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Q8CGA0

- PPM1F_MOUSE

UniProt

Q8CGA0 - PPM1F_MOUSE

Protein

Protein phosphatase 1F

Gene

Ppm1f

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi195 – 1951Manganese 1By similarity
    Metal bindingi195 – 1951Manganese 2By similarity
    Metal bindingi196 – 1961Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi357 – 3571Manganese 2By similarity
    Metal bindingi401 – 4011Manganese 2By similarity

    GO - Molecular functioni

    1. calmodulin-dependent protein phosphatase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. protein serine/threonine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to drug Source: UniProtKB
    2. histone dephosphorylation Source: Ensembl
    3. intrinsic apoptotic signaling pathway Source: UniProtKB
    4. negative regulation of peptidyl-serine phosphorylation Source: UniProtKB
    5. negative regulation of protein kinase activity Source: UniProtKB
    6. negative regulation of protein kinase activity by regulation of protein phosphorylation Source: UniProtKB
    7. negative regulation of transcription, DNA-templated Source: UniProtKB
    8. peptidyl-threonine dephosphorylation Source: UniProtKB
    9. positive regulation of cell-substrate adhesion Source: UniProtKB
    10. positive regulation of chemotaxis Source: UniProtKB
    11. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    12. positive regulation of epithelial cell migration Source: UniProtKB
    13. positive regulation of focal adhesion assembly Source: UniProtKB
    14. positive regulation of gene expression Source: UniProtKB
    15. positive regulation of growth Source: UniProtKB
    16. positive regulation of stress fiber assembly Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1F (EC:3.1.3.16)
    Alternative name(s):
    Ca(2+)/calmodulin-dependent protein kinase phosphatase
    Short name:
    CaM-kinase phosphatase
    Short name:
    CaMKPase
    Gene namesi
    Name:Ppm1f
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1918464. Ppm1f.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. perinuclear region of cytoplasm Source: Ensembl
    3. protein complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Protein phosphatase 1FPRO_0000057759Add
    BLAST

    Proteomic databases

    MaxQBiQ8CGA0.
    PaxDbiQ8CGA0.
    PRIDEiQ8CGA0.

    PTM databases

    PhosphoSiteiQ8CGA0.

    Expressioni

    Gene expression databases

    BgeeiQ8CGA0.
    CleanExiMM_PPM1F.
    GenevestigatoriQ8CGA0.

    Interactioni

    Subunit structurei

    Associates with FEM1B.By similarity

    Protein-protein interaction databases

    BioGridi212948. 1 interaction.
    IntActiQ8CGA0. 3 interactions.
    MINTiMINT-4115705.
    STRINGi10090.ENSMUSP00000027373.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CGA0.
    SMRiQ8CGA0. Positions 114-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi99 – 11012Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00740000114971.
    HOGENOMiHOG000232094.
    HOVERGENiHBG053656.
    InParanoidiQ8CGA0.
    KOiK17502.
    OMAiGDVFQKP.
    OrthoDBiEOG7D2FDH.
    PhylomeDBiQ8CGA0.
    TreeFamiTF317617.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CGA0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASGAAQNSS QMACDSEIPG FLDAFLQDFP APLSLESPLP WKVPGTVLSQ    50
    EEVEAELIEL ALGFLGSRNA PPSFAVAVTH EAISQLLQTD LSEFKRLPEQ 100
    EEEEEEEEEE KALVTLLDAK GLARSFFNCL WKVCSQWQKQ VPLTAQAPQW 150
    QWLVSIHAIR NTRRKMEDRH VSLPAFNHLF GLSDSVHRAY FAVFDGHGGV 200
    DAARYASVHV HTNASHQPEL RTNPAAALKE AFRLTDEMFL QKAKRERLQS 250
    GTTGVCALIA GAALHVAWLG DSQVILVQQG RVVKLMEPHK PERQDEKARI 300
    EALGGFVSLM DCWRVNGTLA VSRAIGDVFQ KPYVSGEADA ASRELTGSED 350
    YLLLACDGFF DVVPHHEVTG LVHGHLLRHK GNGMRIAEEL VAVARDRGSH 400
    DNITVMVVFL REPLELLEGG VQGTGDAQAD VGSQDLSTGL SELEISNTSQ 450
    RS 452
    Length:452
    Mass (Da):49,611
    Last modified:March 1, 2003 - v1
    Checksum:i7C8ED2E597F9D1B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK154192 mRNA. Translation: BAE32429.1.
    AK164964 mRNA. Translation: BAE37981.1.
    BC042570 mRNA. Translation: AAH42570.1.
    CCDSiCCDS27991.1.
    RefSeqiNP_789803.1. NM_176833.4.
    XP_006522570.1. XM_006522507.1.
    UniGeneiMm.230296.

    Genome annotation databases

    EnsembliENSMUST00000027373; ENSMUSP00000027373; ENSMUSG00000026181.
    GeneIDi68606.
    KEGGimmu:68606.
    UCSCiuc007yjo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK154192 mRNA. Translation: BAE32429.1 .
    AK164964 mRNA. Translation: BAE37981.1 .
    BC042570 mRNA. Translation: AAH42570.1 .
    CCDSi CCDS27991.1.
    RefSeqi NP_789803.1. NM_176833.4.
    XP_006522570.1. XM_006522507.1.
    UniGenei Mm.230296.

    3D structure databases

    ProteinModelPortali Q8CGA0.
    SMRi Q8CGA0. Positions 114-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212948. 1 interaction.
    IntActi Q8CGA0. 3 interactions.
    MINTi MINT-4115705.
    STRINGi 10090.ENSMUSP00000027373.

    PTM databases

    PhosphoSitei Q8CGA0.

    Proteomic databases

    MaxQBi Q8CGA0.
    PaxDbi Q8CGA0.
    PRIDEi Q8CGA0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027373 ; ENSMUSP00000027373 ; ENSMUSG00000026181 .
    GeneIDi 68606.
    KEGGi mmu:68606.
    UCSCi uc007yjo.2. mouse.

    Organism-specific databases

    CTDi 9647.
    MGIi MGI:1918464. Ppm1f.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00740000114971.
    HOGENOMi HOG000232094.
    HOVERGENi HBG053656.
    InParanoidi Q8CGA0.
    KOi K17502.
    OMAi GDVFQKP.
    OrthoDBi EOG7D2FDH.
    PhylomeDBi Q8CGA0.
    TreeFami TF317617.

    Miscellaneous databases

    ChiTaRSi PPM1F. mouse.
    NextBioi 327542.
    PROi Q8CGA0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CGA0.
    CleanExi MM_PPM1F.
    Genevestigatori Q8CGA0.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.

    Entry informationi

    Entry nameiPPM1F_MOUSE
    AccessioniPrimary (citable) accession number: Q8CGA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3