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Protein

TBC1 domain family member 14

Gene

Tbc1d14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of starvation-induced autophagosome formation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 14
Gene namesi
Name:Tbc1d14
Synonyms:D5Ertd110e, Kiaa1322
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1098708. Tbc1d14.

Subcellular locationi

  • Golgi apparatuscis-Golgi network By similarity
  • Golgi apparatustrans-Golgi network By similarity

  • Note: After amino acid starvation, Golgi apparatus-associated protein levels increase compared with fed conditions. May be cycling between the Golgi apparatus and an endosomal pool, redistributing to the Golgi apparatus upon starvation (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694TBC1 domain family member 14PRO_0000208041Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei92 – 921PhosphoserineCombined sources
Modified residuei296 – 2961PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CGA2.
MaxQBiQ8CGA2.
PaxDbiQ8CGA2.
PRIDEiQ8CGA2.

PTM databases

iPTMnetiQ8CGA2.
PhosphoSiteiQ8CGA2.

Expressioni

Gene expression databases

CleanExiMM_TBC1D14.

Interactioni

Subunit structurei

Interacts with ULK1. May interact with RAB11A and RAB11B, but does not exhibit any GTPase-activating activity toward these proteins (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116519.

Structurei

3D structure databases

ProteinModelPortaliQ8CGA2.
SMRiQ8CGA2. Positions 372-680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini402 – 612211Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2223. Eukaryota.
COG5210. LUCA.
HOGENOMiHOG000016604.
HOVERGENiHBG061665.
InParanoidiQ8CGA2.
KOiK20167.
PhylomeDBiQ8CGA2.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CGA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDGNLSTSM NGVALMGILD GRQGDSLQDL QHLSIKAAPR SLSVPEYGPS
60 70 80 90 100
LKLGALEDRH SLQSVDSGIP TLEIGNPEPV PCSVVHVKRK QSESEIVPER
110 120 130 140 150
AFQSACPLPS CTPSAPTCSE REQVVRKSST FPRTGYDSVK LYSPTSKALS
160 170 180 190 200
RSDNVSVCSV SSLGTELSTT LSVSNEDILD LMVTSNSSAI VTLENDDDPQ
210 220 230 240 250
FTDVTLSSIN ETSDLHQQDC VAETEEGRKL KLLHPFSHFF TRNLLARKQN
260 270 280 290 300
ARLDRQRDLG WKLFGKVPLR ETAQKDSKKT QKEYEDKAGR PSRPPSPKQN
310 320 330 340 350
VRKNLDFEPL STTALILEDR PANLPAKPAE EAQKHRQQYE EMVLQAKKRE
360 370 380 390 400
LKEAQRRRKQ LEERCKVEES IGNAVLTWNN EILPNWETMW CSKKVRDLWW
410 420 430 440 450
QGIPPSVRGK VWSLAIGNEL NITHELFDIC LARAKERWRS LSTGGSEVEN
460 470 480 490 500
EDAGFSAADR EASLELIKLD ISRTFPNLCI FQQGGPYHDM LHSILGAYTC
510 520 530 540 550
YRPDVGYVQG MSFIAAVLIL NLDTADAFIA FSNLLNKPCQ MAFFRVDHGL
560 570 580 590 600
MLTYFAAFEV FFEENLPKLF AHFKKNNLTA DIYLIDWIFT LYSKSLPLDL
610 620 630 640 650
ACRIWDVFCR DGEEFLFRTA LGILKLFEDI LTRMDFIHSA QFLTRLPEDL
660 670 680 690
PADEVFAAIS TVQMQSRNKK WAQVLSALQK DSREMEKGSP SLRH
Length:694
Mass (Da):78,315
Last modified:February 26, 2008 - v2
Checksum:iC696A829263CA33E
GO

Sequence cautioni

The sequence AAH42515 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH96446 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE20781 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461E → D in AAH96446 (PubMed:15489334).Curated
Sequence conflicti46 – 461E → D in BAE20781 (PubMed:16141072).Curated
Sequence conflicti234 – 2341H → Q in AAH42515 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC096446 mRNA. Translation: AAH96446.1. Different initiation.
BC042515 mRNA. Translation: AAH42515.1. Different initiation.
AK131724 mRNA. Translation: BAE20781.1. Different initiation.
AB093293 mRNA. Translation: BAC41476.1.
CCDSiCCDS19240.2.
RefSeqiNP_001106833.1. NM_001113362.1.
NP_001106835.1. NM_001113364.1.
NP_598671.3. NM_133910.3.
UniGeneiMm.486203.

Genome annotation databases

GeneIDi100855.
KEGGimmu:100855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC096446 mRNA. Translation: AAH96446.1. Different initiation.
BC042515 mRNA. Translation: AAH42515.1. Different initiation.
AK131724 mRNA. Translation: BAE20781.1. Different initiation.
AB093293 mRNA. Translation: BAC41476.1.
CCDSiCCDS19240.2.
RefSeqiNP_001106833.1. NM_001113362.1.
NP_001106835.1. NM_001113364.1.
NP_598671.3. NM_133910.3.
UniGeneiMm.486203.

3D structure databases

ProteinModelPortaliQ8CGA2.
SMRiQ8CGA2. Positions 372-680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116519.

PTM databases

iPTMnetiQ8CGA2.
PhosphoSiteiQ8CGA2.

Proteomic databases

EPDiQ8CGA2.
MaxQBiQ8CGA2.
PaxDbiQ8CGA2.
PRIDEiQ8CGA2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100855.
KEGGimmu:100855.

Organism-specific databases

CTDi57533.
MGIiMGI:1098708. Tbc1d14.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2223. Eukaryota.
COG5210. LUCA.
HOGENOMiHOG000016604.
HOVERGENiHBG061665.
InParanoidiQ8CGA2.
KOiK20167.
PhylomeDBiQ8CGA2.

Miscellaneous databases

ChiTaRSiTbc1d14. mouse.
PROiQ8CGA2.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TBC1D14.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBC14_MOUSE
AccessioniPrimary (citable) accession number: Q8CGA2
Secondary accession number(s): Q3V2L6, Q4VAC6, Q8CHA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: February 26, 2008
Last modified: September 7, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.