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Protein

Protein fantom

Gene

Rpgrip1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (By similarity). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions in kidney cells together with NPHP1 and NPHP4. Does not seem to be strictly required for ciliogenesis.By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

  • brain development Source: MGI
  • camera-type eye development Source: MGI
  • cerebellum development Source: MGI
  • cilium assembly Source: MGI
  • cilium morphogenesis Source: MGI
  • cochlea development Source: MGI
  • corpus callosum development Source: MGI
  • determination of left/right symmetry Source: MGI
  • embryonic forelimb morphogenesis Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • establishment of planar polarity Source: MGI
  • establishment or maintenance of cell polarity Source: MGI
  • head development Source: MGI
  • in utero embryonic development Source: MGI
  • kidney development Source: MGI
  • lateral ventricle development Source: MGI
  • limb morphogenesis Source: MGI
  • liver development Source: MGI
  • negative regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
  • neural tube patterning Source: MGI
  • nose development Source: MGI
  • olfactory bulb development Source: MGI
  • pericardium development Source: MGI
  • regulation of smoothened signaling pathway Source: MGI
  • telencephalon development Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-5610787. Hedgehog 'off' state.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-5632684. Hedgehog 'on' state.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fantom
Alternative name(s):
Nephrocystin-8
RPGR-interacting protein 1-like protein
Short name:
RPGRIP1-like protein
Gene namesi
Name:Rpgrip1l
Synonyms:Ftm, Nphp8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1920563. Rpgrip1l.

Subcellular locationi

GO - Cellular componenti

  • axoneme Source: MGI
  • bicellular tight junction Source: UniProtKB-SubCell
  • cell-cell junction Source: UniProtKB
  • centrosome Source: MGI
  • ciliary basal body Source: MGI
  • ciliary transition zone Source: MGI
  • cilium Source: MGI
  • cytoplasm Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12641264Protein fantomPRO_0000291268Add
BLAST

Proteomic databases

MaxQBiQ8CG73.
PaxDbiQ8CG73.
PeptideAtlasiQ8CG73.
PRIDEiQ8CG73.

PTM databases

iPTMnetiQ8CG73.
PhosphoSiteiQ8CG73.

Expressioni

Tissue specificityi

Ubiquitously expressed. Not found in heart and skin.1 Publication

Developmental stagei

Expression was detected throughout embryonic development as early as E8.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000033282.
CleanExiMM_RPGRIP1L.
ExpressionAtlasiQ8CG73. baseline and differential.

Interactioni

Subunit structurei

Interacts with NPHP4 in a complex containing NPHP1, NPHP4 and RPGRIP1L/NPHP8. Interacts with TBXA2R (via C-terminus). Interacts with IQCB1; the interaction likely requires additional interactors. Interacts with RPGR. Interacts with NEK4.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Iqcb1Q8BP002EBI-4281130,EBI-4282243
Nphp4P592404EBI-4281130,EBI-4281265

GO - Molecular functioni

Protein-protein interaction databases

BioGridi232664. 43 interactions.
IntActiQ8CG73. 279 interactions.
STRINGi10090.ENSMUSP00000042702.

Structurei

3D structure databases

ProteinModelPortaliQ8CG73.
SMRiQ8CG73. Positions 595-737, 790-904, 1077-1261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini615 – 71298C2 1Add
BLAST
Domaini777 – 881105C2 2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili64 – 14380Sequence analysisAdd
BLAST
Coiled coili196 – 26873Sequence analysisAdd
BLAST
Coiled coili299 – 454156Sequence analysisAdd
BLAST
Coiled coili488 – 55568Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the RPGRIP1 family.Curated
Contains 2 C2 domains.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IGZN. Eukaryota.
ENOG410YNUX. LUCA.
GeneTreeiENSGT00520000055620.
HOGENOMiHOG000168391.
HOVERGENiHBG106574.
InParanoidiQ8CG73.
KOiK16550.
OMAiIRDNVEM.
OrthoDBiEOG091G03K7.
TreeFamiTF328883.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR021656. C2-C2_1.
IPR000008. C2_dom.
IPR031139. RPGRIP1_fam.
IPR031136. RPGRIP1L.
[Graphical view]
PANTHERiPTHR14240. PTHR14240. 1 hit.
PTHR14240:SF4. PTHR14240:SF4. 1 hit.
PfamiPF00168. C2. 1 hit.
PF11618. C2-C2_1. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8CG73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGPSDETAG DLPVKDTGLN LFGVGGLQET STARTVKTRQ AVSRVSREEL
60 70 80 90 100
EDRFLRLHDE NILLKQHARK QEDKIKRMAT KLIRLVNDKK RYERVGGGPK
110 120 130 140 150
RLGRDVEMEE MIEQLQEKVH ELERQNEVLK NRLISAKQQL QVQGHRQTSY
160 170 180 190 200
SRVQARVNTG RRRASASAGS QECPGKGLRF QNVDEAETVQ PTLTKYSNSL
210 220 230 240 250
LEEARGEIRN LENVIQSQRG QIEELEHLAE ILKTQLKRKE NEIELSLLQL
260 270 280 290 300
REQQATDQRS NIRDNVETIK LHKQLVEKSN ALSVIEGKFI QLQEKQRTLR
310 320 330 340 350
ISHDALMANG DELNKQLKEQ RLKCCSLEKQ LHSVRFSERR VEELQDRIND
360 370 380 390 400
LEKERELLKE NYDKLYNSAF SAAHEEQWKL KEQQMKVQIA QLETALKSDL
410 420 430 440 450
TDKTEVLDKL KTERDQNEKL VQENRDLQLQ CLQQKQRLHE LQSRLKFFNQ
460 470 480 490 500
ESDINADDLS EALLLIKAQK EQKNGDLSFL EKVDSKINKD LDRSMKELQA
510 520 530 540 550
THAETVQELE KTRNMLIMQH KINKDYQMEV ETVTQKMENL QQDYELKVEQ
560 570 580 590 600
YVHLLDIRAA RIQKLEAQLK DIAYGTKQYK FKPEIMPDDS VDEFDETIHL
610 620 630 640 650
ERGENLFEIH INKVTFSSEV LRASGDKELV TFCTYAFYDF ELQTTPIVRG
660 670 680 690 700
LYPEYNFTSQ YLVHVNDLFL QYIQKNTVTL ELHQAHSTDY ETIAACQLRF
710 720 730 740 750
HEILEKSGRI FCTTSLVGTK GDIPNFGTVE YWFRLRVPMD QAIRLYRERA
760 770 780 790 800
KALGYITSNF KKPEKMQLSS QQAATTAQIS PAESTDGNLN ELHVTVKCCT
810 820 830 840 850
GLQSRASYLQ PHAYVVYKFF DFPDHDTAIV PSSNDPQFDD HMCFPVPMNM
860 870 880 890 900
DLDRYLKSES LSFYVFDDSD TQENIYMGKV NVPLISLAHD KCISGIFELM
910 920 930 940 950
DKEKHAAGTI QVILKWKFTY LPPSGSITTE DLGKFVCREE PEAVQRLPPK
960 970 980 990 1000
SSDVTSVVAP KPKPRQRLTF VDKKVSFADT ISHPSPETSP PPKDIKDSSP
1010 1020 1030 1040 1050
EVGPKPENGL SAVAYPSKES GVAKVEENVG EMQQGKEDDI SFLSEGQLAS
1060 1070 1080 1090 1100
GSVASSEDET EITEELEPED EDRSASDSDD CIIPSSVSTN TKQPSEEIRI
1110 1120 1130 1140 1150
EIIALNLNDS QITREDTIQR LFIECRFYSL PAEETPMSLP KPQSGQWVYY
1160 1170 1180 1190 1200
NYSNVIYLDK ENNPAVRDIL KAILQRRELP HRSVRFTVVS DPPEDEQDLE
1210 1220 1230 1240 1250
CEDIGVAHVD LADLFQKGRD IIEQDIDVLD ARTDGGTIGK LKVTVEALHA
1260
LRSVYEQNRK DLEA
Length:1,264
Mass (Da):145,000
Last modified:October 3, 2012 - v2
Checksum:iAA1A5A7F9AC2AD1E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti759 – 7591N → S in CAC87257 (PubMed:11956760).Curated
Sequence conflicti797 – 7971K → R in CAC87257 (PubMed:11956760).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344253 mRNA. Translation: CAC87257.1.
AC139351 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11076.1.
CCDSiCCDS22520.1.
RefSeqiNP_775607.2. NM_173431.2.
UniGeneiMm.324592.

Genome annotation databases

EnsembliENSMUST00000047783; ENSMUSP00000042702; ENSMUSG00000033282.
GeneIDi244585.
KEGGimmu:244585.
UCSCiuc009msp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344253 mRNA. Translation: CAC87257.1.
AC139351 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11076.1.
CCDSiCCDS22520.1.
RefSeqiNP_775607.2. NM_173431.2.
UniGeneiMm.324592.

3D structure databases

ProteinModelPortaliQ8CG73.
SMRiQ8CG73. Positions 595-737, 790-904, 1077-1261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232664. 43 interactions.
IntActiQ8CG73. 279 interactions.
STRINGi10090.ENSMUSP00000042702.

PTM databases

iPTMnetiQ8CG73.
PhosphoSiteiQ8CG73.

Proteomic databases

MaxQBiQ8CG73.
PaxDbiQ8CG73.
PeptideAtlasiQ8CG73.
PRIDEiQ8CG73.

Protocols and materials databases

DNASUi244585.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047783; ENSMUSP00000042702; ENSMUSG00000033282.
GeneIDi244585.
KEGGimmu:244585.
UCSCiuc009msp.1. mouse.

Organism-specific databases

CTDi23322.
MGIiMGI:1920563. Rpgrip1l.

Phylogenomic databases

eggNOGiENOG410IGZN. Eukaryota.
ENOG410YNUX. LUCA.
GeneTreeiENSGT00520000055620.
HOGENOMiHOG000168391.
HOVERGENiHBG106574.
InParanoidiQ8CG73.
KOiK16550.
OMAiIRDNVEM.
OrthoDBiEOG091G03K7.
TreeFamiTF328883.

Enzyme and pathway databases

ReactomeiR-MMU-5610787. Hedgehog 'off' state.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-5632684. Hedgehog 'on' state.

Miscellaneous databases

PROiQ8CG73.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033282.
CleanExiMM_RPGRIP1L.
ExpressionAtlasiQ8CG73. baseline and differential.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR021656. C2-C2_1.
IPR000008. C2_dom.
IPR031139. RPGRIP1_fam.
IPR031136. RPGRIP1L.
[Graphical view]
PANTHERiPTHR14240. PTHR14240. 1 hit.
PTHR14240:SF4. PTHR14240:SF4. 1 hit.
PfamiPF00168. C2. 1 hit.
PF11618. C2-C2_1. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiFTM_MOUSE
AccessioniPrimary (citable) accession number: Q8CG73
Secondary accession number(s): G3X958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.