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Q8CG65

- SSPO_MOUSE

UniProt

Q8CG65 - SSPO_MOUSE

Protein

SCO-spondin

Gene

Sspo

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system By similarity.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SCO-spondin
    Gene namesi
    Name:Sspo
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2674311. Sspo.

    Subcellular locationi

    Secretedextracellular space By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 49984981SCO-spondinPRO_0000245043Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 4990By similarity
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi698 – 6981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi771 – 7711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi790 – 7901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi824 – 8241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi866 – 8661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1230 – 12301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1254 ↔ 1267By similarity
    Disulfide bondi1261 ↔ 1280By similarity
    Disulfide bondi1274 ↔ 1289By similarity
    Disulfide bondi1294 ↔ 1306By similarity
    Disulfide bondi1301 ↔ 1319By similarity
    Disulfide bondi1313 ↔ 1328By similarity
    Disulfide bondi1330 ↔ 1342By similarity
    Disulfide bondi1337 ↔ 1355By similarity
    Disulfide bondi1349 ↔ 1364By similarity
    Disulfide bondi1370 ↔ 1382By similarity
    Disulfide bondi1377 ↔ 1395By similarity
    Disulfide bondi1389 ↔ 1406By similarity
    Disulfide bondi1443 ↔ 1455By similarity
    Disulfide bondi1450 ↔ 1468By similarity
    Disulfide bondi1462 ↔ 1477By similarity
    Disulfide bondi1481 ↔ 1494By similarity
    Disulfide bondi1488 ↔ 1507By similarity
    Disulfide bondi1501 ↔ 1518By similarity
    Glycosylationi1528 – 15281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1534 ↔ 1544By similarity
    Disulfide bondi1539 ↔ 1557By similarity
    Disulfide bondi1551 ↔ 1572By similarity
    Disulfide bondi1584 ↔ 1620By similarity
    Disulfide bondi1588 ↔ 1625By similarity
    Glycosylationi1598 – 15981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1599 ↔ 1610By similarity
    Disulfide bondi1640 ↔ 1680By similarity
    Disulfide bondi1644 ↔ 1685By similarity
    Disulfide bondi1654 ↔ 1664By similarity
    Glycosylationi1687 – 16871N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1772 ↔ 1811By similarity
    Disulfide bondi1783 ↔ 1787By similarity
    Disulfide bondi1821 ↔ 1826By similarity
    Glycosylationi1892 – 18921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1989 – 19891N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2092 ↔ 2104By similarity
    Disulfide bondi2099 ↔ 2117By similarity
    Disulfide bondi2111 ↔ 2126By similarity
    Disulfide bondi2243 ↔ 2255By similarity
    Disulfide bondi2250 ↔ 2268By similarity
    Disulfide bondi2262 ↔ 2277By similarity
    Disulfide bondi2300 ↔ 2312By similarity
    Disulfide bondi2307 ↔ 2325By similarity
    Disulfide bondi2319 ↔ 2334By similarity
    Disulfide bondi2337 ↔ 2373By similarity
    Disulfide bondi2348 ↔ 2352By similarity
    Disulfide bondi2383 ↔ 2388By similarity
    Disulfide bondi2403 ↔ 2440By similarity
    Disulfide bondi2407 ↔ 2445By similarity
    Disulfide bondi2418 ↔ 2430By similarity
    Glycosylationi2481 – 24811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2530 – 25301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2552 ↔ 2590By similarity
    Disulfide bondi2563 ↔ 2567By similarity
    Disulfide bondi2600 ↔ 2604By similarity
    Disulfide bondi2620 ↔ 2658By similarity
    Disulfide bondi2624 ↔ 2663By similarity
    Disulfide bondi2640 ↔ 2648By similarity
    Disulfide bondi2678 ↔ 2713By similarity
    Disulfide bondi2682 ↔ 2718By similarity
    Disulfide bondi2693 ↔ 2703By similarity
    Glycosylationi2772 – 27721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2802 – 28021N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2821 ↔ 2859By similarity
    Disulfide bondi2832 ↔ 2836By similarity
    Disulfide bondi2869 ↔ 2874By similarity
    Glycosylationi2897 – 28971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2952 – 29521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2999 – 29991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3009 – 30091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3031 ↔ 3080By similarity
    Disulfide bondi3035 ↔ 3085By similarity
    Disulfide bondi3046 ↔ 3070By similarity
    Disulfide bondi3100 ↔ 3137By similarity
    Disulfide bondi3104 ↔ 3142By similarity
    Disulfide bondi3115 ↔ 3127By similarity
    Glycosylationi3146 – 31461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3235 – 32351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3256 ↔ 3299By similarity
    Disulfide bondi3260 ↔ 3305By similarity
    Disulfide bondi3271 ↔ 3283By similarity
    Glycosylationi3301 – 33011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3320 ↔ 3355By similarity
    Disulfide bondi3323 ↔ 3362By similarity
    Disulfide bondi3333 ↔ 3345By similarity
    Glycosylationi3357 – 33571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3435 – 34351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3462 – 34621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3493 ↔ 3523By similarity
    Disulfide bondi3497 ↔ 3528By similarity
    Disulfide bondi3508 ↔ 3513By similarity
    Glycosylationi3638 – 36381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3669 ↔ 3707By similarity
    Disulfide bondi3673 ↔ 3712By similarity
    Disulfide bondi3685 ↔ 3697By similarity
    Glycosylationi3761 – 37611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3794 ↔ 3830By similarity
    Disulfide bondi3805 ↔ 3809By similarity
    Disulfide bondi3843 ↔ 3848By similarity
    Disulfide bondi3863 ↔ 3900By similarity
    Disulfide bondi3867 ↔ 3905By similarity
    Disulfide bondi3878 ↔ 3890By similarity
    Glycosylationi3986 – 39861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4007 ↔ 4043By similarity
    Disulfide bondi4018 ↔ 4022By similarity
    Disulfide bondi4053 ↔ 4058By similarity
    Disulfide bondi4112 ↔ 4149By similarity
    Disulfide bondi4116 ↔ 4154By similarity
    Disulfide bondi4127 ↔ 4139By similarity
    Disulfide bondi4169 ↔ 4207By similarity
    Disulfide bondi4173 ↔ 4212By similarity
    Disulfide bondi4184 ↔ 4195By similarity
    Glycosylationi4196 – 41961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4216 ↔ 4253By similarity
    Disulfide bondi4227 ↔ 4229By similarity
    Disulfide bondi4263 ↔ 4268By similarity
    Glycosylationi4267 – 42671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4408 – 44081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4463 – 44631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4466 ↔ 4500By similarity
    Disulfide bondi4477 ↔ 4481By similarity
    Disulfide bondi4510 ↔ 4515By similarity
    Glycosylationi4584 – 45841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4601 – 46011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4606 – 46061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4628 ↔ 4663By similarity
    Disulfide bondi4632 ↔ 4668By similarity
    Disulfide bondi4643 ↔ 4652By similarity
    Glycosylationi4716 – 47161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4756 – 47561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4799 – 47991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4806 – 48061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4892 ↔ 4952By similarity
    Glycosylationi4912 – 49121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4918 ↔ 4969By similarity
    Disulfide bondi4928 ↔ 4985By similarity
    Disulfide bondi4932 ↔ 4987By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8CG65.

    PTM databases

    PhosphoSiteiQ8CG65.

    Expressioni

    Tissue specificityi

    Subcommissural organ.1 Publication

    Developmental stagei

    Weakly expressed at E14 and E15 in the SCO anlage; increasing progressively until E17 dpc.1 Publication

    Gene expression databases

    BgeeiQ8CG65.
    CleanExiMM_SSPO.
    GenevestigatoriQ8CG65.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CG65.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 10285EMIAdd
    BLAST
    Domaini163 – 288126VWFD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini349 – 40456TIL 1Add
    BLAST
    Domaini404 – 49693VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini443 – 652210VWFD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini706 – 75954TIL 2Add
    BLAST
    Domaini893 – 1097205VWFD 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1153 – 120957TIL 3Add
    BLAST
    Domaini1253 – 129038LDL-receptor class A 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1293 – 132836LDL-receptor class A 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1329 – 136537LDL-receptor class A 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1369 – 140739LDL-receptor class A 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1442 – 147837LDL-receptor class A 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1480 – 151940LDL-receptor class A 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1533 – 157139LDL-receptor class A 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1572 – 162655TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1628 – 168659TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1702 – 174140EGF-like 1Add
    BLAST
    Domaini1742 – 176827EGF-like 2Add
    BLAST
    Domaini1771 – 182757TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1827 – 188761VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1929 – 2085157F5/8 type CPROSITE-ProRule annotationAdd
    BLAST
    Domaini2091 – 212737LDL-receptor class A 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini2242 – 227837LDL-receptor class A 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini2299 – 233537LDL-receptor class A 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini2336 – 238954TSP type-1 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini2391 – 244656TSP type-1 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini2469 – 251143TIL 4Add
    BLAST
    Domaini2551 – 260555TSP type-1 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini2609 – 266456TSP type-1 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini2666 – 271954TSP type-1 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini2820 – 287556TSP type-1 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini2876 – 291944TSP type-1 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini2926 – 297853TIL 5Add
    BLAST
    Domaini3019 – 308668TSP type-1 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini3088 – 314356TSP type-1 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini3147 – 320155TIL 6Add
    BLAST
    Domaini3244 – 330663TSP type-1 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini3308 – 336356TSP type-1 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini3481 – 352949TSP type-1 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini3657 – 371357TSP type-1 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini3727 – 377953TSP type-1 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini3793 – 384957TSP type-1 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini3851 – 390656TSP type-1 19PROSITE-ProRule annotationAdd
    BLAST
    Domaini3909 – 396456TIL 7Add
    BLAST
    Domaini4006 – 405954TSP type-1 20PROSITE-ProRule annotationAdd
    BLAST
    Domaini4100 – 415556TSP type-1 21PROSITE-ProRule annotationAdd
    BLAST
    Domaini4157 – 421357TSP type-1 22PROSITE-ProRule annotationAdd
    BLAST
    Domaini4215 – 426955TSP type-1 23PROSITE-ProRule annotationAdd
    BLAST
    Domaini4465 – 451652TSP type-1 24PROSITE-ProRule annotationAdd
    BLAST
    Domaini4616 – 466954TSP type-1 25PROSITE-ProRule annotationAdd
    BLAST
    Domaini4835 – 489359VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini4892 – 4991100CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the thrombospondin family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 2 EGF-like domains.Curated
    Contains 1 EMI domain.Curated
    Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
    Contains 10 LDL-receptor class A domains.PROSITE-ProRule annotation
    Contains 25 TSP type-1 domains.PROSITE-ProRule annotation
    Contains 3 VWFC domains.PROSITE-ProRule annotation
    Contains 3 VWFD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00730000110607.
    HOGENOMiHOG000154433.
    HOVERGENiHBG080794.
    InParanoidiQ8CG65.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    4.10.400.10. 8 hits.
    InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR006207. Cys_knot_C.
    IPR008979. Galactose-bd-like.
    IPR001545. Gonadotropin_bsu.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR000884. Thrombospondin_1_rpt.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR006552. VWC_out.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF08742. C8. 3 hits.
    PF00754. F5_F8_type_C. 1 hit.
    PF00057. Ldl_recept_a. 7 hits.
    PF01826. TIL. 13 hits.
    PF00090. TSP_1. 22 hits.
    PF00093. VWC. 1 hit.
    PF00094. VWD. 3 hits.
    [Graphical view]
    PRINTSiPR00261. LDLRECEPTOR.
    SMARTiSM00832. C8. 3 hits.
    SM00231. FA58C. 1 hit.
    SM00068. GHB. 1 hit.
    SM00192. LDLa. 10 hits.
    SM00209. TSP1. 25 hits.
    SM00214. VWC. 4 hits.
    SM00215. VWC_out. 1 hit.
    SM00216. VWD. 2 hits.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF57424. SSF57424. 9 hits.
    SSF57567. SSF57567. 14 hits.
    SSF82895. SSF82895. 24 hits.
    PROSITEiPS01225. CTCK_2. 1 hit.
    PS01186. EGF_2. 2 hits.
    PS50022. FA58C_3. 1 hit.
    PS01209. LDLRA_1. 8 hits.
    PS50068. LDLRA_2. 10 hits.
    PS50092. TSP1. 25 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CG65-1 [UniParc]FASTAAdd to Basket

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    MLPLALLFGM LWTQANGHWC EQIETVHVEE EVTPRQEDLV PCTSLYHYSR     50
    LGWQLDLSWS GRVGLTRPPA LGLCAIYKPP ETRPATWNRT VRACCPGWGG 100
    AHCTDALAET SPKGHCFVTW HCQPLAGSAN SSAGSLEDPA DELGVWPLTL 150
    NDPILFPGMS LQWQGDWLVL SGGLGVVVRL DRSSSISISV DHEFWGRTQG 200
    LCGLYNGRPE DDFVEPGGGL ATLAATFGNS WKLPGSEPGC LDAVEVAWGC 250
    ESLLGGTLTD LEAVKLQAQA QDMCHQLLEG PFWQCHGQVQ PDEYHETCLF 300
    AYCVGATAGN GPEGQLEAVC ATFANYAQAC ARQHIYVHWR KPGFCERVCP 350
    GGQLYSDCVS SCPPSCSAVA QGEEGSCGKE CVSGCECPTG LFWDGALCVP 400
    AAHCPCYHRR QRYAPGDTVK QQCNPCVCQD GRWHCAQALC PAECAVGGDG 450
    HYFTFDGRSF FFRGTPGCHY SLVQDSVKGQ LLVVLEHGAC DTGSCLHALS 500
    VFLGNTHIQL RYSGAVLVDG EDVDLPWIGV EGFNISWASS TFLLLHWPGA 550
    WVLWGVAEPA AYITLDPRHA YQVQGLCGTF TWKQQDDFLT PAGDIETSVT 600
    AFASKFQVSG DGRCPLVDKS PLFCSSYSQH LTFTEAACAI LHGHAFQECH 650
    GLVDREPFRL RCLEAVCGCA PGRDCLCPVL SAYTRHCAQE GVLLQWRNET 700
    LCPVSCPGGQ VYQECAPVCG HHCGEPEDCK ELGICVAGCN CPPGLLWDLE 750
    GQCVPPSMCH CQFGGHRYTI NTTTVRDCSH CICQERGLWN CTAHHCPRQW 800
    ALCPRELIYV PGACLLTCDS PRANHSCWAG STDGCVCPPG TVLLDKHCVS 850
    PDLCPCRHNG QWYPPNATIQ EDCNICVCQG QRWHCTGQRC SGWCQASGAP 900
    HYVTFDGLVF TFPGACEYLL VREAGGRFSV SVQNLPCGAS GLTCTKALVV 950
    RLDSTVVHML RGQAVTVNGV SIRLPKVYTG PGLSLHHAGL FLLLTTRLGL 1000
    TLLWDGGTRV LVQLSPHFHG RVAGLCGNFD SDASNDLRSR QGVLEPTAEL 1050
    TAHSWRLNPL CPEPGDLPHP VNAHRANWAR ARCEVILQPI FAPCHTEVPP 1100
    QQYYEWCVYD ACGCDTGGDC ECLCSAIATY ADECARHRHH VRWRSQELCP 1150
    LQCEGGQVYE PCGSTCPPTC HDHHSELRWH CQVITCVEGC FCPEGTLLHG 1200
    GACMKLAACP CEWQGSFFPP GTVLQKDCGN CTCQGSQWHC DRGGAPCEDM 1250
    EPGCAEGETL CRENGHCVPL EWLCDNQDDC GDGSDEEGCA TSVCGEGQMS 1300
    CQSGHCLPLS LICDGQDDCG DGTDEQGCLC PHGSLACADG RCLPPALLCN 1350
    GHPDCLDAAD EESCLGPVSC ISGEVSCVDG TCVRTIQLCD GVWDCPDGAD 1400
    EGPSHCSLPS LPTPPGGIGQ NPSTSSLDTA PSPVGSTSPA SPCSLLEFQC 1450
    NSGECTPRGW RCDQEEDCTD GSDELDCGGP CMLYQVPCAH SPHCVSPGQL 1500
    CDGVTQCPDG SDEDPDVCEE QSASGGANRT GAPCPEFSCP DGTCIDFLLV 1550
    CDGNPDCELA DETEPSLDEQ GCGAWGSWGP WAPCSQTCGS GTRSRNRNCS 1600
    TSSLQVLQNC PGLQHQSQAC FTEACPVDGE WSSWSPWSPC SEPCGGTTTR 1650
    HRQCRPPQNG GQDCALLPGS THSTRQTSPC PQEGCLNATC FGELVFRTCA 1700
    PCPLTCDDIS GQAACPPDRP CSSPGCWCPD GKVLNTEGQC VRPRQCPCLV 1750
    DGAHYWPGQR IKMDCQLCFL DCGWSSWSPW AECLGPCSSQ SLQWSFRSPN 1800
    NPRLSGHGRQ CRGIHRKARR CQTEACEGCE QWGLMYNVGE RWRGGPCMVC 1850
    ECLHSSITHC SPYCPIGSCP QGWVLVEGMG ESCCHCALPE KNQTVIHMTT 1900
    PAPAPASAPS PQIGAHLVTY VLPPTADACY SPLGLAGLPM WAPSQHWEHI 1950
    TRADPVEAPM AGPGPREGAS AEWHTQPLYL QLDLRRPRNL TGIIVQRAGS 2000
    SAAYVSTLSL QFSSDNLQWH NYVNSLSSTL SPPKPSPESS NHMAPEVWTF 2050
    DQMVQARYIR VWPHSGHLRD NNQHDIFLWV ELLGLSPLAP LCPGSRHRCA 2100
    SGECAPKGGP CDGAVDCDDG SDEEGCGSLH ASTTSRTPAL SPTQPGKFPR 2150
    EVSEDLRQGA EAMTSHSPPS SGETAGLIPA SEGTLPVSGQ PMQTLSATST 2200
    FPPGAKSLHP GMAAVTVHPP HSVTPGAPVG QTVSPRPFPP MPCGPGQVPC 2250
    DVLGCVEQEQ LCDGREDCLD GSDEQHCASA EPFTVPTTAL PGLPASKALC 2300
    SPSQLRCGSG ECLPFEHRCD LQVNCQDGSD EDNCVDCVLA PWSGWSDCSR 2350
    SCGLGLIFQH RELLRLPLPG GSCLLDQFRS QSCFVQACPV AGAWAEWGPW 2400
    TACSVSCGGG HQSRQRSCVD PPPKNGGAPC PGPSHEKAPC NLQLCPGDTD 2450
    CEPGLVHVNA ELCQKGLVPP CPPSCLDPEA NRSCSGHCME GCRCPPGLLL 2500
    QDSHCLPLSE CPCLVGQKLI QPRLAFLLDN CSQCICEKGT LLCKPGACSQ 2550
    SCGWSAWSPW TACDRSCGSG VRARFRSPTN PPVAFGGSPC EGDRQELQAC 2600
    YTDCGTEIPG WTPWTSWSSC SQSCLVPGGD PGWRQRSRLC PSSRDTFCPG 2650
    EATQEEPCSP PVCPVPSAWG LWASWSTCSA SCNGGIQTRG RSCSGSAPGN 2700
    PVCLGPHTQT RDCNMHPCTA QCPGNMVFRS AEQCLEEGGP CPQLCLAQDP 2750
    GVECTGSCAP SCNCPPGLFL HNASCLPRSQ CPCQLHGQLY APGAVAHLDC 2800
    NNCTCISGEM VCTSKRCPVA CGWSPWTPWS PCSQSCNVGI RRRFRAGTEP 2850
    PAAFGGAECQ GPNLDAEFCS LRPCRGPGAA WSSWTPCSVP CGGGYRNRTQ 2900
    GSGPHSPIEF STCSLQPCAG PVPGVCPEDQ QWLDCAQGPA SCAHLSIPGE 2950
    ANQTCHPGCY CLSGMLLLNN VCVPVQDCPC AHRGRLYSPG SAVHLPCENC 3000
    SCISGLITNC SSWPCEEGQP AWSSWTPWSV CSASCNPARR HRHRFCARPP 3050
    HRAPFSLVLL TTVAAPTTLC PGPEAEEEPC LLPGCNQAGG WSPWSPWSGC 3100
    SRSCGGGLRS RTRACDQPSP QGLGDFCEGP QAQGEACQAQ PCPVTNCSAM 3150
    EGAEYSPCGP PCPRSCDDLV HCVWRCQPGC YCPLGKVLSA DGAICVKPSY 3200
    CSCLDLLTGK RHHAGTQLMR PDGCNHCTCM EGRLNCTDLP CQVSGDWCPW 3250
    SKWTACSQPC RGQTRTRSRA CVCPAPQHGG SPCPEESGGT GVQHQMEACP 3300
    NATACPVDGA WSPWGPWSSC DACLGQSYRS RVCSHPPISD GGKPCLGGYQ 3350
    QSRPCRNSST LCTDCGGGQD LLPCGQPCPH SCQDLSLGST CQPGSAGCQS 3400
    GCGCPPGQLS QDGLCVFPVD CHCHFQPRAM GIPENRSRSV GSTLSSWESL 3450
    EPGEVVTGPC DNCTCVAGIL QCHEVPSCPG PGIWSSWGPW EKCSVSCGGG 3500
    EQLRSRQCAR PPCPGLAQQS RICHIHVCRE TGCPAGRLYR ECQPSDGCPF 3550
    SCAHVTGQVA CFSERCKEGC HCPEGTFQHH VACVQECPCV LTVLLLQELG 3600
    LASAALGSYP TLLGDEGKPL GPGVELLPGQ MLQTDCGNCS CVHGKLSCSM 3650
    VECSRVHGSF GPWGMWSLCS RSCGGLGTRT RTRQCVLPTL APGGLSCRGP 3700
    LQDLEYCFSP ECPGTAGSTV EPVTGLAGGW GPWSPWSPCS HSCTDPAHPA 3750
    WRSRTRLCLA NCTVGDSSQE RPCNLPSCAA LLPCPGPGCG SGNCFWTSWA 3800
    PWEPCSRSCG VGQQRRLRAY HPPGPGGHWC PDILTAYQER RFCNLRACPV 3850
    PGGWSHWSPW SWCDRSCGGG RSLRSRSCSS PPPKNGGTSC VGERHHVRPC 3900
    NPMPCEEGCP AGMEMVSCAN HCPYSCSDLQ EGGMCQEDQA CQLGCRCSEG 3950
    FLEQDGGCVP VGHCECTDAQ GRSWAPGSQH QDACNNCSCQ AGQLSCTAQL 4000
    CSPPAHCAWS HWSAWSSCSH SCGPQGQQSR FRSSTSGSWA LECQKEQSQS 4050
    QPCPEVPCPP LCLHEAHLHE LGDNWLHGEC QQCSCTPEGA ICKDTDCAVP 4100
    RGWTLWSSWS YCSVSCGGGS QVRTRSCTVS APPHGSLSCE GPDTQTRHCG 4150
    QQLCLQKLER CSWGPWGPCS RSCGTGLASR SGSCPCLLTK EDSKCNDTFL 4200
    GLDTQACYSG PCQDDCTWGD WSSWTRCSCK VLVQQRYRHQ VPAPGQAGEG 4250
    TPCTRLDGHF RPCTIGNCSE DSCPPPFEFQ SCGSPCAGLC ATHLNHRLCQ 4300
    DLPPCQPGCY CPKGLLEQAG SCILPEQCNC WHISGEGARV TLAPGDRLQL 4350
    GCKECVCRRG ELQCSSQGCE GLLPLTGWSE WSPCGPCLPQ SALAPASRTA 4400
    LEGHWPLNTS DLPPPSVTLL ASEQYRHRLC LDPETRRPWA GDPALCTVPL 4450
    SQQRLCPDPG ACNDTCQWGP WGPWSPCQMP CSGGFKLRWR VARDTSAGEC 4500
    PGPWAQTESC NMGSCPGESC ETRDTVFTLD CANQCPRSCA DLWDGVQCLQ 4550
    GPCSPGCRCP PGQLVQDGHC VPISSCRCGL PSANASWELA PTQVVQLDCH 4600
    NCTCINGTLM CPHLECPVLG PWSAWSECSA VCGKGTMVRH RSCEEHPDRE 4650
    PCQALDLQQW QECNLQACPE CPPGQVLSTC ATMCPSLCSH LWPGTICVRE 4700
    PCQLGCGCPG GQLLYNGTCI PPEACPCTQF SLPWGLTLPL EEQARELPSG 4750
    TVLTRNCTHC TCQGGAFICS LTDCQECAPG EIWQHGKLGP CEKTCPEMNM 4800
    TQAWSNCTEA QAPGCVCQLG YFRSQTGLCV PEDHCECWHH GSPHLPGSEW 4850
    QEACESCRCL HGKSVCIRHC PELSCAQGEV IMQEPGSCCP ICQQDTLKEE 4900
    PVSCRYLTEL RNLTKGPCHL DQIEVSYCSG HCRSSTNVMT EEPYLQSQCD 4950
    CCSYRLDPDS PVRILNLLCP DGHTEPVVLP VIHSCQCSAC QGGDFSKH 4998
    Length:4,998
    Mass (Da):534,975
    Last modified:July 27, 2011 - v2
    Checksum:i52726F62E3639AEC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti192 – 1921H → Q in CAD42654. (PubMed:12909363)Curated
    Sequence conflicti1043 – 10431V → L in CAD42654. (PubMed:12909363)Curated
    Sequence conflicti1049 – 10491E → Y in CAD42654. (PubMed:12909363)Curated
    Sequence conflicti1071 – 10711V → W in CAD42654. (PubMed:12909363)Curated
    Sequence conflicti1080 – 10801R → P in CAD42654. (PubMed:12909363)Curated
    Sequence conflicti1769 – 17691F → G in CAD42654. (PubMed:12909363)Curated
    Sequence conflicti3379 – 33791P → R in CAD42654. (PubMed:12909363)Curated
    Sequence conflicti3412 – 34121D → H in CAD42654. (PubMed:12909363)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ491857 mRNA. Translation: CAD42654.1.
    AC153815 Genomic DNA. No translation available.
    UniGeneiMm.25039.

    Genome annotation databases

    EnsembliENSMUST00000043676; ENSMUSP00000047991; ENSMUSG00000029797.
    UCSCiuc009bul.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ491857 mRNA. Translation: CAD42654.1 .
    AC153815 Genomic DNA. No translation available.
    UniGenei Mm.25039.

    3D structure databases

    ProteinModelPortali Q8CG65.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8CG65.

    Proteomic databases

    PRIDEi Q8CG65.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043676 ; ENSMUSP00000047991 ; ENSMUSG00000029797 .
    UCSCi uc009bul.1. mouse.

    Organism-specific databases

    MGIi MGI:2674311. Sspo.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00730000110607.
    HOGENOMi HOG000154433.
    HOVERGENi HBG080794.
    InParanoidi Q8CG65.

    Miscellaneous databases

    PROi Q8CG65.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CG65.
    CleanExi MM_SSPO.
    Genevestigatori Q8CG65.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    4.10.400.10. 8 hits.
    InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR006207. Cys_knot_C.
    IPR008979. Galactose-bd-like.
    IPR001545. Gonadotropin_bsu.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR000884. Thrombospondin_1_rpt.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR006552. VWC_out.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF08742. C8. 3 hits.
    PF00754. F5_F8_type_C. 1 hit.
    PF00057. Ldl_recept_a. 7 hits.
    PF01826. TIL. 13 hits.
    PF00090. TSP_1. 22 hits.
    PF00093. VWC. 1 hit.
    PF00094. VWD. 3 hits.
    [Graphical view ]
    PRINTSi PR00261. LDLRECEPTOR.
    SMARTi SM00832. C8. 3 hits.
    SM00231. FA58C. 1 hit.
    SM00068. GHB. 1 hit.
    SM00192. LDLa. 10 hits.
    SM00209. TSP1. 25 hits.
    SM00214. VWC. 4 hits.
    SM00215. VWC_out. 1 hit.
    SM00216. VWD. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF57424. SSF57424. 9 hits.
    SSF57567. SSF57567. 14 hits.
    SSF82895. SSF82895. 24 hits.
    PROSITEi PS01225. CTCK_2. 1 hit.
    PS01186. EGF_2. 2 hits.
    PS50022. FA58C_3. 1 hit.
    PS01209. LDLRA_1. 8 hits.
    PS50068. LDLRA_2. 10 hits.
    PS50092. TSP1. 25 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain."
      Goncalves-Mendes N., Simon-Chazottes D., Creveaux I., Meiniel A., Guenet J.-L., Meiniel R.
      Gene 312:263-270(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
      Strain: ICR.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiSSPO_MOUSE
    AccessioniPrimary (citable) accession number: Q8CG65
    Secondary accession number(s): E9QMN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3