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Protein

Large neutral amino acids transporter small subunit 4

Gene

Slc43a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-, chloride-, and pH-independent, high affinity transport of large neutral amino acids.1 Publication

GO - Molecular functioni

  • L-amino acid transmembrane transporter activity Source: MGI

GO - Biological processi

  • L-alpha-amino acid transmembrane transport Source: GOC
  • L-amino acid transport Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Large neutral amino acids transporter small subunit 4
Alternative name(s):
L-type amino acid transporter 4
Solute carrier family 43 member 2
Gene namesi
Name:Slc43a2
Synonyms:Lat4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2442746. Slc43a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence analysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence analysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence analysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence analysisAdd
BLAST
Transmembranei319 – 34123HelicalSequence analysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence analysisAdd
BLAST
Transmembranei434 – 45421HelicalSequence analysisAdd
BLAST
Transmembranei461 – 48121HelicalSequence analysisAdd
BLAST
Transmembranei489 – 50921HelicalSequence analysisAdd
BLAST
Transmembranei515 – 53521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Large neutral amino acids transporter small subunit 4PRO_0000307273Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Modified residuei274 – 2741PhosphoserineBy similarity
Modified residuei278 – 2781PhosphoserineBy similarity
Modified residuei297 – 2971PhosphoserineCombined sources

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8CGA3.
MaxQBiQ8CGA3.
PaxDbiQ8CGA3.
PRIDEiQ8CGA3.

PTM databases

iPTMnetiQ8CGA3.
PhosphoSiteiQ8CGA3.

Expressioni

Tissue specificityi

Expressed in intestine, kidney, brain and adipose tissue, heart and testis. In the kidney, is detected in epithelial cells of the distal tubule and collecting duct. In the intestine, is expressed mainly in crypt cells of the intestinal microvilli and epithelial cells in the base of the villus.1 Publication

Gene expression databases

BgeeiQ8CGA3.
CleanExiMM_SLC43A2.
ExpressionAtlasiQ8CGA3. baseline and differential.
GenevisibleiQ8CGA3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046074.

Structurei

3D structure databases

ProteinModelPortaliQ8CGA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJQ. Eukaryota.
ENOG410XS1N. LUCA.
GeneTreeiENSGT00530000063043.
HOGENOMiHOG000231937.
HOVERGENiHBG072879.
InParanoidiQ8CGA3.
KOiK08229.
OMAiRMNGWLS.
OrthoDBiEOG712TWX.
PhylomeDBiQ8CGA3.
TreeFamiTF328358.

Family and domain databases

InterProiIPR027201. LAT4.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR20766:SF2. PTHR20766:SF2. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.

Sequencei

Sequence statusi: Complete.

Q8CGA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTLATAHR RRWWMACTAV LENLLFSAVL LGWGSLLIML KSEGFYSYLC
60 70 80 90 100
TKPENVTNST VGGSAEPEPE ELSLVNGWLS CKAQDEILNL AFTVGSFLLS
110 120 130 140 150
AITLPLGIIM DKYGPRKLRL LGSACFAVSC LLIAYGASNP DSLSVLIFIA
160 170 180 190 200
LALNGFGGMC MTFTSLTLPN MFGDLRSTFI ALMIGSYASS AVTFPGIKLI
210 220 230 240 250
YDAGASFIGI LVVWAGCSGL VFFNCFFNWP LEPFPGPEDM DYSVKIKFSW
260 270 280 290 300
LGFDHKITGK QFYKQVTTVG RRLSVGSSMR TAKEQAALQE GHKLCLSTVD
310 320 330 340 350
LEVKCQPDAA AAPSFMHSVF SPLLVLSLVT MCVTQLRLIF YMGAMNSILE
360 370 380 390 400
FLVRGDQKTV ALYTSIFGAL QLLCLLTAPV IGYIMDWKLK ECEDTSEEPE
410 420 430 440 450
EKEGTQGEKK QKRDRQIQKV TNAMRAFAFT NVLLVGFGVT CLIPNLPLQI
460 470 480 490 500
FSFVLHTIVR GFIHSAVGGL YAAVYPSTQF GSLTGLQSLV SALFALLQQP
510 520 530 540 550
LYLAMMGPLG GDPLWVNVGL LAMSMLGFCL PLYLICYRRQ LERQLQQKRE
560
DSKLFLKING SSNREAFV
Length:568
Mass (Da):62,430
Last modified:March 1, 2003 - v1
Checksum:i02F076C32FE5988E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371P → S in BAD91090 (Ref. 2) Curated
Sequence conflicti402 – 4021K → E in BAD91090 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK005643 mRNA. Translation: DAA05677.1.
AB120363 mRNA. Translation: BAD91090.1.
AK143773 mRNA. Translation: BAE25533.1.
AK159144 mRNA. Translation: BAE34852.1.
AL591440, AL591496 Genomic DNA. Translation: CAI24094.1.
AL591496, AL591440 Genomic DNA. Translation: CAI35390.1.
BC042513 mRNA. Translation: AAH42513.1.
CCDSiCCDS25051.1.
RefSeqiNP_001186212.1. NM_001199283.1.
NP_001186213.1. NM_001199284.1.
NP_775564.1. NM_173388.2.
XP_006532890.1. XM_006532827.2.
UniGeneiMm.11186.

Genome annotation databases

EnsembliENSMUST00000042561; ENSMUSP00000046074; ENSMUSG00000038178.
ENSMUST00000108433; ENSMUSP00000104071; ENSMUSG00000038178.
ENSMUST00000169547; ENSMUSP00000126838; ENSMUSG00000038178.
GeneIDi215113.
KEGGimmu:215113.
UCSCiuc007keb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK005643 mRNA. Translation: DAA05677.1.
AB120363 mRNA. Translation: BAD91090.1.
AK143773 mRNA. Translation: BAE25533.1.
AK159144 mRNA. Translation: BAE34852.1.
AL591440, AL591496 Genomic DNA. Translation: CAI24094.1.
AL591496, AL591440 Genomic DNA. Translation: CAI35390.1.
BC042513 mRNA. Translation: AAH42513.1.
CCDSiCCDS25051.1.
RefSeqiNP_001186212.1. NM_001199283.1.
NP_001186213.1. NM_001199284.1.
NP_775564.1. NM_173388.2.
XP_006532890.1. XM_006532827.2.
UniGeneiMm.11186.

3D structure databases

ProteinModelPortaliQ8CGA3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046074.

PTM databases

iPTMnetiQ8CGA3.
PhosphoSiteiQ8CGA3.

Proteomic databases

EPDiQ8CGA3.
MaxQBiQ8CGA3.
PaxDbiQ8CGA3.
PRIDEiQ8CGA3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042561; ENSMUSP00000046074; ENSMUSG00000038178.
ENSMUST00000108433; ENSMUSP00000104071; ENSMUSG00000038178.
ENSMUST00000169547; ENSMUSP00000126838; ENSMUSG00000038178.
GeneIDi215113.
KEGGimmu:215113.
UCSCiuc007keb.2. mouse.

Organism-specific databases

CTDi124935.
MGIiMGI:2442746. Slc43a2.

Phylogenomic databases

eggNOGiENOG410IHJQ. Eukaryota.
ENOG410XS1N. LUCA.
GeneTreeiENSGT00530000063043.
HOGENOMiHOG000231937.
HOVERGENiHBG072879.
InParanoidiQ8CGA3.
KOiK08229.
OMAiRMNGWLS.
OrthoDBiEOG712TWX.
PhylomeDBiQ8CGA3.
TreeFamiTF328358.

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSiSlc43a2. mouse.
NextBioi374612.
PROiQ8CGA3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CGA3.
CleanExiMM_SLC43A2.
ExpressionAtlasiQ8CGA3. baseline and differential.
GenevisibleiQ8CGA3. MM.

Family and domain databases

InterProiIPR027201. LAT4.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR20766:SF2. PTHR20766:SF2. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 4 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of LAT4, a novel amino acid transporter with system L activity."
    Bodoy S., Martin L., Zorzano A., Palacin M., Estevez R., Bertran J.
    J. Biol. Chem. 280:12002-12011(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, GLYCOSYLATION, FUNCTION.
    Strain: FVB/N.
  2. "Identification of a novel epithelial type neutral amino acid transporter with the properties of system L2."
    Chairoungdua A., Kanai Y., Babu E., Iribe Y., Kim D., Tangtrongsup S., Jutabha P., Li Y., Anzai N., Endou H.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Pancreas and Spleen.

Entry informationi

Entry nameiLAT4_MOUSE
AccessioniPrimary (citable) accession number: Q8CGA3
Secondary accession number(s): Q5CD76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.