UniProtKB - Q8CG79 (ASPP2_MOUSE)
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Protein
Apoptosis-stimulating of p53 protein 2
Gene
Tp53bp2
Organism
Mus musculus (Mouse)
Status
Functioni
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates p53/TP53 by enhancing the DNA binding and transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42 (By similarity).By similarity
GO - Molecular functioni
- identical protein binding Source: MGI
- NF-kappaB binding Source: MGI
- p53 binding Source: MGI
- SH3 domain binding Source: UniProtKB-KW
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- central nervous system development Source: MGI
- embryo development ending in birth or egg hatching Source: MGI
- heart development Source: MGI
- intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
- positive regulation of execution phase of apoptosis Source: MGI
- response to ionizing radiation Source: MGI
Keywordsi
Biological process | Apoptosis, Cell cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Apoptosis-stimulating of p53 protein 2Alternative name(s): Tumor suppressor p53-binding protein 2 Short name: 53BP2 Short name: p53-binding protein 2 Short name: p53BP2 |
Gene namesi | Name:Tp53bp2 Synonyms:Aspp2, Trp53bp2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2138319. Trp53bp2. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066965 | 1 – 1128 | Apoptosis-stimulating of p53 protein 2Add BLAST | 1128 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 479 | PhosphoserineCombined sources | 1 | |
Modified residuei | 555 | PhosphoserineBy similarity | 1 | |
Modified residuei | 568 | PhosphoserineBy similarity | 1 | |
Modified residuei | 571 | PhosphoserineBy similarity | 1 | |
Modified residuei | 575 | PhosphoserineBy similarity | 1 | |
Modified residuei | 697 | PhosphoserineCombined sources | 1 | |
Modified residuei | 713 | PhosphoserineCombined sources | 1 | |
Modified residuei | 736 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8CG79. |
MaxQBi | Q8CG79. |
PaxDbi | Q8CG79. |
PRIDEi | Q8CG79. |
PTM databases
iPTMneti | Q8CG79. |
PhosphoSitePlusi | Q8CG79. |
Interactioni
Subunit structurei
Binds to the central domain of p53/TP53 as well as to BCL2. Interacts with protein phosphatase 1. Interacts with RELA NF-kappa-B subunit. This interaction probably prevents the activation of apoptosis, possibly by preventing its interaction with p53/TP53. Interacts with APC2 and APPBP1. Interacts with DDX42 (via the C-terminus); the interaction is not inhibited by TP53BP2 ubiquitination and is independent of p53/TP53 (By similarity).By similarity
GO - Molecular functioni
- identical protein binding Source: MGI
- NF-kappaB binding Source: MGI
- p53 binding Source: MGI
- SH3 domain binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGridi | 229080. 2 interactors. |
IntActi | Q8CG79. 4 interactors. |
STRINGi | 10090.ENSMUSP00000112508. |
Structurei
3D structure databases
ProteinModelPortali | Q8CG79. |
SMRi | Q8CG79. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 958 – 987 | ANK 1Add BLAST | 30 | |
Repeati | 991 – 1020 | ANK 2Add BLAST | 30 | |
Domaini | 1057 – 1119 | SH3PROSITE-ProRule annotationAdd BLAST | 63 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 332 – 348 | Interaction with APPBP1By similarityAdd BLAST | 17 | |
Regioni | 876 – 1128 | Mediates interaction with APC2By similarityAdd BLAST | 253 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 866 – 875 | SH3-bindingSequence analysis | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 92 – 133 | Gln-richAdd BLAST | 42 | |
Compositional biasi | 132 – 173 | Gln-richAdd BLAST | 42 |
Domaini
The ankyrin repeats and the SH3 domain are required for a specific interactions with p53/TP53.By similarity
Sequence similaritiesi
Belongs to the ASPP family.Curated
Keywords - Domaini
ANK repeat, Repeat, SH3 domain, SH3-bindingPhylogenomic databases
eggNOGi | KOG0515. Eukaryota. ENOG410Y17W. LUCA. |
HOGENOMi | HOG000034106. |
HOVERGENi | HBG050596. |
InParanoidi | Q8CG79. |
KOi | K16823. |
PhylomeDBi | Q8CG79. |
Family and domain databases
CDDi | cd00204. ANK. 1 hit. |
Gene3Di | 1.25.40.20. 1 hit. |
InterProi | View protein in InterPro IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR036770. Ankyrin_rpt-contain_sf. IPR036028. SH3-like_dom_sf. IPR001452. SH3_domain. IPR029071. Ubiquitin-like_domsf. |
Pfami | View protein in Pfam PF12796. Ank_2. 1 hit. PF00018. SH3_1. 1 hit. |
SMARTi | View protein in SMART SM00248. ANK. 2 hits. SM00326. SH3. 1 hit. |
SUPFAMi | SSF48403. SSF48403. 1 hit. SSF50044. SSF50044. 1 hit. SSF54236. SSF54236. 1 hit. |
PROSITEi | View protein in PROSITE PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS50002. SH3. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q8CG79-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMPMFLTVYL SNSEQHFTEV PVTPETICRD VVDLCKEPGE NDCHLAEVWC
60 70 80 90 100
GSERPVADNE RMFDVLQRFG SQRNEVRFFL RHERPPNRDI VSGPRSQDPS
110 120 130 140 150
VKRNGVKVPG EHRRKENGVN SPRLDLTLAE LQEMASRQQQ QIEAQQQMLA
160 170 180 190 200
TKEQRLKFLK QQDQRQQQQA AEQEKLKRLR EIAESQEAKL KKVRALKGHV
210 220 230 240 250
EQKRLSNGKL VEEIEQMNSL FQQKQRELVL AVSKVEELTR QLEMLKNGRI
260 270 280 290 300
DGHHDNQSAV AELDRLYKEL QLRNKLNQEQ NAKLQQQREC LNKRNSEVAV
310 320 330 340 350
MDKRVSELRD RLWKKKAALQ QKENLPVSPD GNLPQQAVSA PSRVAAVGPY
360 370 380 390 400
IQSSTMPRMP SRPELLVKPA LPDGSLLMQS AEGPMKIQTL PNMRSGAASQ
410 420 430 440 450
SKGSKAHPAS PDWNPSNADL LPSQGSSVPQ SAGTALDQVD DGEIAVREKE
460 470 480 490 500
KKVRPFSMFD TVDQCAAPPS FGTLRKNQSS EDILRDAQAV NKNVAKVPPP
510 520 530 540 550
VPTKPKQIHL PYFGQTAQSP SDMKPDGNAQ QLPIAATSVG AKLKPAGPQA
560 570 580 590 600
RMLLSPGAPS GGQDQVLSPA SKQESPPAAA VRPFTPQPSK DTFPPAFRKP
610 620 630 640 650
QTVAASSIYS MYTQQQAPGK NFQQAVQSAL TKTQPRGPHF SSVYGKPVIA
660 670 680 690 700
AAQNPQQHPE NIYSCSQGKP GSPEPETETV SSVHESHENE RIPRPLSPTK
710 720 730 740 750
LLPFLSNPYR NQSDADLEAL RKKLSNAPRP LKKRSSITEP EGPNGPNIQK
760 770 780 790 800
LLYQRTTIAA METISVPSHP SKSPGSVTVN PESSVEIPNP YLHVEPEKEV
810 820 830 840 850
GSLVPEPLSP EDMGSASTEN SDVPAPSAGL EYVSEGVTDS STNLQNNVEE
860 870 880 890 900
TNPEAPHLLE VYLEEYPPYP PPPYPSGEPE VSEEDSARMR PPEITGQVSL
910 920 930 940 950
PPGKRTNLRK TGSERIAHGM RVKFNPLALL LDSSLEGEFD LVQRIIYEVD
960 970 980 990 1000
DPSLPNDEGI TALHNAVCAG HTEIVKFLVQ FGVNVNAADS DGWTPLHCAA
1010 1020 1030 1040 1050
SCNNVQVCKF LVESGAAVFA MTYSDMQTAA DKCEEMEEGY TQCSQFLYGV
1060 1070 1080 1090 1100
QEKMGIMNKG VIYALWDYEP QHDDELLMKE GDCMTVIRRE DEEEIEWWWA
1110 1120
RLNDKEGYVP RNLLGLYPRI KPRQRSLA
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 270 | L → V in BAE22185 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 367 – 382 | VKPAL…MQSAE → DAWVAHASAHASAHAS in AAH30894 (PubMed:15489334).CuratedAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC131742 Genomic DNA. No translation available. BC030894 mRNA. Translation: AAH30894.1. BC042874 mRNA. No translation available. CB248714 mRNA. No translation available. AK134556 mRNA. Translation: BAE22185.1. |
RefSeqi | NP_775554.2. NM_173378.2. |
UniGenei | Mm.287450. |
Genome annotation databases
GeneIDi | 209456. |
KEGGi | mmu:209456. |
UCSCi | uc007dyd.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | ASPP2_MOUSE | |
Accessioni | Q8CG79Primary (citable) accession number: Q8CG79 Secondary accession number(s): Q3UYM7, Q8K2L5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | January 9, 2007 | |
Last modified: | March 28, 2018 | |
This is version 131 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |