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Q8CG65

- SSPO_MOUSE

UniProt

Q8CG65 - SSPO_MOUSE

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Protein

SCO-spondin

Gene
Sspo
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
SCO-spondin
Gene namesi
Name:Sspo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2674311. Sspo.

Subcellular locationi

Secretedextracellular space By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 49984981SCO-spondinPRO_0000245043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 4990 By similarity
Glycosylationi88 – 881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi534 – 5341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi698 – 6981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi771 – 7711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi790 – 7901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi824 – 8241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi866 – 8661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1230 – 12301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1254 ↔ 1267 By similarity
Disulfide bondi1261 ↔ 1280 By similarity
Disulfide bondi1274 ↔ 1289 By similarity
Disulfide bondi1294 ↔ 1306 By similarity
Disulfide bondi1301 ↔ 1319 By similarity
Disulfide bondi1313 ↔ 1328 By similarity
Disulfide bondi1330 ↔ 1342 By similarity
Disulfide bondi1337 ↔ 1355 By similarity
Disulfide bondi1349 ↔ 1364 By similarity
Disulfide bondi1370 ↔ 1382 By similarity
Disulfide bondi1377 ↔ 1395 By similarity
Disulfide bondi1389 ↔ 1406 By similarity
Disulfide bondi1443 ↔ 1455 By similarity
Disulfide bondi1450 ↔ 1468 By similarity
Disulfide bondi1462 ↔ 1477 By similarity
Disulfide bondi1481 ↔ 1494 By similarity
Disulfide bondi1488 ↔ 1507 By similarity
Disulfide bondi1501 ↔ 1518 By similarity
Glycosylationi1528 – 15281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1534 ↔ 1544 By similarity
Disulfide bondi1539 ↔ 1557 By similarity
Disulfide bondi1551 ↔ 1572 By similarity
Disulfide bondi1584 ↔ 1620 By similarity
Disulfide bondi1588 ↔ 1625 By similarity
Glycosylationi1598 – 15981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1599 ↔ 1610 By similarity
Disulfide bondi1640 ↔ 1680 By similarity
Disulfide bondi1644 ↔ 1685 By similarity
Disulfide bondi1654 ↔ 1664 By similarity
Glycosylationi1687 – 16871N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1772 ↔ 1811 By similarity
Disulfide bondi1783 ↔ 1787 By similarity
Disulfide bondi1821 ↔ 1826 By similarity
Glycosylationi1892 – 18921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1989 – 19891N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2092 ↔ 2104 By similarity
Disulfide bondi2099 ↔ 2117 By similarity
Disulfide bondi2111 ↔ 2126 By similarity
Disulfide bondi2243 ↔ 2255 By similarity
Disulfide bondi2250 ↔ 2268 By similarity
Disulfide bondi2262 ↔ 2277 By similarity
Disulfide bondi2300 ↔ 2312 By similarity
Disulfide bondi2307 ↔ 2325 By similarity
Disulfide bondi2319 ↔ 2334 By similarity
Disulfide bondi2337 ↔ 2373 By similarity
Disulfide bondi2348 ↔ 2352 By similarity
Disulfide bondi2383 ↔ 2388 By similarity
Disulfide bondi2403 ↔ 2440 By similarity
Disulfide bondi2407 ↔ 2445 By similarity
Disulfide bondi2418 ↔ 2430 By similarity
Glycosylationi2481 – 24811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2530 – 25301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2552 ↔ 2590 By similarity
Disulfide bondi2563 ↔ 2567 By similarity
Disulfide bondi2600 ↔ 2604 By similarity
Disulfide bondi2620 ↔ 2658 By similarity
Disulfide bondi2624 ↔ 2663 By similarity
Disulfide bondi2640 ↔ 2648 By similarity
Disulfide bondi2678 ↔ 2713 By similarity
Disulfide bondi2682 ↔ 2718 By similarity
Disulfide bondi2693 ↔ 2703 By similarity
Glycosylationi2772 – 27721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2802 – 28021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2821 ↔ 2859 By similarity
Disulfide bondi2832 ↔ 2836 By similarity
Disulfide bondi2869 ↔ 2874 By similarity
Glycosylationi2897 – 28971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2952 – 29521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2999 – 29991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3009 – 30091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3031 ↔ 3080 By similarity
Disulfide bondi3035 ↔ 3085 By similarity
Disulfide bondi3046 ↔ 3070 By similarity
Disulfide bondi3100 ↔ 3137 By similarity
Disulfide bondi3104 ↔ 3142 By similarity
Disulfide bondi3115 ↔ 3127 By similarity
Glycosylationi3146 – 31461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3235 – 32351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3256 ↔ 3299 By similarity
Disulfide bondi3260 ↔ 3305 By similarity
Disulfide bondi3271 ↔ 3283 By similarity
Glycosylationi3301 – 33011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3320 ↔ 3355 By similarity
Disulfide bondi3323 ↔ 3362 By similarity
Disulfide bondi3333 ↔ 3345 By similarity
Glycosylationi3357 – 33571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3435 – 34351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3462 – 34621N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3493 ↔ 3523 By similarity
Disulfide bondi3497 ↔ 3528 By similarity
Disulfide bondi3508 ↔ 3513 By similarity
Glycosylationi3638 – 36381N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3669 ↔ 3707 By similarity
Disulfide bondi3673 ↔ 3712 By similarity
Disulfide bondi3685 ↔ 3697 By similarity
Glycosylationi3761 – 37611N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3794 ↔ 3830 By similarity
Disulfide bondi3805 ↔ 3809 By similarity
Disulfide bondi3843 ↔ 3848 By similarity
Disulfide bondi3863 ↔ 3900 By similarity
Disulfide bondi3867 ↔ 3905 By similarity
Disulfide bondi3878 ↔ 3890 By similarity
Glycosylationi3986 – 39861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4007 ↔ 4043 By similarity
Disulfide bondi4018 ↔ 4022 By similarity
Disulfide bondi4053 ↔ 4058 By similarity
Disulfide bondi4112 ↔ 4149 By similarity
Disulfide bondi4116 ↔ 4154 By similarity
Disulfide bondi4127 ↔ 4139 By similarity
Disulfide bondi4169 ↔ 4207 By similarity
Disulfide bondi4173 ↔ 4212 By similarity
Disulfide bondi4184 ↔ 4195 By similarity
Glycosylationi4196 – 41961N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4216 ↔ 4253 By similarity
Disulfide bondi4227 ↔ 4229 By similarity
Disulfide bondi4263 ↔ 4268 By similarity
Glycosylationi4267 – 42671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4408 – 44081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4463 – 44631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4466 ↔ 4500 By similarity
Disulfide bondi4477 ↔ 4481 By similarity
Disulfide bondi4510 ↔ 4515 By similarity
Glycosylationi4584 – 45841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4601 – 46011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4606 – 46061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4628 ↔ 4663 By similarity
Disulfide bondi4632 ↔ 4668 By similarity
Disulfide bondi4643 ↔ 4652 By similarity
Glycosylationi4716 – 47161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4756 – 47561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4799 – 47991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4806 – 48061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4892 ↔ 4952 By similarity
Glycosylationi4912 – 49121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4918 ↔ 4969 By similarity
Disulfide bondi4928 ↔ 4985 By similarity
Disulfide bondi4932 ↔ 4987 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8CG65.

PTM databases

PhosphoSiteiQ8CG65.

Expressioni

Tissue specificityi

Subcommissural organ.1 Publication

Developmental stagei

Weakly expressed at E14 and E15 in the SCO anlage; increasing progressively until E17 dpc.1 Publication

Gene expression databases

BgeeiQ8CG65.
CleanExiMM_SSPO.
GenevestigatoriQ8CG65.

Structurei

3D structure databases

ProteinModelPortaliQ8CG65.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 10285EMIAdd
BLAST
Domaini163 – 288126VWFD 1Add
BLAST
Domaini349 – 40456TIL 1Add
BLAST
Domaini404 – 49693VWFC 1Add
BLAST
Domaini443 – 652210VWFD 2Add
BLAST
Domaini706 – 75954TIL 2Add
BLAST
Domaini893 – 1097205VWFD 3Add
BLAST
Domaini1153 – 120957TIL 3Add
BLAST
Domaini1253 – 129038LDL-receptor class A 1Add
BLAST
Domaini1293 – 132836LDL-receptor class A 2Add
BLAST
Domaini1329 – 136537LDL-receptor class A 3Add
BLAST
Domaini1369 – 140739LDL-receptor class A 4Add
BLAST
Domaini1442 – 147837LDL-receptor class A 5Add
BLAST
Domaini1480 – 151940LDL-receptor class A 6Add
BLAST
Domaini1533 – 157139LDL-receptor class A 7Add
BLAST
Domaini1572 – 162655TSP type-1 1Add
BLAST
Domaini1628 – 168659TSP type-1 2Add
BLAST
Domaini1702 – 174140EGF-like 1Add
BLAST
Domaini1742 – 176827EGF-like 2Add
BLAST
Domaini1771 – 182757TSP type-1 3Add
BLAST
Domaini1827 – 188761VWFC 2Add
BLAST
Domaini1929 – 2085157F5/8 type CAdd
BLAST
Domaini2091 – 212737LDL-receptor class A 8Add
BLAST
Domaini2242 – 227837LDL-receptor class A 9Add
BLAST
Domaini2299 – 233537LDL-receptor class A 10Add
BLAST
Domaini2336 – 238954TSP type-1 4Add
BLAST
Domaini2391 – 244656TSP type-1 5Add
BLAST
Domaini2469 – 251143TIL 4Add
BLAST
Domaini2551 – 260555TSP type-1 6Add
BLAST
Domaini2609 – 266456TSP type-1 7Add
BLAST
Domaini2666 – 271954TSP type-1 8Add
BLAST
Domaini2820 – 287556TSP type-1 9Add
BLAST
Domaini2876 – 291944TSP type-1 10Add
BLAST
Domaini2926 – 297853TIL 5Add
BLAST
Domaini3019 – 308668TSP type-1 11Add
BLAST
Domaini3088 – 314356TSP type-1 12Add
BLAST
Domaini3147 – 320155TIL 6Add
BLAST
Domaini3244 – 330663TSP type-1 13Add
BLAST
Domaini3308 – 336356TSP type-1 14Add
BLAST
Domaini3481 – 352949TSP type-1 15Add
BLAST
Domaini3657 – 371357TSP type-1 16Add
BLAST
Domaini3727 – 377953TSP type-1 17Add
BLAST
Domaini3793 – 384957TSP type-1 18Add
BLAST
Domaini3851 – 390656TSP type-1 19Add
BLAST
Domaini3909 – 396456TIL 7Add
BLAST
Domaini4006 – 405954TSP type-1 20Add
BLAST
Domaini4100 – 415556TSP type-1 21Add
BLAST
Domaini4157 – 421357TSP type-1 22Add
BLAST
Domaini4215 – 426955TSP type-1 23Add
BLAST
Domaini4465 – 451652TSP type-1 24Add
BLAST
Domaini4616 – 466954TSP type-1 25Add
BLAST
Domaini4835 – 489359VWFC 3Add
BLAST
Domaini4892 – 4991100CTCKAdd
BLAST

Sequence similaritiesi

Belongs to the thrombospondin family.
Contains 2 EGF-like domains.
Contains 1 EMI domain.
Contains 1 F5/8 type C domain.
Contains 25 TSP type-1 domains.
Contains 3 VWFC domains.
Contains 3 VWFD domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000110607.
HOGENOMiHOG000154433.
HOVERGENiHBG080794.
InParanoidiQ8CG65.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
4.10.400.10. 8 hits.
InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR001545. Gonadotropin_bsu.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR000884. Thrombospondin_1_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 7 hits.
PF01826. TIL. 13 hits.
PF00090. TSP_1. 22 hits.
PF00093. VWC. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00832. C8. 3 hits.
SM00231. FA58C. 1 hit.
SM00068. GHB. 1 hit.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 2 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF57424. SSF57424. 9 hits.
SSF57567. SSF57567. 14 hits.
SSF82895. SSF82895. 24 hits.
PROSITEiPS01225. CTCK_2. 1 hit.
PS01186. EGF_2. 2 hits.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 10 hits.
PS50092. TSP1. 25 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CG65-1 [UniParc]FASTAAdd to Basket

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MLPLALLFGM LWTQANGHWC EQIETVHVEE EVTPRQEDLV PCTSLYHYSR     50
LGWQLDLSWS GRVGLTRPPA LGLCAIYKPP ETRPATWNRT VRACCPGWGG 100
AHCTDALAET SPKGHCFVTW HCQPLAGSAN SSAGSLEDPA DELGVWPLTL 150
NDPILFPGMS LQWQGDWLVL SGGLGVVVRL DRSSSISISV DHEFWGRTQG 200
LCGLYNGRPE DDFVEPGGGL ATLAATFGNS WKLPGSEPGC LDAVEVAWGC 250
ESLLGGTLTD LEAVKLQAQA QDMCHQLLEG PFWQCHGQVQ PDEYHETCLF 300
AYCVGATAGN GPEGQLEAVC ATFANYAQAC ARQHIYVHWR KPGFCERVCP 350
GGQLYSDCVS SCPPSCSAVA QGEEGSCGKE CVSGCECPTG LFWDGALCVP 400
AAHCPCYHRR QRYAPGDTVK QQCNPCVCQD GRWHCAQALC PAECAVGGDG 450
HYFTFDGRSF FFRGTPGCHY SLVQDSVKGQ LLVVLEHGAC DTGSCLHALS 500
VFLGNTHIQL RYSGAVLVDG EDVDLPWIGV EGFNISWASS TFLLLHWPGA 550
WVLWGVAEPA AYITLDPRHA YQVQGLCGTF TWKQQDDFLT PAGDIETSVT 600
AFASKFQVSG DGRCPLVDKS PLFCSSYSQH LTFTEAACAI LHGHAFQECH 650
GLVDREPFRL RCLEAVCGCA PGRDCLCPVL SAYTRHCAQE GVLLQWRNET 700
LCPVSCPGGQ VYQECAPVCG HHCGEPEDCK ELGICVAGCN CPPGLLWDLE 750
GQCVPPSMCH CQFGGHRYTI NTTTVRDCSH CICQERGLWN CTAHHCPRQW 800
ALCPRELIYV PGACLLTCDS PRANHSCWAG STDGCVCPPG TVLLDKHCVS 850
PDLCPCRHNG QWYPPNATIQ EDCNICVCQG QRWHCTGQRC SGWCQASGAP 900
HYVTFDGLVF TFPGACEYLL VREAGGRFSV SVQNLPCGAS GLTCTKALVV 950
RLDSTVVHML RGQAVTVNGV SIRLPKVYTG PGLSLHHAGL FLLLTTRLGL 1000
TLLWDGGTRV LVQLSPHFHG RVAGLCGNFD SDASNDLRSR QGVLEPTAEL 1050
TAHSWRLNPL CPEPGDLPHP VNAHRANWAR ARCEVILQPI FAPCHTEVPP 1100
QQYYEWCVYD ACGCDTGGDC ECLCSAIATY ADECARHRHH VRWRSQELCP 1150
LQCEGGQVYE PCGSTCPPTC HDHHSELRWH CQVITCVEGC FCPEGTLLHG 1200
GACMKLAACP CEWQGSFFPP GTVLQKDCGN CTCQGSQWHC DRGGAPCEDM 1250
EPGCAEGETL CRENGHCVPL EWLCDNQDDC GDGSDEEGCA TSVCGEGQMS 1300
CQSGHCLPLS LICDGQDDCG DGTDEQGCLC PHGSLACADG RCLPPALLCN 1350
GHPDCLDAAD EESCLGPVSC ISGEVSCVDG TCVRTIQLCD GVWDCPDGAD 1400
EGPSHCSLPS LPTPPGGIGQ NPSTSSLDTA PSPVGSTSPA SPCSLLEFQC 1450
NSGECTPRGW RCDQEEDCTD GSDELDCGGP CMLYQVPCAH SPHCVSPGQL 1500
CDGVTQCPDG SDEDPDVCEE QSASGGANRT GAPCPEFSCP DGTCIDFLLV 1550
CDGNPDCELA DETEPSLDEQ GCGAWGSWGP WAPCSQTCGS GTRSRNRNCS 1600
TSSLQVLQNC PGLQHQSQAC FTEACPVDGE WSSWSPWSPC SEPCGGTTTR 1650
HRQCRPPQNG GQDCALLPGS THSTRQTSPC PQEGCLNATC FGELVFRTCA 1700
PCPLTCDDIS GQAACPPDRP CSSPGCWCPD GKVLNTEGQC VRPRQCPCLV 1750
DGAHYWPGQR IKMDCQLCFL DCGWSSWSPW AECLGPCSSQ SLQWSFRSPN 1800
NPRLSGHGRQ CRGIHRKARR CQTEACEGCE QWGLMYNVGE RWRGGPCMVC 1850
ECLHSSITHC SPYCPIGSCP QGWVLVEGMG ESCCHCALPE KNQTVIHMTT 1900
PAPAPASAPS PQIGAHLVTY VLPPTADACY SPLGLAGLPM WAPSQHWEHI 1950
TRADPVEAPM AGPGPREGAS AEWHTQPLYL QLDLRRPRNL TGIIVQRAGS 2000
SAAYVSTLSL QFSSDNLQWH NYVNSLSSTL SPPKPSPESS NHMAPEVWTF 2050
DQMVQARYIR VWPHSGHLRD NNQHDIFLWV ELLGLSPLAP LCPGSRHRCA 2100
SGECAPKGGP CDGAVDCDDG SDEEGCGSLH ASTTSRTPAL SPTQPGKFPR 2150
EVSEDLRQGA EAMTSHSPPS SGETAGLIPA SEGTLPVSGQ PMQTLSATST 2200
FPPGAKSLHP GMAAVTVHPP HSVTPGAPVG QTVSPRPFPP MPCGPGQVPC 2250
DVLGCVEQEQ LCDGREDCLD GSDEQHCASA EPFTVPTTAL PGLPASKALC 2300
SPSQLRCGSG ECLPFEHRCD LQVNCQDGSD EDNCVDCVLA PWSGWSDCSR 2350
SCGLGLIFQH RELLRLPLPG GSCLLDQFRS QSCFVQACPV AGAWAEWGPW 2400
TACSVSCGGG HQSRQRSCVD PPPKNGGAPC PGPSHEKAPC NLQLCPGDTD 2450
CEPGLVHVNA ELCQKGLVPP CPPSCLDPEA NRSCSGHCME GCRCPPGLLL 2500
QDSHCLPLSE CPCLVGQKLI QPRLAFLLDN CSQCICEKGT LLCKPGACSQ 2550
SCGWSAWSPW TACDRSCGSG VRARFRSPTN PPVAFGGSPC EGDRQELQAC 2600
YTDCGTEIPG WTPWTSWSSC SQSCLVPGGD PGWRQRSRLC PSSRDTFCPG 2650
EATQEEPCSP PVCPVPSAWG LWASWSTCSA SCNGGIQTRG RSCSGSAPGN 2700
PVCLGPHTQT RDCNMHPCTA QCPGNMVFRS AEQCLEEGGP CPQLCLAQDP 2750
GVECTGSCAP SCNCPPGLFL HNASCLPRSQ CPCQLHGQLY APGAVAHLDC 2800
NNCTCISGEM VCTSKRCPVA CGWSPWTPWS PCSQSCNVGI RRRFRAGTEP 2850
PAAFGGAECQ GPNLDAEFCS LRPCRGPGAA WSSWTPCSVP CGGGYRNRTQ 2900
GSGPHSPIEF STCSLQPCAG PVPGVCPEDQ QWLDCAQGPA SCAHLSIPGE 2950
ANQTCHPGCY CLSGMLLLNN VCVPVQDCPC AHRGRLYSPG SAVHLPCENC 3000
SCISGLITNC SSWPCEEGQP AWSSWTPWSV CSASCNPARR HRHRFCARPP 3050
HRAPFSLVLL TTVAAPTTLC PGPEAEEEPC LLPGCNQAGG WSPWSPWSGC 3100
SRSCGGGLRS RTRACDQPSP QGLGDFCEGP QAQGEACQAQ PCPVTNCSAM 3150
EGAEYSPCGP PCPRSCDDLV HCVWRCQPGC YCPLGKVLSA DGAICVKPSY 3200
CSCLDLLTGK RHHAGTQLMR PDGCNHCTCM EGRLNCTDLP CQVSGDWCPW 3250
SKWTACSQPC RGQTRTRSRA CVCPAPQHGG SPCPEESGGT GVQHQMEACP 3300
NATACPVDGA WSPWGPWSSC DACLGQSYRS RVCSHPPISD GGKPCLGGYQ 3350
QSRPCRNSST LCTDCGGGQD LLPCGQPCPH SCQDLSLGST CQPGSAGCQS 3400
GCGCPPGQLS QDGLCVFPVD CHCHFQPRAM GIPENRSRSV GSTLSSWESL 3450
EPGEVVTGPC DNCTCVAGIL QCHEVPSCPG PGIWSSWGPW EKCSVSCGGG 3500
EQLRSRQCAR PPCPGLAQQS RICHIHVCRE TGCPAGRLYR ECQPSDGCPF 3550
SCAHVTGQVA CFSERCKEGC HCPEGTFQHH VACVQECPCV LTVLLLQELG 3600
LASAALGSYP TLLGDEGKPL GPGVELLPGQ MLQTDCGNCS CVHGKLSCSM 3650
VECSRVHGSF GPWGMWSLCS RSCGGLGTRT RTRQCVLPTL APGGLSCRGP 3700
LQDLEYCFSP ECPGTAGSTV EPVTGLAGGW GPWSPWSPCS HSCTDPAHPA 3750
WRSRTRLCLA NCTVGDSSQE RPCNLPSCAA LLPCPGPGCG SGNCFWTSWA 3800
PWEPCSRSCG VGQQRRLRAY HPPGPGGHWC PDILTAYQER RFCNLRACPV 3850
PGGWSHWSPW SWCDRSCGGG RSLRSRSCSS PPPKNGGTSC VGERHHVRPC 3900
NPMPCEEGCP AGMEMVSCAN HCPYSCSDLQ EGGMCQEDQA CQLGCRCSEG 3950
FLEQDGGCVP VGHCECTDAQ GRSWAPGSQH QDACNNCSCQ AGQLSCTAQL 4000
CSPPAHCAWS HWSAWSSCSH SCGPQGQQSR FRSSTSGSWA LECQKEQSQS 4050
QPCPEVPCPP LCLHEAHLHE LGDNWLHGEC QQCSCTPEGA ICKDTDCAVP 4100
RGWTLWSSWS YCSVSCGGGS QVRTRSCTVS APPHGSLSCE GPDTQTRHCG 4150
QQLCLQKLER CSWGPWGPCS RSCGTGLASR SGSCPCLLTK EDSKCNDTFL 4200
GLDTQACYSG PCQDDCTWGD WSSWTRCSCK VLVQQRYRHQ VPAPGQAGEG 4250
TPCTRLDGHF RPCTIGNCSE DSCPPPFEFQ SCGSPCAGLC ATHLNHRLCQ 4300
DLPPCQPGCY CPKGLLEQAG SCILPEQCNC WHISGEGARV TLAPGDRLQL 4350
GCKECVCRRG ELQCSSQGCE GLLPLTGWSE WSPCGPCLPQ SALAPASRTA 4400
LEGHWPLNTS DLPPPSVTLL ASEQYRHRLC LDPETRRPWA GDPALCTVPL 4450
SQQRLCPDPG ACNDTCQWGP WGPWSPCQMP CSGGFKLRWR VARDTSAGEC 4500
PGPWAQTESC NMGSCPGESC ETRDTVFTLD CANQCPRSCA DLWDGVQCLQ 4550
GPCSPGCRCP PGQLVQDGHC VPISSCRCGL PSANASWELA PTQVVQLDCH 4600
NCTCINGTLM CPHLECPVLG PWSAWSECSA VCGKGTMVRH RSCEEHPDRE 4650
PCQALDLQQW QECNLQACPE CPPGQVLSTC ATMCPSLCSH LWPGTICVRE 4700
PCQLGCGCPG GQLLYNGTCI PPEACPCTQF SLPWGLTLPL EEQARELPSG 4750
TVLTRNCTHC TCQGGAFICS LTDCQECAPG EIWQHGKLGP CEKTCPEMNM 4800
TQAWSNCTEA QAPGCVCQLG YFRSQTGLCV PEDHCECWHH GSPHLPGSEW 4850
QEACESCRCL HGKSVCIRHC PELSCAQGEV IMQEPGSCCP ICQQDTLKEE 4900
PVSCRYLTEL RNLTKGPCHL DQIEVSYCSG HCRSSTNVMT EEPYLQSQCD 4950
CCSYRLDPDS PVRILNLLCP DGHTEPVVLP VIHSCQCSAC QGGDFSKH 4998
Length:4,998
Mass (Da):534,975
Last modified:July 27, 2011 - v2
Checksum:i52726F62E3639AEC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921H → Q in CAD42654. 1 Publication
Sequence conflicti1043 – 10431V → L in CAD42654. 1 Publication
Sequence conflicti1049 – 10491E → Y in CAD42654. 1 Publication
Sequence conflicti1071 – 10711V → W in CAD42654. 1 Publication
Sequence conflicti1080 – 10801R → P in CAD42654. 1 Publication
Sequence conflicti1769 – 17691F → G in CAD42654. 1 Publication
Sequence conflicti3379 – 33791P → R in CAD42654. 1 Publication
Sequence conflicti3412 – 34121D → H in CAD42654. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ491857 mRNA. Translation: CAD42654.1.
AC153815 Genomic DNA. No translation available.
UniGeneiMm.25039.

Genome annotation databases

EnsembliENSMUST00000043676; ENSMUSP00000047991; ENSMUSG00000029797.
UCSCiuc009bul.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ491857 mRNA. Translation: CAD42654.1 .
AC153815 Genomic DNA. No translation available.
UniGenei Mm.25039.

3D structure databases

ProteinModelPortali Q8CG65.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8CG65.

Proteomic databases

PRIDEi Q8CG65.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043676 ; ENSMUSP00000047991 ; ENSMUSG00000029797 .
UCSCi uc009bul.1. mouse.

Organism-specific databases

MGIi MGI:2674311. Sspo.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000110607.
HOGENOMi HOG000154433.
HOVERGENi HBG080794.
InParanoidi Q8CG65.

Miscellaneous databases

PROi Q8CG65.
SOURCEi Search...

Gene expression databases

Bgeei Q8CG65.
CleanExi MM_SSPO.
Genevestigatori Q8CG65.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
4.10.400.10. 8 hits.
InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR001545. Gonadotropin_bsu.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR000884. Thrombospondin_1_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 7 hits.
PF01826. TIL. 13 hits.
PF00090. TSP_1. 22 hits.
PF00093. VWC. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view ]
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00832. C8. 3 hits.
SM00231. FA58C. 1 hit.
SM00068. GHB. 1 hit.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 2 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF57424. SSF57424. 9 hits.
SSF57567. SSF57567. 14 hits.
SSF82895. SSF82895. 24 hits.
PROSITEi PS01225. CTCK_2. 1 hit.
PS01186. EGF_2. 2 hits.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 10 hits.
PS50092. TSP1. 25 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain."
    Goncalves-Mendes N., Simon-Chazottes D., Creveaux I., Meiniel A., Guenet J.-L., Meiniel R.
    Gene 312:263-270(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: ICR.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiSSPO_MOUSE
AccessioniPrimary (citable) accession number: Q8CG65
Secondary accession number(s): E9QMN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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