLKGKY EGASAEVGKL RSQIKQSEML VGEFKRDEGR LVEENKRLQK 610 620 630 640 650 660 ECGTCEVELE RRGRRVVELE GQLKELGAKL ALSVPTEKFE SMKSSLSNDI NEKVKRLAEV 670 680 690 700 710 720 GRDYESAQGE IRQLKRDLES VRAQHIRPEE HEQLRSRLEQ KSGELGKKVS ELTLKNQTLQ 730 740 750 760 770 780 KDVEKLHADN KLLNQQVHSL TVEMKTRYVP LRVSEEMKRS HDVNVEDLNK KLSEATQRYA 790 800 810 820 830 840 EKKQEAERLL AENDKLTKNV SRLEAVFVAP EKHEKELMGL KSNIAELKKQ LSELNKKCGE 850 860 870 880 890 900 GQEKIRALMS ENSSLKKTLS SQYVPAKTHE EVKASLNSTV EKTNRALLEA KKRFDDTSQE 910 920 930 940 950 960 VSKLRDENEV LRRNLENVQN QMKADYVSLE EHSRRMSTVS QSLKEAQEAN AAILADHRQG 970 980 990 1000 1010 1020 QEEIVSLHAE IKAQKKELDT IQECIKLKYA PLARLEECER KFKATEKGLK EQLSEQTHKC 1030 1040 1050 1060 1070 1080 RQRDEEVKKG KQENERLRAD LAALQKELQD RNALAEEARE AERALSGKAD ELSKQLKDLS 1090 1100 1110 1120 1130 1140 QKYSDVKSER EKLVEEKAKQ ASEILAAQNL LQKQPVPLEQ VEALKKSLNG TIEQLKEELR 1150 1160 1170 1180 1190 1200 SKQRCLEREQ QTVSQLQQLL ENQKNSSVTL AEHLKLKEAL EKEVGIMKAS LREKEEESQK 1210 1220 1230 1240 1250 1260 KTKEVSKLQT EVQTTKQALK NLETREVVDM SKYKATKNDL ETQISNLNDK LASLNRKYDQ 1270 1280 1290 1300 1310 1320 ACEEKVSAKD EKELLHLSIE QEIRDQKERC DKSLTTIMEL QQRIQESAKQ IEAKDNKITE 1330 1340 1350 1360 1370 1380 LLNDVERLKQ ALNGLSQLTY SSGSPTKRQS QLVDTLQQRV RDLQQQLADA DRQHQEVIAI 1390 1400 1410 YRTHLLSAAQ GHMDEDVQAA LLQIIQMRQG LVC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel, embryonal carcinoma cell-associated molecule, nucling, that is up-regulated during cardiac muscle differentiation." Sakai T., Liu L., Shishido Y., Fukui K. J. Biochem. 133:429-436(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION. Strain: 129.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H. DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Embryonic intestine.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Strain: FVB/N. Tissue: Mammary gland and Salivary gland.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-306. Strain: C57BL/6J. Tissue: Eye.
[5]	"Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis." Sakai T., Liu L., Teng X., Mukai-Sakai R., Shimada H., Kaji R., Mitani T., Matsumoto M., Toida K., Ishimura K., Shishido Y., Mak T.W., Fukui K. J. Biol. Chem. 279:41131-41140(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH APAF1.
[6]	"Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling." Liu L., Sakai T., Sano N., Fukui K. Biochem. J. 380:31-41(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH LGALS3, DISRUPTION PHENOTYPE.
[7]	"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-453, MASS SPECTROMETRY. Tissue: Liver.
[8]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB030647 mRNA. Translation: BAC78213.1. Different initiation. AK173203 mRNA. Translation: BAD32481.1. Different initiation. BC042415 mRNA. Translation: AAH42415.1. AK087466 mRNA. Translation: BAC39886.1.
IPI	IPI00229465. IPI00742350. IPI00742359.
RefSeq	NP_082559.1. NM_028283.2.
UniGene	Mm.68819.
3D structure databases
ProteinModelPortal	Q8CGB3.
SMR	Q8CGB3. Positions 39-257.
ModBase	Search...
PTM databases
PhosphoSite	Q8CGB3.
Proteomic databases
PaxDb	Q8CGB3.
PRIDE	Q8CGB3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000050183; ENSMUSP00000062047; ENSMUSG00000034485.
GeneID	72565.
KEGG	mmu:72565.
UCSC	uc009pzi.1. mouse. uc009pzk.1. mouse.
Organism-specific databases
CTD	55075.
MGI	MGI:1919815. Uaca.
Rouge	Search...
Phylogenomic databases
eggNOG	COG0666.
GeneTree	ENSGT00530000063369.
HOGENOM	HOG000147885.
HOVERGEN	HBG066395.
InParanoid	Q8CGB3.
OrthoDB	EOG42RD6F.
Gene expression databases
Bgee	Q8CGB3.
Genevestigator	Q8CGB3.
GermOnline	ENSMUSG00000034485. Mus musculus.
Family and domain databases
Gene3D	1.25.40.20. 2 hits.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR000727. T_SNARE_dom. [Graphical view]
Pfam	PF12796. Ank_2. 2 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 6 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. PS50192. T_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	UACA. mouse.
NextBio	336503.
SOURCE	Search...

Entry information

Entry name

UACA_MOUSE

Accession

Primary (citable) accession number: Q8CGB3
Secondary accession number(s): Q69ZG3, Q7TN77, Q8BJC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	May 29, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program