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Protein

Protein phosphatase 1F

Gene

Ppm1f

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi195Manganese 1By similarity1
Metal bindingi195Manganese 2By similarity1
Metal bindingi196Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi357Manganese 2By similarity1
Metal bindingi401Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processApoptosis
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1F (EC:3.1.3.16)
Alternative name(s):
Ca(2+)/calmodulin-dependent protein kinase phosphatase
Short name:
CaM-kinase phosphatase
Short name:
CaMKPase
Gene namesi
Name:Ppm1f
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1918464. Ppm1f.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577591 – 452Protein phosphatase 1FAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei452PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CGA0.
MaxQBiQ8CGA0.
PaxDbiQ8CGA0.
PeptideAtlasiQ8CGA0.
PRIDEiQ8CGA0.

PTM databases

iPTMnetiQ8CGA0.
PhosphoSitePlusiQ8CGA0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026181.
CleanExiMM_PPM1F.
GenevisibleiQ8CGA0. MM.

Interactioni

Subunit structurei

Associates with FEM1B.By similarity

Protein-protein interaction databases

BioGridi212948. 1 interactor.
IntActiQ8CGA0. 3 interactors.
MINTiMINT-4115705.
STRINGi10090.ENSMUSP00000027373.

Structurei

3D structure databases

ProteinModelPortaliQ8CGA0.
SMRiQ8CGA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 410PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST258

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi99 – 110Poly-GluAdd BLAST12

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00880000137882.
HOGENOMiHOG000232094.
HOVERGENiHBG053656.
InParanoidiQ8CGA0.
KOiK17502.
OMAiPLPWKAP.
OrthoDBiEOG091G08KG.
PhylomeDBiQ8CGA0.
TreeFamiTF317617.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiView protein in Pfam
PF00481. PP2C. 1 hit.
SMARTiView protein in SMART
SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiView protein in PROSITE
PS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CGA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGAAQNSS QMACDSEIPG FLDAFLQDFP APLSLESPLP WKVPGTVLSQ
60 70 80 90 100
EEVEAELIEL ALGFLGSRNA PPSFAVAVTH EAISQLLQTD LSEFKRLPEQ
110 120 130 140 150
EEEEEEEEEE KALVTLLDAK GLARSFFNCL WKVCSQWQKQ VPLTAQAPQW
160 170 180 190 200
QWLVSIHAIR NTRRKMEDRH VSLPAFNHLF GLSDSVHRAY FAVFDGHGGV
210 220 230 240 250
DAARYASVHV HTNASHQPEL RTNPAAALKE AFRLTDEMFL QKAKRERLQS
260 270 280 290 300
GTTGVCALIA GAALHVAWLG DSQVILVQQG RVVKLMEPHK PERQDEKARI
310 320 330 340 350
EALGGFVSLM DCWRVNGTLA VSRAIGDVFQ KPYVSGEADA ASRELTGSED
360 370 380 390 400
YLLLACDGFF DVVPHHEVTG LVHGHLLRHK GNGMRIAEEL VAVARDRGSH
410 420 430 440 450
DNITVMVVFL REPLELLEGG VQGTGDAQAD VGSQDLSTGL SELEISNTSQ

RS
Length:452
Mass (Da):49,611
Last modified:March 1, 2003 - v1
Checksum:i7C8ED2E597F9D1B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154192 mRNA. Translation: BAE32429.1.
AK164964 mRNA. Translation: BAE37981.1.
BC042570 mRNA. Translation: AAH42570.1.
CCDSiCCDS27991.1.
RefSeqiNP_789803.1. NM_176833.4.
XP_017172613.1. XM_017317124.1.
UniGeneiMm.230296.

Genome annotation databases

EnsembliENSMUST00000027373; ENSMUSP00000027373; ENSMUSG00000026181.
GeneIDi68606.
KEGGimmu:68606.
UCSCiuc007yjo.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPPM1F_MOUSE
AccessioniPrimary (citable) accession number: Q8CGA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families