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Q8CG65 (SSPO_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SCO-spondin
Gene names
Name:Sspo
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length4998 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system By similarity.

Subcellular location

Secretedextracellular space By similarity.

Tissue specificity

Subcommissural organ. Ref.1

Developmental stage

Weakly expressed at E14 and E15 in the SCO anlage; increasing progressively until E17 dpc. Ref.1

Sequence similarities

Belongs to the thrombospondin family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 2 EGF-like domains.

Contains 1 EMI domain.

Contains 1 F5/8 type C domain.

Contains 10 LDL-receptor class A domains.

Contains 7 TIL (trypsin inhibitory-like) domains.

Contains 25 TSP type-1 domains.

Contains 3 VWFC domains.

Contains 3 VWFD domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentSecreted
   DomainEGF-like domain
Repeat
Signal
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from direct assay Ref.1. Source: MGI

extracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 49984981SCO-spondin
PRO_0000245043

Regions

Domain18 – 10285EMI
Domain163 – 288126VWFD 1
Domain349 – 40456TIL 1
Domain404 – 49693VWFC 1
Domain443 – 652210VWFD 2
Domain706 – 75954TIL 2
Domain893 – 1097205VWFD 3
Domain1153 – 120957TIL 3
Domain1253 – 129038LDL-receptor class A 1
Domain1293 – 132836LDL-receptor class A 2
Domain1329 – 136537LDL-receptor class A 3
Domain1369 – 140739LDL-receptor class A 4
Domain1442 – 147837LDL-receptor class A 5
Domain1480 – 151940LDL-receptor class A 6
Domain1533 – 157139LDL-receptor class A 7
Domain1572 – 162655TSP type-1 1
Domain1628 – 168659TSP type-1 2
Domain1702 – 174140EGF-like 1
Domain1742 – 176827EGF-like 2
Domain1771 – 182757TSP type-1 3
Domain1827 – 188761VWFC 2
Domain1929 – 2085157F5/8 type C
Domain2091 – 212737LDL-receptor class A 8
Domain2242 – 227837LDL-receptor class A 9
Domain2299 – 233537LDL-receptor class A 10
Domain2336 – 238954TSP type-1 4
Domain2391 – 244656TSP type-1 5
Domain2469 – 251143TIL 4
Domain2551 – 260555TSP type-1 6
Domain2609 – 266456TSP type-1 7
Domain2666 – 271954TSP type-1 8
Domain2820 – 287556TSP type-1 9
Domain2876 – 291944TSP type-1 10
Domain2926 – 297853TIL 5
Domain3019 – 308668TSP type-1 11
Domain3088 – 314356TSP type-1 12
Domain3147 – 320155TIL 6
Domain3244 – 330663TSP type-1 13
Domain3308 – 336356TSP type-1 14
Domain3481 – 352949TSP type-1 15
Domain3657 – 371357TSP type-1 16
Domain3727 – 377953TSP type-1 17
Domain3793 – 384957TSP type-1 18
Domain3851 – 390656TSP type-1 19
Domain3909 – 396456TIL 7
Domain4006 – 405954TSP type-1 20
Domain4100 – 415556TSP type-1 21
Domain4157 – 421357TSP type-1 22
Domain4215 – 426955TSP type-1 23
Domain4465 – 451652TSP type-1 24
Domain4616 – 466954TSP type-1 25
Domain4835 – 489359VWFC 3
Domain4892 – 4991100CTCK

Amino acid modifications

Glycosylation881N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation5341N-linked (GlcNAc...) Potential
Glycosylation6981N-linked (GlcNAc...) Potential
Glycosylation7711N-linked (GlcNAc...) Potential
Glycosylation7901N-linked (GlcNAc...) Potential
Glycosylation8241N-linked (GlcNAc...) Potential
Glycosylation8661N-linked (GlcNAc...) Potential
Glycosylation12301N-linked (GlcNAc...) Potential
Glycosylation15281N-linked (GlcNAc...) Potential
Glycosylation15981N-linked (GlcNAc...) Potential
Glycosylation16871N-linked (GlcNAc...) Potential
Glycosylation18921N-linked (GlcNAc...) Potential
Glycosylation19891N-linked (GlcNAc...) Potential
Glycosylation24811N-linked (GlcNAc...) Potential
Glycosylation25301N-linked (GlcNAc...) Potential
Glycosylation27721N-linked (GlcNAc...) Potential
Glycosylation28021N-linked (GlcNAc...) Potential
Glycosylation28971N-linked (GlcNAc...) Potential
Glycosylation29521N-linked (GlcNAc...) Potential
Glycosylation29991N-linked (GlcNAc...) Potential
Glycosylation30091N-linked (GlcNAc...) Potential
Glycosylation31461N-linked (GlcNAc...) Potential
Glycosylation32351N-linked (GlcNAc...) Potential
Glycosylation33011N-linked (GlcNAc...) Potential
Glycosylation33571N-linked (GlcNAc...) Potential
Glycosylation34351N-linked (GlcNAc...) Potential
Glycosylation34621N-linked (GlcNAc...) Potential
Glycosylation36381N-linked (GlcNAc...) Potential
Glycosylation37611N-linked (GlcNAc...) Potential
Glycosylation39861N-linked (GlcNAc...) Potential
Glycosylation41961N-linked (GlcNAc...) Potential
Glycosylation42671N-linked (GlcNAc...) Potential
Glycosylation44081N-linked (GlcNAc...) Potential
Glycosylation44631N-linked (GlcNAc...) Potential
Glycosylation45841N-linked (GlcNAc...) Potential
Glycosylation46011N-linked (GlcNAc...) Potential
Glycosylation46061N-linked (GlcNAc...) Potential
Glycosylation47161N-linked (GlcNAc...) Potential
Glycosylation47561N-linked (GlcNAc...) Potential
Glycosylation47991N-linked (GlcNAc...) Potential
Glycosylation48061N-linked (GlcNAc...) Potential
Glycosylation49121N-linked (GlcNAc...) Potential
Disulfide bond1254 ↔ 1267 By similarity
Disulfide bond1261 ↔ 1280 By similarity
Disulfide bond1274 ↔ 1289 By similarity
Disulfide bond1294 ↔ 1306 By similarity
Disulfide bond1301 ↔ 1319 By similarity
Disulfide bond1313 ↔ 1328 By similarity
Disulfide bond1330 ↔ 1342 By similarity
Disulfide bond1337 ↔ 1355 By similarity
Disulfide bond1349 ↔ 1364 By similarity
Disulfide bond1370 ↔ 1382 By similarity
Disulfide bond1377 ↔ 1395 By similarity
Disulfide bond1389 ↔ 1406 By similarity
Disulfide bond1443 ↔ 1455 By similarity
Disulfide bond1450 ↔ 1468 By similarity
Disulfide bond1462 ↔ 1477 By similarity
Disulfide bond1481 ↔ 1494 By similarity
Disulfide bond1488 ↔ 1507 By similarity
Disulfide bond1501 ↔ 1518 By similarity
Disulfide bond1534 ↔ 1544 By similarity
Disulfide bond1539 ↔ 1557 By similarity
Disulfide bond1551 ↔ 1572 By similarity
Disulfide bond1584 ↔ 1620 By similarity
Disulfide bond1588 ↔ 1625 By similarity
Disulfide bond1599 ↔ 1610 By similarity
Disulfide bond1640 ↔ 1680 By similarity
Disulfide bond1644 ↔ 1685 By similarity
Disulfide bond1654 ↔ 1664 By similarity
Disulfide bond1772 ↔ 1811 By similarity
Disulfide bond1783 ↔ 1787 By similarity
Disulfide bond1821 ↔ 1826 By similarity
Disulfide bond2092 ↔ 2104 By similarity
Disulfide bond2099 ↔ 2117 By similarity
Disulfide bond2111 ↔ 2126 By similarity
Disulfide bond2243 ↔ 2255 By similarity
Disulfide bond2250 ↔ 2268 By similarity
Disulfide bond2262 ↔ 2277 By similarity
Disulfide bond2300 ↔ 2312 By similarity
Disulfide bond2307 ↔ 2325 By similarity
Disulfide bond2319 ↔ 2334 By similarity
Disulfide bond2337 ↔ 2373 By similarity
Disulfide bond2348 ↔ 2352 By similarity
Disulfide bond2383 ↔ 2388 By similarity
Disulfide bond2403 ↔ 2440 By similarity
Disulfide bond2407 ↔ 2445 By similarity
Disulfide bond2418 ↔ 2430 By similarity
Disulfide bond2552 ↔ 2590 By similarity
Disulfide bond2563 ↔ 2567 By similarity
Disulfide bond2600 ↔ 2604 By similarity
Disulfide bond2620 ↔ 2658 By similarity
Disulfide bond2624 ↔ 2663 By similarity
Disulfide bond2640 ↔ 2648 By similarity
Disulfide bond2678 ↔ 2713 By similarity
Disulfide bond2682 ↔ 2718 By similarity
Disulfide bond2693 ↔ 2703 By similarity
Disulfide bond2821 ↔ 2859 By similarity
Disulfide bond2832 ↔ 2836 By similarity
Disulfide bond2869 ↔ 2874 By similarity
Disulfide bond3031 ↔ 3080 By similarity
Disulfide bond3035 ↔ 3085 By similarity
Disulfide bond3046 ↔ 3070 By similarity
Disulfide bond3100 ↔ 3137 By similarity
Disulfide bond3104 ↔ 3142 By similarity
Disulfide bond3115 ↔ 3127 By similarity
Disulfide bond3256 ↔ 3299 By similarity
Disulfide bond3260 ↔ 3305 By similarity
Disulfide bond3271 ↔ 3283 By similarity
Disulfide bond3320 ↔ 3355 By similarity
Disulfide bond3323 ↔ 3362 By similarity
Disulfide bond3333 ↔ 3345 By similarity
Disulfide bond3493 ↔ 3523 By similarity
Disulfide bond3497 ↔ 3528 By similarity
Disulfide bond3508 ↔ 3513 By similarity
Disulfide bond3669 ↔ 3707 By similarity
Disulfide bond3673 ↔ 3712 By similarity
Disulfide bond3685 ↔ 3697 By similarity
Disulfide bond3794 ↔ 3830 By similarity
Disulfide bond3805 ↔ 3809 By similarity
Disulfide bond3843 ↔ 3848 By similarity
Disulfide bond3863 ↔ 3900 By similarity
Disulfide bond3867 ↔ 3905 By similarity
Disulfide bond3878 ↔ 3890 By similarity
Disulfide bond4007 ↔ 4043 By similarity
Disulfide bond4018 ↔ 4022 By similarity
Disulfide bond4053 ↔ 4058 By similarity
Disulfide bond4112 ↔ 4149 By similarity
Disulfide bond4116 ↔ 4154 By similarity
Disulfide bond4127 ↔ 4139 By similarity
Disulfide bond4169 ↔ 4207 By similarity
Disulfide bond4173 ↔ 4212 By similarity
Disulfide bond4184 ↔ 4195 By similarity
Disulfide bond4216 ↔ 4253 By similarity
Disulfide bond4227 ↔ 4229 By similarity
Disulfide bond4263 ↔ 4268 By similarity
Disulfide bond4466 ↔ 4500 By similarity
Disulfide bond4477 ↔ 4481 By similarity
Disulfide bond4510 ↔ 4515 By similarity
Disulfide bond4628 ↔ 4663 By similarity
Disulfide bond4632 ↔ 4668 By similarity
Disulfide bond4643 ↔ 4652 By similarity
Disulfide bond4892 ↔ 4952 By similarity
Disulfide bond4918 ↔ 4969 By similarity
Disulfide bond4928 ↔ 4985 By similarity
Disulfide bond4932 ↔ 4987 By similarity
Disulfide bond? ↔ 4990 By similarity

Experimental info

Sequence conflict1921H → Q in CAD42654. Ref.1
Sequence conflict10431V → L in CAD42654. Ref.1
Sequence conflict10491E → Y in CAD42654. Ref.1
Sequence conflict10711V → W in CAD42654. Ref.1
Sequence conflict10801R → P in CAD42654. Ref.1
Sequence conflict17691F → G in CAD42654. Ref.1
Sequence conflict33791P → R in CAD42654. Ref.1
Sequence conflict34121D → H in CAD42654. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8CG65 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 52726F62E3639AEC

FASTA4,998534,975
        10         20         30         40         50         60 
MLPLALLFGM LWTQANGHWC EQIETVHVEE EVTPRQEDLV PCTSLYHYSR LGWQLDLSWS 

        70         80         90        100        110        120 
GRVGLTRPPA LGLCAIYKPP ETRPATWNRT VRACCPGWGG AHCTDALAET SPKGHCFVTW 

       130        140        150        160        170        180 
HCQPLAGSAN SSAGSLEDPA DELGVWPLTL NDPILFPGMS LQWQGDWLVL SGGLGVVVRL 

       190        200        210        220        230        240 
DRSSSISISV DHEFWGRTQG LCGLYNGRPE DDFVEPGGGL ATLAATFGNS WKLPGSEPGC 

       250        260        270        280        290        300 
LDAVEVAWGC ESLLGGTLTD LEAVKLQAQA QDMCHQLLEG PFWQCHGQVQ PDEYHETCLF 

       310        320        330        340        350        360 
AYCVGATAGN GPEGQLEAVC ATFANYAQAC ARQHIYVHWR KPGFCERVCP GGQLYSDCVS 

       370        380        390        400        410        420 
SCPPSCSAVA QGEEGSCGKE CVSGCECPTG LFWDGALCVP AAHCPCYHRR QRYAPGDTVK 

       430        440        450        460        470        480 
QQCNPCVCQD GRWHCAQALC PAECAVGGDG HYFTFDGRSF FFRGTPGCHY SLVQDSVKGQ 

       490        500        510        520        530        540 
LLVVLEHGAC DTGSCLHALS VFLGNTHIQL RYSGAVLVDG EDVDLPWIGV EGFNISWASS 

       550        560        570        580        590        600 
TFLLLHWPGA WVLWGVAEPA AYITLDPRHA YQVQGLCGTF TWKQQDDFLT PAGDIETSVT 

       610        620        630        640        650        660 
AFASKFQVSG DGRCPLVDKS PLFCSSYSQH LTFTEAACAI LHGHAFQECH GLVDREPFRL 

       670        680        690        700        710        720 
RCLEAVCGCA PGRDCLCPVL SAYTRHCAQE GVLLQWRNET LCPVSCPGGQ VYQECAPVCG 

       730        740        750        760        770        780 
HHCGEPEDCK ELGICVAGCN CPPGLLWDLE GQCVPPSMCH CQFGGHRYTI NTTTVRDCSH 

       790        800        810        820        830        840 
CICQERGLWN CTAHHCPRQW ALCPRELIYV PGACLLTCDS PRANHSCWAG STDGCVCPPG 

       850        860        870        880        890        900 
TVLLDKHCVS PDLCPCRHNG QWYPPNATIQ EDCNICVCQG QRWHCTGQRC SGWCQASGAP 

       910        920        930        940        950        960 
HYVTFDGLVF TFPGACEYLL VREAGGRFSV SVQNLPCGAS GLTCTKALVV RLDSTVVHML 

       970        980        990       1000       1010       1020 
RGQAVTVNGV SIRLPKVYTG PGLSLHHAGL FLLLTTRLGL TLLWDGGTRV LVQLSPHFHG 

      1030       1040       1050       1060       1070       1080 
RVAGLCGNFD SDASNDLRSR QGVLEPTAEL TAHSWRLNPL CPEPGDLPHP VNAHRANWAR 

      1090       1100       1110       1120       1130       1140 
ARCEVILQPI FAPCHTEVPP QQYYEWCVYD ACGCDTGGDC ECLCSAIATY ADECARHRHH 

      1150       1160       1170       1180       1190       1200 
VRWRSQELCP LQCEGGQVYE PCGSTCPPTC HDHHSELRWH CQVITCVEGC FCPEGTLLHG 

      1210       1220       1230       1240       1250       1260 
GACMKLAACP CEWQGSFFPP GTVLQKDCGN CTCQGSQWHC DRGGAPCEDM EPGCAEGETL 

      1270       1280       1290       1300       1310       1320 
CRENGHCVPL EWLCDNQDDC GDGSDEEGCA TSVCGEGQMS CQSGHCLPLS LICDGQDDCG 

      1330       1340       1350       1360       1370       1380 
DGTDEQGCLC PHGSLACADG RCLPPALLCN GHPDCLDAAD EESCLGPVSC ISGEVSCVDG 

      1390       1400       1410       1420       1430       1440 
TCVRTIQLCD GVWDCPDGAD EGPSHCSLPS LPTPPGGIGQ NPSTSSLDTA PSPVGSTSPA 

      1450       1460       1470       1480       1490       1500 
SPCSLLEFQC NSGECTPRGW RCDQEEDCTD GSDELDCGGP CMLYQVPCAH SPHCVSPGQL 

      1510       1520       1530       1540       1550       1560 
CDGVTQCPDG SDEDPDVCEE QSASGGANRT GAPCPEFSCP DGTCIDFLLV CDGNPDCELA 

      1570       1580       1590       1600       1610       1620 
DETEPSLDEQ GCGAWGSWGP WAPCSQTCGS GTRSRNRNCS TSSLQVLQNC PGLQHQSQAC 

      1630       1640       1650       1660       1670       1680 
FTEACPVDGE WSSWSPWSPC SEPCGGTTTR HRQCRPPQNG GQDCALLPGS THSTRQTSPC 

      1690       1700       1710       1720       1730       1740 
PQEGCLNATC FGELVFRTCA PCPLTCDDIS GQAACPPDRP CSSPGCWCPD GKVLNTEGQC 

      1750       1760       1770       1780       1790       1800 
VRPRQCPCLV DGAHYWPGQR IKMDCQLCFL DCGWSSWSPW AECLGPCSSQ SLQWSFRSPN 

      1810       1820       1830       1840       1850       1860 
NPRLSGHGRQ CRGIHRKARR CQTEACEGCE QWGLMYNVGE RWRGGPCMVC ECLHSSITHC 

      1870       1880       1890       1900       1910       1920 
SPYCPIGSCP QGWVLVEGMG ESCCHCALPE KNQTVIHMTT PAPAPASAPS PQIGAHLVTY 

      1930       1940       1950       1960       1970       1980 
VLPPTADACY SPLGLAGLPM WAPSQHWEHI TRADPVEAPM AGPGPREGAS AEWHTQPLYL 

      1990       2000       2010       2020       2030       2040 
QLDLRRPRNL TGIIVQRAGS SAAYVSTLSL QFSSDNLQWH NYVNSLSSTL SPPKPSPESS 

      2050       2060       2070       2080       2090       2100 
NHMAPEVWTF DQMVQARYIR VWPHSGHLRD NNQHDIFLWV ELLGLSPLAP LCPGSRHRCA 

      2110       2120       2130       2140       2150       2160 
SGECAPKGGP CDGAVDCDDG SDEEGCGSLH ASTTSRTPAL SPTQPGKFPR EVSEDLRQGA 

      2170       2180       2190       2200       2210       2220 
EAMTSHSPPS SGETAGLIPA SEGTLPVSGQ PMQTLSATST FPPGAKSLHP GMAAVTVHPP 

      2230       2240       2250       2260       2270       2280 
HSVTPGAPVG QTVSPRPFPP MPCGPGQVPC DVLGCVEQEQ LCDGREDCLD GSDEQHCASA 

      2290       2300       2310       2320       2330       2340 
EPFTVPTTAL PGLPASKALC SPSQLRCGSG ECLPFEHRCD LQVNCQDGSD EDNCVDCVLA 

      2350       2360       2370       2380       2390       2400 
PWSGWSDCSR SCGLGLIFQH RELLRLPLPG GSCLLDQFRS QSCFVQACPV AGAWAEWGPW 

      2410       2420       2430       2440       2450       2460 
TACSVSCGGG HQSRQRSCVD PPPKNGGAPC PGPSHEKAPC NLQLCPGDTD CEPGLVHVNA 

      2470       2480       2490       2500       2510       2520 
ELCQKGLVPP CPPSCLDPEA NRSCSGHCME GCRCPPGLLL QDSHCLPLSE CPCLVGQKLI 

      2530       2540       2550       2560       2570       2580 
QPRLAFLLDN CSQCICEKGT LLCKPGACSQ SCGWSAWSPW TACDRSCGSG VRARFRSPTN 

      2590       2600       2610       2620       2630       2640 
PPVAFGGSPC EGDRQELQAC YTDCGTEIPG WTPWTSWSSC SQSCLVPGGD PGWRQRSRLC 

      2650       2660       2670       2680       2690       2700 
PSSRDTFCPG EATQEEPCSP PVCPVPSAWG LWASWSTCSA SCNGGIQTRG RSCSGSAPGN 

      2710       2720       2730       2740       2750       2760 
PVCLGPHTQT RDCNMHPCTA QCPGNMVFRS AEQCLEEGGP CPQLCLAQDP GVECTGSCAP 

      2770       2780       2790       2800       2810       2820 
SCNCPPGLFL HNASCLPRSQ CPCQLHGQLY APGAVAHLDC NNCTCISGEM VCTSKRCPVA 

      2830       2840       2850       2860       2870       2880 
CGWSPWTPWS PCSQSCNVGI RRRFRAGTEP PAAFGGAECQ GPNLDAEFCS LRPCRGPGAA 

      2890       2900       2910       2920       2930       2940 
WSSWTPCSVP CGGGYRNRTQ GSGPHSPIEF STCSLQPCAG PVPGVCPEDQ QWLDCAQGPA 

      2950       2960       2970       2980       2990       3000 
SCAHLSIPGE ANQTCHPGCY CLSGMLLLNN VCVPVQDCPC AHRGRLYSPG SAVHLPCENC 

      3010       3020       3030       3040       3050       3060 
SCISGLITNC SSWPCEEGQP AWSSWTPWSV CSASCNPARR HRHRFCARPP HRAPFSLVLL 

      3070       3080       3090       3100       3110       3120 
TTVAAPTTLC PGPEAEEEPC LLPGCNQAGG WSPWSPWSGC SRSCGGGLRS RTRACDQPSP 

      3130       3140       3150       3160       3170       3180 
QGLGDFCEGP QAQGEACQAQ PCPVTNCSAM EGAEYSPCGP PCPRSCDDLV HCVWRCQPGC 

      3190       3200       3210       3220       3230       3240 
YCPLGKVLSA DGAICVKPSY CSCLDLLTGK RHHAGTQLMR PDGCNHCTCM EGRLNCTDLP 

      3250       3260       3270       3280       3290       3300 
CQVSGDWCPW SKWTACSQPC RGQTRTRSRA CVCPAPQHGG SPCPEESGGT GVQHQMEACP 

      3310       3320       3330       3340       3350       3360 
NATACPVDGA WSPWGPWSSC DACLGQSYRS RVCSHPPISD GGKPCLGGYQ QSRPCRNSST 

      3370       3380       3390       3400       3410       3420 
LCTDCGGGQD LLPCGQPCPH SCQDLSLGST CQPGSAGCQS GCGCPPGQLS QDGLCVFPVD 

      3430       3440       3450       3460       3470       3480 
CHCHFQPRAM GIPENRSRSV GSTLSSWESL EPGEVVTGPC DNCTCVAGIL QCHEVPSCPG 

      3490       3500       3510       3520       3530       3540 
PGIWSSWGPW EKCSVSCGGG EQLRSRQCAR PPCPGLAQQS RICHIHVCRE TGCPAGRLYR 

      3550       3560       3570       3580       3590       3600 
ECQPSDGCPF SCAHVTGQVA CFSERCKEGC HCPEGTFQHH VACVQECPCV LTVLLLQELG 

      3610       3620       3630       3640       3650       3660 
LASAALGSYP TLLGDEGKPL GPGVELLPGQ MLQTDCGNCS CVHGKLSCSM VECSRVHGSF 

      3670       3680       3690       3700       3710       3720 
GPWGMWSLCS RSCGGLGTRT RTRQCVLPTL APGGLSCRGP LQDLEYCFSP ECPGTAGSTV 

      3730       3740       3750       3760       3770       3780 
EPVTGLAGGW GPWSPWSPCS HSCTDPAHPA WRSRTRLCLA NCTVGDSSQE RPCNLPSCAA 

      3790       3800       3810       3820       3830       3840 
LLPCPGPGCG SGNCFWTSWA PWEPCSRSCG VGQQRRLRAY HPPGPGGHWC PDILTAYQER 

      3850       3860       3870       3880       3890       3900 
RFCNLRACPV PGGWSHWSPW SWCDRSCGGG RSLRSRSCSS PPPKNGGTSC VGERHHVRPC 

      3910       3920       3930       3940       3950       3960 
NPMPCEEGCP AGMEMVSCAN HCPYSCSDLQ EGGMCQEDQA CQLGCRCSEG FLEQDGGCVP 

      3970       3980       3990       4000       4010       4020 
VGHCECTDAQ GRSWAPGSQH QDACNNCSCQ AGQLSCTAQL CSPPAHCAWS HWSAWSSCSH 

      4030       4040       4050       4060       4070       4080 
SCGPQGQQSR FRSSTSGSWA LECQKEQSQS QPCPEVPCPP LCLHEAHLHE LGDNWLHGEC 

      4090       4100       4110       4120       4130       4140 
QQCSCTPEGA ICKDTDCAVP RGWTLWSSWS YCSVSCGGGS QVRTRSCTVS APPHGSLSCE 

      4150       4160       4170       4180       4190       4200 
GPDTQTRHCG QQLCLQKLER CSWGPWGPCS RSCGTGLASR SGSCPCLLTK EDSKCNDTFL 

      4210       4220       4230       4240       4250       4260 
GLDTQACYSG PCQDDCTWGD WSSWTRCSCK VLVQQRYRHQ VPAPGQAGEG TPCTRLDGHF 

      4270       4280       4290       4300       4310       4320 
RPCTIGNCSE DSCPPPFEFQ SCGSPCAGLC ATHLNHRLCQ DLPPCQPGCY CPKGLLEQAG 

      4330       4340       4350       4360       4370       4380 
SCILPEQCNC WHISGEGARV TLAPGDRLQL GCKECVCRRG ELQCSSQGCE GLLPLTGWSE 

      4390       4400       4410       4420       4430       4440 
WSPCGPCLPQ SALAPASRTA LEGHWPLNTS DLPPPSVTLL ASEQYRHRLC LDPETRRPWA 

      4450       4460       4470       4480       4490       4500 
GDPALCTVPL SQQRLCPDPG ACNDTCQWGP WGPWSPCQMP CSGGFKLRWR VARDTSAGEC 

      4510       4520       4530       4540       4550       4560 
PGPWAQTESC NMGSCPGESC ETRDTVFTLD CANQCPRSCA DLWDGVQCLQ GPCSPGCRCP 

      4570       4580       4590       4600       4610       4620 
PGQLVQDGHC VPISSCRCGL PSANASWELA PTQVVQLDCH NCTCINGTLM CPHLECPVLG 

      4630       4640       4650       4660       4670       4680 
PWSAWSECSA VCGKGTMVRH RSCEEHPDRE PCQALDLQQW QECNLQACPE CPPGQVLSTC 

      4690       4700       4710       4720       4730       4740 
ATMCPSLCSH LWPGTICVRE PCQLGCGCPG GQLLYNGTCI PPEACPCTQF SLPWGLTLPL 

      4750       4760       4770       4780       4790       4800 
EEQARELPSG TVLTRNCTHC TCQGGAFICS LTDCQECAPG EIWQHGKLGP CEKTCPEMNM 

      4810       4820       4830       4840       4850       4860 
TQAWSNCTEA QAPGCVCQLG YFRSQTGLCV PEDHCECWHH GSPHLPGSEW QEACESCRCL 

      4870       4880       4890       4900       4910       4920 
HGKSVCIRHC PELSCAQGEV IMQEPGSCCP ICQQDTLKEE PVSCRYLTEL RNLTKGPCHL 

      4930       4940       4950       4960       4970       4980 
DQIEVSYCSG HCRSSTNVMT EEPYLQSQCD CCSYRLDPDS PVRILNLLCP DGHTEPVVLP 

      4990 
VIHSCQCSAC QGGDFSKH 

« Hide

References

« Hide 'large scale' references
[1]"Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain."
Goncalves-Mendes N., Simon-Chazottes D., Creveaux I., Meiniel A., Guenet J.-L., Meiniel R.
Gene 312:263-270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
Strain: ICR.
Tissue: Brain.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ491857 mRNA. Translation: CAD42654.1.
AC153815 Genomic DNA. No translation available.
UniGeneMm.25039.

3D structure databases

ProteinModelPortalQ8CG65.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8CG65.

Proteomic databases

PRIDEQ8CG65.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000043676; ENSMUSP00000047991; ENSMUSG00000029797.
UCSCuc009bul.1. mouse.

Organism-specific databases

MGIMGI:2674311. Sspo.

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00730000110607.
HOGENOMHOG000154433.
HOVERGENHBG080794.
InParanoidQ8CG65.

Gene expression databases

ArrayExpressQ8CG65.
BgeeQ8CG65.
CleanExMM_SSPO.
GenevestigatorQ8CG65.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
4.10.400.10. 8 hits.
InterProIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR001545. Gonadotropin_bsu.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR028504. SCO-spondin.
IPR000884. Thrombospondin_1_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PANTHERPTHR22905. PTHR22905. 1 hit.
PfamPF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 7 hits.
PF01826. TIL. 13 hits.
PF00090. TSP_1. 22 hits.
PF00093. VWC. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view]
PRINTSPR00261. LDLRECEPTOR.
SMARTSM00832. C8. 3 hits.
SM00231. FA58C. 1 hit.
SM00068. GHB. 1 hit.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 2 hits.
[Graphical view]
SUPFAMSSF49785. SSF49785. 1 hit.
SSF57424. SSF57424. 9 hits.
SSF57567. SSF57567. 14 hits.
SSF82895. SSF82895. 24 hits.
PROSITEPS01225. CTCK_2. 1 hit.
PS01186. EGF_2. 2 hits.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 10 hits.
PS50092. TSP1. 25 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ8CG65.
SOURCESearch...

Entry information

Entry nameSSPO_MOUSE
AccessionPrimary (citable) accession number: Q8CG65
Secondary accession number(s): E9QMN0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 27, 2011
Last modified: February 19, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot