Tp53bp2

Functionⁱ

Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates p53/TP53 by enhancing the DNA binding and transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42 (By similarity).By similarity

GO - Molecular functionⁱ

identical protein binding Source: MGI
NF-kappaB binding Source: MGI
p53 binding Source: MGI
SH3 domain binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
central nervous system development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16702401
embryo development ending in birth or egg hatching
Source: MGI
Inferred from genetic interactionⁱ
- 16702401
heart development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16702401
intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
positive regulation of execution phase of apoptosis Source: MGI
response to ionizing radiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16702401

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Cell cycle

Biological process

Apoptosis, Cell cycle

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Apoptosis-stimulating of p53 protein 2 Alternative name(s): Tumor suppressor p53-binding protein 2 Short name: 53BP2 Short name: p53-binding protein 2 Short name: p53BP2
Gene namesⁱ	Name:Tp53bp2 Synonyms:Aspp2, Trp53bp2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:2138319. Trp53bp2.

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000066965	1 – 1128	Apoptosis-stimulating of p53 protein 2Add BLAST		1128

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	479	PhosphoserineCombined sources	1
Modified residueⁱ	555	PhosphoserineBy similarity	1
Modified residueⁱ	568	PhosphoserineBy similarity	1
Modified residueⁱ	571	PhosphoserineBy similarity	1
Modified residueⁱ	575	PhosphoserineBy similarity	1
Modified residueⁱ	697	PhosphoserineCombined sources	1
Modified residueⁱ	713	PhosphoserineCombined sources	1
Modified residueⁱ	736	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8CG79.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8CG79.
PaxDbⁱ	Q8CG79.
PRIDEⁱ	Q8CG79.

PTM databases

iPTMnetⁱ	Q8CG79.
PhosphoSitePlusⁱ	Q8CG79.

Interactionⁱ

Subunit structureⁱ

Binds to the central domain of p53/TP53 as well as to BCL2. Interacts with protein phosphatase 1. Interacts with RELA NF-kappa-B subunit. This interaction probably prevents the activation of apoptosis, possibly by preventing its interaction with p53/TP53. Interacts with APC2 and APPBP1. Interacts with DDX42 (via the C-terminus); the interaction is not inhibited by TP53BP2 ubiquitination and is independent of p53/TP53 (By similarity).By similarity

GO - Molecular functionⁱ

identical protein binding Source: MGI
NF-kappaB binding Source: MGI
p53 binding Source: MGI
SH3 domain binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	229080. 2 interactors.
IntActⁱ	Q8CG79. 4 interactors.
STRINGⁱ	10090.ENSMUSP00000112508.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8CG79.
SMRⁱ	Q8CG79.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	958 – 987	ANK 1Add BLAST	30
Repeatⁱ	991 – 1020	ANK 2Add BLAST	30
Domainⁱ	1057 – 1119	SH3PROSITE-ProRule annotationAdd BLAST	63

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	332 – 348	Interaction with APPBP1By similarityAdd BLAST		17
Regionⁱ	876 – 1128	Mediates interaction with APC2By similarityAdd BLAST		253

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	866 – 875	SH3-bindingSequence analysis		10

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	92 – 133	Gln-richAdd BLAST		42
Compositional biasⁱ	132 – 173	Gln-richAdd BLAST		42

Domainⁱ

The ankyrin repeats and the SH3 domain are required for a specific interactions with p53/TP53.By similarity

Sequence similaritiesⁱ

Belongs to the ASPP family.Curated

Keywords - Domainⁱ

ANK repeat, Repeat, SH3 domain, SH3-binding

Phylogenomic databases

eggNOGⁱ	KOG0515. Eukaryota. ENOG410Y17W. LUCA.
HOGENOMⁱ	HOG000034106.
HOVERGENⁱ	HBG050596.
InParanoidⁱ	Q8CG79.
KEGG Orthology (KO) More...KOⁱ	K16823.
PhylomeDBⁱ	Q8CG79.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204. ANK. 1 hit.
Gene3Dⁱ	1.25.40.20. 1 hit.
InterProⁱ	View protein in InterPro IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR036770. Ankyrin_rpt-contain_sf. IPR036028. SH3-like_dom_sf. IPR001452. SH3_domain. IPR029071. Ubiquitin-like_domsf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796. Ank_2. 1 hit. PF00018. SH3_1. 1 hit.
SMARTⁱ	View protein in SMART SM00248. ANK. 2 hits. SM00326. SH3. 1 hit.
SUPFAMⁱ	SSF48403. SSF48403. 1 hit. SSF50044. SSF50044. 1 hit. SSF54236. SSF54236. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS50002. SH3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8CG79-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMPMFLTVYL SNSEQHFTEV PVTPETICRD VVDLCKEPGE NDCHLAEVWC 
        60         70         80         90        100
GSERPVADNE RMFDVLQRFG SQRNEVRFFL RHERPPNRDI VSGPRSQDPS 
       110        120        130        140        150
VKRNGVKVPG EHRRKENGVN SPRLDLTLAE LQEMASRQQQ QIEAQQQMLA 
       160        170        180        190        200
TKEQRLKFLK QQDQRQQQQA AEQEKLKRLR EIAESQEAKL KKVRALKGHV 
       210        220        230        240        250
EQKRLSNGKL VEEIEQMNSL FQQKQRELVL AVSKVEELTR QLEMLKNGRI 
       260        270        280        290        300
DGHHDNQSAV AELDRLYKEL QLRNKLNQEQ NAKLQQQREC LNKRNSEVAV 
       310        320        330        340        350
MDKRVSELRD RLWKKKAALQ QKENLPVSPD GNLPQQAVSA PSRVAAVGPY 
       360        370        380        390        400
IQSSTMPRMP SRPELLVKPA LPDGSLLMQS AEGPMKIQTL PNMRSGAASQ 
       410        420        430        440        450
SKGSKAHPAS PDWNPSNADL LPSQGSSVPQ SAGTALDQVD DGEIAVREKE 
       460        470        480        490        500
KKVRPFSMFD TVDQCAAPPS FGTLRKNQSS EDILRDAQAV NKNVAKVPPP 
       510        520        530        540        550
VPTKPKQIHL PYFGQTAQSP SDMKPDGNAQ QLPIAATSVG AKLKPAGPQA 
       560        570        580        590        600
RMLLSPGAPS GGQDQVLSPA SKQESPPAAA VRPFTPQPSK DTFPPAFRKP 
       610        620        630        640        650
QTVAASSIYS MYTQQQAPGK NFQQAVQSAL TKTQPRGPHF SSVYGKPVIA 
       660        670        680        690        700
AAQNPQQHPE NIYSCSQGKP GSPEPETETV SSVHESHENE RIPRPLSPTK 
       710        720        730        740        750
LLPFLSNPYR NQSDADLEAL RKKLSNAPRP LKKRSSITEP EGPNGPNIQK 
       760        770        780        790        800
LLYQRTTIAA METISVPSHP SKSPGSVTVN PESSVEIPNP YLHVEPEKEV 
       810        820        830        840        850
GSLVPEPLSP EDMGSASTEN SDVPAPSAGL EYVSEGVTDS STNLQNNVEE 
       860        870        880        890        900
TNPEAPHLLE VYLEEYPPYP PPPYPSGEPE VSEEDSARMR PPEITGQVSL 
       910        920        930        940        950
PPGKRTNLRK TGSERIAHGM RVKFNPLALL LDSSLEGEFD LVQRIIYEVD 
       960        970        980        990       1000
DPSLPNDEGI TALHNAVCAG HTEIVKFLVQ FGVNVNAADS DGWTPLHCAA 
      1010       1020       1030       1040       1050
SCNNVQVCKF LVESGAAVFA MTYSDMQTAA DKCEEMEEGY TQCSQFLYGV 
      1060       1070       1080       1090       1100
QEKMGIMNKG VIYALWDYEP QHDDELLMKE GDCMTVIRRE DEEEIEWWWA 
      1110       1120 
RLNDKEGYVP RNLLGLYPRI KPRQRSLA

Length:1,128

Mass (Da):125,301

Last modified:January 9, 2007 - v3

Checksum:ⁱC5FF5D37D73187A0

GO

Sequence cautionⁱ

The sequence BC042874 differs from that shown. Reason: Frameshift at position 23.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	270	L → V in BAE22185 (PubMed:16141072).Curated		1
Sequence conflictⁱ	367 – 382	VKPAL…MQSAE → DAWVAHASAHASAHAS in AAH30894 (PubMed:15489334).CuratedAdd BLAST		16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC131742 Genomic DNA. No translation available. BC030894 mRNA. Translation: AAH30894.1. BC042874 mRNA. No translation available. CB248714 mRNA. No translation available. AK134556 mRNA. Translation: BAE22185.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_775554.2. NM_173378.2.
UniGeneⁱ	Mm.287450.

Genome annotation databases

GeneIDⁱ	209456.
KEGGⁱ	mmu:209456.
UCSC genome browser More...UCSCⁱ	uc007dyd.1. mouse.

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8CG79	E9QJU8 Q3UZC5	Mus musculus (Mouse)	1,128	UniRef100_Q8CG79	Cluster: Apoptosis-stimulating of p53 protein 2	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8CG79	Q13625 Q13625-3 B7Z2E9 B4DH76 Q13625-2 UPI0000D4B2A1 A0A2J8U2A7 A0A2J8U2B6 A0A2J8U2D2 A0A2I3MLL6 +146	Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Papio anubis (Olive baboon) Castor canadensis (Beaver) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Ovis aries (Sheep) Ovis aries musimon (Mouflon) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Physeter catodon (Sperm whale) (Physeter macrocephalus) And more	1,128	UniRef90_Q13625	Cluster: Apoptosis-stimulating of p53 protein 2	157

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8CG79	Q13625 Q13625-3 B7Z2E9 B4DH76 Q13625-2 UPI0000D4B2A1 A0A2J8U2A7 A0A2J8U2B6 A0A2J8U2D2 A0A2I3MLL6 +160	Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Papio anubis (Olive baboon) Castor canadensis (Beaver) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni) Ovis aries (Sheep) Ovis aries musimon (Mouflon) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) And more	1,128	UniRef50_Q13625	Cluster: Apoptosis-stimulating of p53 protein 2	171

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC131742 Genomic DNA. No translation available. BC030894 mRNA. Translation: AAH30894.1. BC042874 mRNA. No translation available. CB248714 mRNA. No translation available. AK134556 mRNA. Translation: BAE22185.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_775554.2. NM_173378.2.
UniGeneⁱ	Mm.287450.

3D structure databases

ProteinModelPortalⁱ	Q8CG79.
SMRⁱ	Q8CG79.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	229080. 2 interactors.
IntActⁱ	Q8CG79. 4 interactors.
STRINGⁱ	10090.ENSMUSP00000112508.

PTM databases

iPTMnetⁱ	Q8CG79.
PhosphoSitePlusⁱ	Q8CG79.

Proteomic databases

EPDⁱ	Q8CG79.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8CG79.
PaxDbⁱ	Q8CG79.
PRIDEⁱ	Q8CG79.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	209456.
KEGGⁱ	mmu:209456.
UCSC genome browser More...UCSCⁱ	uc007dyd.1. mouse.

Organism-specific databases

CTDⁱ	209456.
MGIⁱ	MGI:2138319. Trp53bp2.

Phylogenomic databases

eggNOGⁱ	KOG0515. Eukaryota. ENOG410Y17W. LUCA.
HOGENOMⁱ	HOG000034106.
HOVERGENⁱ	HBG050596.
InParanoidⁱ	Q8CG79.
KEGG Orthology (KO) More...KOⁱ	K16823.
PhylomeDBⁱ	Q8CG79.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8CG79.
SOURCEⁱ	Search...

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204. ANK. 1 hit.
Gene3Dⁱ	1.25.40.20. 1 hit.
InterProⁱ	View protein in InterPro IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR036770. Ankyrin_rpt-contain_sf. IPR036028. SH3-like_dom_sf. IPR001452. SH3_domain. IPR029071. Ubiquitin-like_domsf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796. Ank_2. 1 hit. PF00018. SH3_1. 1 hit.
SMARTⁱ	View protein in SMART SM00248. ANK. 2 hits. SM00326. SH3. 1 hit.
SUPFAMⁱ	SSF48403. SSF48403. 1 hit. SSF50044. SSF50044. 1 hit. SSF54236. SSF54236. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS50002. SH3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ASPP2_MOUSE
Accessionⁱ	Q8CG79Primary (citable) accession number: Q8CG79 Secondary accession number(s): Q3UYM7, Q8K2L5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
	Last sequence update:	January 9, 2007
	Last modified:	March 28, 2018
	This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8CG79 (ASPP2_MOUSE)

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Apoptosis-stimulating of p53 protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ